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Conserved domains on  [gi|1034585265|ref|XP_016876348|]
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peptide chain release factor 1, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

PrfA superfamily protein( domain architecture ID 1907968)

PrfA superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 131-452 8.32e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.60  E-value: 8.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 131 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 208
Cdd:COG0216     6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 209 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 285
Cdd:COG0216    83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 286 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 362
Cdd:COG0216   158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 363 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 442
Cdd:COG0216   232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                         330
                  ....*....|
gi 1034585265 443 TQDRVSDHRI 452
Cdd:COG0216   312 PQGRVTDHRI 321
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 131-452 8.32e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.60  E-value: 8.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 131 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 208
Cdd:COG0216     6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 209 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 285
Cdd:COG0216    83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 286 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 362
Cdd:COG0216   158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 363 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 442
Cdd:COG0216   232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                         330
                  ....*....|
gi 1034585265 443 TQDRVSDHRI 452
Cdd:COG0216   312 PQGRVTDHRI 321
prfA PRK00591
peptide chain release factor 1; Validated
 131-454 7.53e-133

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 388.67  E-value: 7.53e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 131 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 208
Cdd:PRK00591    8 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEEL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 209 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLH 288
Cdd:PRK00591   85 KELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 289 HAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQ 365
Cdd:PRK00591  163 EVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 366 HVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQD 445
Cdd:PRK00591  237 HVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQG 316


                  ....*....
gi 1034585265 446 RVSDHRIAY 454
Cdd:PRK00591  317 RVTDHRINL 325
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 125-454 5.35e-111

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 333.20  E-value: 5.35e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 125 KALQKYMENLSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSlnkqDEKQLQE 202
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDPEVisDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 203 LALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPA 282
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 283 DYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 362
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 363 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 442
Cdd:TIGR00019 234 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNF 313

                         330
                  ....*....|..
gi 1034585265 443 TQDRVSDHRIAY 454
Cdd:TIGR00019 314 PQNRVTDHRINL 325
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 134-334 6.38e-66

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 210.70  E-value: 6.38e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 134 LSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKslnkqdEKQLQELALEERQTI 211
Cdd:pfam03462   1 LEERYEELEALLSDPDVwdDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 212 DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAA 291
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034585265 292 ARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 334
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
190-306 1.76e-35

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 127.96  E-value: 1.76e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265  190 KSLNKQDEKQLQELALEERQTI-DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSC 268
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034585265  269 YKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYE 306
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 131-452 8.32e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.60  E-value: 8.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 131 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 208
Cdd:COG0216     6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 209 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 285
Cdd:COG0216    83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 286 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 362
Cdd:COG0216   158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 363 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 442
Cdd:COG0216   232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                         330
                  ....*....|
gi 1034585265 443 TQDRVSDHRI 452
Cdd:COG0216   312 PQGRVTDHRI 321
prfA PRK00591
peptide chain release factor 1; Validated
 131-454 7.53e-133

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 388.67  E-value: 7.53e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 131 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 208
Cdd:PRK00591    8 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEEL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 209 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLH 288
Cdd:PRK00591   85 KELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 289 HAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQ 365
Cdd:PRK00591  163 EVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 366 HVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQD 445
Cdd:PRK00591  237 HVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQG 316


                  ....*....
gi 1034585265 446 RVSDHRIAY 454
Cdd:PRK00591  317 RVTDHRINL 325
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 125-454 5.35e-111

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 333.20  E-value: 5.35e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 125 KALQKYMENLSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSlnkqDEKQLQE 202
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDPEVisDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 203 LALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPA 282
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 283 DYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 362
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 363 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 442
Cdd:TIGR00019 234 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNF 313

                         330
                  ....*....|..
gi 1034585265 443 TQDRVSDHRIAY 454
Cdd:TIGR00019 314 PQNRVTDHRINL 325
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 164-461 5.36e-69

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 225.04  E-value: 5.36e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 164 ELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLyneLFQSLVpKEKYDKNDVILEVTA 243
Cdd:TIGR00020  57 ERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKALEKKLAEL---ELRTML-SGEYDANNAYLTIQA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 244 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 323
Cdd:TIGR00020 133 G--AGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGR 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 324 MqriHTGTMSVIVLPQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 402
Cdd:TIGR00020 211 R---HTSFASVFVMPEvDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMK 287

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034585265 403 VLRARLYQQIIEKdkrqQQSARKLQVGTRAQS---ERIRTYNF-TQDRVSDHRIAYEVRDIKA 461
Cdd:TIGR00020 288 VLKAKLYELEMEK----EQAEKDAKEGEKSEIgwgSQIRSYVLhPYSMVKDLRTGYETGNVQA 346
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 134-334 6.38e-66

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 210.70  E-value: 6.38e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 134 LSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKslnkqdEKQLQELALEERQTI 211
Cdd:pfam03462   1 LEERYEELEALLSDPDVwdDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 212 DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAA 291
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034585265 292 ARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 334
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 341-451 2.10e-58

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 188.40  E-value: 2.10e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 341 DEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQqiIEKDKRQQ 420
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034585265 421 QSAR-KLQVGTRAQSERIRTYNFT-QDRVSDHR 451
Cdd:pfam00472  79 KKRRiKSQVGSGDRSEQIRTYNFKpQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 178-461 8.07e-54

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 183.85  E-value: 8.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 178 TEQAIEELESMCKSLNKQDEKQLQELaLEERQTIDQKINMLYNELFQSlvpkEKYDKNDVILEVTAGrtTGGDICQQFTR 257
Cdd:PRK05589   33 LRNRIEDIEVLCEMMSEEDDEMKKEI-ISEVKNIKEEIDRFKIETLLS----GEYDRNNAILTLHSG--VGGTDAQDWTE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 258 EIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQrihTGTMSVIVL 337
Cdd:PRK05589  106 MLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQ---TSFASVEVL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 338 PQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQ--QIIE 414
Cdd:PRK05589  183 PElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLVElkERAH 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1034585265 415 KDKRQQQSARKLQVGTRAQserIRTYNF-TQDRVSDHRIAYEVRDIKA 461
Cdd:PRK05589  263 KEKIEDLTGELKDMGWGSQ---IRSYVFhPYNLVKDHRTGVETSNVDS 307
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 164-461 3.61e-49

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 171.84  E-value: 3.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 164 ELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINmlynELFQSLVPKEKYDKNDVILEVTA 243
Cdd:PRK06746   19 EANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMN----EYELQLLLSDPYDKNNAILELHP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 244 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 323
Cdd:PRK06746   95 G--AGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 324 MqriHTGTMSVIVLPQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 402
Cdd:PRK06746  173 R---HTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMK 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034585265 403 VLRARLYQQIIEKDKRQQQSARKLQ--VGTRAQserIRTYNF-TQDRVSDHRIAYEVRDIKA 461
Cdd:PRK06746  250 MLKAKLYQKKLEEQQAELDEIRGEQkeIGWGSQ---IRSYVFhPYSLVKDHRTNTEVGNVQA 308
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 163-460 1.18e-48

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 169.84  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 163 AELAPLAAIYQEiQETEQAIeelesmcksLNKQDEKQLQELALEerqtidqkinmlYNELFQSlvpkeKYDKNDVILEVT 242
Cdd:PRK08787   20 GELLDLAESEQD-EDTALAV---------IADLDKYQAHVEKLE------------FQRMFSG-----QMDGANAFVDIQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 243 AGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSS 322
Cdd:PRK08787   73 AG--AGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 323 RMqriHTGTMSVIVLPQPDE-VDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAF 401
Cdd:PRK08787  151 RR---HTSFTSVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAM 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034585265 402 RVLRARLYQQIIEKDKRQQQS--ARKLQVGTRAQserIRTYNFTQDRVSDHRIAYEVRDIK 460
Cdd:PRK08787  228 KMLAAKLYELEVQKRNAEKDAleATKSDIGWGSQ---IRNYVLDQSRIKDLRTGIERSDTQ 285
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 173-440 3.80e-45

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 161.20  E-value: 3.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 173 QEIQETEQAIEELESMCKSLNkqDEKQLQELALEER-----QTIDQKINMLYNEL----FQSLVPKEKyDKNDVILEVTA 243
Cdd:PRK07342   20 RERQQLDDSINGINHLEQTLN--DNIELIAMGEEEGdksivEDAEKTIRDLKDEIdrrqIDALLSGEA-DANDTYLEVHA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 244 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 323
Cdd:PRK07342   97 G--AGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNAR 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 324 MqriHTGTMSVIVLPQPDE-VDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 402
Cdd:PRK07342  175 R---HTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWS 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1034585265 403 VLRARLYQQIIEK--DKRQQQSARKLQVGTRAQserIRTY 440
Cdd:PRK07342  252 MLRARLYEEELKKreEATNAAAASKTDIGWGHQ---IRSY 288
PCRF smart00937
This domain is found in peptide chain release factors;
190-306 1.76e-35

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 127.96  E-value: 1.76e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265  190 KSLNKQDEKQLQELALEERQTI-DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSC 268
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034585265  269 YKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYE 306
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 344-451 3.01e-33

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 122.93  E-value: 3.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 344 DVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVH------------IPTGLVVECQQERSQIKNKEIAFRVLRARLYQQ 411
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034585265 412 IIEKDKRQQQSARKLQVGTRAQSERIRTynftqdRVSDHR 451
Cdd:COG1186   100 ELEPKERRATKPTRGSKKRRLWGKQIRS------MVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 349-424 8.96e-21

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 90.22  E-value: 8.96e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034585265 349 PKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSAR 424
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
344-408 5.84e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 54.39  E-value: 5.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 344 DVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLV------HIP---------------TG---LVVECQQERSQIKNKEI 399
Cdd:PRK09256    7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghriTKdgvIVIKAQEFRSQERNRED 86


                  ....*....
gi 1034585265 400 AfrvlRARL 408
Cdd:PRK09256   87 A----LERL 91
EAD9 pfam19962
Effector-associated domain 9; Effector-associated domains (EADs) are predicted to function as ...
 123-185 3.16e-03

Effector-associated domain 9; Effector-associated domains (EADs) are predicted to function as adaptor domains mediating protein-protein interactions. The EADs show a characteriztic architectural pattern. One copy is always fused, typically to the N- or C-terminus, of a core component of a biological conflict system; examples include VMAP, iSTAND, or GAP1. Further copies of the same EAD are fused to either effector or signal-transducing domains, or additional EADs. EAD pairs are frequently observed together on the genome in conserved gene neighborhoods, but can also be severed from such neighborhoods and located in distant regions, indicating EAD-EAD protein domain coupling attenuates collinear transcription requirements.


Pssm-ID: 437794 [Multi-domain]  Cd Length: 62  Bit Score: 36.04  E-value: 3.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034585265 123 KHKALQKYMENLSKEYQTLEQCLQHiPVNEENRRSLNRRhaelapLAAIYQEIQETEQAIEEL 185
Cdd:pfam19962   7 KRKFLEKRLAALEEEYEAVNNQLNY-TLDAVDRNRLQRQ------LERLEQEMEKVESELNQL 62
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
119-259 9.14e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034585265 119 KMLWKHKALQKYMENLSKEYQTLEQCLQHIpvnEENRRSLNRRHAEL-APLAAIYQEIQETEQAIEELESMCKSLNKQDE 197
Cdd:COG4372    91 AAQAELAQAQEELESLQEEAEELQEELEEL---QKERQDLEQQRKQLeAQIAELQSEIAEREEELKELEEQLESLQEELA 167

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034585265 198 KQLQELALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREI 259
Cdd:COG4372   168 ALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEA 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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