NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1031914749|gb|ANG55587|]
View 

glucocorticoid receptor, partial [Lamprotornis fischeri]

Protein Classification

glucocorticoid receptor( domain architecture ID 10490010)

glucocorticoid receptor (GR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily; it binds with high affinity to cortisol and other glucocorticoids. GR is expressed in almost every cell in the body and regulates genes controlling a wide variety of processes including the development, metabolism, and immune response of the organism

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GCR pfam02155
Glucocorticoid receptor;
1-320 1.16e-173

Glucocorticoid receptor;


:

Pssm-ID: 426625  Cd Length: 377  Bit Score: 485.92  E-value: 1.16e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749   1 MDFHPPFRGGATVQAPVSTSPLPASSQSQSSQQPALADFPKGLGNNVPQPDLSKAVSLSMGLYMGETDAKVMGNDLGFSH 80
Cdd:pfam02155   2 MDFNKTLRGGARIKSTASSAPLAVVSQSDSKQQPVLGDFSKGLSNNATQPDLSKAVSLSMGLYMGETDTKVMGNDLGFPQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749  81 QGQIGIPSGETDFRLLEESIASLNKSSSLAEDAKGAASSAA------PDFPGMAGRGGPAEPGAAVQSQVGSNGGTLKLF 154
Cdd:pfam02155  82 QGQISFSSGETDFRLLEESIASLNKSSSVPESLKGGVSPNLfplkteKDFPGMAKCDLSLEQDTFAQGQKGTNGGNLKLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 155 SEDQSTLDILQDLELPPVSPGKEPNGSPWRLDPLLDDGGLLSPISADDAFLLEGSLGEDCKPPLLSDTKPKINDRGDLL- 233
Cdd:pfam02155 162 SEDQSTFDILQDLELPPVSPGKETNGSPWRLDPLLDEGGLLSPLGADDPFLLEGNANEDCKPLILPDTKPKINETGDLLl 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 234 -PSSKMPMPQVKTEKEDYIELHTPGSIKQESTSPLYCQANFSSSSVLGTKVSAISIHGVSTSGGQMYHYDLNTASLSQQQ 312
Cdd:pfam02155 242 sSASTSQLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQAGFPGANILGNKVSAISIHGVSTSGGQMYHYDLNTASVSQQQ 321


                  ....*...
gi 1031914749 313 DQKPIFNI 320
Cdd:pfam02155 322 DQKPIFNM 329
 
Name Accession Description Interval E-value
GCR pfam02155
Glucocorticoid receptor;
1-320 1.16e-173

Glucocorticoid receptor;


Pssm-ID: 426625  Cd Length: 377  Bit Score: 485.92  E-value: 1.16e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749   1 MDFHPPFRGGATVQAPVSTSPLPASSQSQSSQQPALADFPKGLGNNVPQPDLSKAVSLSMGLYMGETDAKVMGNDLGFSH 80
Cdd:pfam02155   2 MDFNKTLRGGARIKSTASSAPLAVVSQSDSKQQPVLGDFSKGLSNNATQPDLSKAVSLSMGLYMGETDTKVMGNDLGFPQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749  81 QGQIGIPSGETDFRLLEESIASLNKSSSLAEDAKGAASSAA------PDFPGMAGRGGPAEPGAAVQSQVGSNGGTLKLF 154
Cdd:pfam02155  82 QGQISFSSGETDFRLLEESIASLNKSSSVPESLKGGVSPNLfplkteKDFPGMAKCDLSLEQDTFAQGQKGTNGGNLKLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 155 SEDQSTLDILQDLELPPVSPGKEPNGSPWRLDPLLDDGGLLSPISADDAFLLEGSLGEDCKPPLLSDTKPKINDRGDLL- 233
Cdd:pfam02155 162 SEDQSTFDILQDLELPPVSPGKETNGSPWRLDPLLDEGGLLSPLGADDPFLLEGNANEDCKPLILPDTKPKINETGDLLl 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 234 -PSSKMPMPQVKTEKEDYIELHTPGSIKQESTSPLYCQANFSSSSVLGTKVSAISIHGVSTSGGQMYHYDLNTASLSQQQ 312
Cdd:pfam02155 242 sSASTSQLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQAGFPGANILGNKVSAISIHGVSTSGGQMYHYDLNTASVSQQQ 321


                  ....*...
gi 1031914749 313 DQKPIFNI 320
Cdd:pfam02155 322 DQKPIFNM 329
 
Name Accession Description Interval E-value
GCR pfam02155
Glucocorticoid receptor;
1-320 1.16e-173

Glucocorticoid receptor;


Pssm-ID: 426625  Cd Length: 377  Bit Score: 485.92  E-value: 1.16e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749   1 MDFHPPFRGGATVQAPVSTSPLPASSQSQSSQQPALADFPKGLGNNVPQPDLSKAVSLSMGLYMGETDAKVMGNDLGFSH 80
Cdd:pfam02155   2 MDFNKTLRGGARIKSTASSAPLAVVSQSDSKQQPVLGDFSKGLSNNATQPDLSKAVSLSMGLYMGETDTKVMGNDLGFPQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749  81 QGQIGIPSGETDFRLLEESIASLNKSSSLAEDAKGAASSAA------PDFPGMAGRGGPAEPGAAVQSQVGSNGGTLKLF 154
Cdd:pfam02155  82 QGQISFSSGETDFRLLEESIASLNKSSSVPESLKGGVSPNLfplkteKDFPGMAKCDLSLEQDTFAQGQKGTNGGNLKLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 155 SEDQSTLDILQDLELPPVSPGKEPNGSPWRLDPLLDDGGLLSPISADDAFLLEGSLGEDCKPPLLSDTKPKINDRGDLL- 233
Cdd:pfam02155 162 SEDQSTFDILQDLELPPVSPGKETNGSPWRLDPLLDEGGLLSPLGADDPFLLEGNANEDCKPLILPDTKPKINETGDLLl 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031914749 234 -PSSKMPMPQVKTEKEDYIELHTPGSIKQESTSPLYCQANFSSSSVLGTKVSAISIHGVSTSGGQMYHYDLNTASLSQQQ 312
Cdd:pfam02155 242 sSASTSQLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQAGFPGANILGNKVSAISIHGVSTSGGQMYHYDLNTASVSQQQ 321


                  ....*...
gi 1031914749 313 DQKPIFNI 320
Cdd:pfam02155 322 DQKPIFNM 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH