|
Name |
Accession |
Description |
Interval |
E-value |
| Zona_pellucida |
pfam00100 |
Zona pellucida-like domain; |
1017-1257 |
6.04e-40 |
|
Zona pellucida-like domain;
:
Pssm-ID: 459673 [Multi-domain] Cd Length: 254 Bit Score: 148.91 E-value: 6.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1017 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1091
Cdd:pfam00100 1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1092 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1165
Cdd:pfam00100 80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1166 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1239
Cdd:pfam00100 158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237
|
250
....*....|....*...
gi 1034627714 1240 KLRVCmESPGATCKINCN 1257
Cdd:pfam00100 238 SVSVC-SSDSNSCGKSCS 254
|
|
| WAP |
pfam00095 |
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ... |
13-53 |
1.19e-10 |
|
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.
:
Pssm-ID: 459672 [Multi-domain] Cd Length: 42 Bit Score: 57.82 E-value: 1.19e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1034627714 13 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 53
Cdd:pfam00095 1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
|
|
| Herpes_BLLF1 super family |
cl37540 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
458-679 |
3.63e-09 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
The actual alignment was detected with superfamily member pfam05109:
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.47 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 458 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 536
Cdd:pfam05109 447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 537 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 616
Cdd:pfam05109 525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627714 617 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 679
Cdd:pfam05109 601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
403-433 |
5.51e-07 |
|
Calcium-binding EGF domain;
:
Pssm-ID: 429571 Cd Length: 32 Bit Score: 46.85 E-value: 5.51e-07
10 20 30
....*....|....*....|....*....|.
gi 1034627714 403 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 433
Cdd:pfam07645 1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
921-952 |
2.85e-06 |
|
Calcium-binding EGF-like domain;
:
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 2.85e-06
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:smart00179 1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
|
|
| SEA super family |
cl02507 |
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ... |
820-907 |
3.16e-06 |
|
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.
The actual alignment was detected with superfamily member smart00200:
Pssm-ID: 470595 Cd Length: 121 Bit Score: 47.41 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 820 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 895
Cdd:smart00200 14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90
|
90
....*....|..
gi 1034627714 896 VSAAFLTAFQTV 907
Cdd:smart00200 91 DLLQVIKQAAYS 102
|
|
| SEA |
pfam01390 |
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ... |
294-370 |
5.01e-06 |
|
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.
:
Pssm-ID: 460188 Cd Length: 100 Bit Score: 46.46 E-value: 5.01e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627714 294 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 370
Cdd:pfam01390 1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
160-190 |
1.69e-03 |
|
Calcium-binding EGF-like domain;
:
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.23 E-value: 1.69e-03
10 20 30
....*....|....*....|....*....|.
gi 1034627714 160 DVNECfyEELNACSGRELCANLEGSYWCVCH 190
Cdd:smart00179 1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
727-803 |
9.56e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 36.71 E-value: 9.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 727 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACG 799
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....
gi 1034627714 800 KEGA 803
Cdd:cd00063 81 GESP 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Zona_pellucida |
pfam00100 |
Zona pellucida-like domain; |
1017-1257 |
6.04e-40 |
|
Zona pellucida-like domain;
Pssm-ID: 459673 [Multi-domain] Cd Length: 254 Bit Score: 148.91 E-value: 6.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1017 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1091
Cdd:pfam00100 1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1092 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1165
Cdd:pfam00100 80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1166 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1239
Cdd:pfam00100 158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237
|
250
....*....|....*...
gi 1034627714 1240 KLRVCmESPGATCKINCN 1257
Cdd:pfam00100 238 SVSVC-SSDSNSCGKSCS 254
|
|
| ZP |
smart00241 |
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ... |
1017-1257 |
1.12e-30 |
|
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).
Pssm-ID: 214579 Cd Length: 252 Bit Score: 122.11 E-value: 1.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1017 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1094
Cdd:smart00241 2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1095 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1170
Cdd:smart00241 82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1171 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1248
Cdd:smart00241 161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240
|
250
....*....|
gi 1034627714 1249 GATCK-INCN 1257
Cdd:smart00241 241 GSSCDgPACS 250
|
|
| WAP |
pfam00095 |
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ... |
13-53 |
1.19e-10 |
|
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.
Pssm-ID: 459672 [Multi-domain] Cd Length: 42 Bit Score: 57.82 E-value: 1.19e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1034627714 13 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 53
Cdd:pfam00095 1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
458-679 |
3.63e-09 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.47 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 458 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 536
Cdd:pfam05109 447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 537 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 616
Cdd:pfam05109 525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627714 617 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 679
Cdd:pfam05109 601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
403-433 |
5.51e-07 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 46.85 E-value: 5.51e-07
10 20 30
....*....|....*....|....*....|.
gi 1034627714 403 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 433
Cdd:pfam07645 1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
921-952 |
2.85e-06 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 2.85e-06
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:smart00179 1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
|
|
| SEA |
smart00200 |
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ... |
820-907 |
3.16e-06 |
|
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.
Pssm-ID: 214554 Cd Length: 121 Bit Score: 47.41 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 820 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 895
Cdd:smart00200 14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90
|
90
....*....|..
gi 1034627714 896 VSAAFLTAFQTV 907
Cdd:smart00200 91 DLLQVIKQAAYS 102
|
|
| SEA |
pfam01390 |
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ... |
294-370 |
5.01e-06 |
|
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.
Pssm-ID: 460188 Cd Length: 100 Bit Score: 46.46 E-value: 5.01e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627714 294 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 370
Cdd:pfam01390 1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
921-952 |
1.17e-05 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 43.38 E-value: 1.17e-05
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:pfam07645 1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
405-433 |
1.44e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 43.00 E-value: 1.44e-05
10 20
....*....|....*....|....*....
gi 1034627714 405 DECVDsaEHDCSPAAWCINLEGSYTCQCR 433
Cdd:smart00179 3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
921-952 |
2.65e-05 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.24 E-value: 2.65e-05
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:cd00054 1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
405-433 |
8.13e-05 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.08 E-value: 8.13e-05
10 20
....*....|....*....|....*....
gi 1034627714 405 DECVDsaEHDCSPAAWCINLEGSYTCQCR 433
Cdd:cd00054 3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
|
|
| WAP |
cd00199 |
whey acidic protein-type four-disulfide core domains. Members of the family include whey ... |
13-53 |
1.18e-04 |
|
whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.
Pssm-ID: 238120 [Multi-domain] Cd Length: 60 Bit Score: 41.28 E-value: 1.18e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1034627714 13 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 53
Cdd:cd00199 16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
486-727 |
1.56e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 486 PSPGYPQGTPAAG--QAWTPEPSPRRGGSNVVGYDRNnTGKGVEQEVPSTAPGLGMDQGSPSQVNPS------------Q 551
Cdd:PHA03247 2552 PPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppppS 2630
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 552 GSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSpsqgspsqeSPSQGSTSQASPShrnTIGVIGTT 631
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS---------SPPQRPRRRAARP---TVGSLTSL 2698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 632 SSPKATGSTHSFPPGATDG--PLALPGQLQGNSIMEPPSWPSPTEDPTGHFL-----WHATRSTRETLLNPTWLRNEDSG 704
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260
....*....|....*....|...
gi 1034627714 705 PSGSVDLPLTSTLTALKTPACVP 727
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSP 2801
|
|
| WAP |
smart00217 |
Four-disulfide core domains; |
13-54 |
1.60e-04 |
|
Four-disulfide core domains;
Pssm-ID: 197580 [Multi-domain] Cd Length: 47 Bit Score: 40.43 E-value: 1.60e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1034627714 13 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 54
Cdd:smart00217 1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
160-190 |
1.69e-03 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.23 E-value: 1.69e-03
10 20 30
....*....|....*....|....*....|.
gi 1034627714 160 DVNECfyEELNACSGRELCANLEGSYWCVCH 190
Cdd:smart00179 1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
160-189 |
2.09e-03 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.83 E-value: 2.09e-03
10 20 30
....*....|....*....|....*....|
gi 1034627714 160 DVNECFyEELNACSGRELCANLEGSYWCVC 189
Cdd:pfam07645 1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
727-803 |
9.56e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 36.71 E-value: 9.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 727 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACG 799
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....
gi 1034627714 800 KEGA 803
Cdd:cd00063 81 GESP 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Zona_pellucida |
pfam00100 |
Zona pellucida-like domain; |
1017-1257 |
6.04e-40 |
|
Zona pellucida-like domain;
Pssm-ID: 459673 [Multi-domain] Cd Length: 254 Bit Score: 148.91 E-value: 6.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1017 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1091
Cdd:pfam00100 1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1092 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1165
Cdd:pfam00100 80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1166 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1239
Cdd:pfam00100 158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237
|
250
....*....|....*...
gi 1034627714 1240 KLRVCmESPGATCKINCN 1257
Cdd:pfam00100 238 SVSVC-SSDSNSCGKSCS 254
|
|
| ZP |
smart00241 |
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ... |
1017-1257 |
1.12e-30 |
|
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).
Pssm-ID: 214579 Cd Length: 252 Bit Score: 122.11 E-value: 1.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1017 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1094
Cdd:smart00241 2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1095 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1170
Cdd:smart00241 82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 1171 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1248
Cdd:smart00241 161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240
|
250
....*....|
gi 1034627714 1249 GATCK-INCN 1257
Cdd:smart00241 241 GSSCDgPACS 250
|
|
| WAP |
pfam00095 |
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ... |
13-53 |
1.19e-10 |
|
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.
Pssm-ID: 459672 [Multi-domain] Cd Length: 42 Bit Score: 57.82 E-value: 1.19e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1034627714 13 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 53
Cdd:pfam00095 1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
458-679 |
3.63e-09 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.47 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 458 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 536
Cdd:pfam05109 447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 537 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 616
Cdd:pfam05109 525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627714 617 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 679
Cdd:pfam05109 601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
403-433 |
5.51e-07 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 46.85 E-value: 5.51e-07
10 20 30
....*....|....*....|....*....|.
gi 1034627714 403 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 433
Cdd:pfam07645 1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
921-952 |
2.85e-06 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 2.85e-06
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:smart00179 1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
|
|
| SEA |
smart00200 |
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ... |
820-907 |
3.16e-06 |
|
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.
Pssm-ID: 214554 Cd Length: 121 Bit Score: 47.41 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 820 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 895
Cdd:smart00200 14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90
|
90
....*....|..
gi 1034627714 896 VSAAFLTAFQTV 907
Cdd:smart00200 91 DLLQVIKQAAYS 102
|
|
| SEA |
pfam01390 |
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ... |
294-370 |
5.01e-06 |
|
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.
Pssm-ID: 460188 Cd Length: 100 Bit Score: 46.46 E-value: 5.01e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627714 294 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 370
Cdd:pfam01390 1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
921-952 |
1.17e-05 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 43.38 E-value: 1.17e-05
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:pfam07645 1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
435-690 |
1.24e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.91 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 435 TRDATPSRAGRACEGDLVS-PMGGGLSAATGVTVPGLGTGTAALGlenfTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSN 513
Cdd:pfam05109 531 TPNATSPTLGKTSPTSAVTtPTPNATSPTPAVTTPTPNATIPTLG----KTSPTSAVTTPTPNATSPTVGETSPQANTTN 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 514 vvgydrNNTGKGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQA---SPSQRSTSQ------GSPS---- 580
Cdd:pfam05109 607 ------HTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETlspSTSDNSTSHmplltsAHPTggen 680
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 581 --QVNPSQRSTSHANssqgspsqgsPSQESPSQGSTSQASPShrntiGVIGTTSSPKATGSTHSFPPGATDGPLALPGQL 658
Cdd:pfam05109 681 itQVTPASTSTHHVS----------TSSPAPRPGTTSQASGP-----GNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQK 745
|
250 260 270
....*....|....*....|....*....|..
gi 1034627714 659 QGNSIMEPPSWPSPTEDPTGHFLWHATRSTRE 690
Cdd:pfam05109 746 TAVPTVTSTGGKANSTTGGKHTTGHGARTSTE 777
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
405-433 |
1.44e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 43.00 E-value: 1.44e-05
10 20
....*....|....*....|....*....
gi 1034627714 405 DECVDsaEHDCSPAAWCINLEGSYTCQCR 433
Cdd:smart00179 3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
410-659 |
2.28e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 48.80 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 410 SAEHDCSPAAWciNLEGSYTCQCRTTRDATPSRAGRACEGDLVSPMGGGLSAATGVTVPGLGTGTAALGlenfTLSPSPG 489
Cdd:pfam17823 166 SAPHAASPAPR--TAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVG----NSSPAAG 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 490 ypqGTPAAGQAWTPEpsprrggsnVVGydrnnTGKGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQASP 569
Cdd:pfam17823 240 ---TVTAAVGTVTPA---------ALA-----TLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQ 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 570 SQRSTSQGSPSQ--VNPSQRST-SHANSSQGSPSQGSPSQESPSQGSTSQAS---PShRNTIGVIGTTSSP--KATGSTH 641
Cdd:pfam17823 303 AQGPIIQVSTDQpvHNTAGEPTpSPSNTTLEPNTPKSVASTNLAVVTTTKAQakePS-ASPVPVLHTSMIPevEATSPTT 381
|
250
....*....|....*...
gi 1034627714 642 SFPPGATDGPLALPGQLQ 659
Cdd:pfam17823 382 QPSPLLPTQGAAGPGILL 399
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
921-952 |
2.65e-05 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.24 E-value: 2.65e-05
10 20 30
....*....|....*....|....*....|..
gi 1034627714 921 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 952
Cdd:cd00054 1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
405-433 |
8.13e-05 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.08 E-value: 8.13e-05
10 20
....*....|....*....|....*....
gi 1034627714 405 DECVDsaEHDCSPAAWCINLEGSYTCQCR 433
Cdd:cd00054 3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
|
|
| WAP |
cd00199 |
whey acidic protein-type four-disulfide core domains. Members of the family include whey ... |
13-53 |
1.18e-04 |
|
whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.
Pssm-ID: 238120 [Multi-domain] Cd Length: 60 Bit Score: 41.28 E-value: 1.18e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1034627714 13 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 53
Cdd:cd00199 16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
486-727 |
1.56e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 486 PSPGYPQGTPAAG--QAWTPEPSPRRGGSNVVGYDRNnTGKGVEQEVPSTAPGLGMDQGSPSQVNPS------------Q 551
Cdd:PHA03247 2552 PPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppppS 2630
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 552 GSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSpsqgspsqeSPSQGSTSQASPShrnTIGVIGTT 631
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS---------SPPQRPRRRAARP---TVGSLTSL 2698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 632 SSPKATGSTHSFPPGATDG--PLALPGQLQGNSIMEPPSWPSPTEDPTGHFL-----WHATRSTRETLLNPTWLRNEDSG 704
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260
....*....|....*....|...
gi 1034627714 705 PSGSVDLPLTSTLTALKTPACVP 727
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSP 2801
|
|
| WAP |
smart00217 |
Four-disulfide core domains; |
13-54 |
1.60e-04 |
|
Four-disulfide core domains;
Pssm-ID: 197580 [Multi-domain] Cd Length: 47 Bit Score: 40.43 E-value: 1.60e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1034627714 13 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 54
Cdd:smart00217 1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
418-633 |
3.10e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 45.06 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 418 AAWCINLEGsytcQCRTTRDATPSRA-----------GRACEGDLVSPMGGGLSAATGVTVPGLGTGTAAlglenftLSP 486
Cdd:PRK14959 330 ACWQMTLEG----QRRVLTSLEPAMAlellllnlamlPRLMPVESLRPSGGGASAPSGSAAEGPASGGAA-------TIP 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 487 SPGY--PQGT-PAAG----QAWTPEPSPRRGGSNVVGYDrnntgkgveqEVPSTAPglgmDQGSPSQVNPSQGSPSQGSL 559
Cdd:PRK14959 399 TPGTqgPQGTaPAAGmtpsSAAPATPAPSAAPSPRVPWD----------DAPPAPP----RSGIPPRPAPRMPEASPVPG 464
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627714 560 RQESTSqaspsqrSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSPSQESPSQGSTS-----QASPSHRNTIGVIGTTSS 633
Cdd:PRK14959 465 APDSVA-------SASDAPPTLGDPSDTAEHTPSGPRTWDGFLEFCQGRNGQGGRLatvlrQATPEHADGRLRLATMSS 536
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
491-676 |
3.53e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.06 E-value: 3.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 491 PQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVPSTAPglgmdqGSPSQVNPSQGSPSQgslRQESTSQASPS 570
Cdd:PHA03378 727 PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP------GAPTPQPPPQAPPAP---QQRPRGAPTPQ 797
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 571 QRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSPSQESpsqGSTSQASPSHRNTIGVIGTTSSPKATGSTHS------FP 644
Cdd:PHA03378 798 PPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKR---GRPSLKKPAALERQAAAGPTPSPGSGTSDKIvqapvfYP 874
|
170 180 190
....*....|....*....|....*....|...
gi 1034627714 645 PGATdgPLALPGQLQGNSIMEPPSWP-SPTEDP 676
Cdd:PHA03378 875 PVLQ--PIQVMRQLGSVRAAAASTVTqAPTEYT 905
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
160-190 |
1.69e-03 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.23 E-value: 1.69e-03
10 20 30
....*....|....*....|....*....|.
gi 1034627714 160 DVNECfyEELNACSGRELCANLEGSYWCVCH 190
Cdd:smart00179 1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
160-189 |
2.09e-03 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.83 E-value: 2.09e-03
10 20 30
....*....|....*....|....*....|
gi 1034627714 160 DVNECFyEELNACSGRELCANLEGSYWCVC 189
Cdd:pfam07645 1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
|
|
| EGF_3 |
pfam12947 |
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
413-434 |
4.17e-03 |
|
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.
Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 36.04 E-value: 4.17e-03
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
727-803 |
9.56e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 36.71 E-value: 9.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627714 727 PVSIGRIMVSNVTSTGFHLAWEADLAMDS-------TFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACG 799
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpitgyvvEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....
gi 1034627714 800 KEGA 803
Cdd:cd00063 81 GESP 84
|
|
| |
