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Conserved domains on  [gi|1034576408|ref|XP_016874083|]
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centrosomal protein of 57 kDa isoform X5 [Homo sapiens]

Protein Classification

Cep57_CLD and Cep57_MT_bd domain-containing protein( domain architecture ID 12163498)

Cep57_CLD and Cep57_MT_bd domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cep57_CLD super family cl26051
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 68-194 2.98e-48

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


The actual alignment was detected with superfamily member pfam14073:

Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 162.03  E-value: 2.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  68 AIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQL 147
Cdd:pfam14073   1 AVLSALKNLQEKIRRLELERKQAEDNLKQLSRETSHYKEVLQKENDARDPSRGEVSKQNQELISQLAAAESRCSLLEKQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408 148 EYMRNMIKHAEMERTSVLEKQ---------------------------------------KKMQELEAKLHEEEQERKRM 188
Cdd:pfam14073  81 EYMRKMVENAEKERTAVLEKQaslerersqdsselqaqleklekleqeylrltrtqslaeTKIKELEEKLQEEEHQRKLV 160


                  ....*.
gi 1034576408 189 QAKAAE 194
Cdd:pfam14073 161 QEKAAQ 166
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 247-320 8.28e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


:

Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 71.84  E-value: 8.28e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034576408 247 VTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQE---SPTVELKDKLECELEALVGRMEAKANQITKVRKY 320
Cdd:pfam06657   1 ATMRPSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 68-194 2.98e-48

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 162.03  E-value: 2.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  68 AIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQL 147
Cdd:pfam14073   1 AVLSALKNLQEKIRRLELERKQAEDNLKQLSRETSHYKEVLQKENDARDPSRGEVSKQNQELISQLAAAESRCSLLEKQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408 148 EYMRNMIKHAEMERTSVLEKQ---------------------------------------KKMQELEAKLHEEEQERKRM 188
Cdd:pfam14073  81 EYMRKMVENAEKERTAVLEKQaslerersqdsselqaqleklekleqeylrltrtqslaeTKIKELEEKLQEEEHQRKLV 160


                  ....*.
gi 1034576408 189 QAKAAE 194
Cdd:pfam14073 161 QEKAAQ 166
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 247-320 8.28e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 71.84  E-value: 8.28e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034576408 247 VTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQE---SPTVELKDKLECELEALVGRMEAKANQITKVRKY 320
Cdd:pfam06657   1 ATMRPSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 67-194 6.89e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 6.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  67 RAIFSALKNLQDKIRRLELERIQAEESVKTLSREtieyKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQ 146
Cdd:COG1196   228 ELLLLKLRELEAELEELEAELEELEAELEELEAE----LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034576408 147 LEYMRNMIKHAEMERtsvLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:COG1196   304 IARLEERRRELEERL---EELEEELAELEEELEELEEELEELEEELEE 348
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 72-191 2.43e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408   72 ALKNLQDKIRRLELERIQAE-ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM 150
Cdd:TIGR02169  780 ALNDLEARLSHSRIPEIQAElSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL 859

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1034576408  151 RnmIKHAEMERtSVLEKQKKMQELEAKLHEEEQERKRMQAK 191
Cdd:TIGR02169  860 N--GKKEELEE-ELEELEAALRDLESRLGDLKKERDELEAQ 897
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 68-194 2.98e-48

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 162.03  E-value: 2.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  68 AIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQL 147
Cdd:pfam14073   1 AVLSALKNLQEKIRRLELERKQAEDNLKQLSRETSHYKEVLQKENDARDPSRGEVSKQNQELISQLAAAESRCSLLEKQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408 148 EYMRNMIKHAEMERTSVLEKQ---------------------------------------KKMQELEAKLHEEEQERKRM 188
Cdd:pfam14073  81 EYMRKMVENAEKERTAVLEKQaslerersqdsselqaqleklekleqeylrltrtqslaeTKIKELEEKLQEEEHQRKLV 160


                  ....*.
gi 1034576408 189 QAKAAE 194
Cdd:pfam14073 161 QEKAAQ 166
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 247-320 8.28e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 71.84  E-value: 8.28e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034576408 247 VTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQE---SPTVELKDKLECELEALVGRMEAKANQITKVRKY 320
Cdd:pfam06657   1 ATMRPSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 67-194 6.89e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 6.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  67 RAIFSALKNLQDKIRRLELERIQAEESVKTLSREtieyKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQ 146
Cdd:COG1196   228 ELLLLKLRELEAELEELEAELEELEAELEELEAE----LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034576408 147 LEYMRNMIKHAEMERtsvLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:COG1196   304 IARLEERRRELEERL---EELEEELAELEEELEELEEELEELEEELEE 348
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 73-194 9.25e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 9.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRN 152
Cdd:COG1196   311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1034576408 153 MIKHAEMERTSVLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:COG1196   391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAE 432
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 71-194 9.34e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 9.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  71 SALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM 150
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034576408 151 RNMIKHAEMERTSVLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 72-194 9.75e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  72 ALKNLQDKIRRLELERIQAEESVKTLSRETIEykkvLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMR 151
Cdd:COG1196   282 ELEEAQAEEYELLAELARLEQDIARLEERRRE----LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1034576408 152 NMIKHAEMERtsvLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:COG1196   358 AELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAE 397
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 78-194 1.97e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  78 DKIRRLELERIQAEESVKtlSRETIEYKKVLDEQIQERENSKNEE------SKHNQELTSQLLAAENKCNLLEKQLEYMR 151
Cdd:pfam17380 449 ERVRLEEQERQQQVERLR--QQEEERKRKKLELEKEKRDRKRAEEqrrkilEKELEERKQAMIEEERKRKLLEKEMEERQ 526

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034576408 152 NMIkHAEMERTSVLEKQKKMQELEAKLHEEEQ------ERKRMQAKAAE 194
Cdd:pfam17380 527 KAI-YEEERRREAEEERRKQQEMEERRRIQEQmrkateERSRLEAMERE 574
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 72-191 2.43e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408   72 ALKNLQDKIRRLELERIQAE-ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM 150
Cdd:TIGR02169  780 ALNDLEARLSHSRIPEIQAElSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL 859

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1034576408  151 RnmIKHAEMERtSVLEKQKKMQELEAKLHEEEQERKRMQAK 191
Cdd:TIGR02169  860 N--GKKEELEE-ELEELEAALRDLESRLGDLKKERDELEAQ 897
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 81-194 4.64e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAEnKCNLLEKQLEymrNMIKHAEME 160
Cdd:pfam17380 346 RERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAAR-KVKILEEERQ---RKIQQQKVE 421

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034576408 161 RTSVLEKQKKMQELEAKLHEEEQERKRMQAKAAE 194
Cdd:pfam17380 422 MEQIRAEQEEARQREVRRLEEERAREMERVRLEE 455
HAP1_N pfam04849
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ...
 53-191 6.21e-03

HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.


Pssm-ID: 461455 [Multi-domain]  Cd Length: 309  Bit Score: 38.47  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  53 SPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKK-----VLD--EQIQERENS------- 118
Cdd:pfam04849 146 SCSTPLRRNESFSSLHGCVQLDALQEKLRGLEEENLKLRSEASHLKTETDTYEEkeqqlMSDcvEQLSEANQQmaelsee 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408 119 ---KNEESKHNQE----LTSQLLAAENKCNLLEKQLEYMRNMI---KHAEMERTSVL-EKQKKMQELEAKLHEEEQERKR 187
Cdd:pfam04849 226 larKMEENLRQQEeitsLLAQIVDLQHKCKELGIENEELQQHLqasKEAQRQLTSELqELQDRYAECLGMLHEAQEELKE 305


                  ....
gi 1034576408 188 MQAK 191
Cdd:pfam04849 306 LRKK 309
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 71-319 6.78e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 6.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408   71 SALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLdEQIQERENSKNEESKhnqELTSQLLAAENKCNLLEKQLEYM 150
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEELEEEL-EQLRKELEELSRQIS---ALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  151 RNMIKHAEMERTSVLEKqkkMQELEAKLHEEEQERKRMQAKAAEstspshavvanvqlvlhLMKQHSKalcNDRVINSip 230
Cdd:TIGR02168  753 SKELTELEAEIEELEER---LEEAEEELAEAEAEIEELEAQIEQ-----------------LKEELKA---LREALDE-- 807

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576408  231 LAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESptVELKDKLECELEALVGRMEAK 310
Cdd:TIGR02168  808 LRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEEL--EELIEELESELEALLNERASL 885


                   ....*....
gi 1034576408  311 ANQITKVRK 319
Cdd:TIGR02168  886 EEALALLRS 894
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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