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Conserved domains on  [gi|1034559340|ref|XP_016857006|]
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matrix remodeling-associated protein 8 isoform X2 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10542315)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, similar to Homo sapiens T-cell antigen CD7 and voltage-gated sodium channel beta3 subunit Ig Domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 71-190 5.45e-16

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340  71 EVLAVARGAPALLTCVnrghvWTDRHVEEaQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 150
Cdd:pfam07686   4 REVTVALGGSVTLPCT-----YSSSMSEA-STSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034559340 151 RGDFSLRIEPLEVADEGTYSCHLHHHYCGlHERRVFHLTV 190
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 71-190 5.45e-16

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340  71 EVLAVARGAPALLTCVnrghvWTDRHVEEaQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 150
Cdd:pfam07686   4 REVTVALGGSVTLPCT-----YSSSMSEA-STSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034559340 151 RGDFSLRIEPLEVADEGTYSCHLHHHYCGlHERRVFHLTV 190
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
83-171 2.65e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 2.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340   83 LTCVNRGHVWTDrhveeaqQVVHWDRQPPGvphdRADRLLdLYASGERRAYGPLFLRDRVAVGADaFERGDFSLRIEPLE 162
Cdd:smart00406   4 LSCKFSGSTFSS-------YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLR 70


                   ....*....
gi 1034559340  163 VADEGTYSC 171
Cdd:smart00406  71 VEDTGTYYC 79
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 114-171 1.75e-05

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 43.21  E-value: 1.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340 114 PHDRADRLLDLYASGerRAYGPLF--LRDRVAVgADAFERGDFSLRIEPLEVADEGTYSC 171
Cdd:cd20960    42 PSDKVEKVVITYSGD--RVYNHYYpaLKGRVAF-TSNDLSGDASLNISNLKLSDTGTYQC 98
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 71-190 5.45e-16

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340  71 EVLAVARGAPALLTCVnrghvWTDRHVEEaQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 150
Cdd:pfam07686   4 REVTVALGGSVTLPCT-----YSSSMSEA-STSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034559340 151 RGDFSLRIEPLEVADEGTYSCHLHHHYCGlHERRVFHLTV 190
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
83-171 2.65e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 2.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340   83 LTCVNRGHVWTDrhveeaqQVVHWDRQPPGvphdRADRLLdLYASGERRAYGPLFLRDRVAVGADaFERGDFSLRIEPLE 162
Cdd:smart00406   4 LSCKFSGSTFSS-------YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLR 70


                   ....*....
gi 1034559340  163 VADEGTYSC 171
Cdd:smart00406  71 VEDTGTYYC 79
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 114-171 1.75e-05

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 43.21  E-value: 1.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340 114 PHDRADRLLDLYASGerRAYGPLF--LRDRVAVgADAFERGDFSLRIEPLEVADEGTYSC 171
Cdd:cd20960    42 PSDKVEKVVITYSGD--RVYNHYYpaLKGRVAF-TSNDLSGDASLNISNLKLSDTGTYQC 98
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 73-171 4.75e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.24  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034559340  73 LAVARGAPALLTCVNRGHVWTDRhveeaqqvVHWDRQPPGVPHdradRLLdLYASGERRAYGPLFlRDRVAVGADafERG 152
Cdd:cd00099     8 LSVQEGESVTLSCEVSSSFSSTY--------IYWYRQKPGQGP----EFL-IYLSSSKGKTKGGV-PGRFSGSRD--GTS 71

                          90
                  ....*....|....*....
gi 1034559340 153 DFSLRIEPLEVADEGTYSC 171
Cdd:cd00099    72 SFSLTISNLQPEDSGTYYC 90
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 134-173 8.12e-04

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 38.30  E-value: 8.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034559340 134 GPLFLRDRVAVGADAFERGDFSLRIEPLEVADEGTYSCHL 173
Cdd:cd07690    47 GPSKLNDRADSRRNLWDQGSFPLIIKNLKIEDSDTYICEV 86
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 140-171 2.57e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 37.20  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034559340 140 DRVAVGADAFERGDFSLRIEPLEVADEGTYSC 171
Cdd:cd20934    64 NRTALFPDLLAQGNASLRLQRVRVADEGSYTC 95
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 149-185 5.59e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.00  E-value: 5.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034559340 149 FERGDFSLRIEPLEVADEGTYSCHLHHHYCGLHERRV 185
Cdd:cd00096    34 SELGNGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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