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Conserved domains on  [gi|1034572871|ref|XP_016872971|]
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echinoderm microtubule-associated protein-like 3 isoform X10 [Homo sapiens]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 12044477)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 101-169 2.63e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.63e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572871 101 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 169
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
389-753 8.80e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 8.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 389 GIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 467
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 468 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGL-CADFHPSGAVVAVGLNTGR 545
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 546 WLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdGAKSSRFGrcmGHSSFITHLDWSKDGNFI 625
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 626 MSNSGDYEILYWDVAGGcKQLKnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 705
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572871 706 QypcARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDASIFQWRV 753
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
183-509 3.00e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 183 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 262
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 263 VDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGVfgkyk 341
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLL---RTLTGHSGS----- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 342 kpkfIPCFVFLPDGDIL-TGDSEGNILTWGRspsdsktpgrggakETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 420
Cdd:COG2319   249 ----VRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 421 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 498
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1034572871 499 CGHDRQLCLWD 509
Cdd:COG2319   390 GSADGTVRLWD 400
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 101-169 2.63e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.63e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572871 101 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 169
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
389-753 8.80e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 8.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 389 GIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 467
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 468 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGL-CADFHPSGAVVAVGLNTGR 545
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 546 WLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdGAKSSRFGrcmGHSSFITHLDWSKDGNFI 625
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 626 MSNSGDYEILYWDVAGGcKQLKnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 705
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572871 706 QypcARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDASIFQWRV 753
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 435-752 3.34e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 435 AEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGES 512
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVwDLETGELLrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 513 HALAWSIDL-KETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY 591
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 592 SVSSdgakssrfGRCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGcKQLknryesrdrewatytCVLGFH 667
Cdd:cd00200   163 DLRT--------GKCVatltGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCL---------------GTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 668 VYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQYpcaRAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDAS 747
Cdd:cd00200   219 ENGVN----------SVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGT 284


                  ....*
gi 1034572871 748 IFQWR 752
Cdd:cd00200   285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
183-509 3.00e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 183 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 262
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 263 VDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGVfgkyk 341
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLL---RTLTGHSGS----- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 342 kpkfIPCFVFLPDGDIL-TGDSEGNILTWGRspsdsktpgrggakETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 420
Cdd:COG2319   249 ----VRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 421 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 498
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1034572871 499 CGHDRQLCLWD 509
Cdd:COG2319   390 GSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-509 1.92e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 183 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWDSETllKLQEIGLGAFERGVGALAFSAADQGAFLCv 262
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASG- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 263 vddSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGvfgkyk 341
Cdd:cd00200    70 ---SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKtIKVWDVETGKCL---TTLRGHTD------ 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 342 kpkFIPCFVFLPDGDILT-GDSEGNILTWgrspsDSKTPgrggaketyGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 420
Cdd:cd00200   137 ---WVNSVAFSPDGTFVAsSSQDGTIKLW-----DLRTG---------KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 421 RLVQWGPGLVALQeAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 498
Cdd:cd00200   200 TIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVwDLRTGeCVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         330
                  ....*....|.
gi 1034572871 499 CGHDRQLCLWD 509
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-509 4.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034572871  476 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 509
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-509 4.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034572871 476 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 509
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-227 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034572871  183 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 227
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASG-----SDDGT-----IKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
182-227 4.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034572871 182 QRHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 227
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASG-----SDDGT-----VKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 101-169 2.63e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.63e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572871 101 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 169
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
389-753 8.80e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 8.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 389 GIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 467
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 468 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGL-CADFHPSGAVVAVGLNTGR 545
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 546 WLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdGAKSSRFGrcmGHSSFITHLDWSKDGNFI 625
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 626 MSNSGDYEILYWDVAGGcKQLKnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 705
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572871 706 QypcARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDASIFQWRV 753
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
195-641 4.88e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 4.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 195 LAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEigLGAFERGVGALAFSAADQGaflcVVDDSNEHMLSVW 274
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 275 DCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGvfgkykkpkFIPCFVFLP 353
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLATGKLL---RTLTGHSG---------AVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 354 DGDIL-TGDSEGNILTWgrspsDSKTPGRggaketygiVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWgpglval 432
Cdd:COG2319   173 DGKLLaSGSDDGTVRLW-----DLATGKL---------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW------- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 433 qeaeipehfgavraiaeglgsellvgttknallrgDLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGE 511
Cdd:COG2319   232 -----------------------------------DLATGKLLrTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 512 SHALAWSIDLKETGLCA-DFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYI 590
Cdd:COG2319   277 TGELLRTLTGHSGGVNSvAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034572871 591 YSVSSDGAKssrfGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAG 641
Cdd:COG2319   357 WDLATGELL----RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 435-752 3.34e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 435 AEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGES 512
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVwDLETGELLrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 513 HALAWSIDL-KETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY 591
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 592 SVSSdgakssrfGRCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGcKQLknryesrdrewatytCVLGFH 667
Cdd:cd00200   163 DLRT--------GKCVatltGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCL---------------GTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 668 VYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQYpcaRAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDAS 747
Cdd:cd00200   219 ENGVN----------SVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGT 284


                  ....*
gi 1034572871 748 IFQWR 752
Cdd:cd00200   285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
406-753 4.10e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 406 LRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDEL 484
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGaLLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 485 WGLCTHPSQNRFLTCGHDRQLCLWDGES-HALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDG 563
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATgLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 564 NEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdGAKSSRFGrcmGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGc 643
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 644 KQLKnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQypcARAKAPSRMYGGHG 723
Cdd:COG2319   237 KLLR---------------TLTGHSGSVR----------SVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHS 288

                         330       340       350
                  ....*....|....*....|....*....|
gi 1034572871 724 SHVTSVRFTHDDSHLVSlGGKDASIFQWRV 753
Cdd:COG2319   289 GGVNSVAFSPDGKLLAS-GSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
183-509 3.00e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 183 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 262
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 263 VDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGVfgkyk 341
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLL---RTLTGHSGS----- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 342 kpkfIPCFVFLPDGDIL-TGDSEGNILTWGRspsdsktpgrggakETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 420
Cdd:COG2319   249 ----VRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 421 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 498
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1034572871 499 CGHDRQLCLWD 509
Cdd:COG2319   390 GSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
446-753 1.08e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 446 AIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG 525
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 526 LCA-DFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdgakssrfG 604
Cdd:COG2319    81 VLSvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--------G 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 605 RCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGckqlknryesrdREWATYTcvlgfhvygvwpdGSDGTd 680
Cdd:COG2319   153 KLLrtltGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------------KLLRTLT-------------GHTGA- 206

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572871 681 INSLCRSHNERVVAVADDFCKVHLFQypcARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSlGGKDASIFQWRV 753
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 282-638 1.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 282 LAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVgvpgngTLTRKQGvfgkykKPKFIPCFVFLPDGD-ILT 359
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGtIKVWDLETGE------LLRTLKG------HTGPVRDVAASADGTyLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 360 GDSEGNILTWgrspsDSKTPGrggaketygIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWgPGLVALQEAEIPE 439
Cdd:cd00200    69 GSSDKTIRLW-----DLETGE---------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW-DVETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 440 HFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGfSPV--IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDgeshala 516
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVASSSQDGTIKlWDLRTG-KCVatLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD------- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 517 wsidlketglcadfhpsgavvavgLNTGRWL-VLDTETREIVSdvidgneqlsvVRYSPDGLYLAIGSHDNVIYIYSVSS 595
Cdd:cd00200   206 ------------------------LSTGKCLgTLRGHENGVNS-----------VAFSPDGYLLASGSEDGTIRVWDLRT 250

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1034572871 596 dgakssrfGRCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWD 638
Cdd:cd00200   251 --------GECVqtlsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-509 1.92e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 183 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWDSETllKLQEIGLGAFERGVGALAFSAADQGAFLCv 262
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASG- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 263 vddSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPrDSSCIVTSGKSH-VHFWNWSGGVGVpgnGTLTRKQGvfgkyk 341
Cdd:cd00200    70 ---SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKtIKVWDVETGKCL---TTLRGHTD------ 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 342 kpkFIPCFVFLPDGDILT-GDSEGNILTWgrspsDSKTPgrggaketyGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 420
Cdd:cd00200   137 ---WVNSVAFSPDGTFVAsSSQDGTIKLW-----DLRTG---------KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 421 RLVQWGPGLVALQeAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 498
Cdd:cd00200   200 TIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVwDLRTGeCVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         330
                  ....*....|.
gi 1034572871 499 CGHDRQLCLWD 509
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 527-753 1.55e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 527 CADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSdGAKSSRFGrc 606
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTLT-- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 607 mGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGckqlKNRYESRDREwATYTCVL----GFHVYGVWPDGS----DG 678
Cdd:cd00200    91 -GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG----KCLTTLRGHT-DWVNSVAfspdGTFVASSSQDGTiklwDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 679 T-------------DINSLCRSHNERVVAVA--DDFCKVHLFqypcaRAKAPSRMYGGHGSHVTSVRFtHDDSHLVSLGG 743
Cdd:cd00200   165 RtgkcvatltghtgEVNSVAFSPDGEKLLSSssDGTIKLWDL-----STGKCLGTLRGHENGVNSVAF-SPDGYLLASGS 238

                         250
                  ....*....|
gi 1034572871 744 KDASIFQWRV 753
Cdd:cd00200   239 EDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 608-753 8.06e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572871 608 GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGckQLKNRYESRDREWATYTCVlgfhvygvwpdgsdgtdinslcrS 687
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAAS-----------------------A 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572871 688 HNERVVAVADDFCkVHLFQYpcaRAKAPSRMYGGHGSHVTSVRFtHDDSHLVSLGGKDASIFQWRV 753
Cdd:cd00200    62 DGTYLASGSSDKT-IRLWDL---ETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDV 122
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-509 4.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034572871  476 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 509
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-509 4.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034572871 476 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 509
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 606-638 1.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034572871  606 CMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 638
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-227 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034572871  183 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 227
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASG-----SDDGT-----IKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
182-227 4.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034572871 182 QRHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 227
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASG-----SDDGT-----VKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
608-638 5.79e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.79e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034572871 608 GHSSFITHLDWSKDGNFIMSNSGDYEILYWD 638
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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