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Conserved domains on  [gi|1034563496|ref|XP_016858355|]
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GDH/6PGL endoplasmic bifunctional protein isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 200-435 1.29e-102

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 304.68  E-value: 1.29e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 279
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 280 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 356
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 357 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 435
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
G6PD_C super family cl47771
Glucose-6-phosphate dehydrogenase, C-terminal domain;
2-148 2.65e-12

Glucose-6-phosphate dehydrogenase, C-terminal domain;


The actual alignment was detected with superfamily member pfam02781:

Pssm-ID: 460694  Cd Length: 295  Bit Score: 67.08  E-value: 2.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496   2 SGKALDERVGYARILFKNQACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLR 81
Cdd:pfam02781 150 TGKRLPERVTEIRIQFKDVPHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034563496  82 LFGSPLS-DYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 148
Cdd:pfam02781 209 LRPVELDfSYSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 200-435 1.29e-102

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 304.68  E-value: 1.29e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 279
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 280 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 356
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 357 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 435
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
202-426 2.49e-87

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 265.25  E-value: 2.49e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 202 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 281
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 282 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 358
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 359 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 426
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 205-428 8.54e-83

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 253.64  E-value: 8.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 205 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 284
Cdd:cd01400     1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 285 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 362
Cdd:cd01400    80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034563496 363 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 428
Cdd:cd01400   154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 204-432 8.05e-59

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 192.68  E-value: 8.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 204 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 280
Cdd:COG0363    10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 281 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 360
Cdd:COG0363    90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 361 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 426
Cdd:COG0363   162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                  ....*.
gi 1034563496 427 YMDYDA 432
Cdd:COG0363   238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 204-432 3.44e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 3.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 204 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 281
Cdd:PLN02360   19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 282 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 350
Cdd:PLN02360   98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 351 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 426
Cdd:PLN02360  172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                  ....*.
gi 1034563496 427 YMDYDA 432
Cdd:PLN02360  252 FLDKPA 257
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
2-148 2.65e-12

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 67.08  E-value: 2.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496   2 SGKALDERVGYARILFKNQACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLR 81
Cdd:pfam02781 150 TGKRLPERVTEIRIQFKDVPHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034563496  82 LFGSPLS-DYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 148
Cdd:pfam02781 209 LRPVELDfSYSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 79-149 2.46e-05

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 46.55  E-value: 2.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034563496  79 GLRLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHK--APRLYPGGA 149
Cdd:PLN02640  478 GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKkiIPELYPYGS 551
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 200-435 1.29e-102

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 304.68  E-value: 1.29e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 279
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 280 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 356
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 357 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 435
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
202-426 2.49e-87

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 265.25  E-value: 2.49e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 202 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 281
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 282 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 358
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 359 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 426
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 205-428 8.54e-83

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 253.64  E-value: 8.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 205 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 284
Cdd:cd01400     1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 285 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 362
Cdd:cd01400    80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034563496 363 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 428
Cdd:cd01400   154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 204-432 8.05e-59

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 192.68  E-value: 8.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 204 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 280
Cdd:COG0363    10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 281 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 360
Cdd:COG0363    90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 361 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 426
Cdd:COG0363   162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                  ....*.
gi 1034563496 427 YMDYDA 432
Cdd:COG0363   238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 204-432 3.44e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 3.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 204 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 281
Cdd:PLN02360   19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 282 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 350
Cdd:PLN02360   98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 351 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 426
Cdd:PLN02360  172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                  ....*.
gi 1034563496 427 YMDYDA 432
Cdd:PLN02360  252 FLDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 200-415 1.23e-16

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 78.68  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLandieatavraVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERcVPLS--DPES 275
Cdd:cd01399     3 MSEAAAELIAEL-----------IREKPPAVLGLATGSTPLGVYEELIELHKegGLSFSNVTTFNLDEY-VGLPpdHPQS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 276 NFQGLQAHLLQHVRIPYYNIHPMPVhlqqrLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD 355
Cdd:cd01399    71 YHYFMRENLFDHIDIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLD 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034563496 356 GE-QLVVLTTSPSQ------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRVGHEP--KKWPIS 415
Cdd:cd01399   141 SRtRVVTLDESTRQanarffdgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
2-148 2.65e-12

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 67.08  E-value: 2.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496   2 SGKALDERVGYARILFKNQACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLR 81
Cdd:pfam02781 150 TGKRLPERVTEIRIQFKDVPHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034563496  82 LFGSPLS-DYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 148
Cdd:pfam02781 209 LRPVELDfSYSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 200-432 5.15e-10

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 59.77  E-value: 5.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLANDIEATAVRavrrfgQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESN 276
Cdd:PTZ00285   12 VADYTSNYIIKRINDFKPTSDR------PFVLGLPTGSTPLPTYQELIRAYRegRVSFSNVVTFNMDEYVgLPRDHPQSY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 277 FQGLQAHLLQHVRIPYYNihpmpVHLQQRLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPtgLDG 356
Cdd:PTZ00285   86 HYFMKENFFDHVDIKEEN-----RHILNGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSS--LDS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 357 EQLVV-LTTSP------------SQ-PHRRMSLSLPLINRAKKVAVLVMGRMKREITT--LVSRVGHepkKWPISGVLPH 420
Cdd:PTZ00285  156 RTRVKsLNQETidanarffgndiSKvPTMALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPASALQMH 232

                         250
                  ....*....|..
gi 1034563496 421 SgQLVWYMDYDA 432
Cdd:PTZ00285  233 P-AAVLCLDEDA 243
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 229-343 1.68e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 56.59  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 229 FHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCA 308
Cdd:cd00458    22 MVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKAC 101

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034563496 309 EEdqgaqiYAREIsaLVANSSFDLVLLGMGADGHT 343
Cdd:cd00458   102 EK------YEREI--LDQVDAIDLAVDGAGYRAGT 128
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 200-415 4.16e-08

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 54.07  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 200 VSAWSEELISKLANDIEATAVRAvrrfgqFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDE-RCVPLSDPES- 275
Cdd:PRK00443   12 VGKWAARHIANRINAFLPTKERP------FVLGLATGSSPLETYKALIELHKagKVDFSRVTTFNLDEyVGLPADHPESy 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 276 -NFqgLQAHLLQHVRIPYYNIHpmpvhLQQRLCAEEDQGAQIYAREIsalVANSSFDLVLLGMGADGHTAslFPQSPTGL 354
Cdd:PRK00443   86 rYF--MRENFFDHVDIPPENIN-----LLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FNEPGSSF 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034563496 355 DGEQLVV-LTTSPSQ-------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIT--TLVSRVGHEpkkWPIS 415
Cdd:PRK00443  154 ASRTRIKtLTEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 204-398 4.42e-07

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 52.34  E-value: 4.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 204 SEELISKLANDIeATAVRAVRRFGQFH-LALSGGSSPVALFQQLATAH--YGFPWAHTHLWLVDERcVPLS--DPESNFQ 278
Cdd:PRK02122   36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreEGLSFKNVITFNLDEY-YPMQpdSLQSYHR 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 279 GLQAHLLQHVRIPYYNIHPMPVHLQQrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD-GE 357
Cdd:PRK02122  114 FMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIG--FNEPGSGRNsRT 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034563496 358 QLVVLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREI 398
Cdd:PRK02122  186 RLVTLDHItrrdaasdffgeENVPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
230-342 4.09e-06

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 47.82  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 230 HLALSGGSSPVALFQQLATAHYGFPW-AHTHLWLVDErcVPLSDPES---NFQGLQAHLLQHVRIPYYNIHPMPVhlqqr 305
Cdd:PRK12358   31 NLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI----- 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034563496 306 lcaeedqgaQIYAREISALVANSSFDLVLLGMGADGH 342
Cdd:PRK12358  104 ---------DNYREHDQKLARDGGLDLVVLGLGADGH 131
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 79-149 2.46e-05

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 46.55  E-value: 2.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034563496  79 GLRLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHK--APRLYPGGA 149
Cdd:PLN02640  478 GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKkiIPELYPYGS 551
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 79-149 7.31e-05

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 44.97  E-value: 7.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034563496  79 GLRLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKA--PRLYPGGA 149
Cdd:PLN02333  507 GMRLDRSNLNLLYAARYSKEiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKiiPEYYPYGS 580
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 223-421 3.67e-03

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 38.66  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 223 VRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLV--DERC-VPLSDPESNFQGLQAHLLQHVRIP---YYNIH 296
Cdd:PRK09762   24 IRSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVklDEWVdLPLTMPGTCETFLQQHIVQPLGLRedqLISFR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563496 297 PMPVHLQQrlCAeedqgaqiyaREISALVANSSFDLVLLGMGADGH------TASLFPQSP-TGLD--GEQLVVLTTSPS 367
Cdd:PRK09762  104 SEEINETE--CE----------RVTNLIARKGGLDLCVLGLGKNGHlglnepGESLQPACHiSQLDarTQQHEMLKTAGR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034563496 368 QPHRRMSLSLPLINRAKKVAVLVMGRMKREITT--LVSRVGHEpkkWPISGVLPHS 421
Cdd:PRK09762  172 PVTRGITLGLKDILNAREVLLLVTGEGKQDATErfLTAKVSTA---IPASFLWLHS 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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