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Conserved domains on  [gi|1034561845|ref|XP_016857825|]
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protein zyg-11 homolog B isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
128-275 4.96e-05

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 4.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561845 128 LGSNKWIQQ--NLQCLVLNSLTLSlEDPYErcFSRLSGLRALSITNVLFynEDL-AEVASLPRLESLDISNTSITDITAL 204
Cdd:COG4886   103 LSGNEELSNltNLESLDLSGNQLT-DLPEE--LANLTNLKELDLSNNQL--TDLpEPLGNLTNLKSLDLSNNQLTDLPEE 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561845 205 LACKDRLKSLTMHHLKClkmttTQILDVVRELKHLNHLDISDDKqfTSDIALRLLEqkdiLPNLVSLDVSG 275
Cdd:COG4886   178 LGNLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQ--LTDLPEPLAN----LTNLETLDLSN 237
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-275 4.96e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 4.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561845 128 LGSNKWIQQ--NLQCLVLNSLTLSlEDPYErcFSRLSGLRALSITNVLFynEDL-AEVASLPRLESLDISNTSITDITAL 204
Cdd:COG4886   103 LSGNEELSNltNLESLDLSGNQLT-DLPEE--LANLTNLKELDLSNNQL--TDLpEPLGNLTNLKSLDLSNNQLTDLPEE 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561845 205 LACKDRLKSLTMHHLKClkmttTQILDVVRELKHLNHLDISDDKqfTSDIALRLLEqkdiLPNLVSLDVSG 275
Cdd:COG4886   178 LGNLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQ--LTDLPEPLAN----LTNLETLDLSN 237
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-275 4.96e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 4.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561845 128 LGSNKWIQQ--NLQCLVLNSLTLSlEDPYErcFSRLSGLRALSITNVLFynEDL-AEVASLPRLESLDISNTSITDITAL 204
Cdd:COG4886   103 LSGNEELSNltNLESLDLSGNQLT-DLPEE--LANLTNLKELDLSNNQL--TDLpEPLGNLTNLKSLDLSNNQLTDLPEE 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561845 205 LACKDRLKSLTMHHLKClkmttTQILDVVRELKHLNHLDISDDKqfTSDIALRLLEqkdiLPNLVSLDVSG 275
Cdd:COG4886   178 LGNLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQ--LTDLPEPLAN----LTNLETLDLSN 237
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-328 1.57e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561845 106 KLVELDATGvNAditITDIISGLGSNKwiqqNLQCLVL--NSLTlSLEDPyercFSRLSGLRALSitnvLFYN--EDLAE 181
Cdd:COG4886   183 NLKELDLSN-NQ---ITDLPEPLGNLT----NLEELDLsgNQLT-DLPEP----LANLTNLETLD----LSNNqlTDLPE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561845 182 VASLPRLESLDISNTSITDITALLACKdRLKSLTMHH--LKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLL 259
Cdd:COG4886   246 LGNLTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034561845 260 EQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIA 328
Cdd:COG4886   325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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