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Conserved domains on  [gi|1032030646|gb|ANG59336|]
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N-acetylglucosamine 6-sulfotransferase [Homo sapiens]

Protein Classification

sulfotransferase family protein( domain architecture ID 229543)

sulfotransferase family protein may utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to its substrate(s)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
179-357 6.64e-09

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 56.20  E-value: 6.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 179 FNLQVLYPLLSDPalNLRIVHLVRDPRAVLRSREQTAkalaRDNGIVLGTNGTWVEADPGLR--VVREVCRSHVRiaEAA 256
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF----RMAKLLKAPGTPFEFVEDFLNgkVNCGSYFDHVK--GWW 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 257 TLKPPPflrgRYRLVRFEDLAREPLAEIRALYAFTGLSLTP-QLEAWIHN----------------ITHGSGPGARREAF 319
Cdd:pfam00685 151 KLRPPG----NILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeELDKIVKHlsfenmkgnpclnyskLPKEVSPFFRKGLV 226

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1032030646 320 KTssrnalnvsqaWRHALPFAKIRRVQELCAGALQLLG 357
Cdd:pfam00685 227 GD-----------WKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
179-357 6.64e-09

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 56.20  E-value: 6.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 179 FNLQVLYPLLSDPalNLRIVHLVRDPRAVLRSREQTAkalaRDNGIVLGTNGTWVEADPGLR--VVREVCRSHVRiaEAA 256
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF----RMAKLLKAPGTPFEFVEDFLNgkVNCGSYFDHVK--GWW 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 257 TLKPPPflrgRYRLVRFEDLAREPLAEIRALYAFTGLSLTP-QLEAWIHN----------------ITHGSGPGARREAF 319
Cdd:pfam00685 151 KLRPPG----NILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeELDKIVKHlsfenmkgnpclnyskLPKEVSPFFRKGLV 226

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1032030646 320 KTssrnalnvsqaWRHALPFAKIRRVQELCAGALQLLG 357
Cdd:pfam00685 227 GD-----------WKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
179-357 6.64e-09

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 56.20  E-value: 6.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 179 FNLQVLYPLLSDPalNLRIVHLVRDPRAVLRSREQTAkalaRDNGIVLGTNGTWVEADPGLR--VVREVCRSHVRiaEAA 256
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF----RMAKLLKAPGTPFEFVEDFLNgkVNCGSYFDHVK--GWW 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 257 TLKPPPflrgRYRLVRFEDLAREPLAEIRALYAFTGLSLTP-QLEAWIHN----------------ITHGSGPGARREAF 319
Cdd:pfam00685 151 KLRPPG----NILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeELDKIVKHlsfenmkgnpclnyskLPKEVSPFFRKGLV 226

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1032030646 320 KTssrnalnvsqaWRHALPFAKIRRVQELCAGALQLLG 357
Cdd:pfam00685 227 GD-----------WKNYFTPEQAEKFDEIYQEKMKGTG 253
Sulfotransfer_3 pfam13469
Sulfotransferase family;
194-297 4.09e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 49.60  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032030646 194 NLRIVHLVRDP-RAVLRSReqtaKALARDNGIVLGTNGTWVEADPGLRVVRevcrsHVRIAEAATLKPPPflrGRYRLVR 272
Cdd:pfam13469  81 DAKFIHLHRDPvDTVISSY----CSLFGFTLSSYSTAFLRDIGLALARWSR-----AYERLMAARARVPP---GRFLDVR 148

                          90       100
                  ....*....|....*....|....*
gi 1032030646 273 FEDLAREPLAEIRALYAFTGLSLTP 297
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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