SAFB-like transcription modulator isoform X6 [Homo sapiens]
RNA-binding protein( domain architecture ID 13917133)
RNA-binding protein recognizes RNA via an RNA recognition motif (RRM); similar to Plasmodium falciparum clustered-asparagine-rich protein (CARP)
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||||
RRM_SF super family | cl17169 | RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ... |
367-392 | 2.01e-11 | ||||||||
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). The actual alignment was detected with superfamily member cd12678: Pssm-ID: 473069 [Multi-domain] Cd Length: 74 Bit Score: 60.48 E-value: 2.01e-11
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SAP | smart00513 | Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
22-56 | 5.05e-08 | ||||||||
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; : Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 49.41 E-value: 5.05e-08
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PTZ00121 super family | cl31754 | MAEBL; Provisional |
139-679 | 3.73e-06 | ||||||||
MAEBL; Provisional The actual alignment was detected with superfamily member PTZ00121: Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 3.73e-06
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PHA03307 super family | cl33723 | transcriptional regulator ICP4; Provisional |
730-965 | 9.56e-04 | ||||||||
transcriptional regulator ICP4; Provisional The actual alignment was detected with superfamily member PHA03307: Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 9.56e-04
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Name | Accession | Description | Interval | E-value | ||||||||
RRM_SLTM | cd12678 | RNA recognition motif (RRM) found in Scaffold attachment factor (SAF)-like transcription ... |
367-392 | 2.01e-11 | ||||||||
RNA recognition motif (RRM) found in Scaffold attachment factor (SAF)-like transcription modulator (SLTM) and similar proteins; This subgroup corresponds to the RRM domain of SLTM, also termed modulator of estrogen-induced transcription, which shares high sequence similarity with scaffold attachment factor B1 (SAFB1). It contains a scaffold attachment factor-box (SAF-box, also known as SAP domain) DNA-binding motif, an RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region rich in glutamine and arginine residues. To a large extent, SLTM co-localizes with SAFB1 in the nucleus, which suggests that they share similar functions, such as the inhibition of an oestrogen reporter gene. However, rather than mediating a specific inhibitory effect on oestrogen action, SLTM is shown to exert a generalized inhibitory effect on gene expression associated with induction of apoptosis in a wide range of cell lines. Pssm-ID: 410079 [Multi-domain] Cd Length: 74 Bit Score: 60.48 E-value: 2.01e-11
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SAP | smart00513 | Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
22-56 | 5.05e-08 | ||||||||
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 49.41 E-value: 5.05e-08
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SAP | pfam02037 | SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ... |
22-56 | 1.77e-07 | ||||||||
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. Pssm-ID: 460424 [Multi-domain] Cd Length: 35 Bit Score: 48.17 E-value: 1.77e-07
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
139-679 | 3.73e-06 | ||||||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 3.73e-06
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RRM | smart00360 | RNA recognition motif; |
367-393 | 9.18e-04 | ||||||||
RNA recognition motif; Pssm-ID: 214636 [Multi-domain] Cd Length: 73 Bit Score: 38.73 E-value: 9.18e-04
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PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
730-965 | 9.56e-04 | ||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 9.56e-04
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Name | Accession | Description | Interval | E-value | ||||||||
RRM_SLTM | cd12678 | RNA recognition motif (RRM) found in Scaffold attachment factor (SAF)-like transcription ... |
367-392 | 2.01e-11 | ||||||||
RNA recognition motif (RRM) found in Scaffold attachment factor (SAF)-like transcription modulator (SLTM) and similar proteins; This subgroup corresponds to the RRM domain of SLTM, also termed modulator of estrogen-induced transcription, which shares high sequence similarity with scaffold attachment factor B1 (SAFB1). It contains a scaffold attachment factor-box (SAF-box, also known as SAP domain) DNA-binding motif, an RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region rich in glutamine and arginine residues. To a large extent, SLTM co-localizes with SAFB1 in the nucleus, which suggests that they share similar functions, such as the inhibition of an oestrogen reporter gene. However, rather than mediating a specific inhibitory effect on oestrogen action, SLTM is shown to exert a generalized inhibitory effect on gene expression associated with induction of apoptosis in a wide range of cell lines. Pssm-ID: 410079 [Multi-domain] Cd Length: 74 Bit Score: 60.48 E-value: 2.01e-11
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RRM_SAFB_like | cd12417 | RNA recognition motif (RRM) found in the scaffold attachment factor (SAFB) family; This ... |
367-394 | 4.68e-10 | ||||||||
RNA recognition motif (RRM) found in the scaffold attachment factor (SAFB) family; This subfamily corresponds to the RRM domain of the SAFB family, including scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), SAFB-like transcriptional modulator (SLTM), and similar proteins, which are ubiquitously expressed. SAFB1, SAFB2 and SLTM have been implicated in many diverse cellular processes including cell growth and transformation, stress response, and apoptosis. They share high sequence similarities and all contain a scaffold attachment factor-box (SAF-box, also known as SAP domain) DNA-binding motif, an RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region rich in glutamine and arginine residues. SAFB1 is a nuclear protein with a distribution similar to that of SLTM, but unlike that of SAFB2, which is also found in the cytoplasm. To a large extent, SAFB1 and SLTM might share similar functions, such as the inhibition of an oestrogen reporter gene. The additional cytoplasmic localization of SAFB2 implies that it could play additional roles in the cytoplasmic compartment which are distinct from the nuclear functions shared with SAFB1 and SLTM. Pssm-ID: 409851 [Multi-domain] Cd Length: 74 Bit Score: 56.49 E-value: 4.68e-10
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RRM_SAFB1_SAFB2 | cd12679 | RNA recognition motif (RRM) found in scaffold attachment factor B1 (SAFB1), scaffold ... |
366-394 | 9.25e-09 | ||||||||
RNA recognition motif (RRM) found in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins; This subgroup corresponds to RRM of SAFB1, also termed scaffold attachment factor B (SAF-B), heat-shock protein 27 estrogen response element ERE and TATA-box-binding protein (HET), or heterogeneous nuclear ribonucleoprotein hnRNP A1- associated protein (HAP), a large multi-domain protein with well-described functions in transcriptional repression, RNA splicing and metabolism, and a proposed role in chromatin organization. Based on the numerous functions, SAFB1 has been implicated in many diverse cellular processes including cell growth and transformation, stress response, and apoptosis. SAFB1 specifically binds to AT-rich scaffold or matrix attachment region DNA elements (S/MAR DNA) by using its N-terminal scaffold attachment factor-box (SAF-box, also known as SAP domain), a homeodomain-like DNA binding motif. The central region of SAFB1 is composed of an RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a nuclear localization signal (NLS). The C-terminus of SAFB1 contains Glu/Arg- and Gly-rich regions that might be involved in protein-protein interaction. Additional studies indicate that the C-terminal region contains a potent and transferable transcriptional repression domain. Another family member is SAFB2, a homolog of SAFB1. Both SAFB1 and SAFB2 are ubiquitously coexpressed and share very high sequence similarity, suggesting that they might function in a similar manner. However, unlike SAFB1, exclusively existing in the nucleus, SAFB2 is also present in the cytoplasm. The additional cytoplasmic localization of SAFB2 implies that it could play additional roles in the cytoplasmic compartment which are distinct from the nuclear functions shared with SAFB1. Pssm-ID: 410080 [Multi-domain] Cd Length: 76 Bit Score: 52.97 E-value: 9.25e-09
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SAP | smart00513 | Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; |
22-56 | 5.05e-08 | ||||||||
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; Pssm-ID: 128789 [Multi-domain] Cd Length: 35 Bit Score: 49.41 E-value: 5.05e-08
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SAP | pfam02037 | SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ... |
22-56 | 1.77e-07 | ||||||||
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. Pssm-ID: 460424 [Multi-domain] Cd Length: 35 Bit Score: 48.17 E-value: 1.77e-07
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
139-679 | 3.73e-06 | ||||||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 3.73e-06
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RRM | smart00360 | RNA recognition motif; |
367-393 | 9.18e-04 | ||||||||
RNA recognition motif; Pssm-ID: 214636 [Multi-domain] Cd Length: 73 Bit Score: 38.73 E-value: 9.18e-04
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PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
730-965 | 9.56e-04 | ||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 9.56e-04
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RRM_SF | cd00590 | RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ... |
368-393 | 2.10e-03 | ||||||||
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). Pssm-ID: 409669 [Multi-domain] Cd Length: 72 Bit Score: 37.65 E-value: 2.10e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
140-668 | 2.12e-03 | ||||||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 2.12e-03
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RRM2_MSI | cd12323 | RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, ... |
368-393 | 7.63e-03 | ||||||||
RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins; This subfamily corresponds to the RRM2.in Musashi-1 (also termed Msi1), a neural RNA-binding protein putatively expressed in central nervous system (CNS) stem cells and neural progenitor cells, and associated with asymmetric divisions in neural progenitor cells. It is evolutionarily conserved from invertebrates to vertebrates. Musashi-1 is a homolog of Drosophila Musashi and Xenopus laevis nervous system-specific RNP protein-1 (Nrp-1). It has been implicated in the maintenance of the stem-cell state, differentiation, and tumorigenesis. It translationally regulates the expression of a mammalian numb gene by binding to the 3'-untranslated region of mRNA of Numb, encoding a membrane-associated inhibitor of Notch signaling, and further influences neural development. Moreover, Musashi-1 represses translation by interacting with the poly(A)-binding protein and competes for binding of the eukaryotic initiation factor-4G (eIF-4G). Musashi-2 (also termed Msi2) has been identified as a regulator of the hematopoietic stem cell (HSC) compartment and of leukemic stem cells after transplantation of cells with loss and gain of function of the gene. It influences proliferation and differentiation of HSCs and myeloid progenitors, and further modulates normal hematopoiesis and promotes aggressive myeloid leukemia. Both, Musashi-1 and Musashi-2, contain two conserved N-terminal tandem RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), along with other domains of unknown function. Pssm-ID: 240769 [Multi-domain] Cd Length: 74 Bit Score: 36.26 E-value: 7.63e-03
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Blast search parameters | ||||
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