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Conserved domains on  [gi|1034572778|ref|XP_016872942|]
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tripartite motif-containing protein 29 isoform X2 [Homo sapiens]

Protein Classification

OmpH family outer membrane protein( domain architecture ID 12048616)

OmpH family outer membrane protein may play an active role either as folding catalysts or as chaperones in extracytoplasmic compartments; similar to Flavobacterium psychrophilum outer membrane protein P18

Gene Ontology:  GO:0051082|GO:0016020
PubMed:  2318304

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-94 6.86e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 85
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 1034572778  86 MDALDERAK 94
Cdd:pfam03938 101 NKAIKEVAK 109
 
Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-94 6.86e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 85
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 1034572778  86 MDALDERAK 94
Cdd:pfam03938 101 NKAIKEVAK 109
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 23-94 4.07e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 40.59  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778  23 EIEDEAEKWQKEKDRI---------------KSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVIM 86
Cdd:COG2825    47 KLEKEFKKRQAELQKLekelqalqeklqkeaATLSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQPIlEKIQ 126


                  ....*...
gi 1034572778  87 DALDERAK 94
Cdd:COG2825   127 KAIKEVAK 134
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-94 5.09e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.87  E-value: 5.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778    7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDrikSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 85
Cdd:smart00935  24 EKEFKKRQAELEKLEKELQKLKEKLQKDAA---TLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKIlDKI 100


                   ....*....
gi 1034572778   86 MDALDERAK 94
Cdd:smart00935 101 NKAIKEVAK 109
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-105 9.59e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 9.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778    5 ISETELSLqkEQLQLKIIEIEDEAEKWQKEKDRIK---SFTTNEKAILEQNFRDLVRD----------LEKQKEEVRAAL 71
Cdd:TIGR02168  262 LQELEEKL--EELRLEVSELEEEIEELQKELYALAneiSRLEQQKQILRERLANLERQleeleaqleeLESKLDELAEEL 339

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034572778   72 EQREQDaVDQVKVIMDALDERAKVLHEDKQTREQ 105
Cdd:TIGR02168  340 AELEEK-LEELKEELESLEAELEELEAELEELES 372
PRK12704 PRK12704
phosphodiesterase; Provisional
 5-110 2.83e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.38  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   5 ISETELSLQKEQLQLKIIEIEDEAEKWQKE-----KDRIKsfttNEKAILEQNFRDLVRDLEK------QKEEV----RA 69
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEAIKKEalleaKEEIH----KLRNEFEKELRERRNELQKlekrllQKEENldrkLE 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034572778  70 ALEQREQDAVDQVKVI---MDALDERAKVLHE-DKQTREQLHSIS 110
Cdd:PRK12704  104 LLEKREEELEKKEKELeqkQQELEKKEEELEElIEEQLQELERIS 148
 
Name Accession Description Interval E-value
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-94 6.86e-05

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 85
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELLQPIqDKI 100


                  ....*....
gi 1034572778  86 MDALDERAK 94
Cdd:pfam03938 101 NKAIKEVAK 109
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 23-94 4.07e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 40.59  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778  23 EIEDEAEKWQKEKDRI---------------KSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVIM 86
Cdd:COG2825    47 KLEKEFKKRQAELQKLekelqalqeklqkeaATLSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQPIlEKIQ 126


                  ....*...
gi 1034572778  87 DALDERAK 94
Cdd:COG2825   127 KAIKEVAK 134
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
15-106 4.70e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778  15 EQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKailEQNFRDLVRDLEKQKEEVRAALEQRE--QDAVDQVKVIMDALDER 92
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLAT---EEELQDLAEELEELQQRLAELEEELEeaQEELEELEEELEQLENE 235

                          90
                  ....*....|....
gi 1034572778  93 AKVLHEDKQTREQL 106
Cdd:COG4717   236 LEAAALEERLKEAR 249
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 7-94 5.09e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.87  E-value: 5.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778    7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDrikSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQV-KVI 85
Cdd:smart00935  24 EKEFKKRQAELEKLEKELQKLKEKLQKDAA---TLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKIlDKI 100


                   ....*....
gi 1034572778   86 MDALDERAK 94
Cdd:smart00935 101 NKAIKEVAK 109
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 15-108 7.39e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.61  E-value: 7.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778  15 EQLQLKIIEIEDEAEKWQKEKDrIKSFttnEKAileQNFRDLVRDLEKQKEEVRAALEQrEQDAVDQVKVIMDALDERAK 94
Cdd:COG0542   414 DELERRLEQLEIEKEALKKEQD-EASF---ERL---AELRDELAELEEELEALKARWEA-EKELIEEIQELKEELEQRYG 485

                          90
                  ....*....|....
gi 1034572778  95 VLHEDKQTREQLHS 108
Cdd:COG0542   486 KIPELEKELAELEE 499
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-105 9.59e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 9.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778    5 ISETELSLqkEQLQLKIIEIEDEAEKWQKEKDRIK---SFTTNEKAILEQNFRDLVRD----------LEKQKEEVRAAL 71
Cdd:TIGR02168  262 LQELEEKL--EELRLEVSELEEEIEELQKELYALAneiSRLEQQKQILRERLANLERQleeleaqleeLESKLDELAEEL 339

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034572778   72 EQREQDaVDQVKVIMDALDERAKVLHEDKQTREQ 105
Cdd:TIGR02168  340 AELEEK-LEELKEELESLEAELEELEAELEELES 372
PRK12704 PRK12704
phosphodiesterase; Provisional
 5-110 2.83e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.38  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   5 ISETELSLQKEQLQLKIIEIEDEAEKWQKE-----KDRIKsfttNEKAILEQNFRDLVRDLEK------QKEEV----RA 69
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEAIKKEalleaKEEIH----KLRNEFEKELRERRNELQKlekrllQKEENldrkLE 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034572778  70 ALEQREQDAVDQVKVI---MDALDERAKVLHE-DKQTREQLHSIS 110
Cdd:PRK12704  104 LLEKREEELEKKEKELeqkQQELEKKEEELEElIEEQLQELERIS 148
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
9-119 3.13e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.37  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   9 ELSLQKEQLQlkiIEIEDEAEKWQKEKDRIKSFTTNEKAI--LEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVI- 85
Cdd:COG4717   129 PLYQELEALE---AELAELPERLEELEERLEELRELEEELeeLEAELAELQEELEELLEQLSLATEEELQDLAEELEELq 205

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034572778  86 --MDALDERAKVLHEDK-QTREQLHSISDSVLFLQEF 119
Cdd:COG4717   206 qrLAELEEELEEAQEELeELEEELEQLENELEAAALE 242
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 7-106 3.16e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   7 ETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSfTTNEKAILEQNFRDLVRDLEKQKEEvRAALEQREQDAVDQVKVIM 86
Cdd:COG1196   266 EAELEELRLELEELELELEEAQAEEYELLAELAR-LEQDIARLEERRRELEERLEELEEE-LAELEEELEELEEELEELE 343

                          90       100
                  ....*....|....*....|
gi 1034572778  87 DALDERAKVLHEDKQTREQL 106
Cdd:COG1196   344 EELEEAEEELEEAEAELAEA 363
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 9-106 4.53e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 4.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778    9 ELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVR---DLEKQKEEVRAALEQREQ------DAV 79
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAlrkDLARLEAEVEQLEERIAQlskeltELE 760

                           90       100
                   ....*....|....*....|....*..
gi 1034572778   80 DQVKVIMDALDERAKVLHEDKQTREQL 106
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEEL 787
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
6-101 8.52e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 8.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572778   6 SETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKsfttNEKAILEQNfrDLVRDLEKQKEEVRAALEQREQDAvDQVKVI 85
Cdd:COG4717   426 DEEELEEELEELEEELEELEEELEELREELAELE----AELEQLEED--GELAELLQELEELKAELRELAEEW-AALKLA 498

                          90
                  ....*....|....*.
gi 1034572778  86 MDALDERAKVLHEDKQ 101
Cdd:COG4717   499 LELLEEAREEYREERL 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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