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Conserved domains on  [gi|1034639767|ref|XP_016863657|]
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leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-170 1.85e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  75 EAFYYLVELQYLWVTYNSVASIdPSSFYNLKQLHELRLDGNSLAAFPwASLLDMPLLRTLDLHNNKITSVPNeaLRYLKN 154
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTN 251

                          90
                  ....*....|....*.
gi 1034639767 155 LAYLDLSSNRLTTLPP 170
Cdd:COG4886   252 LEELDLSNNQLTDLPP 267
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-170 1.85e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  75 EAFYYLVELQYLWVTYNSVASIdPSSFYNLKQLHELRLDGNSLAAFPwASLLDMPLLRTLDLHNNKITSVPNeaLRYLKN 154
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTN 251

                          90
                  ....*....|....*.
gi 1034639767 155 LAYLDLSSNRLTTLPP 170
Cdd:COG4886   252 LEELDLSNNQLTDLPP 267
LRR_8 pfam13855
Leucine rich repeat;
106-165 7.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 7.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767 106 QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 165
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-179 1.45e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  69 IRRIsaEAFYYLVELQYLWVTYNSVASIdpSSFYNLKQLHELRLDGNSLA-----AFPWASLLDM-PLLRTLDLHNNKIT 142
Cdd:cd21340    58 IEKI--ENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNID 133

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034639767 143 SVpnEALRYLKNLAYLDLSSNRLTTLPP--DFLESWTHL 179
Cdd:cd21340   134 SL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSL 170
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-196 2.73e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  38 SRLVLCNDMdmNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELqylWVTYNSVASIDPSSFYNLKQLHElrlDGNSL 117
Cdd:PRK15370  266 SLDLFHNKI--SCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHL---NVQSNSLTALPETLPPGLKTLEA---GENAL 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767 118 AAFPwASLldMPLLRTLDLHNNKITSVPnEALRylKNLAYLDLSSNRLTTLPPD------FLE-SWTHLVSTPSGVLDL- 189
Cdd:PRK15370  338 TSLP-ASL--PPELQVLDVSKNQITVLP-ETLP--PTITTLDVSRNALTNLPENlpaalqIMQaSRNNLVRLPESLPHFr 411

                         170
                  ....*....|.
gi 1034639767 190 ----SPSRIIL 196
Cdd:PRK15370  412 gegpQPTRIIV 422
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-170 1.85e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  75 EAFYYLVELQYLWVTYNSVASIdPSSFYNLKQLHELRLDGNSLAAFPwASLLDMPLLRTLDLHNNKITSVPNeaLRYLKN 154
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTN 251

                          90
                  ....*....|....*.
gi 1034639767 155 LAYLDLSSNRLTTLPP 170
Cdd:COG4886   252 LEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-194 5.92e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 5.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  75 EAFYYLVELQYLWVTYNSVASIdPSSFYNLKQLHELRLDGNSLAAFPwASLLDMPLLRTLDLHNNKITSVPnEALRYLKN 154
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTN 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034639767 155 LAYLDLSSNRLTTLPPDfLESWTHLVStpsgvLDLSPSRI 194
Cdd:COG4886   207 LEELDLSGNQLTDLPEP-LANLTNLET-----LDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-181 5.59e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 5.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  75 EAFYYLVELQYLWVTYNSVASIdPSSFYNLKQLHELRLDGNSLAAFPWasLLDMPLLRTLDLHNNKITSVPNEAlrYLKN 154
Cdd:COG4886   199 EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTN 273

                          90       100
                  ....*....|....*....|....*..
gi 1034639767 155 LAYLDLSSNRLTTLPPDFLESWTHLVS 181
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR_8 pfam13855
Leucine rich repeat;
106-165 7.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 7.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767 106 QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 165
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-190 1.78e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  97 DPSSFYNLKQLHELRLDGNSLAAFPwASLLDMPLLRTLDLHNNKITSVPnEALRYLKNLAYLDLSSNRLTTLpPDFLESW 176
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                          90
                  ....*....|....
gi 1034639767 177 THLVStpsgvLDLS 190
Cdd:COG4886   182 TNLKE-----LDLS 190
LRR_8 pfam13855
Leucine rich repeat;
129-171 3.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.24e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034639767 129 PLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPD 171
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPG 43
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-179 1.45e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  69 IRRIsaEAFYYLVELQYLWVTYNSVASIdpSSFYNLKQLHELRLDGNSLA-----AFPWASLLDM-PLLRTLDLHNNKIT 142
Cdd:cd21340    58 IEKI--ENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNID 133

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034639767 143 SVpnEALRYLKNLAYLDLSSNRLTTLPP--DFLESWTHL 179
Cdd:cd21340   134 SL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSL 170
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-196 2.73e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  38 SRLVLCNDMdmNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELqylWVTYNSVASIDPSSFYNLKQLHElrlDGNSL 117
Cdd:PRK15370  266 SLDLFHNKI--SCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHL---NVQSNSLTALPETLPPGLKTLEA---GENAL 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767 118 AAFPwASLldMPLLRTLDLHNNKITSVPnEALRylKNLAYLDLSSNRLTTLPPD------FLE-SWTHLVSTPSGVLDL- 189
Cdd:PRK15370  338 TSLP-ASL--PPELQVLDVSKNQITVLP-ETLP--PTITTLDVSRNALTNLPENlpaalqIMQaSRNNLVRLPESLPHFr 411

                         170
                  ....*....|.
gi 1034639767 190 ----SPSRIIL 196
Cdd:PRK15370  412 gegpQPTRIIV 422
LRR_8 pfam13855
Leucine rich repeat;
82-141 6.52e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 6.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  82 ELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKI 141
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-179 6.14e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 6.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  80 LVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLD 159
Cdd:PLN00113  235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILH 314

                          90       100
                  ....*....|....*....|
gi 1034639767 160 LSSNRLTTLPPDFLESWTHL 179
Cdd:PLN00113  315 LFSNNFTGKIPVALTSLPRL 334
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-170 1.55e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034639767 129 PLLRTLDLHNNKITSVPNeaLRYLKNLAYLDLSSN-RLTTLPP 170
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-194 3.12e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  82 ELQYLWVTYNSVASIDPSSFYNlKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLS 161
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034639767 162 SNRLTTLPPDFLESWTHLvstpsGVLDLSPSRI 194
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVL-----SQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-179 3.27e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  80 LVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAA-------------------------FPWAsLLDMPLLRTL 134
Cdd:PLN00113  259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGeipelviqlqnleilhlfsnnftgkIPVA-LTSLPRLQVL 337

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034639767 135 DLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHL 179
Cdd:PLN00113  338 QLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNL 382
LRR_8 pfam13855
Leucine rich repeat;
61-117 3.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 3.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034639767  61 KLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSL 117
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-166 4.03e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 4.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034639767 107 LHELRLDGNSLAAFPWASLL----DMPLLRTLDLHNNKIT----SVPNEALRYLKNLAYLDLSSNRLT 166
Cdd:cd00116   167 LKELNLANNGIGDAGIRALAeglkANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLT 234
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-179 5.08e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.69  E-value: 5.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034639767 104 LKQLHELRLDGNSLAAFPwasLLDM-PLLRTLDLHNNKITSVPNeaLRYLKNLAYLDLSSNRLTTLppDFLESWTHL 179
Cdd:cd21340     1 LKRITHLYLNDKNITKID---NLSLcKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNL 70
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 105-166 6.91e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 6.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767 105 KQLHELRLDGNSL---AAFPWASLLDM-PLLRTLDLHNNKIT----SVPNEALRYLKNLAYLDLSSNRLT 166
Cdd:COG5238   208 TTVTTLWLKRNPIgdeGAEILAEALKGnKSLTTLDLSNNQIGdegvIALAEALKNNTTVETLYLSGNQIG 277
PLN03150 PLN03150
hypothetical protein; Provisional
 98-166 9.02e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 36.33  E-value: 9.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639767  98 PSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKIT-SVPnEALRYLKNLAYLDLSSNRLT 166
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLS 503
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 104-167 9.08e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.18  E-value: 9.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034639767 104 LKQLHELRLDGNSLAAFPWASLLD-MPL----LRTLDLHNNKITSVPNEAL-RYLKN---LAYLDLSSNRLTT 167
Cdd:cd00116   220 LKSLEVLNLGDNNLTDAGAAALASaLLSpnisLLTLSLSCNDITDDGAKDLaEVLAEkesLLELDLRGNKFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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