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Conserved domains on  [gi|1034567240|ref|XP_016871418|]
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ankyrin repeat domain-containing protein 26 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1272-1575 1.89e-165

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 1.89e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1272 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1351
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1352 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1431
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1432 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1511
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1512 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1575
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1881-1989 2.30e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1881 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1960
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567240 1961 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1989
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 7.37e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 7.37e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567240  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1105-1772 8.67e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 8.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1105 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1170
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1171 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1243
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1244 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1318
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1319 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1379
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1380 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1445
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1446 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1525
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1526 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1605
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1606 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1675
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1676 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567240 1754 DIQINKLKHKIDDLTAELE 1772
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1752-1925 7.18e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 7.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1831
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1832 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1900
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567240 1901 SQEDFNKTELEKYKQLYlEELKVRK 1925
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1272-1575 1.89e-165

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 1.89e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1272 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1351
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1352 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1431
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1432 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1511
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1512 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1575
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1881-1989 2.30e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1881 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1960
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567240 1961 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1989
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 7.37e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 7.37e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567240  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1105-1772 8.67e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 8.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1105 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1170
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1171 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1243
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1244 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1318
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1319 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1379
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1380 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1445
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1446 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1525
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1526 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1605
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1606 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1675
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1676 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567240 1754 DIQINKLKHKIDDLTAELE 1772
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.62e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.86  E-value: 1.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034567240  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1083-1955 3.99e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 81.76  E-value: 3.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1083 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1161
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1162 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1241
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1242 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1303
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1304 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1376
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1377 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1452
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1453 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1528
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1529 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1604
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1605 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1670
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1671 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1739
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1740 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1819
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1820 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1884
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1885 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1955
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1507-1945 1.98e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1507 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1577
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1578 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1654
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1655 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1730
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1731 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1801
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1802 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1869
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1870 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1929
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 1034567240 1930 KLTKTNERLAEVNTKL 1945
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.27e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567240  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1083-1630 3.34e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1083 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1159
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1160 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1232
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1233 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1312
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1313 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1392
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1393 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1472
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1473 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1546
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1547 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1626
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 1034567240 1627 QLQE 1630
Cdd:COG1196    775 EIEA 778
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1157-1772 2.89e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 2.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1157 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1227
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1228 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1307
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1308 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1387
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1388 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1467
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1468 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1547
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1548 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1618
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1619 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1686
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1687 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1766
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 1034567240 1767 LTAELE 1772
Cdd:COG1196    772 LEREIE 777
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1099-1535 3.70e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.51  E-value: 3.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1099 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1178
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1179 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1237
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1238 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1315
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1316 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1392
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1393 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1460
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567240 1461 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1535
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1158-1726 1.65e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1158 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1236
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1237 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1311
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1312 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1373
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1374 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1450
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1451 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1509
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1510 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1586
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1587 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1666
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1667 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1726
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1752-1925 7.18e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 7.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1831
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1832 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1900
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567240 1901 SQEDFNKTELEKYKQLYlEELKVRK 1925
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 8.00e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 8.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1669-1953 8.57e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 8.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1669 KIEELQKNL--LNANLSEDEK---------EQLKKLMELKQSLEcnldqemkknvELEREITGfkNLLKMTRKKLNEyen 1737
Cdd:TIGR02168  180 KLERTRENLdrLEDILNELERqlkslerqaEKAERYKELKAELR-----------ELELALLV--LRLEELREELEE--- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1738 gefsfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEK-----------LQ 1806
Cdd:TIGR02168  244 --------LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQqkqilrerlanLE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1807 KNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE---ERARQEIAEKLKEVNLFLQAQAASQENLEQFReNNFASMKSQ 1883
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKeelESLEAELEELEAELEELESRLEELEEQLETLR-SKVAQLELQ 394

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240 1884 MEL---RIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELK-VRKSLSSK---LTKTNERLAEVNTKLLVEKQQSR 1953
Cdd:TIGR02168  395 IASlnnEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELeeeLEELQEELERLEEALEELREELE 471
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.25e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567240  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1661-1935 6.61e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1661 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1734
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1735 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1814
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1815 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1888
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1889 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1935
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1618-1950 1.36e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.77  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1618 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1683
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1684 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1751
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1817
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1818 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1888
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567240 1889 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1950
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 8.03e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567240    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1540-1737 1.73e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.05  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1540 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLKKQSmSEASLEVTSRYRiNLEDETQDLKK 1619
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQLIEEG-HPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1620 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1695
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034567240 1696 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1737
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1272-1575 1.89e-165

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 508.76  E-value: 1.89e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1272 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1351
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1352 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1431
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1432 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1511
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1512 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1575
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1881-1989 2.30e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1881 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1960
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1034567240 1961 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1989
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 7.37e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 7.37e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 1034567240  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 6.53e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 6.53e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666     91 LHAAARNGDLEIVK--LLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAV 208
Cdd:COG0666    169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                          170
                   ....*....|
gi 1034567240  209 DKLESSHQLI 218
Cdd:COG0666    249 DKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 1.74e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.22  E-value: 1.74e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 1034567240  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.26e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.13  E-value: 1.26e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 1034567240  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1105-1772 8.67e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 8.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1105 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1170
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1171 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1243
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1244 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1318
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1319 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1379
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1380 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1445
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1446 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1525
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1526 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1605
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1606 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1675
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1676 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1753
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 1034567240 1754 DIQINKLKHKIDDLTAELE 1772
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.62e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.86  E-value: 1.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034567240  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1098-1916 1.75e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 99.36  E-value: 1.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1098 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 1177
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1178 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 1257
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1258 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 1337
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1338 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1415
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1416 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1484
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1485 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNkeLISECNHLKER 1564
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYR--IVTLDGDLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1565 QYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK 1644
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1645 MQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1724
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1725 LKMTRKKLNEYENGEFSF---HGDLKTSQFEMDIQINKLKHKIDDLTAELETAgskclhldtknQILQEELlsmktvQKK 1801
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL-----------EELIEEL------ESE 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1802 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIeERARQEIAEKLKEVNLFLQ-AQAASQENLEQFREN----- 1875
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSEL-RRELEELREKLAQLELRLEgLEVRIDNLQERLSEEysltl 953

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 1034567240 1876 -NFASMKSQMELRIKDLESELSKIKTSQEDF---NKTELEKYKQL 1916
Cdd:TIGR02168  954 eEAEALENKIEDDEEEARRRLKRLENKIKELgpvNLAAIEEYEEL 998
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 5.75e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1034567240  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 1.08e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQqiLLLrKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    157 LHLAAANGNLEIVK--LLL-EAGadVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1111-1917 2.55e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.51  E-value: 2.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1111 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 1187
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1188 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 1266
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1267 DLSHKNSMLQEEIAMLRLEIDTIKNQNQE---KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 1340
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEElesRLEELEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1341 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1415
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1416 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1481
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1482 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQ------------------------ 1537
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDnalelakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1538 --------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1601
Cdd:TIGR02168  657 pggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1602 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnan 1681
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL---- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1682 lsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD---IQIN 1758
Cdd:TIGR02168  813 --TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleEALA 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1759 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE-KLQKNKKKL-EQEVINLRSHIERNMVELGQVKQY 1836
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEA 970

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1837 KQEIeERARQEIAEkLKEVNLflqaqaasqENLEQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYK 1914
Cdd:TIGR02168  971 RRRL-KRLENKIKE-LGPVNL---------AAIEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFK 1035


                   ...
gi 1034567240 1915 QLY 1917
Cdd:TIGR02168 1036 DTF 1038
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 4.06e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.32  E-value: 4.06e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1094-1856 3.97e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 85.12  E-value: 3.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1094 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 1172
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1173 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 1251
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1252 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 1331
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1332 yngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLaaaihdrdqsetSKRELELAFQRARDECSRLQDKMNFDVS 1411
Cdd:TIGR02169  464 ------------------LSKYEQELYDLKEEYDRVEKEL------------SKLQRELAEAEAQARASEERVRGGRAVE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1412 NLKDNNeilSQQLFKTESKLNSLE-----------------------------IEFHHTRDALREKTLGLERVQKDLSQT 1462
Cdd:TIGR02169  514 EVLKAS---IQGVHGTVAQLGSVGeryataievaagnrlnnvvveddavakeaIELLKRRKAGRATFLPLNKMRDERRDL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1463 QCQMK-----------EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML-LRQQLDD---AHNKADNKEKTVINIQD 1527
Cdd:TIGR02169  591 SILSEdgvigfavdlvEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGELFEksgAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1528 QFHAIVQKLQAESEKqsllLEERNKELISECNHLKER--QYQYENEKAEREVVVRQ-----LQQELADTLKKQSMSEASL 1600
Cdd:TIGR02169  671 SEPAELQRLRERLEG----LKRELSSLQSELRRIENRldELSQELSDASRKIGEIEkeieqLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1601 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHK--QKLEKDNAKLKVTVKKQMDKIEELQKNLl 1678
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLE----EALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLREIEQKL- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1679 naNLSEDEKEQLKKLMELKQS----LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEngefSFHGDLKTSQFEMD 1754
Cdd:TIGR02169  822 --NRLTLEKEYLEKEIQELQEqridLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLE----SRLGDLKKERDELE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1755 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-----------------LSMKTVQKKCEKLQKNKKKLEQevI 1817
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiedpkgedeeipeeeLSLEDVQAELQRVEEEIRALEP--V 973

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 1034567240 1818 NLRSHIERNMVELGQVK-QYKQEIEERARQEIAEKLKEVN 1856
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDElKEKRAKLEEERKAILERIEEYE 1013
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1083-1955 3.99e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 81.76  E-value: 3.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1083 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1161
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1162 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1241
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1242 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1303
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1304 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1376
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1377 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1452
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1453 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1528
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1529 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1604
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1605 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1670
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1671 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1739
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1740 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1819
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1820 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1884
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1885 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1955
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1111-1892 2.45e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 79.39  E-value: 2.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1111 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 1190
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1191 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 1268
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1269 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 1341
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1342 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1413
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1414 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1476
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1477 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1550
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1551 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1630
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1631 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1710
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1711 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETA--------GS------ 1776
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrntlksmeGSdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1777 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1842
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034567240 1843 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1892
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1172-1933 1.26e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.03  E-value: 1.26e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1172 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 1249
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1250 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1329
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1330 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1395
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1396 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1465
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1466 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1526
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1527 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1567
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1568 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1625
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1626 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1705
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1706 QEMKKNVELEREITGFKnllkmTRKKLNEYEngefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL---- 1781
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR-----IPEIQAELS--------KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELqeqr 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1782 -DTKNQI--LQEELLSMKT----VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERarqeiAEKLKE 1854
Cdd:TIGR02169  843 iDLKEQIksIEKEIENLNGkkeeLEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ-----IEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1855 VNLFLQAQAASQENLEQFRENNFASMKS---------QMELRIKDLESELSKIktsqEDFNKTELEKYKqlylEELKVRK 1925
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEipeeelsleDVQAELQRVEEEIRAL----EPVNMLAIQEYE----EVLKRLD 989


                   ....*...
gi 1034567240 1926 SLSSKLTK 1933
Cdd:TIGR02169  990 ELKEKRAK 997
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1121-1815 1.43e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.55  E-value: 1.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1121 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 1200
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1201 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 1250
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1251 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 1327
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1328 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1400
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1401 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1478
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1479 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKL---QAESEKQSLLLEERNKELI 1555
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDLtekLSEAEDMLACEQHALLRKL 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1556 SECNHLKERQyQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTS------RYRINLEDETQDLKKKLGQIRNQLQ 1629
Cdd:TIGR00618  622 QPEQDLQDVR-LHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkellASRQLALQKMQSEKEQLTYWKEMLA 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1630 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQslecnldqemK 1709
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELM-----HQARTVLKARTEAHF----------N 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1710 KNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlKTSQFEMDIQiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1789
Cdd:TIGR00618  766 NNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH---LLKTLEAEIG-QEIPSDEDILNLQCETLVQEEEQFLSRLEEKS 841

                          730       740
                   ....*....|....*....|....*.
gi 1034567240 1790 EELLSMKTVQKKCEKLQKNKKKLEQE 1815
Cdd:TIGR00618  842 ATLGEITHQLLKYEECSKQLAQLTQE 867
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1285-1945 1.49e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.21  E-value: 1.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1285 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1358
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1359 RLEAEVESyhsrlaaaihdrdqsetSKRELElafqrardECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1438
Cdd:TIGR04523  121 KLEVELNK-----------------LEKQKK--------ENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1439 HHTRDALREKtlglervQKDLSQTQCQMKEMEQKYQNEQvkvnKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1518
Cdd:TIGR04523  176 NLLEKEKLNI-------QKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEK 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1519 EKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKkqsmsea 1598
Cdd:TIGR04523  245 TTEISNTQTQLNQLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELK------- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1599 slevtsryrinleDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNll 1678
Cdd:TIGR04523  314 -------------SELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE-- 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1679 nanlSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF---KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1755
Cdd:TIGR04523  379 ----NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLqqeKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1756 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1835
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKEL---KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1836 YKQEIEERARQ------EIAEKLKEVNLFLQAQaASQENLEQFRENNFASMKSQMEL--RIKDLESELSKIKTSQEDFNK 1907
Cdd:TIGR04523  532 EKKEKESKISDledelnKDDFELKKENLEKEID-EKNKEIEELKQTQKSLKKKQEEKqeLIDQKEKEKKDLIKEIEEKEK 610

                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 1034567240 1908 TELEKYKQLYLEELKVRKsLSSKLTKTNERLAEVNTKL 1945
Cdd:TIGR04523  611 KISSLEKELEKAKKENEK-LSSIIKNIKSKKNKLKQEV 647
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1507-1945 1.98e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1507 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1577
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1578 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1654
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1655 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1730
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1731 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1801
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1802 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1869
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1870 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1929
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 1034567240 1930 KLTKTNERLAEVNTKL 1945
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1295-1955 7.54e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.32  E-value: 7.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1295 EKEKKCFEDLKIVKEKNEDLQKTI--------KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1366
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrleelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1367 YHSRLAAAihdrdQSETSKRELELAFQRARDEcsrlqdkmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1446
Cdd:TIGR02168  286 LQKELYAL-----ANEISRLEQQKQILRERLA-------------NLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1447 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnkADNKEKTVINIQ 1526
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL---EDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1527 DQfhaivqkLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1606
Cdd:TIGR02168  425 EL-------LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1607 RINLEDETQDLKKKLgQIRNQLQEAQDRHTEAVRCAEK--------MQDHKQKLE--------------KDNAKLKVTV- 1663
Cdd:TIGR02168  498 QENLEGFSEGVKALL-KNQSGLSGILGVLSELISVDEGyeaaieaaLGGRLQAVVvenlnaakkaiaflKQNELGRVTFl 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1664 -----------KKQMDKIEELQKNLLNANLSEDEKEQLKKLME-----------LKQSLEC------------------- 1702
Cdd:TIGR02168  577 pldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddLDNALELakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1703 -----------------NLDQEMKKNV----ELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMDIQINKLK 1761
Cdd:TIGR02168  657 pggvitggsaktnssilERRREIEELEekieELEEKIAELEKALAELRKELEELEEEL----EQLRKELEELSRQISALR 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1762 HKIDDLTAELETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1841
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAE---IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1842 ERARQEIAE--KLKEVNLFLQAQAASQENLEQFRENNFAsmksQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYLE 1919
Cdd:TIGR02168  810 AELTLLNEEaaNLRERLESLERRIAATERRLEDLEEQIE----ELSEDIESLAAEIEELEELIEELES-ELEALLNERAS 884

                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 1034567240 1920 ELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1955
Cdd:TIGR02168  885 LEEALALLRSELEELSEELRELESKRSELRRELEEL 920
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.27e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567240  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1199-1945 1.50e-12

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 73.33  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1199 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 1276
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1277 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 1352
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1353 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD---ECSRLQDKM----NFDVSNLKDN----NEILS 1421
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDvtaKYNRRRSKIkeqnNRDIAGIKDKlakiREARD 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1422 QQLFKTESKLNSLEIEFHHTRDA----LREKTLG----LERVQKDLSQTQCQMKEMEQKYQNeQVKVNKYIGKQESVEER 1493
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAgkleFNEEEYRlksrLGELKLRLNQATATPELLLQLENF-DERIERAREEQEAANAE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1494 LSQLQSEnmllRQQLDDAHNKADNKEKtviniqdQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKA 1573
Cdd:pfam12128  487 VERLQSE----LRQARKRRDQASEALR-------QASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGKVI 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1574 EREVVVR-QLQQELADTLKKQSMSEASLEVTSRyRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAvrcAEKMQDHK 1649
Cdd:pfam12128  556 SPELLHRtDLDPEVWDGSVGGELNLYGVKLDLK-RIDVPEwaaSEEELRERLDKAEEALQSAREKQAAA---EEQLVQAN 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1650 QKLekDNAKLKVTVKKQMDKIEELQKNLLNanlseDEKEQLKklMELKQSLECNLDQEMKKNVELEREitgfKNLLKMTR 1729
Cdd:pfam12128  632 GEL--EKASREETFARTALKNARLDLRRLF-----DEKQSEK--DKKNKALAERKDSANERLNSLEAQ----LKQLDKKH 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1730 KKLNEYENGEFSFHGDLKtsQFEMDIQINKLKHKIDDLTAELETAGSKclhLDTKNQILQEEllsMKTVQKKCEKLQKNK 1809
Cdd:pfam12128  699 QAWLEEQKEQKREARTEK--QAYWQVVEGALDAQLALLKAAIAARRSG---AKAELKALETW---YKRDLASLGVDPDVI 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1810 KKLEQEVINLRSHIERNMVELGQVKQYKQEIEER---ARQEIAEKLKEVN---LFLQAQAASQE-----NLEQFRENNFA 1878
Cdd:pfam12128  771 AKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwlqRRPRLATQLSNIEraiSELQQQLARLIadtklRRAKLEMERKA 850

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567240 1879 SMKSQMEL--RIKDLESELSKIKTSQEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEVNTKL 1945
Cdd:pfam12128  851 SEKQQVRLseNLRGLRCEMSKLATLKEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNVIADH 923
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 839-1630 1.85e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.17  E-value: 1.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  839 SANNYKSMEPELENVRSSpprgdRTSKVSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKEVEeerkkhrnnemEV 918
Cdd:TIGR02168  230 LVLRLEELREELEELQEE-----LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY-----------AL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  919 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN---KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKA 995
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDelaEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  996 SlltgGLLQVDDDSSLSEIDEdegrptkkTSNEKNKVKNQIQSMDD-VDDLTQSSETASEDcelphssyknfmllIEQLG 1074
Cdd:TIGR02168  374 L----EELEEQLETLRSKVAQ--------LELQIASLNNEIERLEArLERLEDRRERLQQE--------------IEELL 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1075 MEckdsvslLKIQDAALSCERLLELKKnhcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLN 1154
Cdd:TIGR02168  428 KK-------LEEAELKELQAELEELEE--------ELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1155 QEEEKRRNADTLYEKIREQLRRK----------------EEQYRKEVEVkqQLELSLQTLEMElrtvksNLNQVVQ---- 1214
Cdd:TIGR02168  493 SLERLQENLEGFSEGVKALLKNQsglsgilgvlselisvDEGYEAAIEA--ALGGRLQAVVVE------NLNAAKKaiaf 564

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1215 -ERNDAQRQL-------------SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEkDLSHKNSMLQEEIA 1280
Cdd:TIGR02168  565 lKQNELGRVTflpldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDNALELAKKLRP 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1281 MLR---LEIDTIKN---------------QNQEKE-KKCFEDLKIVKEKNEDLQKTIKQNEETLtqtiSQYNGRLSVLTA 1341
Cdd:TIGR02168  644 GYRivtLDGDLVRPggvitggsaktnssiLERRREiEELEEKIEELEEKIAELEKALAELRKEL----EELEEELEQLRK 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1342 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsNLKDNNEILS 1421
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE----ELEAQIEQLK 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1422 QQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEn 1501
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE- 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1502 mllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAesekqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1581
Cdd:TIGR02168  875 ------LEALLNERASLEEALALLRSELEELSEELRE--------LESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567240 1582 LQQELADTLkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1630
Cdd:TIGR02168  941 LQERLSEEY------SLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1157-1952 3.08e-12

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 72.31  E-value: 3.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1157 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 1223
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1224 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 1303
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1304 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIhdRDQSET 1383
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK--LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1384 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR-EKTLGLERVQKDLSQT 1462
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1463 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQ-QLDDAHNKADNKEKTVINIQdqfHAIVQKLQAESE 1541
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGgRIISAHGRLGDLGVAVENYK---VAISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1542 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET--QDLKK 1619
Cdd:pfam02463  555 ATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGilKDTEL 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1620 KLGQIRNQLQEAQDRHTEAVRCAEKM-QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQ 1698
Cdd:pfam02463  635 TKLKESAKAKESGLRKGVSLEEGLAEkSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKK 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1699 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKc 1778
Cdd:pfam02463  715 LKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKE- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1779 lhldtKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1858
Cdd:pfam02463  794 -----EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEEL 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1859 LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSL--SSKLTKTNE 1936
Cdd:pfam02463  869 LQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPeeLLLEEADEK 948

                          810
                   ....*....|....*.
gi 1034567240 1937 RLAEVNTKLLVEKQQS 1952
Cdd:pfam02463  949 EKEENNKEEEEERNKR 964
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1083-1630 3.34e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1083 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1159
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1160 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1232
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1233 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1312
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1313 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1392
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1393 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1472
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1473 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1546
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1547 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1626
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 1034567240 1627 QLQE 1630
Cdd:COG1196    775 EIEA 778
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 8.47e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 8.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 1034567240  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 2.68e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1034567240  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1157-1772 2.89e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 2.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1157 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1227
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1228 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1307
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1308 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1387
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1388 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1467
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1468 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1547
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1548 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1618
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1619 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1686
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1687 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1766
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 1034567240 1767 LTAELE 1772
Cdd:COG1196    772 LEREIE 777
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1018-1933 3.31e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 68.92  E-value: 3.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1018 EGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFM---------LLIEQLGMECKDSVSLLKIQD 1088
Cdd:TIGR00606  167 EGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKekaceirdqITSKEAQLESSREIVKSYENE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1089 AALSCERLLELKKNhcellTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYE 1168
Cdd:TIGR00606  247 LDPLKNRLKEIEHN-----LSKIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1169 KIREQLRRKEEQYRKEVEvkqqlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI- 1247
Cdd:TIGR00606  319 RELVDCQRELEKLNKERR-----LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIk 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1248 ---EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KT 1317
Cdd:TIGR00606  394 nfhTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDR 472

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1318 IKQNEETLTQTISQYNgrlsvLTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL------- 1390
Cdd:TIGR00606  473 ILELDQELRKAERELS-----KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmd 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1391 AFQRARDECSRLQDKMNFDVS-------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQK 1457
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGyfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYED 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1458 DLSQTqCQMKEMEQKYQNEQVKVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEK 1520
Cdd:TIGR00606  627 KLFDV-CGSQDEESDLERLKEEIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLR 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1521 TVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSE 1597
Cdd:TIGR00606  706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAK 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1598 ASL-EVTSRYRinLEDETQDLKKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK 1675
Cdd:TIGR00606  786 VCLtDVTIMER--FQMELKDVERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1676 NLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1755
Cdd:TIGR00606  862 LKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1756 QINKLKHKIDDLTAELETAGSKClhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLR-----SHIERNMVEL 1830
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKI--QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRqdidtQKIQERWLQD 1019

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1831 GQVKQYKQEIEERARQEIAEKLKEVNlflQAQAASQENLEQFRENNFASMKSQMEL---RIKDLESEL--SKIKTSQEDF 1905
Cdd:TIGR00606 1020 NLTLRKRENELKEVEEELKQHLKEMG---QMQVLQMKQEHQKLEENIDLIKRNHVLalgRQKGYEKEIkhFKKELREPQF 1096

                          970       980
                   ....*....|....*....|....*...
gi 1034567240 1906 NKTElEKYKQLYLeELKVRKSLSSKLTK 1933
Cdd:TIGR00606 1097 RDAE-EKYREMMI-VMRTTELVNKDLDI 1122
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1099-1535 3.70e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.51  E-value: 3.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1099 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1178
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1179 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1237
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1238 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1315
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1316 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1392
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1393 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1460
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567240 1461 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1535
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1112-1962 5.63e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 68.07  E-value: 5.63e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1112 KKMEDKVNVLQRELSETKEIKSQLEHQKVEwERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL 1191
Cdd:pfam02463  177 KLIEETENLAELIIDLEELKLQELKLKEQA-KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIES 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1192 ELSLQTLEMELRTVKSNLN-------QVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHE 1263
Cdd:pfam02463  256 SKQEIEKEEEKLAQVLKENkeeekekKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEkKKAEKELKKEKE 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1264 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLT------QTISQYNGRLS 1337
Cdd:pfam02463  336 EIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELElkseeeKEAQLLLELAR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1338 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN 1417
Cdd:pfam02463  416 QLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKL 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1418 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyIGKQESVEERLSQL 1497
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV-EERQKLVRALTELP 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1498 QSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERNKELISECnHLKERQYQYENEKAEREV 1577
Cdd:pfam02463  575 LGARKLRLLIPKLKLPLKSIAVLEIDPILNL----AQLDKATLEADEDDKRAKVVEGILKD-TELTKLKESAKAKESGLR 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1578 VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEavrcaEKMQDHKQKLEKDNA 1657
Cdd:pfam02463  650 KGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK-----EELKKLKLEAEELLA 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1658 KLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKlMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1737
Cdd:pfam02463  725 DRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKK-EEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1738 GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELetagskcLHLDTKNQILQEELLSMKT--VQKKCEKLQKNKKKLEQE 1815
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEE-------LALELKEEQKLEKLAEEELerLEEEITKEELLQELLLKE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1816 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFREnnfasMKSQMELRIKDLESEL 1895
Cdd:pfam02463  877 EELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE-----EPEELLLEEADEKEKE 951

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240 1896 SKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1962
Cdd:pfam02463  952 ENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1302-1874 7.89e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.40  E-value: 7.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1302 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 1381
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1382 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1461
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1462 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1541
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1542 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVT--SRYRIN 1609
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELKriEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1610 LEDETQDLKKKLGQIRNQLQEaQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLlnanl 1682
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL----- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1683 sEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQIN 1758
Cdd:PRK03918   545 -KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELEREEK 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1759 KLKhkidDLTAELETAGSKCLHLDTKNQILQEEL--LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQY 1836
Cdd:PRK03918   620 ELK----KLEEELDKAFEELAETEKRLEELRKELeeLEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1034567240 1837 KQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRE 1874
Cdd:PRK03918   696 LEKLKEE-LEEREKAKKELEKLEKALERVEELREKVKK 732
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1172-1924 8.37e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 67.51  E-value: 8.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1172 EQLRRKEEQYRKEVEVKQQLELSLQTLEmelrtvkSNLNQVVQERNDAQRQL---------SREQNARMLQ-----DGIL 1237
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELE-------KKHQQLCEEKNALQEQLqaetelcaeAEEMRARLAArkqelEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1238 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKnsMLQEEIAMLRLEIDtiKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1317
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQ--LDEEEAARQKLQLE--KVTTEAKIKKLEEDILLLEDQNSKLSKE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1318 IKQNEEtltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD 1397
Cdd:pfam01576  154 RKLLEE-----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQE 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1398 ECSRLQDKMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1477
Cdd:pfam01576  223 QIAELQAQI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESER 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1478 VKVNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEER 1550
Cdd:pfam01576  285 AARNKAEKQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEEL 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1551 NKELisecNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQE 1630
Cdd:pfam01576  362 TEQL----EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAE 430

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1631 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQE 1707
Cdd:pfam01576  431 LAEKLSKLQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEE 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1708 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKtsqfemdiqinKLKHKIDDLTAELETAGSKCLHLDTKNQI 1787
Cdd:pfam01576  509 EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK-----------RLQRELEALTQQLEEKAAAYDKLEKTKNR 577

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1788 LQEEL--LSMKTVQKK--CEKLQKNKKKLEQEVINlrshiERNMVelgqvkqyKQEIEERARQEIAEKLKEVNlFLQAQA 1863
Cdd:pfam01576  578 LQQELddLLVDLDHQRqlVSNLEKKQKKFDQMLAE-----EKAIS--------ARYAEERDRAEAEAREKETR-ALSLAR 643

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240 1864 ASQENLEQfrennfasmKSQMELRIKDLESELSKIKTSQEDFNKT--ELEKYKQLY---LEELKVR 1924
Cdd:pfam01576  644 ALEEALEA---------KEELERTNKQLRAEMEDLVSSKDDVGKNvhELERSKRALeqqVEEMKTQ 700
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.04e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.44  E-value: 1.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1170-1849 1.06e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 67.05  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1170 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 1249
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1250 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1329
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1330 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1407
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1408 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1483
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1484 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1539
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1540 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1619
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1620 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQmdkIEELQKNLlnANLSEDEKEQLKKLMELKQS 1699
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQ---IENKNKNI--EELHQENKALKKKGSAENKQ 630

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1700 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN-------KLKHKIDDLTAELE 1772
Cdd:pfam05483  631 LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKlqkeidkRCQHKIAEMVALME 710

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240 1773 TagskclHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1849
Cdd:pfam05483  711 K------HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTA 781
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1070-1633 1.17e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.07  E-value: 1.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1070 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 1145
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1146 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 1204
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1205 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 1277
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1278 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 1338
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1339 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1397
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1398 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1461
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1462 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1533
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1534 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1609
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 1034567240 1610 lEDETQDLKKKLGQIRNQLQEAQD 1633
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1175-1598 1.21e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.02  E-value: 1.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1175 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmlqdgiltnhlsKQKEIEMAQKKM 1254
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-----------------IEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1255 NSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLqktikqneetltqtisqyng 1334
Cdd:TIGR02169  733 EKLK----ERLEELEEDLSSLEQEIENVKSELKELEARIEELE----EDLHKLEEALNDL-------------------- 784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1335 rlsvltaENAMLNSKLENEKQSKErleaEVESYHSRLAAAIHDRDQsETSKRELELAFqrARDECSRLQDKMNfdvsNLK 1414
Cdd:TIGR02169  785 -------EARLSHSRIPEIQAELS----KLEEEVSRIEARLREIEQ-KLNRLTLEKEY--LEKEIQELQEQRI----DLK 846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1415 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1494
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1495 SQLQSENmllrQQLDDAhNKADNKEKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAE 1574
Cdd:TIGR02169  927 EALEEEL----SEIEDP-KGEDEEIPEEELSLEDVQAELQRVEEEIRA----LEPVNMLAIQEYEEVLKRLDELKEKRAK 997

                          410       420
                   ....*....|....*....|....*.
gi 1034567240 1575 REVVVRQLQQELA--DTLKKQSMSEA 1598
Cdd:TIGR02169  998 LEEERKAILERIEeyEKKKREVFMEA 1023
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1158-1726 1.65e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1158 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1236
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1237 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1311
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1312 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1373
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1374 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1450
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1451 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1509
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1510 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1586
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1587 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1666
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1667 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1726
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.85e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 1034567240  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1106-1726 2.13e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 66.40  E-value: 2.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1106 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 1180
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1181 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEIEMAQKKmnsensh 1260
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIREARDRQLA------- 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1261 shEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKEKKCFEDLKIvkeknedLQKTIKQNEETLTQTisqyngrlsvlt 1340
Cdd:pfam12128  412 --VAEDDLQALESELREQLEAGKLEF----NEEEYRLKSRLGELKL-------RLNQATATPELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1341 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK-----------MNFD 1409
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1410 VSNLKDN--NEILSQQLFKT-------------ESKLNSLEI--------EFHHTRDALREKtlgLERVQKDLSQTQCQM 1466
Cdd:pfam12128  544 APDWEQSigKVISPELLHRTdldpevwdgsvggELNLYGVKLdlkridvpEWAASEEELRER---LDKAEEALQSAREKQ 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1467 KEMEQkyqnEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-NKADNKEKTVINIQDQFHAIVQKLQAESE---- 1541
Cdd:pfam12128  621 AAAEE----QLVQANGELEKASREETFARTALKNARLDLRRLFDEKqSEKDKKNKALAERKDSANERLNSLEAQLKqldk 696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1542 KQSLLLEERNKELISecnHLKERQYQYENEKAEREVVVRQLQQELA----------DTLKKQSMSE-ASLEVTSRYRINL 1610
Cdd:pfam12128  697 KHQAWLEEQKEQKRE---ARTEKQAYWQVVEGALDAQLALLKAAIAarrsgakaelKALETWYKRDlASLGVDPDVIAKL 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1611 EDETQDLKKKLGQIrnqlqeAQDRHteAVRCAEKMQDHKQKLEKDNakLKVTVKKQMDKIEELQKNLlnANLSEDEKEQL 1690
Cdd:pfam12128  774 KREIRTLERKIERI------AVRRQ--EVLRYFDWYQETWLQRRPR--LATQLSNIERAISELQQQL--ARLIADTKLRR 841

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034567240 1691 KKLMELKQSLEcnldqemKKNVELEREITGFKNLLK 1726
Cdd:pfam12128  842 AKLEMERKASE-------KQQVRLSENLRGLRCEMS 870
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1265-1955 4.91e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 64.74  E-value: 4.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1265 EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEkNEDLqktIKQNEETltqtiSQYNGRLSVLTAENA 1344
Cdd:pfam05483   98 EAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE-NKDL---IKENNAT-----RHLCNLLKETCARSA 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1345 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQ 1423
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1424 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenml 1503
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI------- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1504 lrqqlddahnkadnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1583
Cdd:pfam05483  322 --------------ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQ 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1584 QEladtlkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHKQKL---------EK 1654
Cdd:pfam05483  388 KK-----------SSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKK----QFEKIAEELKGKEQELifllqarekEI 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1655 DNAKLKVTVKKQMDK-----IEELQKNLLNANLSEDEKEQLKKLMELKQSlecNLDQEMKKNV-ELEREITGFKNLLKMT 1728
Cdd:pfam05483  453 HDLEIQLTAIKTSEEhylkeVEDLKTELEKEKLKNIELTAHCDKLLLENK---ELTQEASDMTlELKKHQEDIINCKKQE 529

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1729 RKKLNEYEN---GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKtvqKKCEKL 1805
Cdd:pfam05483  530 ERMLKQIENleeKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK---KQIENK 606

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1806 QKNKKKLEQE--VINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVNLFLQAQAASQENL----EQFRENNFA 1878
Cdd:pfam05483  607 NKNIEELHQEnkALKKKGSAENKQLNAYEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKISEEKLleevEKAKAIADE 686

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1879 SMKSQMEL------RIKDLESELSKIKTSQEDF---NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEK 1949
Cdd:pfam05483  687 AVKLQKEIdkrcqhKIAEMVALMEKHKHQYDKIieeRDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEK 766


                   ....*.
gi 1034567240 1950 QQSRSL 1955
Cdd:pfam05483  767 EEKEKL 772
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 885-1755 6.90e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 6.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  885 MLKVEFQALEKEKVQLQKEVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSgETDHQQFPRKENKEYASS 964
Cdd:pfam02463  202 LKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK-EEEKLAQVLKENKEEEKE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  965 GPALQMKEVKSTEKEKRTSKEsvnspvfgkasLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDD 1044
Cdd:pfam02463  281 KKLQEEELKLLAKEEEELKSE-----------LLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEI 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1045 LTQSSETASEDCELphssyknfmLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKnhcELLTVKIKKMEDKVNVLQRE 1124
Cdd:pfam02463  350 KREAEEEEEEELEK---------LQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL---ELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1125 LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRT 1204
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEE 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1205 VKSNLnQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL 1284
Cdd:pfam02463  498 RSQKE-SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLG 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1285 EIDTIknqnQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTqtisqyngrlsvltaenAMLNSKLENEKQSKERLEAEV 1364
Cdd:pfam02463  577 ARKLR----LLIPKLKLPLKSIAVLEIDPILNLAQLDKATLE-----------------ADEDDKRAKVVEGILKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1365 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDA 1444
Cdd:pfam02463  636 KLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREK 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1445 LREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVI 1523
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVE 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1524 NIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA----- 1598
Cdd:pfam02463  790 EEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeell 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1599 SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-------RCAEKMQDHKQKLEKDNAKLK------VTVKK 1665
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleekenEIEERIKEEAEILLKYEEEPEellleeADEKE 949

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1666 QMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN---LDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSF 1742
Cdd:pfam02463  950 KEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEeryNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSI 1029

                          890
                   ....*....|...
gi 1034567240 1743 HGDLKTSQFEMDI 1755
Cdd:pfam02463 1030 NKGWNKVFFYLEL 1042
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 7.96e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.93  E-value: 7.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 1034567240  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 1.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 1034567240  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.88e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567240  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 3.02e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 3.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034567240  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.33e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 1034567240  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1385-1941 3.40e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 3.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1385 KRELELAFQRARDECSRLQDkmnfdVSNLKDNNEilsQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLsqtqc 1464
Cdd:PRK03918   171 IKEIKRRIERLEKFIKRTEN-----IEELIKEKE---KELEEVLREINEISSE----LPELREELEKLEKEVKEL----- 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1465 qmKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAdnKEKTVINIQDQFHAIVQKLQAESEKQS 1544
Cdd:PRK03918   234 --EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV--KELKELKEKAEEYIKLSEFYEEYLDEL 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1545 LLLEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQi 1624
Cdd:PRK03918   310 REIEKRLSRLEEEINGIEERIKELEEKEER----LEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTG- 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1625 rNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN-----LLNANLSEDEKEQL--------K 1691
Cdd:PRK03918   384 -LTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELleeytaelK 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1692 KLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMtRKKLNEYENGEFSFHGdlktsqfemdIQINKLKHKiddlTAEL 1771
Cdd:PRK03918   463 RIEKELKEIEEKERKLRKELRELEKVLKKESELIKL-KELAEQLKELEEKLKK----------YNLEELEKK----AEEY 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1772 ETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQEIEERARQEIae 1850
Cdd:PRK03918   528 EKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYL-- 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1851 KLKEVNLFLQAQAASQENLEQFRENNFAsmksQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSK 1930
Cdd:PRK03918   606 ELKDAEKELEREEKELKKLEEELDKAFE----ELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAE 681

                          570
                   ....*....|.
gi 1034567240 1931 LTKTNERLAEV 1941
Cdd:PRK03918   682 LEELEKRREEI 692
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 5.16e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034567240  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 1.13e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1088-1638 1.38e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 60.05  E-value: 1.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1088 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 1162
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1163 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 1235
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1236 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 1315
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1316 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA---------------IHDR-- 1378
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpVEGSph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1379 ----DQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1445
Cdd:PRK02224   467 vetiEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1446 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1517
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1518 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1594
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1034567240 1595 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1638
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 4.45e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 4.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1125-1961 5.21e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 5.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1125 LSETKEIKSQLEH-----QKVEWERELCSLRFSLNQEEEKRRNADTLYEK-------IREQLRRKEEQYRKEVEVKQQLE 1192
Cdd:TIGR00606  165 LSEGKALKQKFDEifsatRYIKALETLRQVRQTQGQKVQEHQMELKYLKQykekaceIRDQITSKEAQLESSREIVKSYE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1193 LSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ--------------DGILTNHLSKQKEIEMAQKKM 1254
Cdd:TIGR00606  245 NELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtdeqlNDLYHNHQRTVREKERELVDC 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1255 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK----------------EKKCFEDLKI------VKEKNE 1312
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldgfERGPFSERQIknfhtlVIERQE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1313 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEkqsKERLEAEVEsyhsRLAAAIHDRDQSETSKR---ELE 1389
Cdd:TIGR00606  405 DEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELK---KEILEKKQE----ELKFVIKELQQLEGSSDrilELD 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1390 LAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM 1469
Cdd:TIGR00606  478 QELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDK 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1470 EQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQDQFHAIVQKLQAESEKQSLLLEE 1549
Cdd:TIGR00606  545 MDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQTRDRLAKLNKELASLEQNKNHINN 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1550 RNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQD---LKKKLGQIRN 1626
Cdd:TIGR00606  613 ELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSccpVCQRVFQTEA 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1627 QLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEC 1702
Cdd:TIGR00606  692 ELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI--PELRNKLQKVNRDIQRLKNDIEE 769

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1703 NLDQEMKKNVELERE---------ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF-----EMDIQINKLKHKIDDLT 1768
Cdd:TIGR00606  770 QETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVnqekqEKQHELDTVVSKIELNR 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1769 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1848
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1849 AEK---LKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEdfnktELEKYKQLYLEELKVRK 1925
Cdd:TIGR00606  930 SSKetsNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLE-----ECEKHQEKINEDMRLMR 1004

                          890       900       910
                   ....*....|....*....|....*....|....*.
gi 1034567240 1926 SlSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1961
Cdd:TIGR00606 1005 Q-DIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1104-1717 8.39e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.81  E-value: 8.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1104 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 1183
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1184 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 1263
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1264 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 1343
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1344 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSET-------SKRELELAFQRARDECSRLQdkmnFDVSNL 1413
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKiaeelkgKEQELIFLLQAREKEIHDLE----IQLTAI 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1414 KDNNEILSQQL--FKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1479
Cdd:pfam05483  463 KTSEEHYLKEVedLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1480 VNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELIS 1556
Cdd:pfam05483  543 EMNLRDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQ 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1557 ECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHT 1636
Cdd:pfam05483  616 ENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIAD 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1637 EAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELE 1715
Cdd:pfam05483  686 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIE 765


                   ..
gi 1034567240 1716 RE 1717
Cdd:pfam05483  766 KE 767
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 8.48e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 8.48e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567240  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1172-1716 8.76e-08

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 57.45  E-value: 8.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1172 EQLRRKEEQYR--KEVEVKQQLELSLQTLEME---------------LRT-------VKSNLNQVVQERNDAQRQLSREQ 1227
Cdd:pfam07111   73 QELRRLEEEVRllRETSLQQKMRLEAQAMELDalavaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQ 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1228 NARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSHSHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK 1305
Cdd:pfam07111  153 LSSLTQahEEALSSLTSKAEGLE---KSLNSLETKRAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLR 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1306 -----------------IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE----- 1363
Cdd:pfam07111  225 kyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkc 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1364 ---VESYHSRLAAAIHDRDQSETSKRElelAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NS 1433
Cdd:pfam07111  305 rslLNRWREKVFALMVQLKAQDLEHRD---SVKQLRGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKG 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1434 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahn 1513
Cdd:pfam07111  378 LQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY----------------- 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1514 kADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLEERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQ 1593
Cdd:pfam07111  441 -AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAPPVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAR 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1594 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKK 1665
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLRE 592

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034567240 1666 QMDKIEElqknllnaNLSEDEKEQLKKLMELKQsLECNLDQEMKKNVELER 1716
Cdd:pfam07111  593 QLSDTKR--------RLNEARREQAKAVVSLRQ-IQHRATQEKERNQELRR 634
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1619-1959 2.28e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 2.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1619 KKLGQIRNQLQEAQDRHTEavrcaekMQDHKQKLEKDnAKLKVTVKKQMDKIEELQKNLLNANLsEDEKEQLKKLMELKQ 1698
Cdd:COG1196    179 RKLEATEENLERLEDILGE-------LERQLEPLERQ-AEKAERYRELKEELKELEAELLLLKL-RELEAELEELEAELE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1699 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1778
Cdd:COG1196    250 ELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE----LLAELARLEQDIARLEERRRELEERLEELEEEL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1779 LHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1858
Cdd:COG1196    326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1859 LQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDfnktELEKYKQLYLEELKVRKSLSSKLTKTNERL 1938
Cdd:COG1196    406 EEAEEALLERLERLEEE-----LEELEEALAELEEEEEEEEEALEE----AAEEEAELEEEEEALLELLAELLEEAALLE 476

                          330       340
                   ....*....|....*....|.
gi 1034567240 1939 AEVNtKLLVEKQQSRSLFTTL 1959
Cdd:COG1196    477 AALA-ELLEELAEAAARLLLL 496
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 3.05e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 3.05e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567240  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1172-1656 4.60e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1172 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 1250
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1251 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 1330
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1331 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1402
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1403 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1482
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1483 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1562
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1563 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1642
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 1034567240 1643 EKMQDHKQKLEKDN 1656
Cdd:COG4717    500 ELLEEAREEYREER 513
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1110-1701 6.31e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 6.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1110 KIKKMEDKVNVLQRELSETKEIKSQLehqkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 1189
Cdd:TIGR04523   97 KINKLNSDLSKINSEIKNDKEQKNKL-------EVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1190 QLELSLQTLEMELRTVKSNLNQVVQERNdaqrqlsreqnarmlqdgILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLS 1269
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLL------------------KLELLLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1270 HKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEEtLTQTISQYNGRLSVLTAE-----NA 1344
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKE-LEKQLNQLKSEISDLNNQkeqdwNK 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1345 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQL 1424
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEI 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1425 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL 1504
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1505 RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1584
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK-ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1585 ELA---DTLKKQsmseaslevtsryriNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1661
Cdd:TIGR04523  546 ELNkddFELKKE---------------NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 1034567240 1662 TVKKQMDKIEELQKNllNANLSEDEKEQLKKLMELKQSLE 1701
Cdd:TIGR04523  611 KISSLEKELEKAKKE--NEKLSSIIKNIKSKKNKLKQEVK 648
PTZ00121 PTZ00121
MAEBL; Provisional
 1465-1950 6.98e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 6.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1465 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1544
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1545 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1624
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1625 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1697
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1698 QSLECNLDQEMKKNVELER--------EITGFKNLLKM-TRKKLNEYENGEFSFHGDLKTSQFEMDIQiNKLKHKIDDLT 1768
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeekkkadELKKAEELKKAeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1769 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE----IEERA 1844
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdkkkAEEAK 1681

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1845 RQEIAEKLKEVNLFLQAQAASQenLEQFRENNFASMKSQMELRikdLESELSKIKTSQEDfNKTELEKYKQlylEELKVR 1924
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKK--AEELKKKEAEEKKKAEELK---KAEEENKIKAEEAK-KEAEEDKKKA---EEAKKD 1752

                          490       500
                   ....*....|....*....|....*.
gi 1034567240 1925 KSLSSKLTKTNERLAEVNTKLLVEKQ 1950
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKE 1778
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 8.06e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 8.06e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1619-1953 9.07e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.30  E-value: 9.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1619 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLKKLMELKQ 1698
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL---EKEVKELEELKEEIE 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1699 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMD--IQINKLKHKIDDLTAELETAGS 1776
Cdd:PRK03918   242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV----KELKELKEKAEeyIKLSEFYEEYLDELREIEKRLS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1777 KclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELGQVKQYKQEIEERARQEIAEKLK 1853
Cdd:PRK03918   318 R---LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHelyEEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1854 EVNlflQAQAASQENLEQFREnnfasMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELK 1922
Cdd:PRK03918   395 ELE---KAKEEIEEEISKITA-----RIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEK 466

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1034567240 1923 VRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1953
Cdd:PRK03918   467 ELKEIEEKERKLRKELRELEKVLKKESELIK 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1371-1634 1.02e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1371 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1450
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1451 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1530
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1531 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1610
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 1034567240 1611 EDETQDLKKKLGQIRNQLQEAQDR 1634
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1079-1698 1.02e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.35  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1079 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEW---EREL--------- 1146
Cdd:pfam15921  208 DSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQlisEHEVeitglteka 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1147 -------CSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV-EVKQQLELSLQTLEMELRTVKSNLNQVVQERNd 1218
Cdd:pfam15921  288 ssarsqaNSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELrEAKRMYEDKIEELEKQLVLANSELTEARTERD- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1219 aqrQLSREQnarmlqdGILTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDT---------- 1288
Cdd:pfam15921  367 ---QFSQES-------GNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlea 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1289 -IKNQNQEKEKKCFEDLKIVKEKNEDLQKT------IKQNEETLTQTISQYNG-RLSVLTAENAM--LNSKLENEKQSKE 1358
Cdd:pfam15921  434 lLKAMKSECQGQMERQMAAIQGKNESLEKVssltaqLESTKEMLRKVVEELTAkKMTLESSERTVsdLTASLQEKERAIE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1359 RLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFD---VSNLKDNNEILSQQLFKTESKLNSLE 1435
Cdd:pfam15921  514 ATNAEITKLRSRVDLKLQELQHLKNEGDHL----RNVQTECEALKLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQ 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1436 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIgkqESVEERLSQLQSenmlLRQQLDDAHNKA 1515
Cdd:pfam15921  590 VEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLV---NAGSERLRAVKD----IKQERDQLLNEV 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1516 DNKEKTVINIQDQFHAIVQKLQAESEKQSLL---LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1592
Cdd:pfam15921  663 KTSRNELNSLSEDYEVLKRNFRNKSEEMETTtnkLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1593 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1672
Cdd:pfam15921  743 IDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAE 822

                          650       660
                   ....*....|....*....|....*.
gi 1034567240 1673 LQkNLLNANLSEDEKEQLKKLMELKQ 1698
Cdd:pfam15921  823 CQ-DIIQRQEQESVRLKLQHTLDVKE 847
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 1.10e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.29e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 1034567240  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1143-1374 1.46e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1143 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 1222
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1223 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1299
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240 1300 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1374
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1488-1959 1.65e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 53.64  E-value: 1.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1488 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEktviniqdqfhAIVQKLQAES----------EKQSLLLEERNKELISE 1557
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEE-----------AARQKLQLEKvtteakikklEEDILLLEDQNSKLSKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1558 CNHLKERQYQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVTSRyriNLEDETQDLKKKLGQIRNQ 1627
Cdd:pfam01576  154 RKLLEERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQ 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1628 LQEAQdrhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ---MDKIEELQKNLLNANLSEDEKEQLKK-----LMELKQS 1699
Cdd:pfam01576  231 IAELR---AQLAKKEEELQAALARLEEETAQKNNALKKIrelEAQISELQEDLESERAARNKAEKQRRdlgeeLEALKTE 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1700 LECNLD-----QEMKKNVELEreitgfknlLKMTRKKLNEyengefsfhgdlKTSQFEMDIQINKLKH--KIDDLTAELE 1772
Cdd:pfam01576  308 LEDTLDttaaqQELRSKREQE---------VTELKKALEE------------ETRSHEAQLQEMRQKHtqALEELTEQLE 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1773 TAGSKCLHLDTKNQILQEELLS----MKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELG-------------- 1831
Cdd:pfam01576  367 QAKRNKANLEKAKQALESENAElqaeLRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAeklsklqselesvs 446

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1832 ------------------QVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFAsmKSQMELRIKDLES 1893
Cdd:pfam01576  447 sllneaegkniklskdvsSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEA--KRNVERQLSTLQA 524

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240 1894 ELSKIKTSQEDFNKT-----ELEKYKQLYLEELKVR----KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTL 1959
Cdd:pfam01576  525 QLSDMKKKLEEDAGTlealeEGKKRLQRELEALTQQleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNL 599
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 2.01e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 2.01e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567240   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1101-1327 2.15e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 53.14  E-value: 2.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1101 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 1180
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1181 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 1257
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240 1258 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLKivKEKnEDLQKTIKQNEETLTQ 1327
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFLT--AQK-EDLTEAKETLEEAIEE 1025
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 3.17e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 3.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034567240   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 4.59e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 4.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567240  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
PTZ00121 PTZ00121
MAEBL; Provisional
 1095-1790 6.01e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 6.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1095 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYekiREQL 1174
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK---KAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1175 RRKEEQYRKEVEVKQQLELSLQTleMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 1254
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1255 NSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisqyng 1334
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE----------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1335 rlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAfqRARDECSRLQDKMNFDVSNL 1413
Cdd:PTZ00121  1430 ---KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEA 1502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1414 KDnneilsqqlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDlsqtqcQMKEMEQKYQNEQVKVNKYIGKQES---V 1490
Cdd:PTZ00121  1503 KK----------AAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD------EAKKAEEKKKADELKKAEELKKAEEkkkA 1566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1491 EERLSQLQSENMLLRQQlddahNKADNKEKTVINIQDQFHAIVQKLQAESEKQSllLEERNK-ELISECNHLKERQYQYE 1569
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKaEELKKAEEEKKKVEQLK 1639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1570 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAqdRHTEAVRCAEKMQDHK 1649
Cdd:PTZ00121  1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA--KKAEELKKKEAEEKKK 1717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1650 -QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1728
Cdd:PTZ00121  1718 aEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567240 1729 RKKLNEYENGEFSFHGDLKTSQFemdiqINKLKHKIDDLTAELetagskclhLDTKNQILQE 1790
Cdd:PTZ00121  1798 KKIKDIFDNFANIIEGGKEGNLV-----INDSKEMEDSAIKEV---------ADSKNMQLEE 1845
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1380-1925 6.76e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 51.28  E-value: 6.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1380 QSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDL 1459
Cdd:pfam05557   13 QLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1460 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaivQKLQAE 1539
Cdd:pfam05557   93 NEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ-----QSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1540 SEKQSLLLEERNKelisecnhlkerqyQYENEKAerevVVRQLQQELADTLKKQSMSEASLEVTSRYRIN------LEDE 1613
Cdd:pfam05557  168 AEQRIKELEFEIQ--------------SQEQDSE----IVKNSKSELARIPELEKELERLREHNKHLNENienkllLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1614 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKqKLEKDNAKLKVTVKKQMDKIEELQ---------KNLLNANLSE 1684
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRSPEDLSRRIEQLQqreivlkeeNSSLTSSARQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1685 DEKEQLKKLMELKQSLECNLDQEM-------------KKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhgDLKTSQF 1751
Cdd:pfam05557  309 LEKARRELEQELAQYLKKIEDLNKklkrhkalvrrlqRRVLLLTKERDGYRAILESYDKELTMSNYSP-----QLLERIE 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTvqkkcEKLQKNKKKLEQEVINLRSHIERNMVELG 1831
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQ-----QESLADPSYSKEEVDSLRRKLETLELERQ 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1832 QVKQYKQEIE-ERARQEIAEKLKEV---------NLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTS 1901
Cdd:pfam05557  459 RLREQKNELEmELERRCLQGDYDPKktkvlhlsmNPAAEAYQQRKNQLEKLQAEI-ERLKRLLKKLEDDLEQVLRLPETT 537

                          570       580
                   ....*....|....*....|....
gi 1034567240 1902 QEDFNKTELEKYKQLYLEELKVRK 1925
Cdd:pfam05557  538 STMNFKEVLDLRKELESAELKNQR 561
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1752-1925 7.18e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 7.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1831
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1832 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1900
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 1034567240 1901 SQEDFNKTELEKYKQLYlEELKVRK 1925
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 8.00e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 8.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1669-1953 8.57e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 8.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1669 KIEELQKNL--LNANLSEDEK---------EQLKKLMELKQSLEcnldqemkknvELEREITGfkNLLKMTRKKLNEyen 1737
Cdd:TIGR02168  180 KLERTRENLdrLEDILNELERqlkslerqaEKAERYKELKAELR-----------ELELALLV--LRLEELREELEE--- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1738 gefsfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEK-----------LQ 1806
Cdd:TIGR02168  244 --------LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQqkqilrerlanLE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1807 KNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE---ERARQEIAEKLKEVNLFLQAQAASQENLEQFReNNFASMKSQ 1883
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKeelESLEAELEELEAELEELESRLEELEEQLETLR-SKVAQLELQ 394

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567240 1884 MEL---RIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELK-VRKSLSSK---LTKTNERLAEVNTKLLVEKQQSR 1953
Cdd:TIGR02168  395 IASlnnEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELeeeLEELQEELERLEEALEELREELE 471
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 870-1768 1.21e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 50.82  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  870 EELQQDMQRFKNEIGMLKVEFQALEKEKVQLQK---EVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSG 946
Cdd:TIGR00606  251 KNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKdnsELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEK 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  947 ETDHQQFPRKENKEYASSGPALQMK-EVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLS---EIDEDEGRPT 1022
Cdd:TIGR00606  331 LNKERRLLNQEKTELLVEQGRLQLQaDRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTlviERQEDEAKTA 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1023 KK-----TSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDsvsLLKIQDAALSCERLL 1097
Cdd:TIGR00606  411 AQlcadlQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDR---ILELDQELRKAEREL 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1098 EL--KKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQL- 1174
Cdd:TIGR00606  488 SKaeKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLg 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1175 -----RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmLQDGILTNHLSKQKEIEM 1249
Cdd:TIGR00606  568 yfpnkKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSS------YEDKLFDVCGSQDEESDL 641

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1250 AQKKmnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEdlqktikqneetltqTI 1329
Cdd:TIGR00606  642 ERLK---------EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE---------------FI 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1330 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhsrlaaaihdrDQSETSKRELELAFQRARDEcsrlqdKMNFD 1409
Cdd:TIGR00606  698 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPG------------RQSIIDLKEKEIPELRNKLQ------KVNRD 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1410 VSNLKDNNEilsqqlfKTESKLNSLEIEFHHTRDALREKTLglervqkdLSQTQCQMKEMEQKYQNEQVKVNKYIG---- 1485
Cdd:TIGR00606  760 IQRLKNDIE-------EQETLLGTIMPEEESAKVCLTDVTI--------MERFQMELKDVERKIAQQAAKLQGSDLdrtv 824

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1486 -----KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQaesekQSLLLEERNKELISECNH 1560
Cdd:TIGR00606  825 qqvnqEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQ-----RRQQFEEQLVELSTEVQS 899

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1561 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASlevtsryrinLEDETQDLKKKLGQ-------IRNQLQEAQD 1633
Cdd:TIGR00606  900 LIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKK----------AQDKVNDIKEKVKNihgymkdIENKIQDGKD 969

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1634 RH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLME-LKQSLECNL 1704
Cdd:TIGR00606  970 DYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQhLKEMGQMQV 1049

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567240 1705 DQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF--------EMDIQINKLKHKIDDLT 1768
Cdd:TIGR00606 1050 LQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFrdaeekyrEMMIVMRTTELVNKDLD 1121
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.25e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567240  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.46e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 1034567240  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1471-1734 1.67e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 1.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1471 QKYQNEQVKVnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKadnkektviniqdqfhaiVQKLQAESekQSLLLEER 1550
Cdd:COG3206    159 EAYLEQNLEL-----RREEARKALEFLEEQLPELRKELEEAEAA------------------LEEFRQKN--GLVDLSEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1551 NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVtsryrinledetQDLKKKLGQIRNQLQE 1630
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVI------------QQLRAQLAELEAELAE 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1631 AQ----DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEElQKNLLNANLsEDEKEQLKKLMELKQSLEcnldq 1706
Cdd:COG3206    282 LSarytPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQA-REASLQAQL-AQLEARLAELPELEAELR----- 354

                          250       260
                   ....*....|....*....|....*...
gi 1034567240 1707 emkknvELEREITGFKNLLKMTRKKLNE 1734
Cdd:COG3206    355 ------RLEREVEVARELYESLLQRLEE 376
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1034-1638 1.74e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1034 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 1101
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1102 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 1181
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1182 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAqrQLSREQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSH 1260
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARLEALLAAL--GLPLPASAEEFAA--------LRAEAAALLEALEEELEA 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1261 SHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN------QNQEK-----EKKC---FEDLKI------VKEKNEDLQKTI-- 1318
Cdd:COG4913    403 LEEALAEAEAALRDLRRELRELEAEIASLERrksnipARLLAlrdalAEALgldEAELPFvgelieVRPEEERWRGAIer 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1319 ------------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSET 1383
Cdd:COG4913    483 vlggfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAEL 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1384 SKR------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlg 1451
Cdd:COG4913    556 GRRfdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE--- 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1452 LERVQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektV 1522
Cdd:COG4913    626 LAEAEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------L 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1523 INIQDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEV 1602
Cdd:COG4913    688 AALEEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034567240 1603 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1638
Cdd:COG4913    764 ERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1400-1874 1.91e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1400 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1476
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1477 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1553
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1554 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----------SLEVTSRYRINLEDE--------- 1613
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTiagvlflvl 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1614 ------TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEK 1687
Cdd:COG4717    284 gllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA---EELE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1688 EQLKkLMELKQSLECNLDQemkKNVELEREItgfknllkmtRKKLNEYEngefsfhgdlktsqfemdiQINKLKHKIDDL 1767
Cdd:COG4717    361 EELQ-LEELEQEIAALLAE---AGVEDEEEL----------RAALEQAE-------------------EYQELKEELEEL 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1768 TAELEtagskclhldtknQILQEELLSMKTVQKkcEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE----- 1842
Cdd:COG4717    408 EEQLE-------------ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgela 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1034567240 1843 RARQEIAEKLKEVNLFLQ---AQAASQENLEQFRE 1874
Cdd:COG4717    473 ELLQELEELKAELRELAEewaALKLALELLEEARE 507
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 2.05e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 2.05e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567240  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.18e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034567240  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1085-1629 3.57e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 3.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1085 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 1164
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1165 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 1243
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1244 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 1320
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1321 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1400
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1401 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1476
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1477 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1543
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1544 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1618
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 1034567240 1619 KKLGQIRNQLQ 1629
Cdd:pfam05483  753 AELLSLKKQLE 763
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1085-1366 4.29e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1085 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 1164
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1165 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 1236
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1237 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 1301
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567240 1302 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1366
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1580-1792 4.35e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 4.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1580 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1659
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1660 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1738
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034567240 1739 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL 1792
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1112-1536 5.61e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.53  E-value: 5.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1112 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyEKIREQLRRKEEQYRKEVEvkqQL 1191
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEI----EKEIEQLEQEEEKLKERLE---EL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1192 ELSLQTLEmelrtvksnlnqvvQERNDAQRQLsrEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSH 1270
Cdd:TIGR02169  743 EEDLSSLE--------------QEIENVKSEL--KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQA 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1271 KNSMLQEEIAMLRLEIDTI-KNQNQEKEKKCFEDLKI--VKEKNEDLQKTIKQNEETLtqtisqyngrlsvltaenAMLN 1347
Cdd:TIGR02169  799 ELSKLEEEVSRIEARLREIeQKLNRLTLEKEYLEKEIqeLQEQRIDLKEQIKSIEKEI------------------ENLN 860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1348 SKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKT 1427
Cdd:TIGR02169  861 GKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1428 ESKLNSLEIEfhhtrdalREKTLGLERVQKDLSQTQCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL-- 1504
Cdd:TIGR02169  937 EDPKGEDEEI--------PEEELSLEDVQAELQRVEEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLee 1000

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1034567240 1505 -RQQLDDAHNKADNKEKTV-----INIQDQFHAIVQKL 1536
Cdd:TIGR02169 1001 eRKAILERIEEYEKKKREVfmeafEAINENFNEIFAEL 1038
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1525-1945 6.03e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 6.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1525 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYenekaerevvvRQLQQELADTLKKQSMSEASLEVTS 1604
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1605 RYRINLEDETQ--DLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQkLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1682
Cdd:COG4717    116 EELEKLEKLLQllPLYQELEALEAELAELPERLEELE---ERLEELRE-LEEELEELEAELAELQEELEELLEQLSLATE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1683 SEDE--KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKL 1760
Cdd:COG4717    192 EELQdlAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1761 KHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK--LEQEVINLRSHIERNMVELGQVKQYKQ 1838
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQE 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1839 EIEERARQEIAEKLKEVNLFLQA--QAASQENLEQFRE-----NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE 1911
Cdd:COG4717    352 LLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1034567240 1912 KYKQLYLEELkvrKSLSSKLTKTNERLAEVNTKL 1945
Cdd:COG4717    432 EELEELEEEL---EELEEELEELREELAELEAEL 462
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1068-1549 6.29e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 6.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1068 LLIEQLGmecKDSVSLLKIQDaalsceRLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELC 1147
Cdd:COG4717     46 MLLERLE---KEADELFKPQG------RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1148 SLRFSLNQEEEKRRNADTL--YEKIREQLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 1225
Cdd:COG4717    113 ELREELEKLEKLLQLLPLYqeLEALEAELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSL 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1226 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQN 1293
Cdd:COG4717    189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1294 QEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1373
Cdd:COG4717    269 LSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1374 AIHDRDQSETSKRELELafQRARDECSRLQDKmnFDVSNLKDNNEILSQ--QLFKTESKLNSLEIEFHHTRDALRE--KT 1449
Cdd:COG4717    349 LQELLREAEELEEELQL--EELEQEIAALLAE--AGVEDEEELRAALEQaeEYQELKEELEELEEQLEELLGELEEllEA 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1450 LGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQD 1527
Cdd:COG4717    425 LDEEELEEELEELEEELEELEEELEELR-------EELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKL 497

                          490       500
                   ....*....|....*....|...
gi 1034567240 1528 QFHAIVQKLQ-AESEKQSLLLEE 1549
Cdd:COG4717    498 ALELLEEAREeYREERLPPVLER 520
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1661-1935 6.61e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1661 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1734
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1735 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1814
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1815 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1888
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1889 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1935
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1358-1921 6.68e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.11  E-value: 6.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1358 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1435
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1436 IEFhhtrDALREKTLGLERVQKDLSQT----QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1511
Cdd:PRK02224   258 AEI----EDLRETIAETEREREELAEEvrdlRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1512 HNKADNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1590
Cdd:PRK02224   334 RVAAQAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1591 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR------CAEKMQDHKQKLEKDnaklkvTVK 1664
Cdd:PRK02224   398 ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkCPECGQPVEGSPHVE------TIE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1665 KQMDKIEELqknllnanlsEDEKEQLK-KLMELKQSLEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYENGefsfh 1743
Cdd:PRK02224   472 EDRERVEEL----------EAELEDLEeEVEEVEERLE-----RAEDLVEAEDRIERLEERREDLEELIAERRET----- 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1744 gdlktsQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmktvqKKCE-KLQKNKKKLEQevinlrsh 1822
Cdd:PRK02224   532 ------IEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEV-------AELNsKLAELKERIES-------- 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1823 IERNMVELGQVKQYKQEIEERA--RQEIAEKLKEvnlflqaqaaSQENLEQFREnnfasmksqmelRIKDLESEL--SKI 1898
Cdd:PRK02224   591 LERIRTLLAAIADAEDEIERLRekREALAELNDE----------RRERLAEKRE------------RKRELEAEFdeARI 648

                          570       580
                   ....*....|....*....|...
gi 1034567240 1899 KTSQEDfnKTELEKYKQLYLEEL 1921
Cdd:PRK02224   649 EEARED--KERAEEYLEQVEEKL 669
PRK11281 PRK11281
mechanosensitive channel MscK;
1307-1511 6.97e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 6.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1307 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 1373
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1374 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1441
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1442 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1496
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 1034567240 1497 -LQSENMLLRQQLDDA 1511
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1094-1542 8.68e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 8.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1094 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 1173
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1174 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 1252
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1253 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 1313
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1314 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 1390
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1391 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1460
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1461 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvQKLQAES 1540
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER-EKAKKEL 713


                   ..
gi 1034567240 1541 EK 1542
Cdd:PRK03918   714 EK 715
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1487-1737 9.78e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 9.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1487 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1557
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1558 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1630
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1631 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1705
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1034567240 1706 QEMKKN-VELEREITGFKNLLKMTRKKLNEYEN 1737
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA 341
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.07e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 1.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1618-1950 1.36e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.77  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1618 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1683
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1684 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1751
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1752 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1817
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1818 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1888
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567240 1889 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1950
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1612-1884 1.37e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1612 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLK 1691
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL--AELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1692 KLMELKQSLEcnldqemkknvelereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ--INKLKHKIDDLTA 1769
Cdd:COG4942     98 ELEAQKEELA--------------------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylAPARREQAEELRA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1770 ELETagskclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1849
Cdd:COG4942    158 DLAE-------LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1034567240 1850 EklkevnlfLQAQAASQEnlEQFRENNFASMKSQM 1884
Cdd:COG4942    231 R--------LEAEAAAAA--ERTPAAGFAALKGKL 255
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1110-1469 1.48e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1110 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 1189
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1190 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 1266
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1267 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 1342
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1343 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1415
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567240 1416 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1469
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 2.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.00e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034567240   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PRK12704 PRK12704
phosphodiesterase; Provisional
 1567-1695 2.07e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1567 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1643
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567240 1644 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1695
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 2.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567240  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1470-1689 2.41e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1470 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1549
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1550 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1611
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567240 1612 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1689
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1547-1855 3.11e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.90  E-value: 3.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1547 LEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKqsmseaslevtsryrinLEDETQDLKKKLGQIRN 1626
Cdd:COG1340     13 LEEKIEELREEIEELKEKRDELNEELKE----LAEKRDELNAQVKE-----------------LREEAQELREKRDELNE 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1627 QLQEAQDRHTEAvrcAEKMQDHKQKLEKDNAKLKVTVKKQMD------KIEELQKNLLNANLS-EDEKEQLKKLMELKQS 1699
Cdd:COG1340     72 KVKELKEERDEL---NEKLNELREELDELRKELAELNKAGGSidklrkEIERLEWRQQTEVLSpEEEKELVEKIKELEKE 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1700 LEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYengefsfHGDLKTSQFEMDI---QINKLKHKIDDLTAELETAgs 1776
Cdd:COG1340    149 LE-----KAKKALEKNEKLKELRAELKELRKEAEEI-------HKKIKELAEEAQElheEMIELYKEADELRKEADEL-- 214

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567240 1777 kclhldtknqilqeellsmktvQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1855
Cdd:COG1340    215 ----------------------HKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAEE 271
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1273-1855 3.23e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.89  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1273 SMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE--ETLTQTISQYNGRLSVLTAENAMLNSKL 1350
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEkrEAEAEEALREQAELNRLKKKYLEALNKK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1351 ENEKQSKerlEAEVESYHSRLAAAIHDRdQSETSKRELELAFQRARDECSR----LQDKMNFDVSNLKDNNEILSQQLFK 1426
Cdd:pfam05557   92 LNEKESQ---LADAREVISCLKNELSEL-RRQIQRAELELQSTNSELEELQerldLLKAKASEAEQLRQNLEKQQSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1427 TESKLNSLEIEFH-HTRDALrektlglerVQKDLSQTQCQMKEMEqkyqneqvkvnKYIGKQESVEERLSQLQSENMLLR 1505
Cdd:pfam05557  168 AEQRIKELEFEIQsQEQDSE---------IVKNSKSELARIPELE-----------KELERLREHNKHLNENIENKLLLK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1506 QQLDDAHNKADNKEKT---VINIQDQFHAIVQKLQA-ESEKQSLLLE--------ERNKELISECNHLKERQYQYENEKA 1573
Cdd:pfam05557  228 EEVEDLKRKLEREEKYreeAATLELEKEKLEQELQSwVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSAR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1574 EREVVVRQLQQELADTLKKqsmseaslevtsryrinledeTQDLKKKLGQIRNQLQEAQDRhteavrcaekmqdhkqkle 1653
Cdd:pfam05557  308 QLEKARRELEQELAQYLKK---------------------IEDLNKKLKRHKALVRRLQRR------------------- 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1654 kdnaklKVTVKKQMDKIEELQKN----LLNANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVE-LEREITGFKNLLKM- 1727
Cdd:pfam05557  348 ------VLLLTKERDGYRAILESydkeLTMSNYSPQLLERIEEAEDMTQKMQ-AHNEEMEAQLSvAEEELGGYKQQAQTl 420

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1728 -----TRKKLNEYENGEFSFHG--DLKTSQFEMDIQINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELLSMKTVQK 1800
Cdd:pfam05557  421 erelqALRQQESLADPSYSKEEvdSLRRKLETLELERQRLREQKNELEMELE---RRCLQGDYDPKKTKVLHLSMNPAAE 497

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240 1801 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1855
Cdd:pfam05557  498 AYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKEL 552
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1458-1638 3.56e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1458 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1537
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1538 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1596
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034567240 1597 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1638
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1171-1835 4.70e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 45.20  E-value: 4.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1171 REQLRRKEE---------QYRKEVEVKQQLELSLQTLEMELRTVKsNLNQVVQ--------------------ERNDAQR 1221
Cdd:pfam10174   43 KERALRKEEaarisvlkeQYRVTQEENQHLQLTIQALQDELRAQR-DLNQLLQqdfttspvdgedkfstpeltEENFRRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1222 QLSREQNARML----------------QDGIL-TNHLSKQKEIEMAQKKMNSENSHSHEEEKdlshknsmlQEEIAMLRL 1284
Cdd:pfam10174  122 QSEHERQAKELfllrktleemelrietQKQTLgARDESIKKLLEMLQSKGLPKKSGEEDWER---------TRRIAEAEM 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1285 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ-----KTIKQNEETLTQTISQYNGRLSVLTAENAML--NSKLENEKQSK 1357
Cdd:pfam10174  193 QLGHLEVLLDQKEKENIHLREELHRRNQLQPdpaktKALQTVIEMKDTKISSLERNIRDLEDEVQMLktNGLLHTEDREE 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1358 ERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-AFQrardecSRLqDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1436
Cdd:pfam10174  273 EIKQMEVYKSHSKFMKNKIDQLKQELSKKESELlALQ------TKL-ETLTNQNSDCKQHIEVLKESLTAKEQRAAILQT 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1437 EFHHTRDALREKTLGLERVQKDLSQTQ----CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLR------Q 1506
Cdd:pfam10174  346 EVDALRLRLEEKESFLNKKTKQLQDLTeeksTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAglkervK 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1507 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQel 1586
Cdd:pfam10174  426 SLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKE-- 503

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1587 adtlKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQIRNQLQEAQDRhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ 1666
Cdd:pfam10174  504 ----HASSLASSGLKKDSKLK-SLEIAVEQKKEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQEVARYKEESGKA 577

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1667 MDKIEELQKNLLNANLSEDEKEqlKKLMELKQSLECNLDQEMKKNVELEREITGfknllkMTRKKLNEYENGefsfhgdl 1746
Cdd:pfam10174  578 QAEVERLLGILREVENEKNDKD--KKIAELESLTLRQMKEQNKKVANIKHGQQE------MKKKGAQLLEEA-------- 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1747 ktSQFEMDIQINKLKHKIDDLTAELETAGSKC----LHLDTKNQILQ-----------------EELLSMK------TVQ 1799
Cdd:pfam10174  642 --RRREDNLADNSQQLQLEELMGALEKTRQELdatkARLSSTQQSLAekdghltnlraerrkqlEEILEMKqeallaAIS 719

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1034567240 1800 KK------CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1835
Cdd:pfam10174  720 EKdanialLELSSSKKKKTQEEVMALKREKDRLVHQLKQQTQ 761
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1116-1342 6.37e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.04  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1116 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 1188
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1189 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1265
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1266 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 1325
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 1034567240 1326 TQTISQYNGRLSVLTAE 1342
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1276-1500 7.34e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 7.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1276 QEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 1355
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE----LAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1356 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1435
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567240 1436 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1500
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 8.03e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567240    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1112-1738 8.16e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 44.68  E-value: 8.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1112 KKMEDKVNVLQRELsETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA---DTLYEKI---REQLRRKEEQYRKEV 1185
Cdd:COG5022    813 RSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLlkkETIYLQSaqrVELAERQLQELKIDV 891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1186 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQnARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1265
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARL-KKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETS 970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1266 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETltqtisqyNGRLSVLTAENAM 1345
Cdd:COG5022    971 EEYEDLLKKSTILVREGNKANSELKNFKKELAEL--------SKQYGALQESTKQLKEL--------PVEVAELQSASKI 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1346 LNSKLENEKQSKErlEAEVESyhsrlaaaIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1425
Cdd:COG5022   1035 ISSESTELSILKP--LQKLKG--------LLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVT 1104

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1426 KTESKLNSLEIEF-----------HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV---KVNKYIGKQESV- 1490
Cdd:COG5022   1105 NRNLVKPANVLQFivaqmiklnllQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpspPPFAALSEKRLYq 1184

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1491 ----EERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQ---FHAIVQKLQAESEKQSLLLEER---NKELISE 1557
Cdd:COG5022   1185 salyDEKSKLSSSEVNDLKNELIalfSKIFSGWPRGDKLKKLISEgwvPTEYSTSLKGFNNLNKKFDTPAsmsNEKLLSL 1264

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1558 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRINlEDETQDLKKKLGQIRNQLQEAQDRHT 1636
Cdd:COG5022   1265 LNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNAlRTKASSLRWKSATEVN-YNSEELDDWCREFEISDVDEELEELI 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1637 EAVRCaekmqdhKQKLEKDNAKLKVTVkkqmdKIEELQKNLLNANLSEDEKEQLKklmelkqslECNLDQEMKKNV---- 1712
Cdd:COG5022   1344 QAVKV-------LQLLKDDLNKLDELL-----DACYSLNPAEIQNLKSRYDPADK---------ENNLPKEILKKIeall 1402

                          650       660
                   ....*....|....*....|....*....
gi 1034567240 1713 ---ELEREITGFKNLLKMTRKKLNEYENG 1738
Cdd:COG5022   1403 ikqELQLSLEGKDETEVHLSEIFSEEKSL 1431
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1397-1564 8.49e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 44.69  E-value: 8.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1397 DE-CSRLqdKMNfdvsnlkdnNEILSQQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEME 1470
Cdd:COG0542    396 DEaAARV--RME---------IDSKPEELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALK 460

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1471 QKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaES 1540
Cdd:COG0542    461 ARWEAEKELIEEIQELKEELEQRYGKIPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EG 535

                          170       180
                   ....*....|....*....|....*
gi 1034567240 1541 EKQSLL-LEErnkelisecnHLKER 1564
Cdd:COG0542    536 EREKLLnLEE----------ELHER 550
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 9.41e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 9.41e-04
                           10        20
                   ....*....|....*....|....*....
gi 1034567240   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Rabaptin pfam03528
Rabaptin;
1488-1708 9.92e-04

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 43.94  E-value: 9.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1488 ESVEERLSQLQSEN---MLLRQQLDDAHNKADNKektviniqdqFHAIVQKLQAESEKQSLLLEERNKELISECNHLKER 1564
Cdd:pfam03528    4 EDLQQRVAELEKENaefYRLKQQLEAEFNQKRAK----------FKELYLAKEEDLKRQNAVLQEAQVELDALQNQLALA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1565 QYQYENEKAeREVVVRQLQQELADTLKKQ----------SMSEASLEVTSRYRINLEDE-------TQDLKKKLGQIRNQ 1627
Cdd:pfam03528   74 RAEMENIKA-VATVSENTKQEAIDEVKSQwqeevaslqaIMKETVREYEVQFHRRLEQEraqwnqyRESAEREIADLRRR 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1628 LQEAQDRhteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLK--KLMELKQSLE---- 1701
Cdd:pfam03528  153 LSEGQEE--------ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEA---EDKIKELEasKMKELNHYLEaeks 221


                   ....*..
gi 1034567240 1702 CNLDQEM 1708
Cdd:pfam03528  222 CRTDLEM 228
PRK11281 PRK11281
mechanosensitive channel MscK;
1110-1468 1.08e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1110 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 1189
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1190 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 1268
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1269 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 1344
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1345 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1422
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567240 1423 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1468
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1618-1927 1.25e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.67  E-value: 1.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1618 KKKLGQIRNQLQEAQDRHteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS------------ED 1685
Cdd:PRK04778   104 KHEINEIESLLDLIEEDI-------EQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSfgpaldelekqlEN 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1686 EKEQLKKLMELKQS---------LEcNLDQEMKknvELEREITGFKNLLKMTRKK----LNEYENGefsfHGDLKTS--- 1749
Cdd:PRK04778   177 LEEEFSQFVELTESgdyveareiLD-QLEEELA---ALEQIMEEIPELLKELQTElpdqLQELKAG----YRELVEEgyh 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1750 --QFEMDIQINKLKHKIDDLTAELETagskcLHLD---TKNQILQEELLSM-----------KTVQKKCEKLQKNKKKLE 1813
Cdd:PRK04778   249 ldHLDIEKEIQDLKEQIDENLALLEE-----LDLDeaeEKNEEIQERIDQLydilerevkarKYVEKNSDTLPDFLEHAK 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1814 QEVINLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAAS--QENLEQfrennfasmks 1882
Cdd:PRK04778   324 EQNKELKEEIDRvkqsytlNESELESVRQLEKQLEslEKQYDEITERIAE-----QEIAYSelQEELEE----------- 387

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1034567240 1883 qmelrikdLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKSL 1927
Cdd:PRK04778   388 --------ILKQLEEIEKEQEKLS----EMLQGLRKDELEAREKL 420
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1260-1578 1.30e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 43.52  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1260 HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKivkeKNEDLQKTIKQNEETltqtISQYNGRLSVL 1339
Cdd:pfam19220   45 QAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVA----RLAKLEAALREAEAA----KEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1340 TAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQ---DKMNFDVSNLKDN 1416
Cdd:pfam19220  117 TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQalsEEQAAELAELTRR 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1417 NEILSQQLFKTESKLNSLEIEFHHTRdALREK----------TLGLER----------------VQKDLSQTQCQMKEME 1470
Cdd:pfam19220  197 LAELETQLDATRARLRALEGQLAAEQ-AERERaeaqleeaveAHRAERaslrmklealtaraaaTEQLLAEARNQLRDRD 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1471 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-------------NKA--------DNKEKTVINIQDQf 1529
Cdd:pfam19220  276 EAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQraraeleeraemlTKAlaakdaalERAEERIASLSDR- 354

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567240 1530 haiVQKLQAESEKQSLLLEERNKELISEcnhlkerqyqYENEKAEREVV 1578
Cdd:pfam19220  355 ---IAELTKRFEVERAALEQANRRLKEE----------LQRERAERALA 390
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.38e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.40  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567240  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1347-1693 1.40e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.59  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1347 NSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdVSNLKDNNEILSQQLFK 1426
Cdd:pfam09731  121 KSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKA---TDSALQKAEALAEKLKE 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1427 TESKLNSLEIEfhhtrdALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYigkQESVEErlsqlqsENMLLRQ 1506
Cdd:pfam09731  198 VINLAKQSEEE------AAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQY---KELVAS-------ERIVFQQ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1507 QLDDAHN------KADNKEKTviniqDQFHAIVQKLQAEsekqsllLEERNKELIsecnHLKERqyqyENEKAEREVVVR 1580
Cdd:pfam09731  262 ELVSIFPdiipvlKEDNLLSN-----DDLNSLIAHAHRE-------IDQLSKKLA----ELKKR----EEKHIERALEKQ 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1581 QLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEK----------MQDHK 1649
Cdd:pfam09731  322 KEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYeEKLRTELERQAEAHEEHLKDVLVeqeielqrefLQDIK 401

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034567240 1650 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1693
Cdd:pfam09731  402 EKVEEERAGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQL 445
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.44e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034567240  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1262-1856 1.45e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1262 HEEEKDLSHKNSMLQEEIAMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNG----RL 1336
Cdd:COG4913    261 AERYAAARERLAELEYLRAALRLWFAQRRlELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdRL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1337 SVLTAEnamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDN 1416
Cdd:COG4913    341 EQLERE-------IERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1417 NEILSQQLFKTESKLNSLE-------IEFHHTRDALREKtLGLERVQ----KDLsqtqCQMKEMEQKYQNeqvKVNKYIG 1485
Cdd:COG4913    414 LRDLRRELRELEAEIASLErrksnipARLLALRDALAEA-LGLDEAElpfvGEL----IEVRPEEERWRG---AIERVLG 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1486 KQesveeRLSqlqsenMLLRQQLDDAHNKA--DNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL 1561
Cdd:COG4913    486 GF-----ALT------LLVPPEHYAAALRWvnRLHLRGRLVYERVRTGLPDPERPRLDPDSLAgkLDFKPHPFRAWLEAE 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1562 KERQYQYEneKAEREvvvrqlqQELADTlkKQSMSEASL--EVTSRYRINLEDET-------QDLKKKLGQIRNQLQEAQ 1632
Cdd:COG4913    555 LGRRFDYV--CVDSP-------EELRRH--PRAITRAGQvkGNGTRHEKDDRRRIrsryvlgFDNRAKLAALEAELAELE 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1633 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD---------KIEELQKNLLNANLSEDE----KEQLKKLMELKQS 1699
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvasaerEIAELEAELERLDASSDDlaalEEQLEELEAELEE 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1700 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFH--------GDLKTSQFEMDIQiNKLKHKIDDLTAEL 1771
Cdd:COG4913    704 LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELralleerfAAALGDAVERELR-ENLEERIDALRARL 782

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1772 ETAGSKCL----------HLDTKNqiLQEELLSMKTVQKKCEKLQKNK-KKLEQEvinLRSHIERNMVElgQVKQYKQEI 1840
Cdd:COG4913    783 NRAEEELEramrafnrewPAETAD--LDADLESLPEYLALLDRLEEDGlPEYEER---FKELLNENSIE--FVADLLSKL 855

                          650
                   ....*....|....*.
gi 1034567240 1841 EeRARQEIAEKLKEVN 1856
Cdd:COG4913    856 R-RAIREIKERIDPLN 870
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1420-1638 1.47e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1420 LSQQLFKTESKLNSLEIEFhhtrDALREKtlgLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyigKQESVEERLSQLQS 1499
Cdd:COG3883     28 LQAELEAAQAELDALQAEL----EELNEE---YNELQAELEALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1500 E-------NMLLRQQ-LDDAHNKADNKEKtvinIQDQFHAIV---QKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1568
Cdd:COG3883     98 SggsvsylDVLLGSEsFSDFLDRLSALSK----IADADADLLeelKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1569 ENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1638
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1540-1737 1.73e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.05  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1540 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLKKQSmSEASLEVTSRYRiNLEDETQDLKK 1619
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQLIEEG-HPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1620 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLLNAnlsedeKEQLKKLME 1695
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEELEAH------EPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034567240 1696 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1737
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 1.75e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1023-1777 1.88e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.50  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1023 KKTSNEKNKVKNQIQSMDDVDDLTQSSETASEdcelphssyknfmllIEQlgmeckdsvsllKIQDAALSCErllelkkn 1102
Cdd:TIGR01612 1139 KKSENYIDEIKAQINDLEDVADKAISNDDPEE---------------IEK------------KIENIVTKID-------- 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1103 hcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQL 1174
Cdd:TIGR01612 1184 -------KKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEI 1255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1175 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKM 1254
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMETFNISHDDDKD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKEL 1327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1255 NSENSHSHEEEKDLSHKNSMLQEEIAMLRL-EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQT 1328
Cdd:TIGR01612 1328 QKNLLDAQKHNSDINLYLNEIANIYNILKLnKIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSK 1407

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1329 ISQyngrlsvlTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQD 1404
Cdd:TIGR01612 1408 IES--------TLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATN 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1405 KMNFDVSNLKDNNEilSQQLFKTESKLNSLEIEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV---- 1480
Cdd:TIGR01612 1480 DHDFNINELKEHID--KSKGCKDEADKNAKAIE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdsei 1548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1481 ---------NKYIGKQESVEERLSQLQSENMllrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERN 1551
Cdd:TIGR01612 1549 iikeikdahKKFILEAEKSEQKIKEIKKEKF----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDI 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1552 KELISECnhLKERQyqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQL 1628
Cdd:TIGR01612 1616 KKKINDC--LKETE---SIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDV 1690

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1629 QEAQDRHTEAV--RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI--EELQKNLLNANLSEDEKEQ---LKKLMELKQSLE 1701
Cdd:TIGR01612 1691 DQHKKNYEIGIieKIKEIAIANKEEIESIKELIEPTIENLISSFntNDLEGIDPNEKLEEYNTEIgdiYEEFIELYNIIA 1770

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1702 CNLDQEMKKNVELER----EITGFKNLLKM--TRKKLNEYENgefsfhgDLKTSQFemDIQINKLKHKIDDLTAELETAG 1775
Cdd:TIGR01612 1771 GCLETVSKEPITYDEikntRINAQNEFLKIieIEKKSKSYLD-------DIEAKEF--DRIINHFKKKLDHVNDKFTKEY 1841


                   ..
gi 1034567240 1776 SK 1777
Cdd:TIGR01612 1842 SK 1843
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.98e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034567240  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1400-1697 2.10e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1400 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1479
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEE 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1480 VNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1559
Cdd:COG4372    110 AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1560 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1639
Cdd:COG4372    190 KEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567240 1640 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELK 1697
Cdd:COG4372    270 EKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1149-1360 2.57e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1149 LRFSLNQEEEKRRNADTLYEK----IREQLRRKE---EQYRKE-------------VEVKQQLELSLQTLEMELRTVKSN 1208
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEqlpeLRKELEEAEaalEEFRQKnglvdlseeakllLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1209 LNQVvqernDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHeeekdlshknsmlqEEIAMLRLEIDT 1288
Cdd:COG3206    242 LAAL-----RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNH--------------PDVIALRAQIAA 302

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567240 1289 IKNQNQEKEKKCFEDLKIVKEknedlqkTIKQNEETLTQTISQYNGRLSVLTAENAMLNSkLENEKQSKERL 1360
Cdd:COG3206    303 LRAQLQQEAQRILASLEAELE-------ALQAREASLQAQLAQLEARLAELPELEAELRR-LEREVEVAREL 366
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1583-1834 3.16e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 3.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1583 QQELADTLKKQSMS----EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK 1658
Cdd:pfam07888   40 LQERAELLQAQEAAnrqrEKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1659 LKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLECNLDQemKKNVELEREitGFKNLLKMTRKKLNEYeNG 1738
Cdd:pfam07888  120 LLAQRAAHEARIRELEEDI--KTLTQRVLERETELERMKERAKKAGAQ--RKEEEAERK--QLQAKLQQTEEELRSL-SK 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1739 EFSfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKclhlDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1818
Cdd:pfam07888  193 EFQ---ELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRK----EAENEALLEE---LRSLQERLNASERKVEGLGEELSS 262

                          250
                   ....*....|....*.
gi 1034567240 1819 LRSHIERNMVELGQVK 1834
Cdd:pfam07888  263 MAAQRDRTQAELHQAR 278
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1124-1404 3.67e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 41.34  E-value: 3.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1124 ELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyekiREQLRRKEeqyrKEVEVKQQLELSLQTLEMEL 1202
Cdd:pfam17045    7 ELQElMKQIDIMVAHKKSEWEGQTRALETRLDIREEELLSA-------RNTLERKH----KEIGLLRQQLEELEKGKQEL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1203 rTVKSNlnqvvQERNDAQRQLSReqnarmlqdgiLTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML 1282
Cdd:pfam17045   76 -VAKYE-----QQLQKLQEELSK-----------LKRSYEK---LQRKQLKEAREEAKSREEDRSELSRLNGKLEEFRQK 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1283 RLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQneetltqtiSQYNGRLSVLTA---ENAMLNSKLENEKQSKER 1359
Cdd:pfam17045  136 SLEWEQQRLQYQQQVASLEAQRKALAEQSSLIQSAAYQ---------VQLEGRKQCLEAsqsEIQRLRSKLERAQDSLCA 206

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1034567240 1360 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1404
Cdd:pfam17045  207 QELELERLRMRVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQN 251
mukB PRK04863
chromosome partition protein MukB;
1105-1818 4.01e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.64  E-value: 4.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1105 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhqkvEWERELCSLRFSLNQEEEKrrnadtlyEKIREQLRRKEEQyRKE 1184
Cdd:PRK04863   445 EEFQAKEQEATEELLSLEQKLSVAQAAHSQFE----QAYQLVRKIAGEVSRSEAW--------DVARELLRRLREQ-RHL 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1185 VEVKQQLELSLQTLEMELRtvksNLNQVVQERNDAQRQLSR-EQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSHSHE 1263
Cdd:PRK04863   512 AEQLQQLRMRLSELEQRLR----QQQRAERLLAEFCKRLGKnLDDEDELEQ--------LQEELEARLESLSESVSEARE 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1264 EEKDLSHKNSMLQEEIAMLR------LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNG 1334
Cdd:PRK04863   580 RRMALRQQLEQLQARIQRLAarapawLAAQDALARLREQSGEEFEDSQDVTEYMQQLLereRELTVERDELAARKQALDE 659

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1335 RLSVLTAENAmlnSKLENEKQSKERLEAEVES------------YHSRL----AAAIHDRDQSeTSKRELElafqrARDE 1398
Cdd:PRK04863   660 EIERLSQPGG---SEDPRLNALAERFGGVLLSeiyddvsledapYFSALygpaRHAIVVPDLS-DAAEQLA-----GLED 730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1399 CSRLQDKMNFDVSNLkDNNEILSQQLFKTES-KLNslEIEFHHTR--------DALREKTLGLERVQKDLSQTQCQMKEM 1469
Cdd:PRK04863   731 CPEDLYLIEGDPDSF-DDSVFSVEELEKAVVvKIA--DRQWRYSRfpevplfgRAAREKRIEQLRAEREELAERYATLSF 807

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1470 E-QKYQNEQVKVNKYIGKQESV------EERLSQLQSEnmllRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1542
Cdd:PRK04863   808 DvQKLQRLHQAFSRFIGSHLAVafeadpEAELRQLNRR----RVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPR 883

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1543 QSLLLEERNKELISECN-HLKE--------RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDE 1613
Cdd:PRK04863   884 LNLLADETLADRVEEIReQLDEaeeakrfvQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTE 963

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1614 tqdlkkkLGQIRNQL--QEAQDRHTEAVRCAEKM-QDHKQKlEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1690
Cdd:PRK04863   964 -------VVQRRAHFsyEDAAEMLAKNSDLNEKLrQRLEQA-EQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQM 1035

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1691 kkLMELKQSLEcnldqemkknvelereitgfknllkmtrkklneyengEFSFHGDlktsqFEMDIQinkLKHKIDDLTAE 1770
Cdd:PRK04863  1036 --LQELKQELQ-------------------------------------DLGVPAD-----SGAEER---ARARRDELHAR 1068

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 1034567240 1771 LETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1818
Cdd:PRK04863  1069 LSANRSRRNQLEKQLTFCEAE---MDNLTKKLRKLERDYHEMREQVVN 1113
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 4.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.02e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1034567240   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1661-1953 4.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 4.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1661 VTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQSLEcnlDQEMKKNVELEREITGF--KNLLKMTRKKLNEYENG 1738
Cdd:pfam17380  284 VSERQQQEKFEKMEQERL-----RQEKEEKAREVERRRKLE---EAEKARQAEMDRQAAIYaeQERMAMERERELERIRQ 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1739 EFSFHGDLKTSQFEMDIQINKLKhkiddltaELETAGskcLHLDTKNQILQEELLSMKTVQKKCEKLQKNkkkleqevin 1818
Cdd:pfam17380  356 EERKRELERIRQEEIAMEISRMR--------ELERLQ---MERQQKNERVRQELEAARKVKILEEERQRK---------- 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1819 lrshIERNMVELGQVKQYKQEIEERARQEIAE-KLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELrikdlESELSK 1897
Cdd:pfam17380  415 ----IQQQKVEMEQIRAEQEEARQREVRRLEEeRAREMERVRLEEQERQQQVERLRQQEEERKRKKLEL-----EKEKRD 485

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567240 1898 IKTSQEDFNKT---ELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1953
Cdd:pfam17380  486 RKRAEEQRRKIlekELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRK 544
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 4.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 1034567240  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1135-1365 4.31e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1135 LEHQKVEWERelcslrfslnQEEEKrrnadtlYEKI-REQLRRKEEQYRKEVEVKQQLELSLQTLEMELR---TVKSNLN 1210
Cdd:pfam17380  278 VQHQKAVSER----------QQQEK-------FEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaAIYAEQE 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1211 QVVQERN---DAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHShEEEKDLSHKNSMLQEE----IAMLR 1283
Cdd:pfam17380  341 RMAMERErelERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERV-RQELEAARKVKILEEErqrkIQQQK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1284 LEIDTIKNQNQEKEKkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAmlNSKLENEKQSKERLEAE 1363
Cdd:pfam17380  420 VEMEQIRAEQEEARQ---REVRRLEEERAREMERVRLEEQERQQQVE----RLRQQEEERK--RKKLELEKEKRDRKRAE 490


                   ..
gi 1034567240 1364 VE 1365
Cdd:pfam17380  491 EQ 492
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1331-1734 4.45e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 4.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1331 QYNGRLSVLTAE--------NAMLNSKLENEKqsKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL 1402
Cdd:COG3096    317 ELSARESDLEQDyqaasdhlNLVQTALRQQEK--IERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSL 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1403 QdkmnfdvSNLKDNNEILSQQlfKTESklnsleIEFHHTRDALREktlglervqkdlSQTQCQMKEMEQkyqnEQVKvnk 1482
Cdd:COG3096    395 K-------SQLADYQQALDVQ--QTRA------IQYQQAVQALEK------------ARALCGLPDLTP----ENAE--- 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1483 yiGKQESVEERLSQLQSENMLLRQQL---DDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERnkelisECN 1559
Cdd:COG3096    441 --DYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEKAYELVCKIAGE----VERSQAWQTARELLRRYR------SQQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1560 HLKERQYQYENEKAEREVVVRQLQ--QELADTLKKQSmseaSLEVTSryRINLEDEtqdlkkklgqiRNQLQEAQDRHTE 1637
Cdd:COG3096    509 ALAQRLQQLRAQLAELEQRLRQQQnaERLLEEFCQRI----GQQLDA--AEELEEL-----------LAELEAQLEELEE 571

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1638 AVR-CAEKMQDHKQKLEKDNAKLKvTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMElkqslecnLDQEMKKNVELER 1716
Cdd:COG3096    572 QAAeAVEQRSELRQQLEQLRARIK-ELAARAPAWLAAQDAL--ERLREQSGEALADSQE--------VTAAMQQLLERER 640

                          410
                   ....*....|....*...
gi 1034567240 1717 EITGFKNLLKMTRKKLNE 1734
Cdd:COG3096    641 EATVERDELAARKQALES 658
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1198-1521 4.55e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.35  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1198 LEMELRTVKSNLN----QVVQERNDAQRQLSR----EQNARMLQDGI-----LTNHLSKQKEIEMAQKKMNSENSHSHEE 1264
Cdd:PRK10929    28 ITQELEQAKAAKTpaqaEIVEALQSALNWLEErkgsLERAKQYQQVIdnfpkLSAELRQQLNNERDEPRSVPPNMSTDAL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1265 EKDLSHKNSMLQEEIAMLrleidtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLtQTISQYN-----GRLSVL 1339
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQA--------QQEQDRAREISDSLSQLPQQQTEARRQLNEIERRL-QTLGTPNtplaqAQLTAL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1340 TAENAMLNSKLE---------NEKQSKERLEAEV-ESYHSRLAAAIHD-RDQ-SETSKRELELAFQRARDECSRLQDKMN 1407
Cdd:PRK10929   179 QAESAALKALVDelelaqlsaNNRQELARLRSELaKKRSQQLDAYLQAlRNQlNSQRQREAERALESTELLAEQSGDLPK 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1408 FDVSNLKDNNEI---LSQQ------LFKTESKLNSLEIEFHHTRDALREKT--LGLERVQKDLSQTQ-CQMKEMEqKYQn 1475
Cdd:PRK10929   259 SIVAQFKINRELsqaLNQQaqrmdlIASQQRQAASQTLQVRQALNTLREQSqwLGVSNALGEALRAQvARLPEMP-KPQ- 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1034567240 1476 eQVKvnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1521
Cdd:PRK10929   337 -QLD-------TEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPLT 374
PHA02946 PHA02946
ankyin-like protein; Provisional
 96-215 5.04e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   96 VTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED--ISVATKLLLYDANIE 173
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034567240  174 AKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1351-1630 5.11e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 5.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1351 ENEKQSKERLEAEVESYHSRLAAAIH---DRDQSETSKRELELAFQRARD-ECSRLQDKMNFDVSNLKDNNEIlsQQLFK 1426
Cdd:pfam17380  322 EKARQAEMDRQAAIYAEQERMAMERErelERIRQEERKRELERIRQEEIAmEISRMRELERLQMERQQKNERV--RQELE 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1427 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVnkyigkqesvEERLSQLQSEnmLLRQ 1506
Cdd:pfam17380  400 AARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL----------EEQERQQQVE--RLRQ 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1507 QLDDAHNKADNKEKTVIN---IQDQFHAIVQKlQAESEKQSLLlEERNKELISEcNHLKERQYQ-YENEKAEREVVVRQL 1582
Cdd:pfam17380  468 QEEERKRKKLELEKEKRDrkrAEEQRRKILEK-ELEERKQAMI-EEERKRKLLE-KEMEERQKAiYEEERRREAEEERRK 544

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1034567240 1583 QQELADTLK-KQSMSEASLEvtsRYRINLEDETQDLKKKLGQIRNQLQE 1630
Cdd:pfam17380  545 QQEMEERRRiQEQMRKATEE---RSRLEAMEREREMMRQIVESEKARAE 590
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1680-1908 5.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1680 ANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsfhgdlktsqfemdiQINK 1759
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ------------------ELAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1760 LKHKIDDLTAELETAGSKclhLDTKNQILQEELLSM-KTVQKKCEKL---QKNKKKLEQEVINLRSHIERNMVELGQVKQ 1835
Cdd:COG4942     81 LEAELAELEKEIAELRAE---LEAQKEELAELLRALyRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRA 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567240 1836 YKQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKT 1908
Cdd:COG4942    158 DLAELAAL-RAELEAERAELEALLAELEEERAALEA-LKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
PRK09039 PRK09039
peptidoglycan -binding protein;
1325-1435 5.42e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.49  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1325 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1404
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034567240 1405 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1435
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
PRK12704 PRK12704
phosphodiesterase; Provisional
 1659-1854 5.46e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 5.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1659 LKVTVKKQMDKIEELQKNLLNAnlSEDEKEQLKKLMELKQSlecnlDQEMKKNVELEREItgfknllkmtRKKLNEYENG 1738
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEE--AKKEAEAIKKEALLEAK-----EEIHKLRNEFEKEL----------RERRNELQKL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1739 EfsfhgdlktsqfemdiqiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN 1818
Cdd:PRK12704    88 E------------------KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISG 149

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034567240 1819 LRSHIERNMVelgqvkqyKQEIEERARQEIAEKLKE 1854
Cdd:PRK12704   150 LTAEEAKEIL--------LEKVEEEARHEAAVLIKE 177
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1157-1902 5.52e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.96  E-value: 5.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1157 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQlELSLQTLEMELRT---VKSNLNQVVQERNDAQRQLSREQNARMLQ 1233
Cdd:TIGR01612  699 DDLKSKIDKEYDKIQNMETATVELHLSNIENKKN-ELLDIIVEIKKHIhgeINKDLNKILEDFKNKEKELSNKINDYAKE 777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1234 DGILTNHLSKQKEIEmaqkkmnsenshsheeekdlSHKNSmlqeeiamlRLEIDTIKNqnqekekkcfEDLKIVKEKNED 1313
Cdd:TIGR01612  778 KDELNKYKSKISEIK--------------------NHYND---------QINIDNIKD----------EDAKQNYDKSKE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1314 LQKTIKQNEETLTQTISQY-NGRLSVLTAENAMLNskLENekQSKERLEAEVESYhsrlaAAIHDRDQSETSKRELELAF 1392
Cdd:TIGR01612  819 YIKTISIKEDEIFKIINEMkFMKDDFLNKVDKFIN--FEN--NCKEKIDSEHEQF-----AELTNKIKAEISDDKLNDYE 889

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1393 QRARDECSRLQDKMNF------DVSNLKDNNEIL------SQQLFKTESKLNSLEIEFHHTRDALREKTLgLERVQKDLS 1460
Cdd:TIGR01612  890 KKFNDSKSLINEINKSieeeyqNINTLKKVDEYIkicentKESIEKFHNKQNILKEILNKNIDTIKESNL-IEKSYKDKF 968

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1461 QTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS------ENMLLRQ------QLDDAHNKADNKEKTVINIQDQ 1528
Cdd:TIGR01612  969 DNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKAnlgknkENMLYHQfdekekATNDIEQKIEDANKNIPNIEIA 1048

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1529 FHAIVQKLQAESEKQ-SLLLEERNKELISEC-------NHLKERQYQYENEKAEREVVVRqlqqeLADTLKKQSMSEASL 1600
Cdd:TIGR01612 1049 IHTSIYNIIDEIEKEiGKNIELLNKEILEEAeinitnfNEIKEKLKHYNFDDFGKEENIK-----YADEINKIKDDIKNL 1123

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1601 EVTSRYRINledETQDLKKKLGQIRNQLQeAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNA 1680
Cdd:TIGR01612 1124 DQKIDHHIK---ALEEIKKKSENYIDEIK-AQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI 1199

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1681 NLSEDEKEQLKKLMELKQSLECNL--------DQEMKKNVELEREITGFKNLLKMTRKKLNEYENgEFSFHGDLKTSQFE 1752
Cdd:TIGR01612 1200 AEIEKDKTSLEEVKGINLSYGKNLgklflekiDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIEN-EMGIEMDIKAEMET 1278

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1753 MDIQINKLK--HKIDDLTAE-LETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQ---EVINLRSHIERN 1826
Cdd:TIGR01612 1279 FNISHDDDKdhHIISKKHDEnISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLylnEIANIYNILKLN 1358

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1827 MVE--LGQVKQYKQEIEERARQEIAEKLKevnlflqaqaaSQENLEQFREN-NFASMKSQMELRI--KDLESELSKIKTS 1901
Cdd:TIGR01612 1359 KIKkiIDEVKEYTKEIEENNKNIKDELDK-----------SEKLIKKIKDDiNLEECKSKIESTLddKDIDECIKKIKEL 1427


                   .
gi 1034567240 1902 Q 1902
Cdd:TIGR01612 1428 K 1428
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1107-1646 6.25e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1107 LTVKIKKMEDKVNVLQRELSETKEIKSQLEH-------QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 1179
Cdd:pfam01576  487 LSTRLRQLEDERNSLQEQLEEEEEAKRNVERqlstlqaQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAA 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1180 QYRKEVEVKQQLELSLQTLEMEL---RTVKSNL------------------NQVVQERNDAQRQlSREQNARMLQ-DGIL 1237
Cdd:pfam01576  567 AYDKLEKTKNRLQQELDDLLVDLdhqRQLVSNLekkqkkfdqmlaeekaisARYAEERDRAEAE-AREKETRALSlARAL 645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1238 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK--KCFEDLKIVKEKNedLQ 1315
Cdd:pfam01576  646 EEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDelQATEDAKLRLEVN--MQ 723

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1316 KTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ-------SKERLEAEVESYHSRLAAAIHDRDQSETSKREL 1388
Cdd:pfam01576  724 ALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKqraqavaAKKKLELDLKELEAQIDAANKGREEAVKQLKKL 803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1389 ELA---FQRARDECSRLQDkmnfdvsnlkdnnEILSQQLfKTESKLNSLEIEFHHtrdaLREKTLGLERVQKdlsQTQCQ 1465
Cdd:pfam01576  804 QAQmkdLQRELEEARASRD-------------EILAQSK-ESEKKLKNLEAELLQ----LQEDLAASERARR---QAQQE 862

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1466 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------ 1539
Cdd:pfam01576  863 RDELADEIASGASGKSALQDEKRRLEARIAQLEEE-------LEEEQSNTELLNDRLRKSTLQVEQLTTELAAErstsqk 935

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1540 SEKQSLLLEERNKELISECNHLKER-QYQYENEKAEREVVVRQLQQELADTLKKQSMS------------EASLEVTSRY 1606
Cdd:pfam01576  936 SESARQQLERQNKELKAKLQEMEGTvKSKFKSSIAALEAKIAQLEEQLEQESRERQAAnklvrrtekklkEVLLQVEDER 1015

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1034567240 1607 RI--NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQ 1646
Cdd:pfam01576 1016 RHadQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 6.64e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 6.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034567240  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 873-1713 6.85e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 6.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  873 QQDMQRFKNEIGMLKVEFQALEKEKVQLQK----------EVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQK 942
Cdd:pfam01576   18 KERQQKAESELKELEKKHQQLCEEKNALQEqlqaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240  943 RKSGETDHQQFPRKENKEYASSgPALQMKEVKSTEKEKRTSKEsvnspvfgkaslltggLLQVDDDSSlseidedegrpt 1022
Cdd:pfam01576   98 KKKMQQHIQDLEEQLDEEEAAR-QKLQLEKVTTEAKIKKLEED----------------ILLLEDQNS------------ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1023 kKTSNEKNKVKNQIQSMDDvddltqssetasedcelphssyknfmllieQLGMECKDSVSLLKIQDAALSCERLLELKKN 1102
Cdd:pfam01576  149 -KLSKERKLLEERISEFTS------------------------------NLAEEEEKAKSLSKLKNKHEAMISDLEERLK 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1103 HCELLTVKIKKMEDKvnvLQRELSETKEiksqlehQKVEWERELCSLRFSLNQEEEKRRNAdtlyekireQLRRKEEQYR 1182
Cdd:pfam01576  198 KEEKGRQELEKAKRK---LEGESTDLQE-------QIAELQAQIAELRAQLAKKEEELQAA---------LARLEEETAQ 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1183 KEVEVKQQLELSLQTLEmelrtVKSNLNQVVQERNDAQRQ---LSREQNA--RMLQDGILT----NHLSKQKEIEMAQ-K 1252
Cdd:pfam01576  259 KNNALKKIRELEAQISE-----LQEDLESERAARNKAEKQrrdLGEELEAlkTELEDTLDTtaaqQELRSKREQEVTElK 333

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1253 KMNSENSHSHEEE-KDLSHKNSMLQEEIAMlRLEIDTIKNQNQEKEKKCFEdlkivkEKNEDLQKTIKqneeTLTQTISQ 1331
Cdd:pfam01576  334 KALEEETRSHEAQlQEMRQKHTQALEELTE-QLEQAKRNKANLEKAKQALE------SENAELQAELR----TLQQAKQD 402

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1332 YNGRLSVLTAENAMLNSKL-ENEKQSKERLEaevesyhsRLAAAIHDRDQSETSKRELELAFQRARDECSRLQdkmnfdv 1410
Cdd:pfam01576  403 SEHKRKKLEGQLQELQARLsESERQRAELAE--------KLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLE------- 467

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1411 SNLKDNNEILS---QQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQ 1487
Cdd:pfam01576  468 SQLQDTQELLQeetRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-------GTL 540

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1488 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ----------DQFHAIVQKLQAESEK-QSLLLEERNkelIS 1556
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQqelddllvdlDHQRQLVSNLEKKQKKfDQMLAEEKA---IS 617

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1557 EcnhlkerQYQYENEKAEREV--------------------------VVRQLQQELADTLKKQSMSEASLEVTSRYRINL 1610
Cdd:pfam01576  618 A-------RYAEERDRAEAEAreketralslaraleealeakeelerTNKQLRAEMEDLVSSKDDVGKNVHELERSKRAL 690

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1611 EDETQDLKKKLGQIRNQLQEAQDrhtEAVRCAEKMQDHKQKLEKDnakLKVTVKKQMDKIEELQKNL--LNANLsEDEKE 1688
Cdd:pfam01576  691 EQQVEEMKTQLEELEDELQATED---AKLRLEVNMQALKAQFERD---LQARDEQGEEKRRQLVKQVreLEAEL-EDERK 763

                          890       900
                   ....*....|....*....|....*
gi 1034567240 1689 QLKKLMELKQSLECNLdQEMKKNVE 1713
Cdd:pfam01576  764 QRAQAVAAKKKLELDL-KELEAQID 787
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1152-1461 8.04e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.36  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1152 SLNQEEEKRRNADTLYEKI---REQLRRKEEQY---RKEVE-VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS 1224
Cdd:pfam12128  595 WAASEEELRERLDKAEEALqsaREKQAAAEEQLvqaNGELEkASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALA 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1225 REQNARMLQ----DGILTNHLSKQKEIEMAQKKMNSENSHSHEE-----EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE 1295
Cdd:pfam12128  675 ERKDSANERlnslEAQLKQLDKKHQAWLEEQKEQKREARTEKQAywqvvEGALDAQLALLKAAIAARRSGAKAELKALET 754

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1296 KEKKCFEDLKIVKEKNEDLQKTIKqneeTLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1375
Cdd:pfam12128  755 WYKRDLASLGVDPDVIAKLKREIR----TLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQL 830

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1376 hDRDQSETSKRELELafQRARDECSRLQDKMNFDVSNLKDNNEILSQqlFKTESKLNSLEIEFHHTRDALREKTLGLERV 1455
Cdd:pfam12128  831 -ARLIADTKLRRAKL--EMERKASEKQQVRLSENLRGLRCEMSKLAT--LKEDANSEQAQGSIGERLAQLEDLKLKRDYL 905


                   ....*.
gi 1034567240 1456 QKDLSQ 1461
Cdd:pfam12128  906 SESVKK 911
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1107-1327 8.13e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 41.43  E-value: 8.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1107 LTVKIKKMEDKVNVLQRE----LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR 1182
Cdd:pfam15964  408 LSQNVAQLEAQVEKVTREknslVSQLEEAQKQLASQEMDVTKVCGEMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKD 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1183 KEVEvKQQLELSLQTLEME-------------------LRTVKSNLNQVVQERNDAQRQLSREQNARMLQdgiltnhlSK 1243
Cdd:pfam15964  488 QEIE-KLGLELSESKQRLEqaqqdaarareeclkltelLGESEHQLHLTRLEKESIQQSFSNEAKAQALQ--------AQ 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1244 QKEIEMAQKKMNSENSHS---HEEEKDLSHKNSM---LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1317
Cdd:pfam15964  559 QREQELTQKMQQMEAQHDktvNEQYSLLTSQNTFiakLKEECCTLAKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKR 638

                          250
                   ....*....|
gi 1034567240 1318 IKQNEETLTQ 1327
Cdd:pfam15964  639 NEELEEQCVQ 648
PTZ00121 PTZ00121
MAEBL; Provisional
 1112-1430 8.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 8.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1112 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKR-----RNADTLYEKIREQLRRKEEQYRKEVE 1186
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKkaeeaKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1187 VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlskqKEIEMAQKKMNSENSHSHEEEK 1266
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK--------------KDEEEKKKIAHLKKEEEKKAEE 1772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1267 DLSHKNSMLQEEiamLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQyngrlsVLTAENAML 1346
Cdd:PTZ00121  1773 IRKEKEAVIEEE---LDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKE------VADSKNMQL 1843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1347 NS--KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDvsnlKDNNEILSQQL 1424
Cdd:PTZ00121  1844 EEadAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMA----GKNNDIIDDKL 1919


                   ....*.
gi 1034567240 1425 FKTESK 1430
Cdd:PTZ00121  1920 DKDEYI 1925
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1419-1640 8.41e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 8.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1419 ILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1498
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1499 SENMLLRQQLDD-----------AHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQSLLLEERNKELISECNHLKERQYQ 1567
Cdd:COG4942     90 KEIAELRAELEAqkeelaellraLYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567240 1568 YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 1640
Cdd:COG4942    169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1271-1654 8.86e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 8.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1271 KNSMLQEEIAMLRLEIDTIKNQNQEkekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAM--LNS 1348
Cdd:COG4717     65 KPELNLKELKELEEELKEAEEKEEE-----YAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELeaLEA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1349 KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTE 1428
Cdd:COG4717    140 ELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1429 SKLNSLEIEFHHTRDALREKTLgLERVQK-----------------------------------------DLSQTQCQMK 1467
Cdd:COG4717    220 EELEELEEELEQLENELEAAAL-EERLKEarlllliaaallallglggsllsliltiagvlflvlgllalLFLLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1468 EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvqKLQAESEKQSLLL 1547
Cdd:COG4717    299 SLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1548 EERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ------ELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKL 1621
Cdd:COG4717    377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEEllgeleELLEALDEEELEEELEELEEELE-ELEEELEELREEL 455

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1034567240 1622 GQIRNQLQEAQDRHteavRCAEKMQDHKQKLEK 1654
Cdd:COG4717    456 AELEAELEQLEEDG----ELAELLQELEELKAE 484
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1094-1297 9.09e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 9.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1094 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRfslnQEEEKRRNADTLYEKIREQ 1173
Cdd:pfam17380  410 ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLR----QQEEERKRKKLELEKEKRD 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1174 LRRKEEQYRKEVEvkQQLELSLQTLEMELRTVKsnlnQVVQERNDAQRQLSREQNARMLQDgiltnhlSKQKEIEMAQKK 1253
Cdd:pfam17380  486 RKRAEEQRRKILE--KELEERKQAMIEEERKRK----LLEKEMEERQKAIYEEERRREAEE-------ERRKQQEMEERR 552

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034567240 1254 MNSENSHSHEEEKDlshKNSMLQEEIAMLRleiDTIKNQNQEKE 1297
Cdd:pfam17380  553 RIQEQMRKATEERS---RLEAMEREREMMR---QIVESEKARAE 590
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1611-1734 9.68e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.43  E-value: 9.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1611 EDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKvTVKKQMD-------------KIEELQKN 1676
Cdd:cd22656    109 DEELEEAKKTIkALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALE-TLEKALKdlltdeggaiarkEIKDLQKE 187

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567240 1677 LLNANlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE 1734
Cdd:cd22656    188 LEKLN--EEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGP 243
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1609-1945 9.80e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 9.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1609 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKE 1688
Cdd:TIGR04523   37 QLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1689 QLKKLMELKQSlecNLDQEMKKNvelEREITGFKNLLKMTRKKLNEYENGefsfHGDLKTSQFEMDIQINKLKHKIDDLT 1768
Cdd:TIGR04523  117 EQKNKLEVELN---KLEKQKKEN---KKNIDKFLTEIKKKEKELEKLNNK----YNDLKKQKEELENELNLLEKEKLNIQ 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1769 AELETAGSKCLHLDTKnqilqeeLLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1848
Cdd:TIGR04523  187 KNIDKIKNKLLKLELL-------LSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1849 AEKLKEVNLFLQAQAASQENLEQfrennfasmksqmelrIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKS-- 1926
Cdd:TIGR04523  260 DEQNKIKKQLSEKQKELEQNNKK----------------IKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKkl 323

                          330       340
                   ....*....|....*....|.
gi 1034567240 1927 --LSSKLTKTNERLAEVNTKL 1945
Cdd:TIGR04523  324 eeIQNQISQNNKIISQLNEQI 344
PRK11281 PRK11281
mechanosensitive channel MscK;
1447-1677 9.87e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.05  E-value: 9.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1447 EKTLGL----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQL---QSENML--LRQQLDDAHNKAD 1516
Cdd:PRK11281    66 EQTLALldkiDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDnDEETRETLSTLslrQLESRLaqTLDQLQNAQNDLA 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1517 NKEKTVINIQDQFHAiVQKLQAESEKQSLLLEER-NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSM 1595
Cdd:PRK11281   146 EYNSQLVSLQTQPER-AQAALYANSQRLQQIRNLlKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSLEGNTQLQDL 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567240 1596 SEASLEVTSRYRINLEDETQDLK-----KKLGQIRNQLQEAQdrhteAVRCAEKMQDH---KQKLEKdNAKLKVTVKKQM 1667
Cdd:PRK11281   225 LQKQRDYLTARIQRLEHQLQLLQeainsKRLTLSEKTVQEAQ-----SQDEAARIQANplvAQELEI-NLQLSQRLLKAT 298

                          250
                   ....*....|.
gi 1034567240 1668 DKIEEL-QKNL 1677
Cdd:PRK11281   299 EKLNTLtQQNL 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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