NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034612382|ref|XP_016859065|]
View 

sprouty-related, EVH1 domain-containing protein 2 isoform X2 [Homo sapiens]

Protein Classification

sprouty family protein( domain architecture ID 10525175)

sprouty family protein may be an inhibitor of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-288 7.57e-42

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


:

Pssm-ID: 461589  Cd Length: 101  Bit Score: 139.77  E-value: 7.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612382 183 RSRCVYCRDMFNHEENRRGHCqdapdSVRTCIRRVSCMWCADSMLYHCMSDPEGDYT-DPCSCdTSDEKFCLRWMALIAL 261
Cdd:pfam05210   1 RCRCVYCQELFTEPRNLPGSC-----SAESCIDYVSCMCCAKGLFYHCMSDAEGDDScDPCSC-CSPHRCCKRWLALALL 74

                          90       100
                  ....*....|....*....|....*..
gi 1034612382 262 SFLAPCMCCYLPLRACYHCGVMCRCCG 288
Cdd:pfam05210  75 SLLLPCLCCYPPLRACHKCCVACGCCG 101
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-288 7.57e-42

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 139.77  E-value: 7.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612382 183 RSRCVYCRDMFNHEENRRGHCqdapdSVRTCIRRVSCMWCADSMLYHCMSDPEGDYT-DPCSCdTSDEKFCLRWMALIAL 261
Cdd:pfam05210   1 RCRCVYCQELFTEPRNLPGSC-----SAESCIDYVSCMCCAKGLFYHCMSDAEGDDScDPCSC-CSPHRCCKRWLALALL 74

                          90       100
                  ....*....|....*....|....*..
gi 1034612382 262 SFLAPCMCCYLPLRACYHCGVMCRCCG 288
Cdd:pfam05210  75 SLLLPCLCCYPPLRACHKCCVACGCCG 101
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-288 7.57e-42

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 139.77  E-value: 7.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612382 183 RSRCVYCRDMFNHEENRRGHCqdapdSVRTCIRRVSCMWCADSMLYHCMSDPEGDYT-DPCSCdTSDEKFCLRWMALIAL 261
Cdd:pfam05210   1 RCRCVYCQELFTEPRNLPGSC-----SAESCIDYVSCMCCAKGLFYHCMSDAEGDDScDPCSC-CSPHRCCKRWLALALL 74

                          90       100
                  ....*....|....*....|....*..
gi 1034612382 262 SFLAPCMCCYLPLRACYHCGVMCRCCG 288
Cdd:pfam05210  75 SLLLPCLCCYPPLRACHKCCVACGCCG 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH