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Conserved domains on  [gi|1034587951|ref|XP_016877079|]
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acyl-coenzyme A thioesterase 1 isoform X2 [Homo sapiens]

Protein Classification

alpha/beta hydrolase; tannase/feruloyl esterase family alpha/beta hydrolase( domain architecture ID 10556038)

uncharacterized alpha/beta hydrolase; may catalyze the cleavage and formation of ester bonds; tannase/feruloyl esterase family alpha/beta hydrolase similar to Aspergillus oryzae tannase and Aspergillus niger feruloyl esterase B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 80-289 3.19e-129

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


:

Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 366.22  E-value: 3.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  80 LHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRI 159
Cdd:pfam08840   1 VDLEYFEEAINYLLRHPKVKGPGIGLLGISKGGELALSMATFLKQITATVSINGSAVVSGDPLVYKDNPLPPLGEGMRRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 160 KVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRR-KPQIICYPETGHY 238
Cdd:pfam08840  81 KVNKDGLLDIRDMFNDPLSKPDPKSLIPVERAKGPFLFVVGQDDHNWPSVFYAKKACERLQKHGKEvEVQLVCYPGAGHL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034587951 239 IEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGG 289
Cdd:pfam08840 161 IEPPYFPHCGASFHALVGMPVLWGGEPKAHAKAQEDAWKKIQAFFHKHLGG 211
 
Name Accession Description Interval E-value
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 80-289 3.19e-129

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 366.22  E-value: 3.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  80 LHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRI 159
Cdd:pfam08840   1 VDLEYFEEAINYLLRHPKVKGPGIGLLGISKGGELALSMATFLKQITATVSINGSAVVSGDPLVYKDNPLPPLGEGMRRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 160 KVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRR-KPQIICYPETGHY 238
Cdd:pfam08840  81 KVNKDGLLDIRDMFNDPLSKPDPKSLIPVERAKGPFLFVVGQDDHNWPSVFYAKKACERLQKHGKEvEVQLVCYPGAGHL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034587951 239 IEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGG 289
Cdd:pfam08840 161 IEPPYFPHCGASFHALVGMPVLWGGEPKAHAKAQEDAWKKIQAFFHKHLGG 211
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-283 6.25e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 61.14  E-value: 6.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  31 PGPFPGIV---DMFGTGGGLlEYRASLLAGKGFAVMALAYYNYEDLPKTMET-----------LHLEYFEEAVNYLLSHP 96
Cdd:COG0412    26 GGPRPGVVvlhEIFGLNPHI-RDVARRLAAAGYVVLAPDLYGRGGPGDDPDEaralmgaldpeLLAADLRAALDWLKAQP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  97 EVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSvanvggtlrykgetlppvgvnrnrikVTKDGYADIVDVLNSP 176
Cdd:COG0412   105 EVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGG--------------------------LPADDLLDLAARIKAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 177 LegpdqksfipveraestfLFLVGQDDHNWKSEfYANEACKRLQAHGRRKpQIICYPETGHyieppyfplcraSLHALvg 256
Cdd:COG0412   159 V------------------LLLYGEKDPLVPPE-QVAALEAALAAAGVDV-ELHVYPGAGH------------GFTNP-- 204

                         250       260
                  ....*....|....*....|....*..
gi 1034587951 257 spiiwgGEPRAHAMAQVDAWKQLQTFF 283
Cdd:COG0412   205 ------GRPRYDPAAAEDAWQRTLAFL 225
 
Name Accession Description Interval E-value
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 80-289 3.19e-129

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 366.22  E-value: 3.19e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  80 LHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRI 159
Cdd:pfam08840   1 VDLEYFEEAINYLLRHPKVKGPGIGLLGISKGGELALSMATFLKQITATVSINGSAVVSGDPLVYKDNPLPPLGEGMRRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 160 KVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRR-KPQIICYPETGHY 238
Cdd:pfam08840  81 KVNKDGLLDIRDMFNDPLSKPDPKSLIPVERAKGPFLFVVGQDDHNWPSVFYAKKACERLQKHGKEvEVQLVCYPGAGHL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034587951 239 IEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGG 289
Cdd:pfam08840 161 IEPPYFPHCGASFHALVGMPVLWGGEPKAHAKAQEDAWKKIQAFFHKHLGG 211
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-283 6.25e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 61.14  E-value: 6.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  31 PGPFPGIV---DMFGTGGGLlEYRASLLAGKGFAVMALAYYNYEDLPKTMET-----------LHLEYFEEAVNYLLSHP 96
Cdd:COG0412    26 GGPRPGVVvlhEIFGLNPHI-RDVARRLAAAGYVVLAPDLYGRGGPGDDPDEaralmgaldpeLLAADLRAALDWLKAQP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  97 EVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSvanvggtlrykgetlppvgvnrnrikVTKDGYADIVDVLNSP 176
Cdd:COG0412   105 EVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGG--------------------------LPADDLLDLAARIKAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 177 LegpdqksfipveraestfLFLVGQDDHNWKSEfYANEACKRLQAHGRRKpQIICYPETGHyieppyfplcraSLHALvg 256
Cdd:COG0412   159 V------------------LLLYGEKDPLVPPE-QVAALEAALAAAGVDV-ELHVYPGAGH------------GFTNP-- 204

                         250       260
                  ....*....|....*....|....*..
gi 1034587951 257 spiiwgGEPRAHAMAQVDAWKQLQTFF 283
Cdd:COG0412   205 ------GRPRYDPAAAEDAWQRTLAFL 225
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
29-245 4.29e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 58.87  E-value: 4.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  29 REPGPFPGIVDMFGTGGGLLE---YRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAVNYLLSHPEVKGPGVGL 105
Cdd:COG1506    18 ADGKKYPVVVYVHGGPGSRDDsflPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARPYVDPDRIGI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951 106 LGISKGGELCLSMASFLKGITAAVVINGSVANvggtlrykgetlppvgvNRNRIKVTKDGYADIVDVLNSPLEGPDQKSf 185
Cdd:COG1506    98 YGHSYGGYMALLAAARHPDRFKAAVALAGVSD-----------------LRSYYGTTREYTERLMGGPWEDPEAYAARS- 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034587951 186 iPVERAEST---FLFLVGQDDHNWKSEfYANEACKRLQAHGRRKpQIICYPETGHYIEPPYFP 245
Cdd:COG1506   160 -PLAYADKLktpLLLIHGEADDRVPPE-QAERLYEALKKAGKPV-ELLVYPGEGHGFSGAGAP 219
DLH pfam01738
Dienelactone hydrolase family;
32-134 1.90e-03

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 38.87  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034587951  32 GPFPGIV---DMFGTGGGLLEYRASLlAGKGFAVMALAYY-------NYEDLPKTMETLH--------LEYFEEAVNYLL 93
Cdd:pfam01738  10 PPWPVVVvfqEIFGVNDNIREIADRL-ADEGYVALAPDLYfrqgdpnDEADAARAMFELVskrvmekvLDDLEAAVNYLK 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034587951  94 SHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGS 134
Cdd:pfam01738  89 SQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDAAVGFYGV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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