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Conserved domains on  [gi|1034607340|ref|XP_016882108|]
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zinc finger protein 780A isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204806)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 4.87e-36

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 4.87e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607340    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-595 5.43e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.90  E-value: 5.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 219 KPFECNECGKAFSLLTLLNRHKNIHTGEKLFEC--KECGKSFNRSSNLVQHQSIHSGVKPYECK---------------- 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 281 ECGKGFNRGAHLIQHQKIHSNEKPFVCKEcgmafRYHYQLIEHCQIHTGEKPFECKEC------------GKAFTLLTKL 348
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDL-----LSISNLRNNPLPGNNSSSVNTPQSnslhpplpanslSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 349 VRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRSSNLVQHQSIHAGIKPYECKECGKGFNR 428
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 429 GAHLIQHQKIHSNE-------KPFVCRECEMAFRYHCQLIEHSR--IHTG--DKPFEC--QDCGKAFNRGSSLVQHQSIH 495
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 496 TGEKPYECKEC-------GKAFRLYLQLSQHQKTHTGEKPFEC--KECGKFFRRGSNLNQHRSIHTGKKP--FECKECGK 564
Cdd:COG5048   347 TSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1034607340 565 AFRLHMHLIRHQKLHTGEKPFECKECGKAFR 595
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-202 3.14e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 179 NLIQHQSIHTGEKPFECKECGKAF 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-623 3.30e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 600 LIRHQKLHTGEKPFECKECGKVFS 623
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 4.87e-36

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 4.87e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607340    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 5.43e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.54  E-value: 5.43e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034607340   5 SVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 2.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 2.76e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034607340   6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-595 5.43e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.90  E-value: 5.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 219 KPFECNECGKAFSLLTLLNRHKNIHTGEKLFEC--KECGKSFNRSSNLVQHQSIHSGVKPYECK---------------- 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 281 ECGKGFNRGAHLIQHQKIHSNEKPFVCKEcgmafRYHYQLIEHCQIHTGEKPFECKEC------------GKAFTLLTKL 348
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDL-----LSISNLRNNPLPGNNSSSVNTPQSnslhpplpanslSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 349 VRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRSSNLVQHQSIHAGIKPYECKECGKGFNR 428
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 429 GAHLIQHQKIHSNE-------KPFVCRECEMAFRYHCQLIEHSR--IHTG--DKPFEC--QDCGKAFNRGSSLVQHQSIH 495
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 496 TGEKPYECKEC-------GKAFRLYLQLSQHQKTHTGEKPFEC--KECGKFFRRGSNLNQHRSIHTGKKP--FECKECGK 564
Cdd:COG5048   347 TSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1034607340 565 AFRLHMHLIRHQKLHTGEKPFECKECGKAFR 595
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 1034607340 376 LNRHKNIHTGEKPFECKECGKSFNR 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-202 3.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 179 NLIQHQSIHTGEKPFECKECGKAF 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-623 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 600 LIRHQKLHTGEKPFECKECGKVFS 623
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 4.87e-36

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 4.87e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607340    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 5.43e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.54  E-value: 5.43e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034607340   5 SVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 2.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 2.76e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034607340   6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-595 5.43e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.90  E-value: 5.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 219 KPFECNECGKAFSLLTLLNRHKNIHTGEKLFEC--KECGKSFNRSSNLVQHQSIHSGVKPYECK---------------- 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 281 ECGKGFNRGAHLIQHQKIHSNEKPFVCKEcgmafRYHYQLIEHCQIHTGEKPFECKEC------------GKAFTLLTKL 348
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDL-----LSISNLRNNPLPGNNSSSVNTPQSnslhpplpanslSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 349 VRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRSSNLVQHQSIHAGIKPYECKECGKGFNR 428
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 429 GAHLIQHQKIHSNE-------KPFVCRECEMAFRYHCQLIEHSR--IHTG--DKPFEC--QDCGKAFNRGSSLVQHQSIH 495
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 496 TGEKPYECKEC-------GKAFRLYLQLSQHQKTHTGEKPFEC--KECGKFFRRGSNLNQHRSIHTGKKP--FECKECGK 564
Cdd:COG5048   347 TSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1034607340 565 AFRLHMHLIRHQKLHTGEKPFECKECGKAFR 595
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-380 3.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 164 PYECKECGKYFSRSANLIQHQSIHTGEKPFECKECGKAFRLHIQFTRHQKFHTGE-------KPFECNECGKAFSLLTLL 236
Cdd:COG5048   226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 237 NRHKN--IHTGEKL--FECKE--CGKSFNRSSNLVQHQSIHSGVKPYECKEC-------GKGFNRGAHLIQHQKIHSNEK 303
Cdd:COG5048   306 TRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDK 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 304 PFVC----KECGMAFRYHYQLIEHCQIHTGEKPFECKECGKAFTLLTKLVRHQKIHTGEKPFECRECGKAFSLLNQLNRH 379
Cdd:COG5048   386 KSETlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465


                  .
gi 1034607340 380 K 380
Cdd:COG5048   466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
359-637 1.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 359 KPFECRECGKAFSLLNQLNRHKNIHTGEKPFEC--KECGKSFNRSSNLVQHQSIH---------AGIKPYECK------- 420
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHhnnpsdlnsKSLPLSNSKassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 421 ECGKGFNRGAHLIQHQKIHSNEKPFV----------CRECEMAFRYHCQLIEHSRIHtGDKPFECQDCGKAFNRGSSLvq 490
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdllsisnlrNNPLPGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLLI-- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 491 HQSIHTGEKPYECKECGKAFRLYLQLSQHQKTHTGEKPFECKECGKFFRRGSNLNQHRSIHTGKKPFECKECGKAFRLHM 570
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607340 571 HLIRHQKLHTGE-------KPFECKECGKAFRLHMQLIRHQ--KLHTGE--KPFECKE--CGKVFSLPTQLNRHKNIHTG 637
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 1034607340 376 LNRHKNIHTGEKPFECKECGKSFNR 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-371 5.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.52e-04
                          10        20
                  ....*....|....*....|....
gi 1034607340 348 LVRHQKIHTGEKPFECRECGKAFS 371
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
571-594 9.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.19e-04
                          10        20
                  ....*....|....*....|....
gi 1034607340 571 HLIRHQKLHTGEKPFECKECGKAF 594
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
516-540 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1034607340 516 LSQHQKTHTGEKPFECKECGKFFRR 540
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-231 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|..
gi 1034607340 210 RHQKFHTGEKPFECNECGKAFS 231
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-484 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1034607340 460 LIEHSRIHTGDKPFECQDCGKAFNR 484
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-202 3.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 179 NLIQHQSIHTGEKPFECKECGKAF 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-623 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 600 LIRHQKLHTGEKPFECKECGKVFS 623
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-566 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 543 NLNQHRSIHTGKKPFECKECGKAF 566
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-343 3.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.46e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 320 LIEHCQIHTGEKPFECKECGKAFT 343
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-260 3.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1034607340 236 LNRHKNIHTGEKLFECKECGKSFNR 260
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-510 4.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.26e-03
                          10        20
                  ....*....|....*....|....
gi 1034607340 487 SLVQHQSIHTGEKPYECKECGKAF 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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