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Conserved domains on  [gi|1034573132|ref|XP_016873065|]
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forkhead box protein R1 isoform X2 [Homo sapiens]

Protein Classification

forkhead box protein( domain architecture ID 165)

forkhead box protein contains a forkhead/winged helix DNA-binding domain and may function as a transcription factor that is involved in regulating diverse biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH_FOX super family cl00061
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
 171-233 6.62e-23

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


The actual alignment was detected with superfamily member cd20036:

Pssm-ID: 469596 [Multi-domain]  Cd Length: 87  Bit Score: 89.68  E-value: 6.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 171 WSRPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSMQGGAstRPRSCL 224
Cdd:cd20036     1 WPKPPLSYPNLIALALRNSETGSLNVQEIYDFIRfhfpffrtapdgwknsvrhnlsfsdsFEKVPTSVSGYG--GRRSCL 78


                  ....*....
gi 1034573132 225 WKLTEEGHR 233
Cdd:cd20036    79 WKLTPEGER 87
 
Name Accession Description Interval E-value
FH_FOXR cd20036
Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily ...
 171-233 6.62e-23

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410810 [Multi-domain]  Cd Length: 87  Bit Score: 89.68  E-value: 6.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 171 WSRPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSMQGGAstRPRSCL 224
Cdd:cd20036     1 WPKPPLSYPNLIALALRNSETGSLNVQEIYDFIRfhfpffrtapdgwknsvrhnlsfsdsFEKVPTSVSGYG--GRRSCL 78


                  ....*....
gi 1034573132 225 WKLTEEGHR 233
Cdd:cd20036    79 WKLTPEGER 87
Forkhead pfam00250
Forkhead domain;
173-235 3.66e-10

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 55.17  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 173 RPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSmqggASTRPRSCLWK 226
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISenfpyyrtadkgwqnsirhnlslnkcFVKVPRP----KDEPGKGSYWT 76


                  ....*....
gi 1034573132 227 LTEEGHRRF 235
Cdd:pfam00250  77 IDPEYEEMF 85
 
Name Accession Description Interval E-value
FH_FOXR cd20036
Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily ...
 171-233 6.62e-23

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410810 [Multi-domain]  Cd Length: 87  Bit Score: 89.68  E-value: 6.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 171 WSRPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSMQGGAstRPRSCL 224
Cdd:cd20036     1 WPKPPLSYPNLIALALRNSETGSLNVQEIYDFIRfhfpffrtapdgwknsvrhnlsfsdsFEKVPTSVSGYG--GRRSCL 78


                  ....*....
gi 1034573132 225 WKLTEEGHR 233
Cdd:cd20036    79 WKLTPEGER 87
Forkhead pfam00250
Forkhead domain;
173-235 3.66e-10

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 55.17  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 173 RPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSmqggASTRPRSCLWK 226
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISenfpyyrtadkgwqnsirhnlslnkcFVKVPRP----KDEPGKGSYWT 76


                  ....*....
gi 1034573132 227 LTEEGHRRF 235
Cdd:pfam00250  77 IDPEYEEMF 85
FH_FOX cd00059
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
 174-202 3.13e-05

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


Pssm-ID: 410788 [Multi-domain]  Cd Length: 75  Bit Score: 41.35  E-value: 3.13e-05
                          10        20
                  ....*....|....*....|....*....
gi 1034573132 174 PPLNYFHLIALALRNSSPCGLNVQQIYSF 202
Cdd:cd00059     1 PPYSYAALIALAILSSPDKRLTLSEIYKW 29
FH_FOXN1-like cd20030
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The ...
 173-227 2.07e-03

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The FOXN1-like group includes two FOXN subfamily winged helix transcription factors, FOXN1 and FOXN4. FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410804 [Multi-domain]  Cd Length: 81  Bit Score: 36.26  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034573132 173 RPPLNYFHLIALALRNSSPCGLNVQQIYSFTR--------------------------FEKVPVSMQGGASTrpRSCLWK 226
Cdd:cd20030     1 KPAYSYSCLIAMALKNSRTGCLPVSEIYSFMCenfpyfktapdgwknsvrhnlslnkcFEKIERPDGNGSSR--KGCLWA 78


                  .
gi 1034573132 227 L 227
Cdd:cd20030    79 L 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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