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Conserved domains on  [gi|1034579810|ref|XP_016874870|]
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desert hedgehog protein isoform X2 [Homo sapiens]

Protein Classification

HH_signal and Hint domain-containing protein( domain architecture ID 11645567)

HH_signal and Hint domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-281 3.87e-104

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


:

Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 301.87  E-value: 3.87e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810  73 KADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810 153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034579810 231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEELL 281
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLLL 211
HH_signal super family cl03090
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 2.85e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


The actual alignment was detected with superfamily member pfam01085:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.32  E-value: 2.85e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034579810   1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-281 3.87e-104

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 301.87  E-value: 3.87e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810  73 KADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810 153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034579810 231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEELL 281
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLLL 211
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 2.85e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.32  E-value: 2.85e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034579810   1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 85-229 3.93e-30

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 110.05  E-value: 3.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810  85 CFPGNATVRLWSGERKGLRELHR--GDWVLAADASGRVVPTPVLLFLDRDlqRRASFVAVETEwPPRKLLLTPWHLVFAA 162
Cdd:cd00081     1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTE-SGREITLTPDHLLFVL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034579810 163 RGpapapGDFAPVFARRLRAGDSVLAPggdalRPARVARVAREEAV-GVFAPLTA-HGTLLVNDVLASC 229
Cdd:cd00081    78 ED-----GELKWVFASDLKPGDYVLVP-----VLEKVKEIEEIEYTgGVYDLTVEdNHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 84-189 5.79e-22

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 87.71  E-value: 5.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810   84 GCFPGNATVRLWSGERKGLRELHRGDWVLAADAsGRVVPTPVLLFLDRDLQRRASFVAVETEwPPRKLLLTPWHLVFAAR 163
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTE-NGREITLTPDHLLLVRD 78

                           90       100
                   ....*....|....*....|....*.
gi 1034579810  164 GpapapGDFAPVFARRLRAGDSVLAP 189
Cdd:smart00306  79 G-----GKLVWVFASELKPGDYVLVP 99
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
22-72 1.66e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 37.97  E-value: 1.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034579810  22 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHVHVSV 72
Cdd:COG3108    82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-281 3.87e-104

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 301.87  E-value: 3.87e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810  73 KADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810 153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034579810 231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEELL 281
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLLL 211
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 2.85e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.32  E-value: 2.85e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034579810   1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 85-229 3.93e-30

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 110.05  E-value: 3.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810  85 CFPGNATVRLWSGERKGLRELHR--GDWVLAADASGRVVPTPVLLFLDRDlqRRASFVAVETEwPPRKLLLTPWHLVFAA 162
Cdd:cd00081     1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTE-SGREITLTPDHLLFVL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034579810 163 RGpapapGDFAPVFARRLRAGDSVLAPggdalRPARVARVAREEAV-GVFAPLTA-HGTLLVNDVLASC 229
Cdd:cd00081    78 ED-----GELKWVFASDLKPGDYVLVP-----VLEKVKEIEEIEYTgGVYDLTVEdNHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 84-189 5.79e-22

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 87.71  E-value: 5.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034579810   84 GCFPGNATVRLWSGERKGLRELHRGDWVLAADAsGRVVPTPVLLFLDRDLQRRASFVAVETEwPPRKLLLTPWHLVFAAR 163
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTE-NGREITLTPDHLLLVRD 78

                           90       100
                   ....*....|....*....|....*.
gi 1034579810  164 GpapapGDFAPVFARRLRAGDSVLAP 189
Cdd:smart00306  79 G-----GKLVWVFASELKPGDYVLVP 99
HintC smart00305
Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. ...
 194-235 1.86e-08

Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197641  Cd Length: 46  Bit Score: 49.48  E-value: 1.86e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034579810  194 LRPARVARVAREEAVGVFAP-LTAHGTLLVNDVLASCYAVLES 235
Cdd:smart00305   4 FRFVRVKSIEETEYTGVYDPtVTENHNFIANGILVHNCAEIET 46
Vint pfam14623
Hint-domain; This short domain is a conserved region of intein-containing proteins from lower ...
 84-157 1.55e-03

Hint-domain; This short domain is a conserved region of intein-containing proteins from lower eukaryotes.


Pssm-ID: 434076  Cd Length: 166  Bit Score: 38.35  E-value: 1.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034579810  84 GCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRV---VPTPVllfldrdlqRRASFVAVEtewpprKLLLTPWH 157
Cdd:pfam14623   1 PCFAGDSLVRLASGRTVPIRELRKGDKVQTPLGPRKVaavLKTPV---------ENEELCRIG------GLLITPWH 62
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
22-72 1.66e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 37.97  E-value: 1.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034579810  22 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHVHVSV 72
Cdd:COG3108    82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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