|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
956-1251 |
3.83e-156 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 473.60 E-value: 3.83e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 956 ALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNT 1035
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1036 WLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAALLEMGKDVDDP 1115
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1116 MVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGeMDIRNILLKQLDQQAIISGESIYWSQKPTPSSNASPWSEPAAVDVE 1195
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRPPPSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034578177 1196 LTAYALLAQLTKPsltQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:cd02897 240 MTAYALLALLSAG---GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
946-1251 |
1.85e-145 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 445.97 E-value: 1.85e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 946 VTVLGDIMGTALQ----NLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNG 1021
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1022 SYSAFGERDGNgnTWLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYV 1101
Cdd:pfam07678 81 SYSAFGHSPGS--TWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1102 TAALLEM-----GKDVDDPMVSQGLRCLKN-SATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISGESIYWSQ 1175
Cdd:pfam07678 159 TIALLEAldingLLQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWER 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034578177 1176 KPTPSSNASPW--SEPAAVDVELTAYALLAQltkpsLTQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:pfam07678 239 DEKSDPQGVPEypPQAPSLEVETTAYALLAY-----LLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
123-1418 |
3.30e-45 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 179.89 E-value: 3.30e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 123 FVQTDKPLYTPGQQVYFR-IVTMDSNFVPVNDKYSmVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAV- 200
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKaLLRDADGKAPAGLPLT-LELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELy 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 201 AEGKT---FGTFSVEEYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGA-VQVSVCQKANT--------YWYR 268
Cdd:COG2373 451 VDPKPalgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPARtafpgypgYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 269 EVEREQLPDKCRNLSGQTDKTGCFSAPVDMATFDLIGYAYshQINIVATVVEEGtG--VEANATQNIYISPQM------- 339
Cdd:COG2373 531 DPDEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPL--RATVEASVFESG-GrpVTRSATVPVHPADFYvgirlpl 607
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 340 GSMTFEDTsnfyhpNFPFsgKIRVRGHDDSFLKNHLVFLVIY----------GTNGTFN------------QTLVTDNNG 397
Cdd:COG2373 608 FDGDPEGA------PATF--EVVAVDPDGKPVAGKGLKVELYreewryvwykSDDGGWRyesqekeepvaeGTLTTGADG 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 398 LAPFTLETSGWngtdvsleGKFQMEdlVYNPEQvpryyqnaylhlrpfYSTTRsflgihrlngplkcgqpQEVLVDYYID 477
Cdd:COG2373 680 PASLSLTPVEW--------GRYRLE--VKDPDG---------------GLATS-----------------VRFYAGGNAS 717
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 478 PADASPDQ-EISF---SY-------YLI-----GKGSLVMEGQKHLNSKKKGLKASFS-LSLTFTSRLAPDpsLVIYAIF 540
Cdd:COG2373 718 WGAERPDRlELSLdkeSYkpgetakLLIqspfaGRALVTVERDGVLETQWVDVKGGGTtVEIPVTEDWAPN--AYVSATL 795
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 541 PSGGVVADK---------IQFSVEMCfDNQVSLGFSPSQQL-PGAEVELQLQAA-----PGSLcALRAVDESVLLLR--- 602
Cdd:COG2373 796 VRPGDSTANdmparaygvAPLPVDPP-ARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGILNLTgyk 873
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 603 -PDrelsnrsvygMFPFWYGHYPYQVAEYDqcpvsgpwDFPQpLIDPMPQGHSSQRSiiwrpsfsegtdlfsffrdvglk 681
Cdd:COG2373 874 tPD----------PLDFFYGKRALGVETRD--------LYGR-LIGAFGGAAGALRS----------------------- 911
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 682 ilsnakikkpvdcshrspeystamgaGGGHPEAFesstplhQAEDSQVRQYFPETWLWD-LFPIGNSGKEAVHVTVPDAI 760
Cdd:COG2373 912 --------------------------GGDGALGR-------GGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFN 958
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 761 TEWKAMSFCTSQSRgFGlSPTVGLTAFKPFFVDLTLPYSVVRGESFRLTATIFNYLKDCIRVQTDLAKSHEYQLESwADS 840
Cdd:COG2373 959 GTLRVMAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEG-EAT 1035
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 841 QTSScLCADDAKTHHWNITAVKLGHINFTISTKildsnepcggqkgfvpQKGRSDTLIKPVLVKPEGVLVEKTHSSLLCP 920
Cdd:COG2373 1036 QTVT-LAAGGRATVRFPLKAPDAGDAKVTVTAT----------------GGGESDAREVELPVRPANPLVTRATSGVLAP 1098
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 921 KgkvASESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLT---EE 997
Cdd:COG2373 1099 G---ESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGdkdAE 1175
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 998 IRSRavgfLEIGYQKELMYKHSNGSYSAFGeRDGNGNTWLTAFVTKCFGQAQKF-IFIDPKNIQDALKWMAgNQLPSGcy 1076
Cdd:COG2373 1176 LRAR----IQAAIARLLSMQNSDGGFGLWP-GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLR-NYLRNP-- 1247
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1077 anvgnllhTAMKGGVDDEVSLTAYVTAALLEMGK-DVDDpmvsqgLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNI 1155
Cdd:COG2373 1248 --------WEIEYDDAYRLAVRAYALYVLARAGKaDLGD------LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEE 1313
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1156 LLKQLDQQAIISGESIYWSQkpTPSSnaspwsepaavDVELTAYAL-LAQLTKPSLTQkeiakATSIVAWLAKQHNAyGG 1234
Cdd:COG2373 1314 LLAAALARLRETGARDYWYG--DYGS-----------PLRDQALALaLLAELGPDAPL-----APKLARWLAKALKS-GR 1374
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1235 FSSTQDTVVALQALAKYAtTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQDTLPNVPgmYTLEASGQGCVYVQTVL 1314
Cdd:COG2373 1375 WLSTQETAWALLALAAYA-RAAGASPDFTATLTLDGKTLPLTGRGPLARVTLPAAELLAGP--LTITNTGDGPLYYTLTL 1451
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1315 RY--NILPPTNMKT-FSLSVEIgKARCEQPTSPRSLT--------LTIHTSyvgSRSSSNMAIVEvkML-SGFspmEGTN 1382
Cdd:COG2373 1452 SGypAEGPPPAASNgLEIERRY-YDLDGKPIDPASLKqgdlvvvrLTVTAP---SGRVENVAVVD--PLpAGF---EIEN 1522
|
1370 1380 1390 1400
....*....|....*....|....*....|....*....|....*.
gi 1034578177 1383 QLLLQQPLVKK----------VEFGTDTLNIYLDelIKNTQTYTFT 1418
Cdd:COG2373 1523 PRLATSGDLGDwlgdswqpdhQEFRDDRVVAAFD--LDPAGTYTFA 1566
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
736-826 |
1.42e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.87 E-value: 1.42e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 736 TWLWDLFPIGNSGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVGLTAFKPFFVDLTLPYSVVRGESFRLTATIFNY 815
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 1034578177 816 LKDCIRVQTDL 826
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
956-1251 |
3.83e-156 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 473.60 E-value: 3.83e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 956 ALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNT 1035
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1036 WLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAALLEMGKDVDDP 1115
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1116 MVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGeMDIRNILLKQLDQQAIISGESIYWSQKPTPSSNASPWSEPAAVDVE 1195
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRPPPSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034578177 1196 LTAYALLAQLTKPsltQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:cd02897 240 MTAYALLALLSAG---GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
946-1251 |
1.85e-145 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 445.97 E-value: 1.85e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 946 VTVLGDIMGTALQ----NLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNG 1021
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1022 SYSAFGERDGNgnTWLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYV 1101
Cdd:pfam07678 81 SYSAFGHSPGS--TWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1102 TAALLEM-----GKDVDDPMVSQGLRCLKN-SATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISGESIYWSQ 1175
Cdd:pfam07678 159 TIALLEAldingLLQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWER 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034578177 1176 KPTPSSNASPW--SEPAAVDVELTAYALLAQltkpsLTQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:pfam07678 239 DEKSDPQGVPEypPQAPSLEVETTAYALLAY-----LLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
956-1251 |
2.91e-108 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 344.37 E-value: 2.91e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 956 ALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGnGNT 1035
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1036 WLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAALLEMGKDVDDP 1115
Cdd:cd02891 80 WLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACDAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1116 MvSQGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISGESIYWsqkptpsSNASPWSEPAAVDVE 1195
Cdd:cd02891 160 I-EKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW-------SLSWPGDYGSSLRVE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034578177 1196 LTAYALLAQltkpsLTQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:cd02891 232 ATAYALLAL-----LKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
959-1251 |
3.53e-76 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 254.89 E-value: 3.53e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 959 NLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGL---LTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNgnT 1035
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS--T 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1036 WLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGV---DDEVSLTAYVTAALLEmGKDV 1112
Cdd:cd02896 82 WLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQE-ARSI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1113 DDPMVsQGLRCLKNSATS--------TTNLYTQALLAYIFSLAGEmDIRNILLKQLDQQAIISGESIYWSQKPTPSSNAS 1184
Cdd:cd02896 161 CPPEV-QNLDQSIRKAISylenqlpnLQRPYALAITAYALALADS-PLSHAANRKLLSLAKRDGNGWYWWTIDSPYWPVP 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034578177 1185 PwsePAAVDVELTAYALLAQLTKpsltqKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKY 1251
Cdd:cd02896 239 G---PSAITVETTAYALLALLKL-----GDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
956-1251 |
1.04e-62 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 216.26 E-value: 1.04e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 956 ALQNLDGLVQMPSG--------CGEQNMVLFAPIIYVLQYLEKAGllteeIRSRAVGFLEIGYQKELMYKHSNGSYSAFG 1027
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1028 ERDGnGNTWLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMkgGVDDEVSLTAYVTAALLE 1107
Cdd:cd00688 76 GNDY-PSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIALAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1108 MGKDVDDPMVSQGLRCLKNSATS--------TTNLYTQALLAYIFSLAGEMDIRNI--LLKQLDQQAIISGESIYWSQKP 1177
Cdd:cd00688 153 LGKLDPDPLIEKALDYLLSCQNYdggfgpggESHGYGTACAAAALALLGDLDSPDAkkALRWLLSRQRPDGGWGEGRDRT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1178 TPSSNaspwsepaAVDVELTAYALLAQltkpsLTQKEIAKATSIVAWLAKQHNAYGGFSS-------TQDTVVALQALAK 1250
Cdd:cd00688 233 NKLSD--------SCYTEWAAYALLAL-----GKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSL 299
|
.
gi 1034578177 1251 Y 1251
Cdd:cd00688 300 Y 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
123-1418 |
3.30e-45 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 179.89 E-value: 3.30e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 123 FVQTDKPLYTPGQQVYFR-IVTMDSNFVPVNDKYSmVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAV- 200
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKaLLRDADGKAPAGLPLT-LELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELy 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 201 AEGKT---FGTFSVEEYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGA-VQVSVCQKANT--------YWYR 268
Cdd:COG2373 451 VDPKPalgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPARtafpgypgYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 269 EVEREQLPDKCRNLSGQTDKTGCFSAPVDMATFDLIGYAYshQINIVATVVEEGtG--VEANATQNIYISPQM------- 339
Cdd:COG2373 531 DPDEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPL--RATVEASVFESG-GrpVTRSATVPVHPADFYvgirlpl 607
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 340 GSMTFEDTsnfyhpNFPFsgKIRVRGHDDSFLKNHLVFLVIY----------GTNGTFN------------QTLVTDNNG 397
Cdd:COG2373 608 FDGDPEGA------PATF--EVVAVDPDGKPVAGKGLKVELYreewryvwykSDDGGWRyesqekeepvaeGTLTTGADG 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 398 LAPFTLETSGWngtdvsleGKFQMEdlVYNPEQvpryyqnaylhlrpfYSTTRsflgihrlngplkcgqpQEVLVDYYID 477
Cdd:COG2373 680 PASLSLTPVEW--------GRYRLE--VKDPDG---------------GLATS-----------------VRFYAGGNAS 717
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 478 PADASPDQ-EISF---SY-------YLI-----GKGSLVMEGQKHLNSKKKGLKASFS-LSLTFTSRLAPDpsLVIYAIF 540
Cdd:COG2373 718 WGAERPDRlELSLdkeSYkpgetakLLIqspfaGRALVTVERDGVLETQWVDVKGGGTtVEIPVTEDWAPN--AYVSATL 795
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 541 PSGGVVADK---------IQFSVEMCfDNQVSLGFSPSQQL-PGAEVELQLQAA-----PGSLcALRAVDESVLLLR--- 602
Cdd:COG2373 796 VRPGDSTANdmparaygvAPLPVDPP-ARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGILNLTgyk 873
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 603 -PDrelsnrsvygMFPFWYGHYPYQVAEYDqcpvsgpwDFPQpLIDPMPQGHSSQRSiiwrpsfsegtdlfsffrdvglk 681
Cdd:COG2373 874 tPD----------PLDFFYGKRALGVETRD--------LYGR-LIGAFGGAAGALRS----------------------- 911
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 682 ilsnakikkpvdcshrspeystamgaGGGHPEAFesstplhQAEDSQVRQYFPETWLWD-LFPIGNSGKEAVHVTVPDAI 760
Cdd:COG2373 912 --------------------------GGDGALGR-------GGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFN 958
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 761 TEWKAMSFCTSQSRgFGlSPTVGLTAFKPFFVDLTLPYSVVRGESFRLTATIFNYLKDCIRVQTDLAKSHEYQLESwADS 840
Cdd:COG2373 959 GTLRVMAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEG-EAT 1035
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 841 QTSScLCADDAKTHHWNITAVKLGHINFTISTKildsnepcggqkgfvpQKGRSDTLIKPVLVKPEGVLVEKTHSSLLCP 920
Cdd:COG2373 1036 QTVT-LAAGGRATVRFPLKAPDAGDAKVTVTAT----------------GGGESDAREVELPVRPANPLVTRATSGVLAP 1098
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 921 KgkvASESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLT---EE 997
Cdd:COG2373 1099 G---ESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGdkdAE 1175
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 998 IRSRavgfLEIGYQKELMYKHSNGSYSAFGeRDGNGNTWLTAFVTKCFGQAQKF-IFIDPKNIQDALKWMAgNQLPSGcy 1076
Cdd:COG2373 1176 LRAR----IQAAIARLLSMQNSDGGFGLWP-GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLR-NYLRNP-- 1247
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1077 anvgnllhTAMKGGVDDEVSLTAYVTAALLEMGK-DVDDpmvsqgLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNI 1155
Cdd:COG2373 1248 --------WEIEYDDAYRLAVRAYALYVLARAGKaDLGD------LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEE 1313
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1156 LLKQLDQQAIISGESIYWSQkpTPSSnaspwsepaavDVELTAYAL-LAQLTKPSLTQkeiakATSIVAWLAKQHNAyGG 1234
Cdd:COG2373 1314 LLAAALARLRETGARDYWYG--DYGS-----------PLRDQALALaLLAELGPDAPL-----APKLARWLAKALKS-GR 1374
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1235 FSSTQDTVVALQALAKYAtTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQDTLPNVPgmYTLEASGQGCVYVQTVL 1314
Cdd:COG2373 1375 WLSTQETAWALLALAAYA-RAAGASPDFTATLTLDGKTLPLTGRGPLARVTLPAAELLAGP--LTITNTGDGPLYYTLTL 1451
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1315 RY--NILPPTNMKT-FSLSVEIgKARCEQPTSPRSLT--------LTIHTSyvgSRSSSNMAIVEvkML-SGFspmEGTN 1382
Cdd:COG2373 1452 SGypAEGPPPAASNgLEIERRY-YDLDGKPIDPASLKqgdlvvvrLTVTAP---SGRVENVAVVD--PLpAGF---EIEN 1522
|
1370 1380 1390 1400
....*....|....*....|....*....|....*....|....*.
gi 1034578177 1383 QLLLQQPLVKK----------VEFGTDTLNIYLDelIKNTQTYTFT 1418
Cdd:COG2373 1523 PRLATSGDLGDwlgdswqpdhQEFRDDRVVAAFD--LDPAGTYTFA 1566
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
736-826 |
1.42e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.87 E-value: 1.42e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 736 TWLWDLFPIGNSGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVGLTAFKPFFVDLTLPYSVVRGESFRLTATIFNY 815
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 1034578177 816 LKDCIRVQTDL 826
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1360-1450 |
3.81e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 120.75 E-value: 3.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 1360 SSSNMAIVEVKMLSGFSPMEGTNQLLLQQPLVKKVE-FGTDTLNIYLDELIKNTQTYTFTISQSVLVTNLKPATIKVYDY 1438
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 1034578177 1439 YLPDEQATIQYS 1450
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
455-601 |
2.80e-28 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 111.29 E-value: 2.80e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 455 IHRLNGPLKCGQPQEVLVDYYIDPADASPdqeiSFSYYLIGKGSLVMEGQKhlnskkkglKASFSLSLTFTSRLAPDPSL 534
Cdd:pfam07703 3 LSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVGRG---------GVTTSFSLPVTAEMAPSARV 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 535 VIYAI---FPSGGVVADKIQFSVEMCFDNQVSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLL 601
Cdd:pfam07703 70 VAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
342-439 |
1.74e-26 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 104.64 E-value: 1.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 342 MTFEDTSNFYHPNFPFSGKIRVRGHDDSFLKNHLVFLVIYgtNGTFNQTLVTDNNGLAPFTLETSGwNGTDVSLEGKFQM 421
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAG--NTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKD 77
|
90
....*....|....*...
gi 1034578177 422 EDLVYNPEQVPRYYQNAY 439
Cdd:pfam17789 78 PDLCPEHQALAEMYAEAY 95
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
123-211 |
1.01e-23 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 96.62 E-value: 1.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 123 FVQTDKPLYTPGQQVYFRIVTMDSNFVPVNDKYSMVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAVAE 202
Cdd:pfam01835 3 FVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRD 82
|
90
....*....|...
gi 1034578177 203 GK----TFGTFSV 211
Cdd:pfam01835 83 GAggslGSGSFRV 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
213-303 |
1.48e-19 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 84.25 E-value: 1.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034578177 213 EYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGAVQVSVCQKantywyreverEQLPDKCRN-LSGQTDKTGC 291
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLK-----------DDSKRKCFEsFSKELDKDGC 69
|
90
....*....|..
gi 1034578177 292 FSAPVDMATFDL 303
Cdd:pfam17791 70 GSASLSTEEFQL 81
|
|
| SVA |
pfam05326 |
Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and ... |
788-858 |
1.96e-04 |
|
Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganizms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4.
Pssm-ID: 398804 Cd Length: 124 Bit Score: 42.77 E-value: 1.96e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034578177 788 KPFFVDLTLPYSVVRGESFRLTATIFNYLKDCIRVQTDLAksHEYQLESWADSQTSSCLCADDAKTHHWNI 858
Cdd:pfam05326 32 KPLSLDLKVPSTAKKNNEVTVTLTVKTNVKECMVVKAYLE--SNPPIKGSFNYIYTACLCNDYPRTFFWDI 100
|
|
| |
