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Conserved domains on  [gi|1034602263|ref|XP_016880886|]
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nuclear receptor corepressor 1 isoform X1 [Homo sapiens]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 11239196)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  20084085|8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 149-238 2.67e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 107.25  E-value: 2.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  149 FGGKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 228
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1034602263  229 EQKHRSIVQI 238
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.38e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.38e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 449-491 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  449 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 491
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
693-867 1.05e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK08691:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 709  Bit Score: 44.31  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  693 KQKTSRKPREERDVSQCESVASTVSAQ----EDEDIEASNEEENPEDSEGAENSSDTESAPSPSP-----VEAVKPSEDS 763
Cdd:PRK08691   387 KETAAKKPQPRPEAETAQTPVQTASAAampsEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsaksIQTASEAETP 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  764 PENATSRgNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVndsiSAETAEQMDVDQQEHSAEEGSVCDPPPAT 843
Cdd:PRK08691   467 PENQVSK-NKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEA----PAEPFYGYGFPDNDCPPEDGAEIPPPDWE 541

                          170       180
                   ....*....|....*....|....*.
gi 1034602263  844 KADSVDVEVRVPENHA--SKVEGDNT 867
Cdd:PRK08691   542 HAAPADTAGGGADEEAeaGGIGGNNT 567
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 149-238 2.67e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 107.25  E-value: 2.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  149 FGGKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 228
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1034602263  229 EQKHRSIVQI 238
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.38e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.38e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 637-680 1.38e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034602263  637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
637-682 2.20e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.20e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1034602263   637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 682
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 449-491 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  449 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 491
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
447-492 4.07e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1034602263   447 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 492
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 449-488 5.40e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034602263  449 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 488
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 693-867 1.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 44.31  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  693 KQKTSRKPREERDVSQCESVASTVSAQ----EDEDIEASNEEENPEDSEGAENSSDTESAPSPSP-----VEAVKPSEDS 763
Cdd:PRK08691   387 KETAAKKPQPRPEAETAQTPVQTASAAampsEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsaksIQTASEAETP 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  764 PENATSRgNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVndsiSAETAEQMDVDQQEHSAEEGSVCDPPPAT 843
Cdd:PRK08691   467 PENQVSK-NKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEA----PAEPFYGYGFPDNDCPPEDGAEIPPPDWE 541

                          170       180
                   ....*....|....*....|....*.
gi 1034602263  844 KADSVDVEVRVPENHA--SKVEGDNT 867
Cdd:PRK08691   542 HAAPADTAGGGADEEAeaGGIGGNNT 567
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 702-920 1.32e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 44.24  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  702 EERDVSQCESVASTVSAQEDEDIEASNEEENPEDS----EGAENSSDTESAPSPSPVEAVKPSEDSPENATSRGNTEPAV 777
Cdd:COG5271    302 ESDDDADDSTLAALEGAAEDTEIATADELAAADDEddddSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADT 381

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  778 ELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQEH----SAEEGSVCDPPPATKADsvDVEVR 853
Cdd:COG5271    382 DAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDASAGETEDEStdvtSAEDDIATDEEADSLAD--EEEEA 459

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034602263  854 VPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQrPEPQSDNDSSATCSADEDVDGEPE 920
Cdd:COG5271    460 EAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAE-AEADSDELTAEETSADDGADTDAA 525
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 149-238 2.67e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 107.25  E-value: 2.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  149 FGGKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 228
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1034602263  229 EQKHRSIVQI 238
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.38e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.38e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 637-680 1.38e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034602263  637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
637-682 2.20e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.20e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1034602263   637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 682
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 449-491 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034602263  449 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 491
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
447-492 4.07e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1034602263   447 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 492
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 449-488 5.40e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034602263  449 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 488
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 449-492 9.96e-04

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 9.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034602263  449 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 492
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 693-867 1.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 44.31  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  693 KQKTSRKPREERDVSQCESVASTVSAQ----EDEDIEASNEEENPEDSEGAENSSDTESAPSPSP-----VEAVKPSEDS 763
Cdd:PRK08691   387 KETAAKKPQPRPEAETAQTPVQTASAAampsEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsaksIQTASEAETP 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  764 PENATSRgNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVndsiSAETAEQMDVDQQEHSAEEGSVCDPPPAT 843
Cdd:PRK08691   467 PENQVSK-NKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEA----PAEPFYGYGFPDNDCPPEDGAEIPPPDWE 541

                          170       180
                   ....*....|....*....|....*.
gi 1034602263  844 KADSVDVEVRVPENHA--SKVEGDNT 867
Cdd:PRK08691   542 HAAPADTAGGGADEEAeaGGIGGNNT 567
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 702-920 1.32e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 44.24  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  702 EERDVSQCESVASTVSAQEDEDIEASNEEENPEDS----EGAENSSDTESAPSPSPVEAVKPSEDSPENATSRGNTEPAV 777
Cdd:COG5271    302 ESDDDADDSTLAALEGAAEDTEIATADELAAADDEddddSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADT 381

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  778 ELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQEH----SAEEGSVCDPPPATKADsvDVEVR 853
Cdd:COG5271    382 DAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDASAGETEDEStdvtSAEDDIATDEEADSLAD--EEEEA 459

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034602263  854 VPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQrPEPQSDNDSSATCSADEDVDGEPE 920
Cdd:COG5271    460 EAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAE-AEADSDELTAEETSADDGADTDAA 525
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 710-922 2.00e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.85  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  710 ESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPSEDSPENATSRgnTEPAVELEPTTETAPST 789
Cdd:COG5271    355 DSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTDE--EEEEADEDASAGETEDE 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  790 SPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQEHSAEegsvcdpppATKADSVDVEVRVPENHASKVEGDNTKE 869
Cdd:COG5271    433 STDVTSAEDDIATDEEADSLADEEEEAEAELDTEEDTESAEED---------ADGDEATDEDDASDDGDEEEAEEDAEAE 503

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034602263  870 RDLDRASEKVEPRDEdlvvAQQINAQRPEPQSDNDSSA--------TCSADEDVDGEPERQ 922
Cdd:COG5271    504 ADSDELTAEETSADD----GADTDAAADPEDSDEDALEdetegeenAPGSDQDADETDEPE 560
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 638-685 3.14e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 3.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034602263  638 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 685
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 755-923 8.11e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.50  E-value: 8.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  755 EAVKPSEDSPENATSRGNTEPAVELEPTTE--TAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQEhSAE 832
Cdd:PRK13108   283 GALRGSEYVVDEALEREPAELAAAAVASAAsaVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE-STP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  833 EGSVCDPPPATKADSVDVEVRVPENHASKVEGdntkERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSAD 912
Cdd:PRK13108   362 AVEETSEADIEREQPGDLAGQAPAAHQVDAEA----ASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGP 437

                          170
                   ....*....|.
gi 1034602263  913 EDVDGEPERQR 923
Cdd:PRK13108   438 GDDPAEPDGIR 448
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 694-920 8.30e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.54  E-value: 8.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  694 QKTSRKPREERDVSQCESVASTvSAQEDEDIEASNEEENPE----DSEGAEN--------SSDTESAPSP-SPVEAVKPS 760
Cdd:COG5271    574 ETEDATENADADETEESADESE-EAEASEDEAAEEEEADDDeadaDADGAADeeeteeeaAEDEAAEPETdASEAADEDA 652

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  761 EDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVE---------TQVNDSISAETAEQMDVDQQEHSA 831
Cdd:COG5271    653 DAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDDEEETEeadedaetaSEEADAEEADTEADGTAEEAEEAA 732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034602263  832 EEGSVCDPPPATKADSVDVEvrvpenhASKVEGDNTKERDLDRASEKVE---PRDEDLVVAQQINAQRPEPQSDNDSSAT 908
Cdd:COG5271    733 EEAESADEEAASLPDEADAE-------EEAEEAEEAEEDDADGLEEALEeekADAEEAATDEEAEAAAEEKEKVADEDQD 805

                          250
                   ....*....|..
gi 1034602263  909 CSADEDVDGEPE 920
Cdd:COG5271    806 TDEDALLDEAEA 817
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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