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Conserved domains on  [gi|1034625426|ref|XP_016883434|]
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zinc finger protein 64 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-601 2.46e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 248 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 324
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 325 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 399
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 400 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 478
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 479 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 544
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034625426 545 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 601
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-601 2.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 248 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 324
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 325 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 399
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 400 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 478
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 479 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 544
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034625426 545 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 601
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 4.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.36e-05
                          10        20
                  ....*....|....*....|....*.
gi 1034625426 314 DLDRHLRIHTGDKPHKCEFCDKCFSR 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-601 2.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 248 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 324
Cdd:COG5048   100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 325 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 399
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 400 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 478
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 479 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 544
Cdd:COG5048   318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034625426 545 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 601
Cdd:COG5048   388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 4.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.36e-05
                          10        20
                  ....*....|....*....|....*.
gi 1034625426 314 DLDRHLRIHTGDKPHKCEFCDKCFSR 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-536 5.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 113 SNENQTATVISLPAKSRTKKPTTPPAQKRLNCCypGCQFKTAYGMKdmeRHLKIHTGDKPHKCEV--CGKCFSRKDKLKT 190
Cdd:COG5048     7 QSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNC--TDSFSRLEHLT---RHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 191 HMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHS-DERPFKCQICPYASRNSSQLTVHLRSHTASELDDDVPKANCLSTE 269
Cdd:COG5048    82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 270 STDTPKAPVITLPseareqmatlgertfnccypgCHFKTVHGMKDLDRHLRIHTGDKPHKCEFCDKCFSRKDNLTMHMRC 349
Cdd:COG5048   162 PQSNSLHPPLPAN---------------------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 350 HTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKCQLCPYASR------NSSQLTVHLRSHTG-DTPFQCWLCSAKFK 422
Cdd:COG5048   221 ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 423 ISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKANLKSHIRIkHTFKCLHCA--------FQGRDRADLLEHSRLHQ 488
Cdd:COG5048   301 RSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL-HTSISPAKEkllnssskFSPLLNNEPPQSLQQYK 379

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034625426 489 ADHPEKCPECSYSCSSAAALR-----VHSRVHCKDRP--FKCDFCSFDTKRPSSL 536
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRPynCKNPPCSKSFNRHYNL 434
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 2.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034625426 159 DMERHLKIHTGDKPHKCEVCGKCFSR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-443 2.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 312 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 381
Cdd:COG5048   302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034625426 382 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 443
Cdd:COG5048   382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-463 3.56e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 380 DERPYKCQL--CPYASRNSSQLTVH-LRSHtgdtpfqcwlCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLK 456
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1034625426 457 SHIRIKH 463
Cdd:COG5189   416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-209 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|..
gi 1034625426 188 LKTHMRCHTGVKPYKCKTCDYA 209
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1034625426 426 DLKRHMIVHSGEKPFKCEFCDVRCT 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-369 3.58e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 199 KPYKCKTCDYAAADSSSLNKHLR--IHSDE--RPFKC--QICPYASRNSSQLTVHLRSHTaselddDVPKANCLSTESTD 272
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT------SISPAKEKLLNSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625426 273 TPKAPVITLPSEAREQMATL-GERTFNCCYPGC--HFKTVHGMKdldRHLRIHTGDKPHKCEF--CDKCFSRKDNLTMHM 347
Cdd:COG5048   362 KFSPLLNNEPPQSLQQYKDLkNDKKSETLSNSCirNFKRDSNLS---LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHK 438

                         170       180
                  ....*....|....*....|..
gi 1034625426 348 RCHTSVKPHKCHLCDYAAVDSS 369
Cdd:COG5048   439 KIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-364 5.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|...
gi 1034625426 342 NLTMHMRCHTSVKPHKCHLCDYA 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
201-224 7.64e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.45  E-value: 7.64e-03
                          10        20
                  ....*....|....*....|....
gi 1034625426 201 YKCKTCDYAAADSSSLNKHLRIHS 224
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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