NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034567248|ref|XP_016871421|]
View 

ankyrin repeat domain-containing protein 26 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 7.67e-164

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 503.75  E-value: 7.67e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1885-1993 4.76e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 192.96  E-value: 4.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1885 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1964
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567248 1965 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1993
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.58e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 1.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567248  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1776 2.80e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 98.59  E-value: 2.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1757
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567248 1758 DIQINKLKHKIDDLTAELE 1776
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1756-1929 1.30e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1835
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1836 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1904
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567248 1905 SQEDFNKTELEKYKQLYlEELKVRK 1929
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 7.67e-164

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 503.75  E-value: 7.67e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1885-1993 4.76e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 192.96  E-value: 4.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1885 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1964
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567248 1965 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1993
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 1.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567248  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 2.11e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 2.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034567248  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1776 2.80e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 98.59  E-value: 2.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1757
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567248 1758 DIQINKLKHKIDDLTAELE 1776
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1087-1959 3.44e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 78.68  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1087 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1165
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1166 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1245
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1246 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1307
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1308 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1380
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1381 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1456
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1457 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1532
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1533 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1608
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1609 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1674
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1675 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1743
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1744 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1823
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1824 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1888
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1889 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1959
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1511-1949 7.38e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.33  E-value: 7.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1511 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1581
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1582 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1658
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1659 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1734
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1735 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1805
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1806 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1873
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1874 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1933
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 1034567248 1934 KLTKTNERLAEVNTKL 1949
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.74e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567248  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1087-1634 4.88e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.51  E-value: 4.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1087 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1163
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1164 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1236
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1237 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1316
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1396
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1397 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1476
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1477 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1550
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1551 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1630
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 1034567248 1631 QLQE 1634
Cdd:COG1196    775 EIEA 778
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1161-1776 5.31e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 5.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1161 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1231
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1232 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1311
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1312 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1391
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1392 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1471
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1472 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1551
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1552 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1622
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1623 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1690
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1691 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1770
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 1034567248 1771 LTAELE 1776
Cdd:COG1196    772 LEREIE 777
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1103-1539 1.86e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.20  E-value: 1.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1103 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1182
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1183 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1241
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1242 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1319
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1320 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1396
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1397 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1464
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567248 1465 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1539
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1162-1730 6.73e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 6.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1162 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1240
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1241 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1315
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1316 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1377
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1378 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1455 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1513
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1514 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1590
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1591 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1670
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1671 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 7.68e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 7.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.23e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567248  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1756-1929 1.30e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1835
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1836 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1904
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567248 1905 SQEDFNKTELEKYKQLYlEELKVRK 1929
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1665-1939 6.34e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1665 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1738
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1739 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1818
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1819 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1892
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1893 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1939
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1622-1954 3.66e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 45.62  E-value: 3.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1622 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1687
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1688 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1755
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1821
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1822 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1892
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567248 1893 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1954
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.79e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.79e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567248    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1544-1741 3.33e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 41.28  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1544 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1623
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1624 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1699
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034567248 1700 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1276-1579 7.67e-164

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 503.75  E-value: 7.67e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1276 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1355
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1356 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1435
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1436 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1516 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1579
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1885-1993 4.76e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 192.96  E-value: 4.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1885 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1964
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567248 1965 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1993
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 1.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567248  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 1.37e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.94  E-value: 1.37e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666     91 LHAAARNGDLEIVK--LLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAV 208
Cdd:COG0666    169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                          170
                   ....*....|
gi 1034567248  209 DKLESSHQLI 218
Cdd:COG0666    249 DKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 3.25e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 3.25e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 1034567248  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 2.14e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 117.36  E-value: 2.14e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 1034567248  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 2.11e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 2.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034567248  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1109-1776 2.80e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 98.59  E-value: 2.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1174
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1175 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1247
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1322
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1323 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1383
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1384 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1449
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1450 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1529
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1530 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1609
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1610 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1679
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1680 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1757
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567248 1758 DIQINKLKHKIDDLTAELE 1776
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1102-1920 6.30e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 97.43  E-value: 6.30e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1102 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 1181
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1182 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 1261
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1262 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 1341
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1342 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1419
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1420 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1488
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1489 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNkeLISECNHLKER 1568
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYR--IVTLDGDLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1569 QYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK 1648
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1649 MQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1728
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1729 LKMTRKKLNEYENGEFSF---HGDLKTSQFEMDIQINKLKHKIDDLTAELETAgskclhldtknQILQEELlsmktvQKK 1805
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL-----------EELIEEL------ESE 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1806 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIeERARQEIAEKLKEVNLFLQ-AQAASQENLEQFREN----- 1879
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSEL-RRELEELREKLAQLELRLEgLEVRIDNLQERLSEEysltl 953

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 1034567248 1880 -NFASMKSQMELRIKDLESELSKIKTSQEDF---NKTELEKYKQL 1920
Cdd:TIGR02168  954 eEAEALENKIEDDEEEARRRLKRLENKIKELgpvNLAAIEEYEEL 998
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 7.55e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 7.55e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1034567248  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 1.80e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 1.80e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQqiLLLrKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    157 LHLAAANGNLEIVK--LLL-EAGadVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1115-1921 8.31e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 93.97  E-value: 8.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1115 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 1191
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1192 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 1270
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1271 DLSHKNSMLQEEIAMLRLEIDTIKNQNQE---KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 1344
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEElesRLEELEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1345 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1419
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1420 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1485
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1486 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQ------------------------ 1541
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDnalelakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1542 --------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1605
Cdd:TIGR02168  657 pggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1606 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnan 1685
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL---- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1686 lsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD---IQIN 1762
Cdd:TIGR02168  813 --TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleEALA 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1763 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE-KLQKNKKKL-EQEVINLRSHIERNMVELGQVKQY 1840
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEA 970

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1841 KQEIeERARQEIAEkLKEVNLflqaqaasqENLEQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYK 1918
Cdd:TIGR02168  971 RRRL-KRLENKIKE-LGPVNL---------AAIEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFK 1035


                   ...
gi 1034567248 1919 QLY 1921
Cdd:TIGR02168 1036 DTF 1038
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 5.72e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 5.72e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1098-1860 1.41e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.19  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1098 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 1176
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1177 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 1255
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1256 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 1335
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1336 yngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLaaaihdrdqsetSKRELELAFQRARDECSRLQDKMNFDVS 1415
Cdd:TIGR02169  464 ------------------LSKYEQELYDLKEEYDRVEKEL------------SKLQRELAEAEAQARASEERVRGGRAVE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1416 NLKDNNeilSQQLFKTESKLNSLE-----------------------------IEFHHTRDALREKTLGLERVQKDLSQT 1466
Cdd:TIGR02169  514 EVLKAS---IQGVHGTVAQLGSVGeryataievaagnrlnnvvveddavakeaIELLKRRKAGRATFLPLNKMRDERRDL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1467 QCQMK-----------EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML-LRQQLDD---AHNKADNKEKTVINIQD 1531
Cdd:TIGR02169  591 SILSEdgvigfavdlvEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGELFEksgAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1532 QFHAIVQKLQAESEKqsllLEERNKELISECNHLKER--QYQYENEKAEREVVVRQ-----LQQELADTLKKQSMSEASL 1604
Cdd:TIGR02169  671 SEPAELQRLRERLEG----LKRELSSLQSELRRIENRldELSQELSDASRKIGEIEkeieqLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1605 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHK--QKLEKDNAKLKVTVKKQMDKIEELQKNLl 1682
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLE----EALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLREIEQKL- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1683 naNLSEDEKEQLKKLMELKQS----LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEngefSFHGDLKTSQFEMD 1758
Cdd:TIGR02169  822 --NRLTLEKEYLEKEIQELQEqridLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLE----SRLGDLKKERDELE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1759 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-----------------LSMKTVQKKCEKLQKNKKKLEQevI 1821
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiedpkgedeeipeeeLSLEDVQAELQRVEEEIRALEP--V 973

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 1034567248 1822 NLRSHIERNMVELGQVK-QYKQEIEERARQEIAEKLKEVN 1860
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDElKEKRAKLEEERKAILERIEEYE 1013
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1087-1959 3.44e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 78.68  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1087 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1165
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1166 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1245
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1246 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1307
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1308 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1380
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1381 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1456
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1457 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1532
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1533 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1608
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1609 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1674
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1675 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1743
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1744 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1823
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1824 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1888
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1889 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1959
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1115-1896 6.98e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.85  E-value: 6.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1115 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 1194
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1195 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 1272
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1273 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 1345
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1346 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1417
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1418 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1480
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1481 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1554
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1555 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1634
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1635 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1714
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1715 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS-------------- 1780
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlksmegsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1781 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1846
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034567248 1847 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1896
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1125-1819 4.68e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 75.01  E-value: 4.68e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1125 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 1204
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1205 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 1254
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1255 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 1331
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1332 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1404
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1405 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1482
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1483 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKL---QAESEKQSLLLEERNKELI 1559
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDLtekLSEAEDMLACEQHALLRKL 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1560 SECNHLKERQyQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTS------RYRINLEDETQDLKKKLGQIRNQLQ 1633
Cdd:TIGR00618  622 QPEQDLQDVR-LHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkellASRQLALQKMQSEKEQLTYWKEMLA 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1634 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQslecnldqemK 1713
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELM-----HQARTVLKARTEAHF----------N 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1714 KNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlKTSQFEMDIQiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1793
Cdd:TIGR00618  766 NNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH---LLKTLEAEIG-QEIPSDEDILNLQCETLVQEEEQFLSRLEEKS 841

                          730       740
                   ....*....|....*....|....*.
gi 1034567248 1794 EELLSMKTVQKKCEKLQKNKKKLEQE 1819
Cdd:TIGR00618  842 ATLGEITHQLLKYEECSKQLAQLTQE 867
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1176-1937 4.95e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.72  E-value: 4.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1176 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 1253
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1254 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1333
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1334 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1399
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1400 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1469
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1470 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1530
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1531 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1571
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1572 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1629
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1630 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1709
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1710 QEMKKNVELEREITGFKnllkmTRKKLNEYEngefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL---- 1785
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR-----IPEIQAELS--------KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELqeqr 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1786 -DTKNQI--LQEELLSMKT----VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERarqeiAEKLKE 1858
Cdd:TIGR02169  843 iDLKEQIksIEKEIENLNGkkeeLEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ-----IEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1859 VNLFLQAQAASQENLEQFRENNFASMKS---------QMELRIKDLESELSKIktsqEDFNKTELEKYKqlylEELKVRK 1929
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEipeeelsleDVQAELQRVEEEIRAL----EPVNMLAIQEYE----EVLKRLD 989


                   ....*...
gi 1034567248 1930 SLSSKLTK 1937
Cdd:TIGR02169  990 ELKEKRAK 997
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1511-1949 7.38e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.33  E-value: 7.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1511 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1581
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1582 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1658
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1659 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1734
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1735 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1805
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1806 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1873
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1874 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1933
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 1034567248 1934 KLTKTNERLAEVNTKL 1949
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1289-1949 1.28e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.13  E-value: 1.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1289 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1362
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1363 RLEAEVESyhsrlaaaihdrdqsetSKRELElafqrardECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1442
Cdd:TIGR04523  121 KLEVELNK-----------------LEKQKK--------ENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1443 HHTRDALREKtlglervQKDLSQTQCQMKEMEQKYQNEQvkvnKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1522
Cdd:TIGR04523  176 NLLEKEKLNI-------QKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEK 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1523 EKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKkqsmsea 1602
Cdd:TIGR04523  245 TTEISNTQTQLNQLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELK------- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1603 slevtsryrinleDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNll 1682
Cdd:TIGR04523  314 -------------SELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE-- 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1683 nanlSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF---KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1759
Cdd:TIGR04523  379 ----NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLqqeKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1760 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1839
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKEL---KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1840 YKQEIEERARQ------EIAEKLKEVNLFLQAQaASQENLEQFRENNFASMKSQMEL--RIKDLESELSKIKTSQEDFNK 1911
Cdd:TIGR04523  532 EKKEKESKISDledelnKDDFELKKENLEKEID-EKNKEIEELKQTQKSLKKKQEEKqeLIDQKEKEKKDLIKEIEEKEK 610

                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 1034567248 1912 TELEKYKQLYLEELKVRKsLSSKLTKTNERLAEVNTKL 1949
Cdd:TIGR04523  611 KISSLEKELEKAKKENEK-LSSIIKNIKSKKNKLKQEV 647
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.74e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567248  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1299-1959 2.22e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.78  E-value: 2.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1299 EKEKKCFEDLKIVKEKNEDLQKTI--------KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1370
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrleelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1371 YHSRLAAAihdrdQSETSKRELELAFQRARDEcsrlqdkmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1450
Cdd:TIGR02168  286 LQKELYAL-----ANEISRLEQQKQILRERLA-------------NLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1451 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnkADNKEKTVINIQ 1530
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL---EDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1531 DQfhaivqkLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1610
Cdd:TIGR02168  425 EL-------LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1611 RINLEDETQDLKKKLgQIRNQLQEAQDRHTEAVRCAEK--------MQDHKQKLE--------------KDNAKLKVTV- 1667
Cdd:TIGR02168  498 QENLEGFSEGVKALL-KNQSGLSGILGVLSELISVDEGyeaaieaaLGGRLQAVVvenlnaakkaiaflKQNELGRVTFl 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1668 -----------KKQMDKIEELQKNLLNANLSEDEKEQLKKLME-----------LKQSLEC------------------- 1706
Cdd:TIGR02168  577 pldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddLDNALELakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1707 -----------------NLDQEMKKNV----ELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMDIQINKLK 1765
Cdd:TIGR02168  657 pggvitggsaktnssilERRREIEELEekieELEEKIAELEKALAELRKELEELEEEL----EQLRKELEELSRQISALR 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1766 HKIDDLTAELETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1845
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAE---IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1846 ERARQ---EIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYL 1922
Cdd:TIGR02168  810 AELTLlneEAANLRERLESLERRIAATERRLEDLEEQ-----IEELSEDIESLAAEIEELEELIEELES-ELEALLNERA 883

                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 1034567248 1923 EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1959
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEEL 920
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1203-1949 4.07e-12

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 71.79  E-value: 4.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1203 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 1280
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1281 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 1356
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1357 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD---ECSRLQDKM----NFDVSNLKDN----NEILS 1425
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDvtaKYNRRRSKIkeqnNRDIAGIKDKlakiREARD 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1426 QQLFKTESKLNSLEIEFHHTRDA----LREKTLG----LERVQKDLSQTQCQMKEMEQKYQNeQVKVNKYIGKQESVEER 1497
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAgkleFNEEEYRlksrLGELKLRLNQATATPELLLQLENF-DERIERAREEQEAANAE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1498 LSQLQSEnmllRQQLDDAHNKADNKEKtviniqdQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKA 1577
Cdd:pfam12128  487 VERLQSE----LRQARKRRDQASEALR-------QASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGKVI 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1578 EREVVVR-QLQQELADTLKKQSMSEASLEVTSRyRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAvrcAEKMQDHK 1653
Cdd:pfam12128  556 SPELLHRtDLDPEVWDGSVGGELNLYGVKLDLK-RIDVPEwaaSEEELRERLDKAEEALQSAREKQAAA---EEQLVQAN 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1654 QKLekDNAKLKVTVKKQMDKIEELQKNLLNanlseDEKEQLKklMELKQSLECNLDQEMKKNVELEREitgfKNLLKMTR 1733
Cdd:pfam12128  632 GEL--EKASREETFARTALKNARLDLRRLF-----DEKQSEK--DKKNKALAERKDSANERLNSLEAQ----LKQLDKKH 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1734 KKLNEYENGEFSFHGDLKtsQFEMDIQINKLKHKIDDLTAELETAGSKclhLDTKNQILQEEllsMKTVQKKCEKLQKNK 1813
Cdd:pfam12128  699 QAWLEEQKEQKREARTEK--QAYWQVVEGALDAQLALLKAAIAARRSG---AKAELKALETW---YKRDLASLGVDPDVI 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1814 KKLEQEVINLRSHIERNMVELGQVKQYKQEIEER---ARQEIAEKLKEVN---LFLQAQAASQE-----NLEQFRENNFA 1882
Cdd:pfam12128  771 AKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwlqRRPRLATQLSNIEraiSELQQQLARLIadtklRRAKLEMERKA 850

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567248 1883 SMKSQMEL--RIKDLESELSKIKTSQEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEVNTKL 1949
Cdd:pfam12128  851 SEKQQVRLseNLRGLRCEMSKLATLKEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNVIADH 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1087-1634 4.88e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.51  E-value: 4.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1087 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1163
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1164 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1236
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1237 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1316
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1396
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1397 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1476
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1477 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1550
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1551 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1630
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 1034567248 1631 QLQE 1634
Cdd:COG1196    775 EIEA 778
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 843-1634 5.52e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.63  E-value: 5.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  843 SANNYKSMEPELENVRSSpprgdRTSKVSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKEVEeerkkhrnnemEV 922
Cdd:TIGR02168  230 LVLRLEELREELEELQEE-----LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY-----------AL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  923 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN---KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKA 999
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDelaEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1000 SlltgGLLQVDDDSSLSEIDEdegrptkkTSNEKNKVKNQIQSMDD-VDDLTQSSETASEDcelphssyknfmllIEQLG 1078
Cdd:TIGR02168  374 L----EELEEQLETLRSKVAQ--------LELQIASLNNEIERLEArLERLEDRRERLQQE--------------IEELL 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1079 MEckdsvslLKIQDAALSCERLLELKKnhcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLN 1158
Cdd:TIGR02168  428 KK-------LEEAELKELQAELEELEE--------ELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1159 QEEEKRRNADTLYEKIREQLRRK----------------EEQYRKEVEVkqQLELSLQTLEMElrtvksNLNQVVQ---- 1218
Cdd:TIGR02168  493 SLERLQENLEGFSEGVKALLKNQsglsgilgvlselisvDEGYEAAIEA--ALGGRLQAVVVE------NLNAAKKaiaf 564

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1219 -ERNDAQRQL-------------SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEkDLSHKNSMLQEEIA 1284
Cdd:TIGR02168  565 lKQNELGRVTflpldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDNALELAKKLRP 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1285 MLR---LEIDTIKN---------------QNQEKE-KKCFEDLKIVKEKNEDLQKTIKqneeTLTQTISQYNGRLSVLTA 1345
Cdd:TIGR02168  644 GYRivtLDGDLVRPggvitggsaktnssiLERRREiEELEEKIEELEEKIAELEKALA----ELRKELEELEEELEQLRK 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1346 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsNLKDNNEILS 1425
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE----ELEAQIEQLK 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1426 QQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEn 1505
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE- 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1506 mllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAesekqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1585
Cdd:TIGR02168  875 ------LEALLNERASLEEALALLRSELEELSEELRE--------LESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567248 1586 LQQELADTLkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1634
Cdd:TIGR02168  941 LQERLSEEY------SLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 1.26e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 1.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 1034567248  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1161-1956 1.37e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 70.00  E-value: 1.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1161 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 1227
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1228 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 1307
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1308 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIhdRDQSET 1387
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK--LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1388 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR-EKTLGLERVQKDLSQT 1466
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1467 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQ-QLDDAHNKADNKEKTVINIQdqfHAIVQKLQAESE 1545
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGgRIISAHGRLGDLGVAVENYK---VAISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1546 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET--QDLKK 1623
Cdd:pfam02463  555 ATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGilKDTEL 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1624 KLGQIRNQLQEAQDRHTEAVRCAEKM-QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQ 1702
Cdd:pfam02463  635 TKLKESAKAKESGLRKGVSLEEGLAEkSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKK 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1703 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKc 1782
Cdd:pfam02463  715 LKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKE- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1783 lhldtKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1862
Cdd:pfam02463  794 -----EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEEL 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1863 LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSL--SSKLTKTNE 1940
Cdd:pfam02463  869 LQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPeeLLLEEADEK 948

                          810
                   ....*....|....*.
gi 1034567248 1941 RLAEVNTKLLVEKQQS 1956
Cdd:pfam02463  949 EKEENNKEEEEERNKR 964
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 2.57e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1034567248  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1161-1776 5.31e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 5.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1161 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1231
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1232 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1311
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1312 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1391
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1392 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1471
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1472 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1551
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1552 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1622
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1623 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1690
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1691 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1770
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 1034567248 1771 LTAELE 1776
Cdd:COG1196    772 LEREIE 777
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.33e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 1.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567248  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1114-1937 1.82e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 66.61  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1114 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEvkq 1193
Cdd:TIGR00606  263 KIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERR--- 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1194 qlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI----EMAQKKMNSENSHSHEEE 1269
Cdd:TIGR00606  337 --LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIknfhTLVIERQEDEAKTAAQLC 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1270 KDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNgrlsv 1342
Cdd:TIGR00606  415 ADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDRILELDQELRKAERELS----- 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1343 LTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-------AFQRARDECSRLQDKMNFDVS 1415
Cdd:TIGR00606  489 KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmdKDEQIRKIKSRHSDELTSLLG 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1416 -------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTqCQMKEMEQKYQNEQV 1482
Cdd:TIGR00606  568 yfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDV-CGSQDEESDLERLKE 646

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1483 KVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1545
Cdd:TIGR00606  647 EIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRD 726

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1546 KQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-EVTSRYRinLEDETQDL 1621
Cdd:TIGR00606  727 EMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLtDVTIMER--FQMELKDV 804

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1622 KKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMEL 1700
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQR 882

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1701 KQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS 1780
Cdd:TIGR00606  883 RQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIEN 962

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1781 KClhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLR-----SHIERNMVELGQVKQYKQEIEERARQEIAEK 1855
Cdd:TIGR00606  963 KI--QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRqdidtQKIQERWLQDNLTLRKRENELKEVEEELKQH 1040

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1856 LKEVNlflQAQAASQENLEQFRENNFASMKSQMEL---RIKDLESEL--SKIKTSQEDFNKTElEKYKQLYLeELKVRKS 1930
Cdd:TIGR00606 1041 LKEMG---QMQVLQMKQEHQKLEENIDLIKRNHVLalgRQKGYEKEIkhFKKELREPQFRDAE-EKYREMMI-VMRTTEL 1115


                   ....*..
gi 1034567248 1931 LSSKLTK 1937
Cdd:TIGR00606 1116 VNKDLDI 1122
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.85e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 1034567248  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1103-1539 1.86e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.20  E-value: 1.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1103 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1182
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1183 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1241
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1242 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1319
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1320 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1396
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1397 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1464
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567248 1465 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1539
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1074-1637 2.10e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 66.30  E-value: 2.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1074 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 1149
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1150 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 1208
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1209 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 1281
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1282 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 1342
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1343 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1401
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1402 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1465
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1466 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1537
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1538 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1613
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 1034567248 1614 lEDETQDLKKKLGQIRNQLQEAQD 1637
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1179-1602 2.50e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.86  E-value: 2.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1179 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmlqdgiltnhlsKQKEIEMAQKKM 1258
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-----------------IEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1259 NSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLqktikqneetltqtisqyng 1338
Cdd:TIGR02169  733 EKLK----ERLEELEEDLSSLEQEIENVKSELKELEARIEELE----EDLHKLEEALNDL-------------------- 784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1339 rlsvltaENAMLNSKLENEKQSKErleaEVESYHSRLAAAIHDRDQsETSKRELELAFqrARDECSRLQDKMNfdvsNLK 1418
Cdd:TIGR02169  785 -------EARLSHSRIPEIQAELS----KLEEEVSRIEARLREIEQ-KLNRLTLEKEY--LEKEIQELQEQRI----DLK 846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1419 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1498
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1499 SQLQSENmllrQQLDDAhNKADNKEKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAE 1578
Cdd:TIGR02169  927 EALEEEL----SEIEDP-KGEDEEIPEEELSLEDVQAELQRVEEEIRA----LEPVNMLAIQEYEEVLKRLDELKEKRAK 997

                          410       420
                   ....*....|....*....|....*.
gi 1034567248 1579 REVVVRQLQQELA--DTLKKQSMSEA 1602
Cdd:TIGR02169  998 LEEERKAILERIEeyEKKKREVFMEA 1023
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1306-1878 2.72e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.86  E-value: 2.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1306 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 1385
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1386 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1465
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1466 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1545
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1546 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVT--SRYRIN 1613
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELKriEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1614 LEDETQDLKKKLGQIRNQLQEaQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLlnanl 1686
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL----- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1687 sEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQIN 1762
Cdd:PRK03918   545 -KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELEREEK 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1763 KLKhkidDLTAELETAGSKCLHLDTKNQILQEEL--LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQY 1840
Cdd:PRK03918   620 ELK----KLEEELDKAFEELAETEKRLEELRKELeeLEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1034567248 1841 KQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRE 1878
Cdd:PRK03918   696 LEKLKEE-LEEREKAKKELEKLEKALERVEELREKVKK 732
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1116-1966 2.99e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 65.76  E-value: 2.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1116 KKMEDKVNVLQRELSETKEIKSQLEHQKVEwERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL 1195
Cdd:pfam02463  177 KLIEETENLAELIIDLEELKLQELKLKEQA-KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIES 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1196 ELSLQTLEMELRTVKSNLN-------QVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHE 1267
Cdd:pfam02463  256 SKQEIEKEEEKLAQVLKENkeeekekKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEkKKAEKELKKEKE 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1268 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLT------QTISQYNGRLS 1341
Cdd:pfam02463  336 EIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELElkseeeKEAQLLLELAR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1342 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN 1421
Cdd:pfam02463  416 QLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKL 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1422 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyIGKQESVEERLSQL 1501
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV-EERQKLVRALTELP 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1502 QSENMLLRQQLDDAHNKADNKEKTViniqDQFHAIVQKLQAESEKQSLLLEERNKELISECnHLKERQYQYENEKAEREV 1581
Cdd:pfam02463  575 LGARKLRLLIPKLKLPLKSIAVLEI----DPILNLAQLDKATLEADEDDKRAKVVEGILKD-TELTKLKESAKAKESGLR 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1582 VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEavrcaEKMQDHKQKLEKDNA 1661
Cdd:pfam02463  650 KGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK-----EELKKLKLEAEELLA 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1662 KLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKlMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:pfam02463  725 DRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKK-EEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1742 GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELetagskcLHLDTKNQILQEELLSMKT--VQKKCEKLQKNKKKLEQE 1819
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEE-------LALELKEEQKLEKLAEEELerLEEEITKEELLQELLLKE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1820 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFREnnfasMKSQMELRIKDLESEL 1899
Cdd:pfam02463  877 EELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE-----EPEELLLEEADEKEKE 951

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567248 1900 SKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1966
Cdd:pfam02463  952 ENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1174-1853 3.61e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 65.13  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1174 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 1253
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1254 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1333
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1334 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1411
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1412 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1487
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1488 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1543
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1544 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1623
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1624 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQmdkIEELQKNLlnANLSEDEKEQLKKLMELKQS 1703
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQ---IENKNKNI--EELHQENKALKKKGSAENKQ 630

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1704 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN-------KLKHKIDDLTAELE 1776
Cdd:pfam05483  631 LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKlqkeidkRCQHKIAEMVALME 710

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567248 1777 TagskclHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1853
Cdd:pfam05483  711 K------HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTA 781
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1176-1928 3.89e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.20  E-value: 3.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1176 EQLRRKEEQYRKEVEVKQQLELSLQTLEmelrtvkSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ 1255
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELE-------KKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1256 KKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE----------KEKKCFEDLKIVKEKNEDLQKTIKQN 1325
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKlqlekvtteaKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1326 EEtltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSR 1405
Cdd:pfam01576  158 EE-----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAE 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1406 LQDKMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVN 1485
Cdd:pfam01576  227 LQAQI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1486 KYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEERNKEL 1558
Cdd:pfam01576  289 KAEKQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEELTEQL 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1559 isecNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQEAQDR 1638
Cdd:pfam01576  366 ----EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAELAEK 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1639 HTEAVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQEMKKN 1715
Cdd:pfam01576  435 LSKLQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEEEEAK 512

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1716 VELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKtsqfemdiqinKLKHKIDDLTAELETAGSKCLHLDTKNQILQEE 1795
Cdd:pfam01576  513 RNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK-----------RLQRELEALTQQLEEKAAAYDKLEKTKNRLQQE 581

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1796 L--LSMKTVQKK--CEKLQKNKKKLEQEVINlrshiERNMVelgqvkqyKQEIEERARQEIAEKLKEVNlFLQAQAASQE 1871
Cdd:pfam01576  582 LddLLVDLDHQRqlVSNLEKKQKKFDQMLAE-----EKAIS--------ARYAEERDRAEAEAREKETR-ALSLARALEE 647

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567248 1872 NLEQfrennfasmKSQMELRIKDLESELSKIKTSQEDFNKT--ELEKYKQLY---LEELKVR 1928
Cdd:pfam01576  648 ALEA---------KEELERTNKQLRAEMEDLVSSKDDVGKNvhELERSKRALeqqVEEMKTQ 700
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1110-1730 4.64e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 65.24  E-value: 4.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1110 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 1184
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1185 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEIEMAQKKmnsensh 1264
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIREARDRQLA------- 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1265 shEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKEKKCFEDLKIvkeknedLQKTIKQNEETLTQTisqyngrlsvlt 1344
Cdd:pfam12128  412 --VAEDDLQALESELREQLEAGKLEF----NEEEYRLKSRLGELKL-------RLNQATATPELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1345 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK-----------MNFD 1413
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1414 VSNLKDN--NEILSQQLFKT-------------ESKLNSLEI--------EFHHTRDALREKtlgLERVQKDLSQTQCQM 1470
Cdd:pfam12128  544 APDWEQSigKVISPELLHRTdldpevwdgsvggELNLYGVKLdlkridvpEWAASEEELRER---LDKAEEALQSAREKQ 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1471 KEMEQkyqnEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-NKADNKEKTVINIQDQFHAIVQKLQAESE---- 1545
Cdd:pfam12128  621 AAAEE----QLVQANGELEKASREETFARTALKNARLDLRRLFDEKqSEKDKKNKALAERKDSANERLNSLEAQLKqldk 696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1546 KQSLLLEERNKELISecnHLKERQYQYENEKAEREVVVRQLQQELA----------DTLKKQSMSE-ASLEVTSRYRINL 1614
Cdd:pfam12128  697 KHQAWLEEQKEQKRE---ARTEKQAYWQVVEGALDAQLALLKAAIAarrsgakaelKALETWYKRDlASLGVDPDVIAKL 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1615 EDETQDLKKKLGQIrnqlqeAQDRHteAVRCAEKMQDHKQKLEKDNakLKVTVKKQMDKIEELQKNLlnANLSEDEKEQL 1694
Cdd:pfam12128  774 KREIRTLERKIERI------AVRRQ--EVLRYFDWYQETWLQRRPR--LATQLSNIERAISELQQQL--ARLIADTKLRR 841

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034567248 1695 KKLMELKQSLEcnldqemKKNVELEREITGFKNLLK 1730
Cdd:pfam12128  842 AKLEMERKASE-------KQQVRLSENLRGLRCEMS 870
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1162-1730 6.73e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 6.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1162 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1240
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1241 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1315
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1316 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1377
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1378 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1455 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1513
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1514 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1590
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1591 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1670
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1671 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 8.66e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.93  E-value: 8.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 1034567248  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.36e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 1.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 1034567248  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.80e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567248  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1269-1959 1.96e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.82  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1269 EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEkNEDLqktIKQNEETltqtiSQYNGRLSVLTAENA 1348
Cdd:pfam05483   98 EAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE-NKDL---IKENNAT-----RHLCNLLKETCARSA 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1349 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQ 1427
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1428 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenml 1507
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI------- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1508 lrqqlddahnkadnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1587
Cdd:pfam05483  322 --------------ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQ 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1588 QEladtlkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHKQKL---------EK 1658
Cdd:pfam05483  388 KK-----------SSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKK----QFEKIAEELKGKEQELifllqarekEI 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1659 DNAKLKVTVKKQ-----MDKIEELQKNLLNANLSEDEKEQLKKLMELKQSlecNLDQEMKKNV-ELEREITGFKNLLKMT 1732
Cdd:pfam05483  453 HDLEIQLTAIKTseehyLKEVEDLKTELEKEKLKNIELTAHCDKLLLENK---ELTQEASDMTlELKKHQEDIINCKKQE 529

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1733 RKKLNEYEN---GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKtvqKKCEKL 1809
Cdd:pfam05483  530 ERMLKQIENleeKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK---KQIENK 606

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1810 QKNKKKLEQE--VINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVNLFLQAQAASQENL----EQFRENNFA 1882
Cdd:pfam05483  607 NKNIEELHQEnkALKKKGSAENKQLNAYEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKISEEKLleevEKAKAIADE 686

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1883 SMKSQMEL------RIKDLESELSKIKTSQEDF---NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEK 1953
Cdd:pfam05483  687 AVKLQKEIdkrcqhKIAEMVALMEKHKHQYDKIieeRDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEK 766


                   ....*.
gi 1034567248 1954 QQSRSL 1959
Cdd:pfam05483  767 EEKEKL 772
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.72e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 1034567248  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 889-1759 3.77e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.30  E-value: 3.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  889 MLKVEFQALEKEKVQLQKEVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSgETDHQQFPRKENKEYASS 968
Cdd:pfam02463  202 LKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK-EEEKLAQVLKENKEEEKE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  969 GPALQMKEVKSTEKEKRTSKEsvnspvfgkasLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDD 1048
Cdd:pfam02463  281 KKLQEEELKLLAKEEEELKSE-----------LLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEI 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1049 LTQSSETASEDCELphssyknfmLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKnhcELLTVKIKKMEDKVNVLQRE 1128
Cdd:pfam02463  350 KREAEEEEEEELEK---------LQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL---ELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1129 LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRT 1208
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEE 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1209 VKSNLnQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL 1288
Cdd:pfam02463  498 RSQKE-SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLG 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1289 EIDTIknqnQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTqtisqyngrlsvltaenAMLNSKLENEKQSKERLEAEV 1368
Cdd:pfam02463  577 ARKLR----LLIPKLKLPLKSIAVLEIDPILNLAQLDKATLE-----------------ADEDDKRAKVVEGILKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1369 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDA 1448
Cdd:pfam02463  636 KLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREK 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1449 LREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVI 1527
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVE 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1528 NIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA----- 1602
Cdd:pfam02463  790 EEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeell 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1603 SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-------RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIE 1675
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleekenEIEERIKEEAEILLKYEEEPEELLLEEADEKE 949

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1676 ELQKNLLNANLSEDEKEQLKKL---------MELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSF 1746
Cdd:pfam02463  950 KEENNKEEEEERNKRLLLAKEElgkvnlmaiEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSI 1029

                          890
                   ....*....|...
gi 1034567248 1747 HGDLKTSQFEMDI 1759
Cdd:pfam02463 1030 NKGWNKVFFYLEL 1042
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 4.95e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 4.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034567248  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 5.33e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.83  E-value: 5.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034567248  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 9.95e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 9.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1389-1945 1.08e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.46  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1389 KRELELAFQRARDECSRLQDkmnfdVSNLKDNNEilsQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLsqtqc 1468
Cdd:PRK03918   171 IKEIKRRIERLEKFIKRTEN-----IEELIKEKE---KELEEVLREINEISSE----LPELREELEKLEKEVKEL----- 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1469 qmKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAdnKEKTVINIQDQFHAIVQKLQAESEKQS 1548
Cdd:PRK03918   234 --EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV--KELKELKEKAEEYIKLSEFYEEYLDEL 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1549 LLLEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQi 1628
Cdd:PRK03918   310 REIEKRLSRLEEEINGIEERIKELEEKEER----LEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTG- 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1629 rNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN-----LLNANLSEDEKEQL--------K 1695
Cdd:PRK03918   384 -LTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELleeytaelK 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1696 KLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMtRKKLNEYENGEFSFHGdlktsqfemdIQINKLKHKiddlTAEL 1775
Cdd:PRK03918   463 RIEKELKEIEEKERKLRKELRELEKVLKKESELIKL-KELAEQLKELEEKLKK----------YNLEELEKK----AEEY 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1776 ETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQEIEERARQEIae 1854
Cdd:PRK03918   528 EKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYL-- 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1855 KLKEVNLFLQAQAASQENLEQFRENNFAsmksQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSK 1934
Cdd:PRK03918   606 ELKDAEKELEREEKELKKLEEELDKAFE----ELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAE 681

                          570
                   ....*....|.
gi 1034567248 1935 LTKTNERLAEV 1945
Cdd:PRK03918   682 LEELEKRREEI 692
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1092-1642 2.21e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 2.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1092 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 1166
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1167 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 1239
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1240 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 1319
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1320 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA--------------------- 1378
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpvegsph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1379 IHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1449
Cdd:PRK02224   467 VETIEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1450 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1521
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1522 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1598
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1034567248 1599 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 5.54e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 5.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567248  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 1.00e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 1.00e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567248  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1176-1720 1.88e-07

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 56.30  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1176 EQLRRKEEQYR--KEVEVKQQLELSLQTLEME---------------LRT-------VKSNLNQVVQERNDAQRQLSREQ 1231
Cdd:pfam07111   73 QELRRLEEEVRllRETSLQQKMRLEAQAMELDalavaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQ 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1232 NARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSHSHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK 1309
Cdd:pfam07111  153 LSSLTQahEEALSSLTSKAEGLE---KSLNSLETKRAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLR 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1310 -----------------IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE----- 1367
Cdd:pfam07111  225 kyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkc 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1368 ---VESYHSRLAAAIHDRDQSETSKRElelAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NS 1437
Cdd:pfam07111  305 rslLNRWREKVFALMVQLKAQDLEHRD---SVKQLRGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKG 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1438 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahn 1517
Cdd:pfam07111  378 LQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY----------------- 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1518 kADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLEERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQ 1597
Cdd:pfam07111  441 -AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAPPVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAR 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1598 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKK 1669
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLRE 592

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034567248 1670 QMDKIEElqknllnaNLSEDEKEQLKKLMELKQsLECNLDQEMKKNVELER 1720
Cdd:pfam07111  593 QLSDTKR--------RLNEARREQAKAVVSLRQ-IQHRATQEKERNQELRR 634
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1129-1965 2.17e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 56.59  E-value: 2.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1129 LSETKEIKSQLEH-----QKVEWERELCSLRFSLNQEEEKRRNADTLYEK-------IREQLRRKEEQYRKEVEVKQQLE 1196
Cdd:TIGR00606  165 LSEGKALKQKFDEifsatRYIKALETLRQVRQTQGQKVQEHQMELKYLKQykekaceIRDQITSKEAQLESSREIVKSYE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1197 LSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ--------------DGILTNHLSKQKEIEMAQKKM 1258
Cdd:TIGR00606  245 NELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtdeqlNDLYHNHQRTVREKERELVDC 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1259 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK----------------EKKCFEDLKI------VKEKNE 1316
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldgfERGPFSERQIknfhtlVIERQE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1317 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEkqsKERLEAEVEsyhsRLAAAIHDRDQSETSKR---ELE 1393
Cdd:TIGR00606  405 DEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELK---KEILEKKQE----ELKFVIKELQQLEGSSDrilELD 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1394 LAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM 1473
Cdd:TIGR00606  478 QELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDK 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1474 EQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQDQFHAIVQKLQAESEKQSLLLEE 1553
Cdd:TIGR00606  545 MDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQTRDRLAKLNKELASLEQNKNHINN 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1554 RNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQD---LKKKLGQIRN 1630
Cdd:TIGR00606  613 ELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSccpVCQRVFQTEA 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1631 QLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEC 1706
Cdd:TIGR00606  692 ELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI--PELRNKLQKVNRDIQRLKNDIEE 769

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1707 NLDQEMKKNVELERE---------ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF-----EMDIQINKLKHKIDDLT 1772
Cdd:TIGR00606  770 QETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVnqekqEKQHELDTVVSKIELNR 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1773 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1852
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1853 AEK---LKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEdfnktELEKYKQLYLEELKVRK 1929
Cdd:TIGR00606  930 SSKetsNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLE-----ECEKHQEKINEDMRLMR 1004

                          890       900       910
                   ....*....|....*....|....*....|....*.
gi 1034567248 1930 SlSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1965
Cdd:TIGR00606 1005 Q-DIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1108-1721 2.19e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 56.27  E-value: 2.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1108 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 1187
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1188 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 1267
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1268 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 1347
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1348 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSETSKREL-----ELAFQRARDECSRLQDKMNFDVSNLKD 1419
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKIAEELkgkeqELIFLLQAREKEIHDLEIQLTAIKTSE 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1420 NNEILSQQLFKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY 1487
Cdd:pfam05483  467 EHYLKEVEDLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNL 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1488 IGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELISECNH 1564
Cdd:pfam05483  547 RDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQENKA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1565 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHTEAVR 1644
Cdd:pfam05483  620 LKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIADEAVK 689

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567248 1645 CAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE 1721
Cdd:pfam05483  690 LQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKE 767
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1112-1772 2.59e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 56.21  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1112 TVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEV 1191
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILEL 476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1192 KQQLELSLQTL---------------EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIemaqK 1256
Cdd:TIGR00606  477 DQELRKAERELskaeknsltetlkkeVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI----R 552

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1257 KMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY 1336
Cdd:TIGR00606  553 KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEI----NQTRDR----LAKLNKELASLEQNKNHINNELESKEEQLSSY 624

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1337 NGRL----SVLTAENAMLNSKLENEKQSKER--LEAEVESYHSRLAAAIH---------DRD-QSETSKRELELAFQRAR 1400
Cdd:TIGR00606  625 EDKLfdvcGSQDEESDLERLKEEIEKSSKQRamLAGATAVYSQFITQLTDenqsccpvcQRVfQTEAELQEFISDLQSKL 704

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1401 DECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:TIGR00606  705 RLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESA 784

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1481 QV------KVNKYIGKQESVEERLSQLQSEN-----MLLRQQLDDAHNKADNKEKTVIniqdQFHAIVQKLQAESEKQSL 1549
Cdd:TIGR00606  785 KVcltdvtIMERFQMELKDVERKIAQQAAKLqgsdlDRTVQQVNQEKQEKQHELDTVV----SKIELNRKLIQDQQEQIQ 860

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1550 LLEERNKELISECNHLKE---RQYQYENEKAEREVVVRQLQQELAD---------TLKKQSMSEASLEVTSRYRIN--LE 1615
Cdd:TIGR00606  861 HLKSKTNELKSEKLQIGTnlqRRQQFEEQLVELSTEVQSLIREIKDakeqdspleTFLEKDQQEKEELISSKETSNkkAQ 940

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1616 DETQDLKKKLGQ-------IRNQLQEAQDRH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN 1680
Cdd:TIGR00606  941 DKVNDIKEKVKNihgymkdIENKIQDGKDDYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDN 1020

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1681 LLNANLSEDEKEQLKKLME-LKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF---- 1755
Cdd:TIGR00606 1021 LTLRKRENELKEVEEELKQhLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFrdae 1100

                          730       740
                   ....*....|....*....|.
gi 1034567248 1756 ----EMDIQINKLKHKIDDLT 1772
Cdd:TIGR00606 1101 ekyrEMMIVMRTTELVNKDLD 1121
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 2.93e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 2.93e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567248  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1623-1963 3.12e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.71  E-value: 3.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1623 KKLGQIRNQLQEAQDRHTEavrcaekMQDHKQKLEKDnAKLKVTVKKQMDKIEELQKNLLNANLsEDEKEQLKKLMELKQ 1702
Cdd:COG1196    179 RKLEATEENLERLEDILGE-------LERQLEPLERQ-AEKAERYRELKEELKELEAELLLLKL-RELEAELEELEAELE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1703 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1782
Cdd:COG1196    250 ELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE----LLAELARLEQDIARLEERRRELEERLEELEEEL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1783 LHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1862
Cdd:COG1196    326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1863 LQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDfnktELEKYKQLYLEELKVRKSLSSKLTKTNERL 1942
Cdd:COG1196    406 EEAEEALLERLERLEEE-----LEELEEALAELEEEEEEEEEALEE----AAEEEAELEEEEEALLELLAELLEEAALLE 476

                          330       340
                   ....*....|....*....|.
gi 1034567248 1943 AEVNtKLLVEKQQSRSLFTTL 1963
Cdd:COG1196    477 AALA-ELLEELAEAAARLLLL 496
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1098-1823 3.37e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.41  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1098 ERLLELKKNHCELLTvKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 1177
Cdd:TIGR04523  131 KQKKENKKNIDKFLT-EIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKK 209

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1178 LRRKEEQYRKEVEVKQQLelslQTLEMELRTVKSNLNQVVQERNDAQRQLsreQNARMLQDGILTNHLSKQKEIEMAQKK 1257
Cdd:TIGR04523  210 IQKNKSLESQISELKKQN----NQLKDNIEKKQQEINEKTTEISNTQTQL---NQLKDEQNKIKKQLSEKQKELEQNNKK 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1258 MNSenshsheeekdlshknsmLQEEIAMLRLEIDTIKNQ-NQEKEKKCFEDLKIVKEKNEDLQKTIKQNEET---LTQTI 1333
Cdd:TIGR04523  283 IKE------------------LEKQLNQLKSEISDLNNQkEQDWNKELKSELKNQEKKLEEIQNQISQNNKIisqLNEQI 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1334 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLaaaihdrDQSETSKRELELAFQrardecsrlqdkmnfd 1413
Cdd:TIGR04523  345 SQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI-------KNLESQINDLESKIQ---------------- 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1414 vsNLKDNNEILSQQLFKTESKLNSLEIEfhhtrdalrektlgLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQES 1493
Cdd:TIGR04523  402 --NQEKLNQQKDEQIKKLQQEKELLEKE--------------IERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRES 465

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1494 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQdqfhaivqklqaeseKQSLLLEERNKELISECNHLKERQYQYE 1573
Cdd:TIGR04523  466 LETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLN---------------EEKKELEEKVKDLTKKISSLKEKIEKLE 530

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1574 NEKAEREVVVRQLQQELA---DTLKKQsmseaslevtsryriNLEDETQDLKKKLgqirNQLQEAQDRhteavrcAEKMQ 1650
Cdd:TIGR04523  531 SEKKEKESKISDLEDELNkddFELKKE---------------NLEKEIDEKNKEI----EELKQTQKS-------LKKKQ 584

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1651 DHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsedeKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLK 1730
Cdd:TIGR04523  585 EEKQELIDQKEKEKKDLIKEIEEKEKKISSL---------EKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIK 655

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1731 MTRKKLNEyengefsfhgdlktsqfeMDIQINKLKHKIDDLT-------AELETAGSKCLHLDTKNQILQEELLSMKTVQ 1803
Cdd:TIGR04523  656 EIRNKWPE------------------IIKKIKESKTKIDDIIelmkdwlKELSLHYKKYITRMIRIKDLPKLEEKYKEIE 717

                          730       740
                   ....*....|....*....|
gi 1034567248 1804 KKCEKLQKNKKKLEQEVINL 1823
Cdd:TIGR04523  718 KELKKLDEFSKELENIIKNF 737
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1176-1660 9.02e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.00  E-value: 9.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1176 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 1254
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1255 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 1334
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1335 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1406
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1407 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1486
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1487 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1566
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1567 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1646
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 1034567248 1647 EKMQDHKQKLEKDN 1660
Cdd:COG4717    500 ELLEEAREEYREER 513
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 9.17e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 9.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 1.06e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
PTZ00121 PTZ00121
MAEBL; Provisional
 1469-1954 1.17e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1469 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1548
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1549 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1628
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1629 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1701
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1702 QSLECNLDQEMKKNVELER--------EITGFKNLLKM-TRKKLNEYENGEFSFHGDLKTSQFEMDIQiNKLKHKIDDLT 1772
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeekkkadELKKAEELKKAeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1773 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE----IEERA 1848
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdkkkAEEAK 1681

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1849 RQEIAEKLKEVNLFLQAQAASQenLEQFRENNFASMKSQMELRikdLESELSKIKTSQEDfNKTELEKYKQlylEELKVR 1928
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKK--AEELKKKEAEEKKKAEELK---KAEEENKIKAEEAK-KEAEEDKKKA---EEAKKD 1752

                          490       500
                   ....*....|....*....|....*.
gi 1034567248 1929 KSLSSKLTKTNERLAEVNTKLLVEKQ 1954
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKE 1778
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.45e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 1034567248  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1375-1638 1.46e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1375 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1454
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1455 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1534
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1535 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1614
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 1034567248 1615 EDETQDLKKKLGQIRNQLQEAQDR 1638
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1083-1702 1.58e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 53.58  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1083 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEW---EREL--------- 1150
Cdd:pfam15921  208 DSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQlisEHEVeitglteka 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1151 -------CSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV-EVKQQLELSLQTLEMELRTVKSNLNQVVQERNd 1222
Cdd:pfam15921  288 ssarsqaNSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELrEAKRMYEDKIEELEKQLVLANSELTEARTERD- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1223 aqrQLSREQnarmlqdGILTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDT---------- 1292
Cdd:pfam15921  367 ---QFSQES-------GNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlea 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1293 -IKNQNQEKEKKCFEDLKIVKEKNEDLQKT------IKQNEETLTQTISQYNG-RLSVLTAENAM--LNSKLENEKQSKE 1362
Cdd:pfam15921  434 lLKAMKSECQGQMERQMAAIQGKNESLEKVssltaqLESTKEMLRKVVEELTAkKMTLESSERTVsdLTASLQEKERAIE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1363 RLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFD---VSNLKDNNEILSQQLFKTESKLNSLE 1439
Cdd:pfam15921  514 ATNAEITKLRSRVDLKLQELQHLKNEGDHL----RNVQTECEALKLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQ 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1440 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIgkqESVEERLSQLQSenmlLRQQLDDAHNKA 1519
Cdd:pfam15921  590 VEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLV---NAGSERLRAVKD----IKQERDQLLNEV 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1520 DNKEKTVINIQDQFHAIVQKLQAESEKQSLL---LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1596
Cdd:pfam15921  663 KTSRNELNSLSEDYEVLKRNFRNKSEEMETTtnkLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1597 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1676
Cdd:pfam15921  743 IDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAE 822

                          650       660
                   ....*....|....*....|....*.
gi 1034567248 1677 LQkNLLNANLSEDEKEQLKKLMELKQ 1702
Cdd:pfam15921  823 CQ-DIIQRQEQESVRLKLQHTLDVKE 847
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1623-1957 1.82e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.14  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1623 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLKKLMELKQ 1702
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL---EKEVKELEELKEEIE 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1703 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMD--IQINKLKHKIDDLTAELETAGS 1780
Cdd:PRK03918   242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV----KELKELKEKAEeyIKLSEFYEEYLDELREIEKRLS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1781 KclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELGQVKQYKQEIEERARQEIAEKLK 1857
Cdd:PRK03918   318 R---LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHelyEEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1858 EVNlflQAQAASQENLEQFREnnfasMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELK 1926
Cdd:PRK03918   395 ELE---KAKEEIEEEISKITA-----RIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEK 466

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1034567248 1927 VRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1957
Cdd:PRK03918   467 ELKEIEEKERKLRKELRELEKVLKKESELIK 497
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 2.09e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 2.09e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567248   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1147-1378 2.20e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 2.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1147 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 1226
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1227 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1303
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248 1304 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1378
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1114-1705 2.81e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 2.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1114 KIKKMEDKVNVLQRELSETKEIKSQLehqkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 1193
Cdd:TIGR04523   97 KINKLNSDLSKINSEIKNDKEQKNKL-------EVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1194 QLELSLQTLEMELRTVKSNLNQVVQERNdaqrqlsreqnarmlqdgILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLS 1273
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLL------------------KLELLLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1274 HKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEEtLTQTISQYNGRLSVLTAE-----NA 1348
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKE-LEKQLNQLKSEISDLNNQkeqdwNK 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1349 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQL 1428
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEI 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1429 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL 1508
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1509 RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1588
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK-ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1589 ELA---DTLKKQsmseaslevtsryriNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1665
Cdd:TIGR04523  546 ELNkddFELKKE---------------NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 1034567248 1666 TVKKQMDKIEELQKNllNANLSEDEKEQLKKLMELKQSLE 1705
Cdd:TIGR04523  611 KISSLEKELEKAKKE--NEKLSSIIKNIKSKKNKLKQEVK 648
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 3.06e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 3.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567248   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1105-1331 3.17e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 3.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1105 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 1184
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1185 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 1261
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248 1262 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLKivKEKnEDLQKTIKQNEETLTQ 1331
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFLT--AQK-EDLTEAKETLEEAIEE 1025
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 5.71e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 5.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567248  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1492-1963 6.17e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 6.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1492 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEktviniqdqfhAIVQKLQAES----------EKQSLLLEERNKELISE 1561
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEE-----------AARQKLQLEKvtteakikklEEDILLLEDQNSKLSKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1562 CNHLKERQYQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVTSRyriNLEDETQDLKKKLGQIRNQ 1631
Cdd:pfam01576  154 RKLLEERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQ 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1632 LQEAQdrhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ---MDKIEELQKNLLNANLSEDEKEQLKK-----LMELKQS 1703
Cdd:pfam01576  231 IAELR---AQLAKKEEELQAALARLEEETAQKNNALKKIrelEAQISELQEDLESERAARNKAEKQRRdlgeeLEALKTE 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1704 LECNLD-----QEMKKNVELEreitgfknlLKMTRKKLNEyengefsfhgdlKTSQFEMDIQINKLKH--KIDDLTAELE 1776
Cdd:pfam01576  308 LEDTLDttaaqQELRSKREQE---------VTELKKALEE------------ETRSHEAQLQEMRQKHtqALEELTEQLE 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1777 TAGSKCLHLDTKNQILQEELLS----MKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELG-------------- 1835
Cdd:pfam01576  367 QAKRNKANLEKAKQALESENAElqaeLRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAeklsklqselesvs 446

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1836 ------------------QVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFAsmKSQMELRIKDLES 1897
Cdd:pfam01576  447 sllneaegkniklskdvsSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEA--KRNVERQLSTLQA 524

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248 1898 ELSKIKTSQEDFNKT-----ELEKYKQLYLEELKVR----KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTL 1963
Cdd:pfam01576  525 QLSDMKKKLEEDAGTlealeEGKKRLQRELEALTQQleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNL 599
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 7.68e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 7.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.23e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567248  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
PTZ00121 PTZ00121
MAEBL; Provisional
 1099-1794 1.29e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1099 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYekiREQL 1178
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK---KAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1179 RRKEEQYRKEVEVKQQLELSLQTleMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 1258
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1259 NSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisqyng 1338
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE----------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1339 rlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAfqRARDECSRLQDKMNFDVSNL 1417
Cdd:PTZ00121  1430 ---KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEA 1502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1418 KDnneilsqqlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDlsqtqcQMKEMEQKYQNEQVKVNKYIGKQES---V 1494
Cdd:PTZ00121  1503 KK----------AAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD------EAKKAEEKKKADELKKAEELKKAEEkkkA 1566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1495 EERLSQLQSENMLLRQQlddahNKADNKEKTVINIQDQFHAIVQKLQAESEKQSllLEERNK-ELISECNHLKERQYQYE 1573
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKaEELKKAEEEKKKVEQLK 1639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1574 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAqdRHTEAVRCAEKMQDHK 1653
Cdd:PTZ00121  1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA--KKAEELKKKEAEEKKK 1717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1654 -QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1732
Cdd:PTZ00121  1718 aEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567248 1733 RKKLNEYENGEFSFHGDLKTSQFemdiqINKLKHKIDDLTAELetagskclhLDTKNQILQE 1794
Cdd:PTZ00121  1798 KKIKDIFDNFANIIEGGKEGNLV-----INDSKEMEDSAIKEV---------ADSKNMQLEE 1845
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1756-1929 1.30e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1835
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1836 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1904
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567248 1905 SQEDFNKTELEKYKQLYlEELKVRK 1929
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1384-1929 1.58e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.12  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1384 QSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDL 1463
Cdd:pfam05557   13 QLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1464 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaivQKLQAE 1543
Cdd:pfam05557   93 NEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ-----QSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1544 SEKQSLLLEERNKelisecnhlkerqyQYENEKAerevVVRQLQQELADTLKKQSMSEASLEVTSRYRIN------LEDE 1617
Cdd:pfam05557  168 AEQRIKELEFEIQ--------------SQEQDSE----IVKNSKSELARIPELEKELERLREHNKHLNENienkllLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1618 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKqKLEKDNAKLKVTVKKQMDKIEELQ---------KNLLNANLSE 1688
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRSPEDLSRRIEQLQqreivlkeeNSSLTSSARQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1689 DEKEQLKKLMELKQSLECNLDQEM-------------KKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhgDLKTSQF 1755
Cdd:pfam05557  309 LEKARRELEQELAQYLKKIEDLNKklkrhkalvrrlqRRVLLLTKERDGYRAILESYDKELTMSNYSP-----QLLERIE 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTvqkkcEKLQKNKKKLEQEVINLRSHIERNMVELG 1835
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQ-----QESLADPSYSKEEVDSLRRKLETLELERQ 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1836 QVKQYKQEIE-ERARQEIAEKLKEV---------NLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTS 1905
Cdd:pfam05557  459 RLREQKNELEmELERRCLQGDYDPKktkvlhlsmNPAAEAYQQRKNQLEKLQAEI-ERLKRLLKKLEDDLEQVLRLPETT 537

                          570       580
                   ....*....|....*....|....
gi 1034567248 1906 QEDFNKTELEKYKQLYLEELKVRK 1929
Cdd:pfam05557  538 STMNFKEVLDLRKELESAELKNQR 561
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.88e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 1034567248  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1475-1738 1.90e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1475 QKYQNEQVKVnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKadnkektviniqdqfhaiVQKLQAESekQSLLLEER 1554
Cdd:COG3206    159 EAYLEQNLEL-----RREEARKALEFLEEQLPELRKELEEAEAA------------------LEEFRQKN--GLVDLSEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1555 NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVtsryrinledetQDLKKKLGQIRNQLQE 1634
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVI------------QQLRAQLAELEAELAE 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1635 AQ----DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEElQKNLLNANLsEDEKEQLKKLMELKQSLEcnldq 1710
Cdd:COG3206    282 LSarytPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQA-REASLQAQL-AQLEARLAELPELEAELR----- 354

                          250       260
                   ....*....|....*....|....*...
gi 1034567248 1711 emkknvELEREITGFKNLLKMTRKKLNE 1738
Cdd:COG3206    355 ------RLEREVEVARELYESLLQRLEE 376
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.97e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567248  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.04e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034567248  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1038-1642 2.93e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 2.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1038 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 1105
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1106 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 1185
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1186 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAqrQLSREQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSH 1264
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARLEALLAAL--GLPLPASAEEFAA--------LRAEAAALLEALEEELEA 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1265 SHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN------QNQEK-----EKKC---FEDLKI------VKEKNEDLQKTI-- 1322
Cdd:COG4913    403 LEEALAEAEAALRDLRRELRELEAEIASLERrksnipARLLAlrdalAEALgldEAELPFvgelieVRPEEERWRGAIer 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1323 ------------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSET 1387
Cdd:COG4913    483 vlggfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAEL 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1388 SKR------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlg 1455
Cdd:COG4913    556 GRRfdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE--- 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1456 LERVQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektV 1526
Cdd:COG4913    626 LAEAEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------L 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1527 INIQDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEV 1606
Cdd:COG4913    688 AALEEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034567248 1607 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG4913    764 ERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1404-1878 4.41e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1404 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1481 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1557
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1558 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----------SLEVTSRYRINLEDE--------- 1617
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTiagvlflvl 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1618 ------TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEK 1691
Cdd:COG4717    284 gllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA---EELE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1692 EQLKkLMELKQSLECNLDQemkKNVELEREItgfknllkmtRKKLNEYEngefsfhgdlktsqfemdiQINKLKHKIDDL 1771
Cdd:COG4717    361 EELQ-LEELEQEIAALLAE---AGVEDEEEL----------RAALEQAE-------------------EYQELKEELEEL 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1772 TAELEtagskclhldtknQILQEELLSMKTVQKkcEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE----- 1846
Cdd:COG4717    408 EEQLE-------------ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgela 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1034567248 1847 RARQEIAEKLKEVNLFLQ---AQAASQENLEQFRE 1878
Cdd:COG4717    473 ELLQELEELKAELRELAEewaALKLALELLEEARE 507
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1584-1796 4.92e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 4.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1584 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1663
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1664 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1742
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567248 1743 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL 1796
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1597-1971 5.24e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.20  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1597 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1676
Cdd:pfam17380  247 EDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKF---EKMEQERLRQEKEEKAREVERRRKLEEAEK 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1677 LQKNLLN---ANLSEDEKEQLKKLMELKQSLECNLDQEMK--KNVELEREITGFKNL--LKMTRKKLNEYENGEFSFHGD 1749
Cdd:pfam17380  324 ARQAEMDrqaAIYAEQERMAMERERELERIRQEERKRELEriRQEEIAMEISRMRELerLQMERQQKNERVRQELEAARK 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1750 LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLhldtknQILQEELlsmktvQKKCEKLQKNKKKLEQEVINLRSHIE- 1828
Cdd:pfam17380  404 VKILEEERQRKIQQQKVEMEQIRAEQEEARQREV------RRLEEER------AREMERVRLEEQERQQQVERLRQQEEe 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1829 --RNMVELGQVKQYKQEIEERARQEIAEKLKEvnlflQAQAASQEnleqfrENNFASMKSQMELRIKDLESELSKIKTSQ 1906
Cdd:pfam17380  472 rkRKKLELEKEKRDRKRAEEQRRKILEKELEE-----RKQAMIEE------ERKRKLLEKEMEERQKAIYEEERRREAEE 540

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248 1907 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT-RPVMEP 1971
Cdd:pfam17380  541 ERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTiKPIYRP 606
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1665-1939 6.34e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1665 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1738
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1739 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1818
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1819 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1892
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1893 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1939
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1089-1370 6.39e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 6.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1089 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 1168
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1169 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 1240
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1241 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 1305
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567248 1306 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1370
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
PRK11281 PRK11281
mechanosensitive channel MscK;
1311-1515 7.99e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 47.98  E-value: 7.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1311 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 1377
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1378 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1445
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1446 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1500
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 1034567248 1501 -LQSENMLLRQQLDDA 1515
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1089-1633 9.08e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.79  E-value: 9.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1089 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 1168
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1169 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 1247
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1248 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 1324
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1325 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1404
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1405 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1480
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1481 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1547
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1548 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1622
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 1034567248 1623 KKLGQIRNQLQ 1633
Cdd:pfam05483  753 AELLSLKKQLE 763
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1529-1949 9.81e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 9.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1529 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYenekaerevvvRQLQQELADTLKKQSMSEASLEVTS 1608
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1609 RYRINLEDETQ--DLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQkLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1686
Cdd:COG4717    116 EELEKLEKLLQllPLYQELEALEAELAELPERLEELE---ERLEELRE-LEEELEELEAELAELQEELEELLEQLSLATE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1687 SEDE--KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKL 1764
Cdd:COG4717    192 EELQdlAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1765 KHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK--LEQEVINLRSHIERNMVELGQVKQYKQ 1842
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQE 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1843 EIEERARQEIAEKLKEVNLFLQA--QAASQENLEQFRE-----NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE 1915
Cdd:COG4717    352 LLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1034567248 1916 KYKQLYLEELkvrKSLSSKLTKTNERLAEVNTKL 1949
Cdd:COG4717    432 EELEELEEEL---EELEEELEELREELAELEAEL 462
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1116-1540 1.04e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.76  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1116 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyEKIREQLRRKEEQYRKEVEvkqQL 1195
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEI----EKEIEQLEQEEEKLKERLE---EL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1196 ELSLQTLEmelrtvksnlnqvvQERNDAQRQLsrEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSH 1274
Cdd:TIGR02169  743 EEDLSSLE--------------QEIENVKSEL--KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQA 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1275 KNSMLQEEIAMLRLEIDTI-KNQNQEKEKKCFEDLKI--VKEKNEDLQKTIKQNEETLtqtisqyngrlsvltaenAMLN 1351
Cdd:TIGR02169  799 ELSKLEEEVSRIEARLREIeQKLNRLTLEKEYLEKEIqeLQEQRIDLKEQIKSIEKEI------------------ENLN 860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1352 SKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKT 1431
Cdd:TIGR02169  861 GKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1432 ESKLNSLEIEfhhtrdalREKTLGLERVQKDLSQTQCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL-- 1508
Cdd:TIGR02169  937 EDPKGEDEEI--------PEEELSLEDVQAELQRVEEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLee 1000

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1034567248 1509 -RQQLDDAHNKADNKEKTV-----INIQDQFHAIVQKL 1540
Cdd:TIGR02169 1001 eRKAILERIEEYEKKKREVfmeafEAINENFNEIFAEL 1038
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1362-1925 1.05e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.34  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1362 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1439
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1440 IEFhhtrDALREKTLGLERVQKDLSQT----QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1515
Cdd:PRK02224   258 AEI----EDLRETIAETEREREELAEEvrdlRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1516 HNKADNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1594
Cdd:PRK02224   334 RVAAQAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1595 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR------CAEKMQDHKQKLEKDnaklkvTVK 1668
Cdd:PRK02224   398 ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkCPECGQPVEGSPHVE------TIE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1669 KQMDKIEELqknllnanlsEDEKEQLK-KLMELKQSLEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYENGefsfh 1747
Cdd:PRK02224   472 EDRERVEEL----------EAELEDLEeEVEEVEERLE-----RAEDLVEAEDRIERLEERREDLEELIAERRET----- 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1748 gdlktsQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmktvqKKCE-KLQKNKKKLEQevinlrsh 1826
Cdd:PRK02224   532 ------IEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEV-------AELNsKLAELKERIES-------- 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1827 IERNMVELGQVKQYKQEIEERA--RQEIAEKLKEvnlflqaqaaSQENLEQFREnnfasmksqmelRIKDLESEL--SKI 1902
Cdd:PRK02224   591 LERIRTLLAAIADAEDEIERLRekREALAELNDE----------RRERLAEKRE------------RKRELEAEFdeARI 648

                          570       580
                   ....*....|....*....|...
gi 1034567248 1903 KTSQEDfnKTELEKYKQLYLEEL 1925
Cdd:PRK02224   649 EEARED--KERAEEYLEQVEEKL 669
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.08e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 1.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1491-1741 1.10e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1491 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1561
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1562 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1634
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1635 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1709
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1034567248 1710 QEMKKN-VELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA 341
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1072-1553 1.28e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.07  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1072 LLIEQLGmecKDSVSLLKIQDaalsceRLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELC 1151
Cdd:COG4717     46 MLLERLE---KEADELFKPQG------RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1152 SLRFSLNQEEEKRRNADTL--YEKIREQLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 1229
Cdd:COG4717    113 ELREELEKLEKLLQLLPLYqeLEALEAELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSL 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1230 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQN 1297
Cdd:COG4717    189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1298 QEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1377
Cdd:COG4717    269 LSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1378 AIHDRDQSETSKRELELafQRARDECSRLQDKmnFDVSNLKDNNEILSQ--QLFKTESKLNSLEIEFHHTRDALRE--KT 1453
Cdd:COG4717    349 LQELLREAEELEEELQL--EELEQEIAALLAE--AGVEDEEELRAALEQaeEYQELKEELEELEEQLEELLGELEEllEA 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1454 LGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQD 1531
Cdd:COG4717    425 LDEEELEEELEELEEELEELEEELEELR-------EELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKL 497

                          490       500
                   ....*....|....*....|...
gi 1034567248 1532 QFHAIVQKLQ-AESEKQSLLLEE 1553
Cdd:COG4717    498 ALELLEEAREeYREERLPPVLER 520
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1114-1473 1.83e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1114 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 1193
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1194 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 1270
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1271 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 1346
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1347 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1419
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567248 1420 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1473
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1616-1888 1.87e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1616 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLK 1695
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL--AELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1696 KLMELKQSLEcnldqemkknvelereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ--INKLKHKIDDLTA 1773
Cdd:COG4942     98 ELEAQKEELA--------------------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylAPARREQAEELRA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1774 ELETagskclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1853
Cdd:COG4942    158 DLAE-------LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1034567248 1854 EklkevnlfLQAQAASQEnlEQFRENNFASMKSQM 1888
Cdd:COG4942    231 R--------LEAEAAAAA--ERTPAAGFAALKGKL 255
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 1.93e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034567248   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 2.29e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567248  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1098-1546 2.63e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.21  E-value: 2.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1098 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 1177
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1178 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 1256
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1257 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 1317
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1318 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 1394
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1395 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1464
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1465 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvQKLQAES 1544
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER-EKAKKEL 713


                   ..
gi 1034567248 1545 EK 1546
Cdd:PRK03918   714 EK 715
PRK12704 PRK12704
phosphodiesterase; Provisional
 1571-1699 2.78e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.92  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1571 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1647
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567248 1648 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1699
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1474-1693 2.90e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1474 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1553
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1554 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1615
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567248 1616 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1693
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1622-1954 3.66e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 45.62  E-value: 3.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1622 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1687
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1688 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1755
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1756 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1821
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1822 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1892
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567248 1893 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1954
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1462-1642 4.25e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 4.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1462 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1541
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1542 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1600
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034567248 1601 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1120-1346 6.38e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.04  E-value: 6.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1120 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 1192
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1193 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1269
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1270 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 1329
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 1034567248 1330 TQTISQYNGRLSVLTAE 1346
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1280-1504 8.76e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 8.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1280 QEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 1359
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE----LAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1360 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1439
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248 1440 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1504
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.79e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.79e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567248    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 9.07e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 9.07e-04
                           10        20
                   ....*....|....*....|....*....
gi 1034567248   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1401-1568 9.10e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 44.30  E-value: 9.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1401 DE-CSRLqdKMNfdvsnlkdnNEILSQQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEME 1474
Cdd:COG0542    396 DEaAARV--RME---------IDSKPEELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALK 460

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1475 QKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaES 1544
Cdd:COG0542    461 ARWEAEKELIEEIQELKEELEQRYGKIPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EG 535

                          170       180
                   ....*....|....*....|....*
gi 1034567248 1545 EKQSLL-LEErnkelisecnHLKER 1568
Cdd:COG0542    536 EREKLLnLEE----------ELHER 550
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1277-1859 1.10e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.96  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1277 SMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE--ETLTQTISQYNGRLSVLTAENAMLNSKL 1354
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEkrEAEAEEALREQAELNRLKKKYLEALNKK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1355 ENEKQSKerlEAEVESYHSRLAAAIHDRdQSETSKRELELAFQRARDECSR----LQDKMNFDVSNLKDNNEILSQQLFK 1430
Cdd:pfam05557   92 LNEKESQ---LADAREVISCLKNELSEL-RRQIQRAELELQSTNSELEELQerldLLKAKASEAEQLRQNLEKQQSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1431 TESKLNSLEIEFH-HTRDALrektlglerVQKDLSQTQCQMKEMEqkyqneqvkvnKYIGKQESVEERLSQLQSENMLLR 1509
Cdd:pfam05557  168 AEQRIKELEFEIQsQEQDSE---------IVKNSKSELARIPELE-----------KELERLREHNKHLNENIENKLLLK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1510 QQLDDAHNKADNKEKT---VINIQDQFHAIVQKLQA-ESEKQSLLLE--------ERNKELISECNHLKERQYQYENEKA 1577
Cdd:pfam05557  228 EEVEDLKRKLEREEKYreeAATLELEKEKLEQELQSwVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSAR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1578 EREVVVRQLQQELADTLKKqsmseaslevtsryrinledeTQDLKKKLGQIRNQLQEAQDRhteavrcaekmqdhkqkle 1657
Cdd:pfam05557  308 QLEKARRELEQELAQYLKK---------------------IEDLNKKLKRHKALVRRLQRR------------------- 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1658 kdnaklKVTVKKQMDKIEELQKN----LLNANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVE-LEREITGFKNLLKM- 1731
Cdd:pfam05557  348 ------VLLLTKERDGYRAILESydkeLTMSNYSPQLLERIEEAEDMTQKMQ-AHNEEMEAQLSvAEEELGGYKQQAQTl 420

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1732 -----TRKKLNEYENGEFSFHG--DLKTSQFEMDIQINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELLSMKTVQK 1804
Cdd:pfam05557  421 erelqALRQQESLADPSYSKEEvdSLRRKLETLELERQRLREQKNELEMELE---RRCLQGDYDPKKTKVLHLSMNPAAE 497

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034567248 1805 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1859
Cdd:pfam05557  498 AYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKEL 552
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1551-1859 1.13e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.36  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1551 LEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKqsmseaslevtsryrinLEDETQDLKKKLGQIRN 1630
Cdd:COG1340     13 LEEKIEELREEIEELKEKRDELNEELKE----LAEKRDELNAQVKE-----------------LREEAQELREKRDELNE 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1631 QLQEAQDRHTEAvrcAEKMQDHKQKLEKDNAKLKVTVKKQMD------KIEELQKNLLNANLS-EDEKEQLKKLMELKQS 1703
Cdd:COG1340     72 KVKELKEERDEL---NEKLNELREELDELRKELAELNKAGGSidklrkEIERLEWRQQTEVLSpEEEKELVEKIKELEKE 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1704 LEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYengefsfHGDLKTSQFEMDI---QINKLKHKIDDLTAELETAgs 1780
Cdd:COG1340    149 LE-----KAKKALEKNEKLKELRAELKELRKEAEEI-------HKKIKELAEEAQElheEMIELYKEADELRKEADEL-- 214

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567248 1781 kclhldtknqilqeellsmktvQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1859
Cdd:COG1340    215 ----------------------HKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAEE 271
PRK11281 PRK11281
mechanosensitive channel MscK;
1114-1472 1.20e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1114 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 1193
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1194 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 1272
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1273 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 1348
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1349 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1426
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567248 1427 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1472
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.39e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034567248  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1175-1839 1.39e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 43.66  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1175 REQLRRKEE---------QYRKEVEVKQQLELSLQTLEMELRTVKsNLNQVVQ--------------------ERNDAQR 1225
Cdd:pfam10174   43 KERALRKEEaarisvlkeQYRVTQEENQHLQLTIQALQDELRAQR-DLNQLLQqdfttspvdgedkfstpeltEENFRRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1226 QLSREQNARML----------------QDGIL-TNHLSKQKEIEMAQKKMNSENSHSHEEEKdlshknsmlQEEIAMLRL 1288
Cdd:pfam10174  122 QSEHERQAKELfllrktleemelrietQKQTLgARDESIKKLLEMLQSKGLPKKSGEEDWER---------TRRIAEAEM 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1289 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ-----KTIKQNEETLTQTISQYNGRLSVLTAENAML--NSKLENEKQSK 1361
Cdd:pfam10174  193 QLGHLEVLLDQKEKENIHLREELHRRNQLQPdpaktKALQTVIEMKDTKISSLERNIRDLEDEVQMLktNGLLHTEDREE 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1362 ERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-AFQrardecSRLqDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1440
Cdd:pfam10174  273 EIKQMEVYKSHSKFMKNKIDQLKQELSKKESELlALQ------TKL-ETLTNQNSDCKQHIEVLKESLTAKEQRAAILQT 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1441 EFHHTRDALREKTLGLERVQKDLSQTQ----CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLR------Q 1510
Cdd:pfam10174  346 EVDALRLRLEEKESFLNKKTKQLQDLTeeksTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAglkervK 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1511 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQel 1590
Cdd:pfam10174  426 SLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKE-- 503

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1591 adtlKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQIRNQLQEAQDRhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ 1670
Cdd:pfam10174  504 ----HASSLASSGLKKDSKLK-SLEIAVEQKKEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQEVARYKEESGKA 577

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1671 MDKIEELQKNLLNANLSEDEKEqlKKLMELKQSLECNLDQEMKKNVELEREITGfknllkMTRKKLNEYENGefsfhgdl 1750
Cdd:pfam10174  578 QAEVERLLGILREVENEKNDKD--KKIAELESLTLRQMKEQNKKVANIKHGQQE------MKKKGAQLLEEA-------- 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1751 ktSQFEMDIQINKLKHKIDDLTAELETAGSKC----LHLDTKNQILQ-----------------EELLSMK------TVQ 1803
Cdd:pfam10174  642 --RRREDNLADNSQQLQLEELMGALEKTRQELdatkARLSSTQQSLAekdghltnlraerrkqlEEILEMKqeallaAIS 719

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1034567248 1804 KK------CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1839
Cdd:pfam10174  720 EKdanialLELSSSKKKKTQEEVMALKREKDRLVHQLKQQTQ 761
Rabaptin pfam03528
Rabaptin;
1492-1712 1.44e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 43.56  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1492 ESVEERLSQLQSEN---MLLRQQLDDAHNKADNKektviniqdqFHAIVQKLQAESEKQSLLLEERNKELISECNHLKER 1568
Cdd:pfam03528    4 EDLQQRVAELEKENaefYRLKQQLEAEFNQKRAK----------FKELYLAKEEDLKRQNAVLQEAQVELDALQNQLALA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1569 QYQYENEKAeREVVVRQLQQELADTLKKQ----------SMSEASLEVTSRYRINLEDE-------TQDLKKKLGQIRNQ 1631
Cdd:pfam03528   74 RAEMENIKA-VATVSENTKQEAIDEVKSQwqeevaslqaIMKETVREYEVQFHRRLEQEraqwnqyRESAEREIADLRRR 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1632 LQEAQDRhteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLK--KLMELKQSLE---- 1705
Cdd:pfam03528  153 LSEGQEE--------ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEA---EDKIKELEasKMKELNHYLEaeks 221


                   ....*..
gi 1034567248 1706 CNLDQEM 1712
Cdd:pfam03528  222 CRTDLEM 228
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1116-1742 1.49e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.91  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1116 KKMEDKVNVLQRELSETKeIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA---DTLYEKI---REQLRRKEEQYRKEV 1189
Cdd:COG5022    813 RSYLACIIKLQKTIKREK-KLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLlkkETIYLQSaqrVELAERQLQELKIDV 891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1190 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQnARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1269
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARL-KKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETS 970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1270 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETltqtisqyNGRLSVLTAENAM 1349
Cdd:COG5022    971 EEYEDLLKKSTILVREGNKANSELKNFKKELAEL--------SKQYGALQESTKQLKEL--------PVEVAELQSASKI 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1350 LNSKLENEKQSKErlEAEVESyhsrlaaaIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1429
Cdd:COG5022   1035 ISSESTELSILKP--LQKLKG--------LLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVT 1104

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1430 KTESKLNSLEIEF-----------HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV---KVNKYIGKQESV- 1494
Cdd:COG5022   1105 NRNLVKPANVLQFivaqmiklnllQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpspPPFAALSEKRLYq 1184

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1495 ----EERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQ---FHAIVQKLQAESEKQSLLLEER---NKELISE 1561
Cdd:COG5022   1185 salyDEKSKLSSSEVNDLKNELIalfSKIFSGWPRGDKLKKLISEgwvPTEYSTSLKGFNNLNKKFDTPAsmsNEKLLSL 1264

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1562 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRINlEDETQDLKKKLGQIRNQLQEAQDRHT 1640
Cdd:COG5022   1265 LNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNAlRTKASSLRWKSATEVN-YNSEELDDWCREFEISDVDEELEELI 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1641 EAVRCaekmqdhKQKLEKDNAKLKVTVkkqmdKIEELQKNLLNANLSEDEKEQLKklmelkqslECNLDQEMKKNV---- 1716
Cdd:COG5022   1344 QAVKV-------LQLLKDDLNKLDELL-----DACYSLNPAEIQNLKSRYDPADK---------ENNLPKEILKKIeall 1402

                          650       660
                   ....*....|....*....|....*....
gi 1034567248 1717 ---ELEREITGFKNLLKMTRKKLNEYENG 1742
Cdd:COG5022   1403 ikqELQLSLEGKDETEVHLSEIFSEEKSL 1431
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.75e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.02  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567248  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1424-1642 1.78e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1424 LSQQLFKTESKLNSLEIEFhhtrDALREKtlgLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyigKQESVEERLSQLQS 1503
Cdd:COG3883     28 LQAELEAAQAELDALQAEL----EELNEE---YNELQAELEALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1504 E-------NMLLRQQ-LDDAHNKADNKEKtvinIQDQFHAIV---QKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1572
Cdd:COG3883     98 SggsvsylDVLLGSEsFSDFLDRLSALSK----IADADADLLeelKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1573 ENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1642
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1351-1697 1.85e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.21  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1351 NSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdVSNLKDNNEILSQQLFK 1430
Cdd:pfam09731  121 KSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKA---TDSALQKAEALAEKLKE 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1431 TESKLNSLEIEfhhtrdALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYigkQESVEErlsqlqsENMLLRQ 1510
Cdd:pfam09731  198 VINLAKQSEEE------AAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQY---KELVAS-------ERIVFQQ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1511 QLDDAHN------KADNKEKTviniqDQFHAIVQKLQAEsekqsllLEERNKELIsecnHLKERqyqyENEKAEREVVVR 1584
Cdd:pfam09731  262 ELVSIFPdiipvlKEDNLLSN-----DDLNSLIAHAHRE-------IDQLSKKLA----ELKKR----EEKHIERALEKQ 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1585 QLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEK----------MQDHK 1653
Cdd:pfam09731  322 KEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYeEKLRTELERQAEAHEEHLKDVLVeqeielqrefLQDIK 401

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034567248 1654 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1697
Cdd:pfam09731  402 EKVEEERAGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQL 445
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.90e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034567248  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1264-1582 2.06e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 42.75  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1264 HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKivkeKNEDLQKTIKQNEETltqtISQYNGRLSVL 1343
Cdd:pfam19220   45 QAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVA----RLAKLEAALREAEAA----KEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1344 TAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQ---DKMNFDVSNLKDN 1420
Cdd:pfam19220  117 TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQalsEEQAAELAELTRR 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1421 NEILSQQLFKTESKLNSLEIEFHHTRdALREK----------TLGLER----------------VQKDLSQTQCQMKEME 1474
Cdd:pfam19220  197 LAELETQLDATRARLRALEGQLAAEQ-AERERaeaqleeaveAHRAERaslrmklealtaraaaTEQLLAEARNQLRDRD 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1475 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-------------NKA--------DNKEKTVINIQDQf 1533
Cdd:pfam19220  276 EAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQraraeleeraemlTKAlaakdaalERAEERIASLSDR- 354

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567248 1534 haiVQKLQAESEKQSLLLEERNKELISEcnhlkerqyqYENEKAEREVV 1582
Cdd:pfam19220  355 ---IAELTKRFEVERAALEQANRRLKEE----------LQRERAERALA 390
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 2.14e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1266-1860 2.34e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 2.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1266 HEEEKDLSHKNSMLQEEIAMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNG----RL 1340
Cdd:COG4913    261 AERYAAARERLAELEYLRAALRLWFAQRRlELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdRL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1341 SVLTAEnamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDN 1420
Cdd:COG4913    341 EQLERE-------IERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1421 NEILSQQLFKTESKLNSLE-------IEFHHTRDALREKtLGLERVQ----KDLsqtqCQMKEMEQKYQNeqvKVNKYIG 1489
Cdd:COG4913    414 LRDLRRELRELEAEIASLErrksnipARLLALRDALAEA-LGLDEAElpfvGEL----IEVRPEEERWRG---AIERVLG 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1490 KQesveeRLSqlqsenMLLRQQLDDAHNKA--DNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL 1565
Cdd:COG4913    486 GF-----ALT------LLVPPEHYAAALRWvnRLHLRGRLVYERVRTGLPDPERPRLDPDSLAgkLDFKPHPFRAWLEAE 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1566 KERQYQYEneKAEREvvvrqlqQELADTlkKQSMSEASL--EVTSRYRINLEDET-------QDLKKKLGQIRNQLQEAQ 1636
Cdd:COG4913    555 LGRRFDYV--CVDSP-------EELRRH--PRAITRAGQvkGNGTRHEKDDRRRIrsryvlgFDNRAKLAALEAELAELE 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1637 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD---------KIEELQKNLLNANLSEDE----KEQLKKLMELKQS 1703
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvasaerEIAELEAELERLDASSDDlaalEEQLEELEAELEE 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1704 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFH--------GDLKTSQFEMDIQiNKLKHKIDDLTAEL 1775
Cdd:COG4913    704 LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELralleerfAAALGDAVERELR-ENLEERIDALRARL 782

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1776 ETAGSKCL----------HLDTKNqiLQEELLSMKTVQKKCEKLQKNK-KKLEQEvinLRSHIERNMVElgQVKQYKQEI 1844
Cdd:COG4913    783 NRAEEELEramrafnrewPAETAD--LDADLESLPEYLALLDRLEEDGlPEYEER---FKELLNENSIE--FVADLLSKL 855

                          650
                   ....*....|....*.
gi 1034567248 1845 EeRARQEIAEKLKEVN 1860
Cdd:COG4913    856 R-RAIREIKERIDPLN 870
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1622-1931 2.72e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.52  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1622 KKKLGQIRNQLQEAQDRHteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS------------ED 1689
Cdd:PRK04778   104 KHEINEIESLLDLIEEDI-------EQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSfgpaldelekqlEN 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1690 EKEQLKKLMELKQS---------LEcNLDQEMKknvELEREITGFKNLLKMTRKK----LNEYENGefsfHGDLKTS--- 1753
Cdd:PRK04778   177 LEEEFSQFVELTESgdyveareiLD-QLEEELA---ALEQIMEEIPELLKELQTElpdqLQELKAG----YRELVEEgyh 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1754 --QFEMDIQINKLKHKIDDLTAELETagskcLHLD---TKNQILQEELLSM-----------KTVQKKCEKLQKNKKKLE 1817
Cdd:PRK04778   249 ldHLDIEKEIQDLKEQIDENLALLEE-----LDLDeaeEKNEEIQERIDQLydilerevkarKYVEKNSDTLPDFLEHAK 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1818 QEVINLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAAS--QENLEQfrennfasmks 1886
Cdd:PRK04778   324 EQNKELKEEIDRvkqsytlNESELESVRQLEKQLEslEKQYDEITERIAE-----QEIAYSelQEELEE----------- 387

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1034567248 1887 qmelrikdLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKSL 1931
Cdd:PRK04778   388 --------ILKQLEEIEKEQEKLS----EMLQGLRKDELEAREKL 420
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1153-1364 2.97e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1153 LRFSLNQEEEKRRNADTLYEK----IREQLRRKE---EQYRKE-------------VEVKQQLELSLQTLEMELRTVKSN 1212
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEqlpeLRKELEEAEaalEEFRQKnglvdlseeakllLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1213 LNQVvqernDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHeeekdlshknsmlqEEIAMLRLEIDT 1292
Cdd:COG3206    242 LAAL-----RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNH--------------PDVIALRAQIAA 302

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567248 1293 IKNQNQEKEKKCFEDLKIVKEknedlqkTIKQNEETLTQTISQYNGRLSVLTAENAMLNSkLENEKQSKERL 1364
Cdd:COG3206    303 LRAQLQQEAQRILASLEAELE-------ALQAREASLQAQLAQLEARLAELPELEAELRR-LEREVEVAREL 366
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1544-1741 3.33e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 41.28  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1544 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1623
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1624 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1699
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034567248 1700 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1741
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1587-1838 4.27e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 4.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1587 QQELADTLKKQSMS----EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK 1662
Cdd:pfam07888   40 LQERAELLQAQEAAnrqrEKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1663 LKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLECNLDQemKKNVELEREitGFKNLLKMTRKKLNEYeNG 1742
Cdd:pfam07888  120 LLAQRAAHEARIRELEEDI--KTLTQRVLERETELERMKERAKKAGAQ--RKEEEAERK--QLQAKLQQTEEELRSL-SK 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1743 EFSfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKclhlDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1822
Cdd:pfam07888  193 EFQ---ELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRK----EAENEALLEE---LRSLQERLNASERKVEGLGEELSS 262

                          250
                   ....*....|....*.
gi 1034567248 1823 LRSHIERNMVELGQVK 1838
Cdd:pfam07888  263 MAAQRDRTQAELHQAR 278
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1404-1701 4.36e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 4.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1404 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1483
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEE 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1484 VNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1563
Cdd:COG4372    110 AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1564 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1643
Cdd:COG4372    190 KEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567248 1644 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELK 1701
Cdd:COG4372    270 EKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 4.36e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.36e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567248   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1202-1525 4.64e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.96  E-value: 4.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1202 LEMELRTVKSNLN----QVVQERNDAQRQLSR----EQNARMLQDGI-----LTNHLSKQKEIEMAQKKMNSENSHSHEE 1268
Cdd:PRK10929    28 ITQELEQAKAAKTpaqaEIVEALQSALNWLEErkgsLERAKQYQQVIdnfpkLSAELRQQLNNERDEPRSVPPNMSTDAL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1269 EKDLSHKNSMLQEEIAMLrleidtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLtQTISQYN-----GRLSVL 1343
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQA--------QQEQDRAREISDSLSQLPQQQTEARRQLNEIERRL-QTLGTPNtplaqAQLTAL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1344 TAENAMLNSKLE---------NEKQSKERLEAEV-ESYHSRLAAAIHD-RDQ-SETSKRELELAFQRARDECSRLQDKMN 1411
Cdd:PRK10929   179 QAESAALKALVDelelaqlsaNNRQELARLRSELaKKRSQQLDAYLQAlRNQlNSQRQREAERALESTELLAEQSGDLPK 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1412 FDVSNLKDNNEI---LSQQ------LFKTESKLNSLEIEFHHTRDALREKT--LGLERVQKDLSQTQ-CQMKEMEqKYQn 1479
Cdd:PRK10929   259 SIVAQFKINRELsqaLNQQaqrmdlIASQQRQAASQTLQVRQALNTLREQSqwLGVSNALGEALRAQvARLPEMP-KPQ- 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567248 1480 eQVKvnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1525
Cdd:PRK10929   337 -QLD-------TEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPLT 374
PHA02946 PHA02946
ankyin-like protein; Provisional
 96-215 4.80e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   96 VTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED--ISVATKLLLYDANIE 173
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034567248  174 AKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 4.89e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 1034567248  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1139-1369 5.71e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 5.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1139 LEHQKVEWERelcslrfslnQEEEKrrnadtlYEKI-REQLRRKEEQYRKEVEVKQQLELSLQTLEMELR---TVKSNLN 1214
Cdd:pfam17380  278 VQHQKAVSER----------QQQEK-------FEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaAIYAEQE 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1215 QVVQERN---DAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHShEEEKDLSHKNSMLQEE----IAMLR 1287
Cdd:pfam17380  341 RMAMERErelERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERV-RQELEAARKVKILEEErqrkIQQQK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1288 LEIDTIKNQNQEKEKkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRlsvltaENAMLNSKLENEKQSKERLEAE 1367
Cdd:pfam17380  420 VEMEQIRAEQEEARQ---REVRRLEEERAREMERVRLEEQERQQQVERLRQQ------EEERKRKKLELEKEKRDRKRAE 490


                   ..
gi 1034567248 1368 VE 1369
Cdd:pfam17380  491 EQ 492
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1027-1669 5.81e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.96  E-value: 5.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1027 KKTSNEKNKVKNQIQSMDDVDDLTQSSETASedcelphssyknfmllieqlGMECKDSVSLLKIQdaalscerllelkkn 1106
Cdd:TIGR01612 1139 KKSENYIDEIKAQINDLEDVADKAISNDDPE--------------------EIEKKIENIVTKID--------------- 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1107 hcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQL 1178
Cdd:TIGR01612 1184 -------KKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEI 1255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1179 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKM 1258
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMETFNISHDDDKD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKEL 1327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1259 NSENSHSHEEEKDLSHKNSMLQEEIAMLRL-EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQT 1332
Cdd:TIGR01612 1328 QKNLLDAQKHNSDINLYLNEIANIYNILKLnKIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSK 1407

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1333 ISQyngrlsvlTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQD 1408
Cdd:TIGR01612 1408 IES--------TLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATN 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1409 KMNFDVSNLKDNNEilSQQLFKTESKLNSLEIEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV---- 1484
Cdd:TIGR01612 1480 DHDFNINELKEHID--KSKGCKDEADKNAKAIE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdsei 1548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1485 ---------NKYIGKQESVEERLSQLQSENMllrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERN 1555
Cdd:TIGR01612 1549 iikeikdahKKFILEAEKSEQKIKEIKKEKF----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDI 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1556 KELISECnhLKERQyqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQL 1632
Cdd:TIGR01612 1616 KKKINDC--LKETE---SIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDV 1690

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1034567248 1633 QEAQDRHTEAV--RCAEKMQDHKQKLEKDNAKLKVTVKK 1669
Cdd:TIGR01612 1691 DQHKKNYEIGIieKIKEIAIANKEEIESIKELIEPTIEN 1729
PRK09039 PRK09039
peptidoglycan -binding protein;
1329-1439 5.88e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.10  E-value: 5.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1329 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1408
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034567248 1409 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1439
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1335-1738 6.03e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.86  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1335 QYNGRLSVLTAE--------NAMLNSKLENEKqsKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL 1406
Cdd:COG3096    317 ELSARESDLEQDyqaasdhlNLVQTALRQQEK--IERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSL 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1407 QdkmnfdvSNLKDNNEILSQQlfKTESklnsleIEFHHTRDALREktlglervqkdlSQTQCQMKEMEQkyqnEQVKvnk 1486
Cdd:COG3096    395 K-------SQLADYQQALDVQ--QTRA------IQYQQAVQALEK------------ARALCGLPDLTP----ENAE--- 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1487 yiGKQESVEERLSQLQSENMLLRQQL---DDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERnkelisECN 1563
Cdd:COG3096    441 --DYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEKAYELVCKIAGE----VERSQAWQTARELLRRYR------SQQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1564 HLKERQYQYENEKAEREVVVRQLQ--QELADTLKKQSmseaSLEVTSryRINLEDEtqdlkkklgqiRNQLQEAQDRHTE 1641
Cdd:COG3096    509 ALAQRLQQLRAQLAELEQRLRQQQnaERLLEEFCQRI----GQQLDA--AEELEEL-----------LAELEAQLEELEE 571

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1642 AVR-CAEKMQDHKQKLEKDNAKLKvTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMElkqslecnLDQEMKKNVELER 1720
Cdd:COG3096    572 QAAeAVEQRSELRQQLEQLRARIK-ELAARAPAWLAAQDAL--ERLREQSGEALADSQE--------VTAAMQQLLERER 640

                          410
                   ....*....|....*...
gi 1034567248 1721 EITGFKNLLKMTRKKLNE 1738
Cdd:COG3096    641 EATVERDELAARKQALES 658
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1355-1634 6.27e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 6.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1355 ENEKQSKERLEAEVESYHSRLAAAIH---DRDQSETSKRELELAFQRARD-ECSRLQDKMNFDVSNLKDNNEIlsQQLFK 1430
Cdd:pfam17380  322 EKARQAEMDRQAAIYAEQERMAMERErelERIRQEERKRELERIRQEEIAmEISRMRELERLQMERQQKNERV--RQELE 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1431 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVnkyigkqesvEERLSQLQSEnmLLRQ 1510
Cdd:pfam17380  400 AARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL----------EEQERQQQVE--RLRQ 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1511 QLDDAHNKADNKEKTVIN---IQDQFHAIVQKlQAESEKQSLLlEERNKELISEcNHLKERQYQ-YENEKAEREVVVRQL 1586
Cdd:pfam17380  468 QEEERKRKKLELEKEKRDrkrAEEQRRKILEK-ELEERKQAMI-EEERKRKLLE-KEMEERQKAiYEEERRREAEEERRK 544

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567248 1587 QQELADTLK-KQSMSEASLEvtsRYRINLEDETQDLKKKLGQIRNQLQE 1634
Cdd:pfam17380  545 QQEMEERRRiQEQMRKATEE---RSRLEAMEREREMMRQIVESEKARAE 590
PRK12704 PRK12704
phosphodiesterase; Provisional
 1663-1858 6.72e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1663 LKVTVKKQMDKIEELQKNLLNAnlSEDEKEQLKKLMELKQSlecnlDQEMKKNVELEREItgfknllkmtRKKLNEYENG 1742
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEE--AKKEAEAIKKEALLEAK-----EEIHKLRNEFEKEL----------RERRNELQKL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1743 EfsfhgdlktsqfemdiqiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN 1822
Cdd:PRK12704    88 E------------------KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISG 149

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034567248 1823 LRSHIERNMVelgqvkqyKQEIEERARQEIAEKLKE 1858
Cdd:PRK12704   150 LTAEEAKEIL--------LEKVEEEARHEAAVLIKE 177
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1684-1912 6.92e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 6.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1684 ANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsfhgdlktsqfemdiQINK 1763
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ------------------ELAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1764 LKHKIDDLTAELETAGSKclhLDTKNQILQEELLSM-KTVQKKCEKL---QKNKKKLEQEVINLRSHIERNMVELGQVKQ 1839
Cdd:COG4942     81 LEAELAELEKEIAELRAE---LEAQKEELAELLRALyRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRA 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567248 1840 YKQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTSQEDFNKT 1912
Cdd:COG4942    158 DLAELAAL-RAELEAERAELEALLAELEEERAALEALKAER-QKLLARLEKELAELAAELAELQQEAEELEAL 228
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1128-1408 7.06e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 40.57  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1128 ELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyekiREQLRRKEeqyrKEVEVKQQLELSLQTLEMEL 1206
Cdd:pfam17045    7 ELQElMKQIDIMVAHKKSEWEGQTRALETRLDIREEELLSA-------RNTLERKH----KEIGLLRQQLEELEKGKQEL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1207 rTVKSNlnqvvQERNDAQRQLSReqnarmlqdgiLTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML 1286
Cdd:pfam17045   76 -VAKYE-----QQLQKLQEELSK-----------LKRSYEK---LQRKQLKEAREEAKSREEDRSELSRLNGKLEEFRQK 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1287 RLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQneetltqtiSQYNGRLSVLTA---ENAMLNSKLENEKQSKER 1363
Cdd:pfam17045  136 SLEWEQQRLQYQQQVASLEAQRKALAEQSSLIQSAAYQ---------VQLEGRKQCLEAsqsEIQRLRSKLERAQDSLCA 206

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1034567248 1364 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1408
Cdd:pfam17045  207 QELELERLRMRVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQN 251
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 7.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 7.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034567248  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
mukB PRK04863
chromosome partition protein MukB;
1109-1822 8.36e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 8.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1109 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhqkvEWERELCSLRFSLNQEEEKrrnadtlyEKIREQLRRKEEQyRKE 1188
Cdd:PRK04863   445 EEFQAKEQEATEELLSLEQKLSVAQAAHSQFE----QAYQLVRKIAGEVSRSEAW--------DVARELLRRLREQ-RHL 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1189 VEVKQQLELSLQTLEMELRtvksNLNQVVQERNDAQRQLSR-EQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSHSHE 1267
Cdd:PRK04863   512 AEQLQQLRMRLSELEQRLR----QQQRAERLLAEFCKRLGKnLDDEDELEQ--------LQEELEARLESLSESVSEARE 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1268 EEKDLSHKNSMLQEEIAMLR------LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNG 1338
Cdd:PRK04863   580 RRMALRQQLEQLQARIQRLAarapawLAAQDALARLREQSGEEFEDSQDVTEYMQQLLereRELTVERDELAARKQALDE 659

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1339 RLSVLTAENAmlnSKLENEKQSKERLEAEVES------------YHSRL----AAAIHDRDQSeTSKRELElafqrARDE 1402
Cdd:PRK04863   660 EIERLSQPGG---SEDPRLNALAERFGGVLLSeiyddvsledapYFSALygpaRHAIVVPDLS-DAAEQLA-----GLED 730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1403 CSRLQDKMNFDVSNLkDNNEILSQQLFKTES-KLNslEIEFHHTR--------DALREKTLGLERVQKDLSQTQCQMKEM 1473
Cdd:PRK04863   731 CPEDLYLIEGDPDSF-DDSVFSVEELEKAVVvKIA--DRQWRYSRfpevplfgRAAREKRIEQLRAEREELAERYATLSF 807

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1474 E-QKYQNEQVKVNKYIGKQESV------EERLSQLQSEnmllRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1546
Cdd:PRK04863   808 DvQKLQRLHQAFSRFIGSHLAVafeadpEAELRQLNRR----RVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPR 883

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1547 QSLLLEERNKELISECN-HLKE--------RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDE 1617
Cdd:PRK04863   884 LNLLADETLADRVEEIReQLDEaeeakrfvQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTE 963

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1618 tqdlkkkLGQIRNQL--QEAQDRHTEAVRCAEKM-QDHKQKlEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1694
Cdd:PRK04863   964 -------VVQRRAHFsyEDAAEMLAKNSDLNEKLrQRLEQA-EQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQM 1035

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1695 kkLMELKQSLEcnldqemkknvelereitgfknllkmtrkklneyengEFSFHGDlktsqFEMDIQinkLKHKIDDLTAE 1774
Cdd:PRK04863  1036 --LQELKQELQ-------------------------------------DLGVPAD-----SGAEER---ARARRDELHAR 1068

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 1034567248 1775 LETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1822
Cdd:PRK04863  1069 LSANRSRRNQLEKQLTFCEAE---MDNLTKKLRKLERDYHEMREQVVN 1113
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1423-1644 9.52e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 9.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1423 ILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1502
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567248 1503 SENMLLRQQLDD-----------AHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQSLLLEERNKELISECNHLKERQYQ 1571
Cdd:COG4942     90 KEIAELRAELEAqkeelaellraLYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567248 1572 YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 1644
Cdd:COG4942    169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH