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Conserved domains on  [gi|1026263879|gb|ANC88251|]
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dehydrogenase [Sphingomonas sp. NIC1]

Protein Classification

methanol/ethanol family PQQ-dependent dehydrogenase( domain architecture ID 10178893)

methanol/ethanol family PQQ-dependent dehydrogenase similar to Thauera butanivorans 1-butanol dehydrogenase (quinone) that catalyzes the oxidation of 1-butanol to 1-butanal and may function primarily in energy generation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 44-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


:

Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 887.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  44 LMNDAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGeKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARS 123
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 124 GEELWQYDARLPDGIMPCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIY 203
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 204 GNSGGEFGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKdstmtgklnaSWQGDQWKNGGGATWLGGTYDPDTNLIYMG 283
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 284 TGNPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDMD----GRKLGAKADRNGYFFVLD 359
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTkngkPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 360 RTNGKFVSANRFVSRTDWATGFTKDGKPIYDPAKRPPapsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGM 439
Cdd:cd10277   310 RTNGKLIWATPFVKKITWASIDLKTGRPIYDEDKVPP----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCM 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 440 DIWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAK 519
Cdd:cd10277   386 DLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAK 465

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 520 TGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKAVQHINQGGALWVFKL 583
Cdd:cd10277   466 TGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 44-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 887.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  44 LMNDAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGeKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARS 123
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 124 GEELWQYDARLPDGIMPCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIY 203
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 204 GNSGGEFGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKdstmtgklnaSWQGDQWKNGGGATWLGGTYDPDTNLIYMG 283
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 284 TGNPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDMD----GRKLGAKADRNGYFFVLD 359
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTkngkPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 360 RTNGKFVSANRFVSRTDWATGFTKDGKPIYDPAKRPPapsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGM 439
Cdd:cd10277   310 RTNGKLIWATPFVKKITWASIDLKTGRPIYDEDKVPP----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCM 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 440 DIWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAK 519
Cdd:cd10277   386 DLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAK 465

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 520 TGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKAVQHINQGGALWVFKL 583
Cdd:cd10277   466 TGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 43-556 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 856.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  43 DLMNDAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGgeKQRGQEAQPIVYDGVIYVTGSYSRLFAFDAR 122
Cdd:TIGR03075  10 DLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVYALDAK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 123 SGEELWQYDARLPDGIMP--CCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGK 200
Cdd:TIGR03075  88 TGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVKGK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 201 VIYGNSGGEFGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKDSTMTGKLNA-SWQGDQWKNGGGATWLGGTYDPDTNL 279
Cdd:TIGR03075 168 VITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAkTWPGDAWKTGGGATWGTGSYDPETNL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 280 IYMGTGNPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYF 355
Cdd:TIGR03075 248 IYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLkkDGkpRKLLAHADRNGFF 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 356 FVLDRTNGKFVSANRFVSRTDWATGF-TKDGKPIYDPAKRPPAPsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPS 434
Cdd:TIGR03075 328 YVLDRTNGKLLSAEPFVDKVNWATGVdLKTGRPIEVPEARSTDG--KKGKPVEVCPGFLGGKNWQPMAYSPKTGLFYVPA 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 435 NEWGMDIWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLK 514
Cdd:TIGR03075 406 NHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLEGYFK 485

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1026263879 515 AFDAKTGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGG 556
Cdd:TIGR03075 486 AFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
50-584 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 726.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  50 TPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGEKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQ 129
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 130 YDARLPDGIMpCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIYGNSGGE 209
Cdd:COG4993    81 YDPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 210 FGIVGKVEARDVNTGELIWSRPTIEGHmgqlngkdstmTGKLNASWQ-GDQWKNGGGATWLGGTYDPDTNLIYMGTGNPA 288
Cdd:COG4993   160 FGPRGVVRAYDARTGKLVWRFDTIPDP-----------GEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 289 P-WNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYFFVLDRTNG 363
Cdd:COG4993   229 PdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLpvDGktRKALVQATKNGFIYVLDRETG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 364 KFVSANRFVSRTDWATGFTKDGkpiYDPAKRPPApsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGMDIWN 443
Cdd:COG4993   309 EPLVTQPFVKPPNWATEIDMWG---ATPIQTPPS---LDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYEL 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 444 EPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQE 523
Cdd:COG4993   383 VPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKE 462

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026263879 524 LWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGgevakavqHINQGGALWVFKLP 584
Cdd:COG4993   463 LWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGL--------YTPQGDYLIAFALP 515
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 100-240 1.91e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 75.90  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMpccdVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNK 179
Cdd:pfam13360  69 PLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEA 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026263879 180 TLA------PYDAGYSFTAAPMIVKGKVIYGNSGGEFGivgkveARDVNTGELIWSRPtIEGHMGQL 240
Cdd:pfam13360 145 PLAaprgtnELERLVDITGTPVVAGGRVFASAYQGRLV------AFDAATGRRLWTRE-ISGPNGPI 204
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 100-229 1.49e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 60.33  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMPccdvVNRGAAIYG------DKIIFGTLDAHMVALNRKTG 173
Cdd:PRK11138   65 PAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS----KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1026263879 174 KVIWNKTlapydAGYSFTAAPMIVKGKVIYGNSGgefgivGKVEARDVNTGELIWS 229
Cdd:PRK11138  141 EVAWQTK-----VAGEALSRPVVSDGLVLVHTSN------GMLQALNESDGAVKWT 185
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 499-528 4.37e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.90  E-value: 4.37e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1026263879  499 TAGNLVFTGTPEGYLKAFDAKTGQELWKFN 528
Cdd:smart00564   4 LSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 44-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 887.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  44 LMNDAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGeKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARS 123
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 124 GEELWQYDARLPDGIMPCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIY 203
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 204 GNSGGEFGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKdstmtgklnaSWQGDQWKNGGGATWLGGTYDPDTNLIYMG 283
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 284 TGNPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDMD----GRKLGAKADRNGYFFVLD 359
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTkngkPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 360 RTNGKFVSANRFVSRTDWATGFTKDGKPIYDPAKRPPapsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGM 439
Cdd:cd10277   310 RTNGKLIWATPFVKKITWASIDLKTGRPIYDEDKVPP----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCM 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 440 DIWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAK 519
Cdd:cd10277   386 DLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAK 465

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 520 TGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKAVQHINQGGALWVFKL 583
Cdd:cd10277   466 TGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 43-556 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 856.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  43 DLMNDAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGgeKQRGQEAQPIVYDGVIYVTGSYSRLFAFDAR 122
Cdd:TIGR03075  10 DLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVYALDAK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 123 SGEELWQYDARLPDGIMP--CCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGK 200
Cdd:TIGR03075  88 TGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVKGK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 201 VIYGNSGGEFGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKDSTMTGKLNA-SWQGDQWKNGGGATWLGGTYDPDTNL 279
Cdd:TIGR03075 168 VITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAkTWPGDAWKTGGGATWGTGSYDPETNL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 280 IYMGTGNPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYF 355
Cdd:TIGR03075 248 IYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLkkDGkpRKLLAHADRNGFF 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 356 FVLDRTNGKFVSANRFVSRTDWATGF-TKDGKPIYDPAKRPPAPsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPS 434
Cdd:TIGR03075 328 YVLDRTNGKLLSAEPFVDKVNWATGVdLKTGRPIEVPEARSTDG--KKGKPVEVCPGFLGGKNWQPMAYSPKTGLFYVPA 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 435 NEWGMDIWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLK 514
Cdd:TIGR03075 406 NHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLEGYFK 485

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1026263879 515 AFDAKTGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGG 556
Cdd:TIGR03075 486 AFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
50-584 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 726.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  50 TPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGEKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQ 129
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 130 YDARLPDGIMpCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIYGNSGGE 209
Cdd:COG4993    81 YDPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 210 FGIVGKVEARDVNTGELIWSRPTIEGHmgqlngkdstmTGKLNASWQ-GDQWKNGGGATWLGGTYDPDTNLIYMGTGNPA 288
Cdd:COG4993   160 FGPRGVVRAYDARTGKLVWRFDTIPDP-----------GEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 289 P-WNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYFFVLDRTNG 363
Cdd:COG4993   229 PdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLpvDGktRKALVQATKNGFIYVLDRETG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 364 KFVSANRFVSRTDWATGFTKDGkpiYDPAKRPPApsaEKGASVFAAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGMDIWN 443
Cdd:COG4993   309 EPLVTQPFVKPPNWATEIDMWG---ATPIQTPPS---LDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYEL 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 444 EPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQE 523
Cdd:COG4993   383 VPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKE 462

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026263879 524 LWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGgevakavqHINQGGALWVFKLP 584
Cdd:COG4993   463 LWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGL--------YTPQGDYLIAFALP 515
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 52-583 8.95e-179

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 516.43  E-value: 8.95e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  52 GDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGEkqRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYD 131
Cdd:cd10279     1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTN--RGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 132 ARLPDGIM--PCCDVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIYGNSGGE 209
Cdd:cd10279    79 PEVDRESGrkACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 210 FGIVGKVEARDVNTGELIWSRPTIEGHMGQLNGKDStMTGKLNASWQGDQWKNGGGAT-WLGGTYDPDTNLIYMGTGNPA 288
Cdd:cd10279   159 FGVRGYVSAYDAETGKLVWRFYTVPGNPAKPFEHAS-LEAAAATWWTGEWWRTGGGGTvWDSITYDPELDLLYIGTGNGS 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 289 PWNSHLRP---GNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYFFVLDRT 361
Cdd:cd10279   238 PWNRKVRSpggGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLeiDGkpRKVLMHAPKNGFFYVLDRA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 362 NGKFVSANRFVsRTDWATGF-TKDGKPIYDPAKRPPapsaEKGASVFaaPSFLGGKNWMPMAYSQQTGMFYIPSNEWGMD 440
Cdd:cd10279   318 TGKLLSAEPFV-PVNWATGIdLKTGRPIENPEARYT----KGPKLVF--PGPLGAHNWHPMSYNPDTGLVYIPAQEIPAV 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 441 IWNEPIAYKK--GAAYLGAGFTIKPLNPDYI--------GVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPE 510
Cdd:cd10279   391 YEDDPGDFGYnpLGWNTGITPDATPPPAAAKralrkatrGRLVAWDPVTQKAAWRVEHPGPWNGGVLATAGNLVFQGTAD 470

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1026263879 511 GYLKAFDAKTGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKAVQHINQGGaLWVFKL 583
Cdd:cd10279   471 GELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGAGALSGGPPGAAGKVQNPGR-LLVFKL 542
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 63-583 1.24e-177

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 513.80  E-value: 1.24e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  63 AQRFSTLTQVNAANVARLVPAFSASLGgeKQRGQEAQPIVYDGVIYVTGSY-SRLFAFD-ARSGEELWQYDARLPDGIMP 140
Cdd:cd10278    10 NTRYSPLAQINKDNVKNLKVAWTFSTG--VLRGHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGKILWKYKPKQDPSAVA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 141 --CCDVVNRGAAiYGD-KIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIYGNSGGEFGIVGKVE 217
Cdd:cd10278    88 vaCCDVVNRGLA-YADgKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEFGVRGYVT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 218 ARDVNTGELIWSR------------PTIEGHMGQLNGKDSTMTgklnaSWQGDQWKNGGGATWLGGTYDPDTNLIYMGTG 285
Cdd:cd10278   167 AYDLKTGKLVWRAystgpdkdvligPDFNPFNPHDGGKDLGLS-----TWPGDAWKIGGGTNWGWYSYDPKLNLVYYGTG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 286 NPAPWNSHLRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDGVNEFIPFDM--DG--RKLGAKADRNGYFFVLDRT 361
Cdd:cd10278   242 NPGPWNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQtvDGkkRKLLVHFDRNGFVYTLDRT 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 362 NGKFVSANRFVSrTDWATGFT-KDGKPIYDPAKRPPAPSAEKGAsvfaAPSFLGGKNWMPMAYSQQTGMFYIPSNEWGMD 440
Cdd:cd10278   322 TGELLSAEKFDP-VNNWKGVDlKTGRPVKDPEKSTHMDHNVTDI----CPSAMGGKDQQPSSYSPKTGLFYVPTNHLCMD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 441 IWNEPIAYKKGAAYLGAGFTIKPLNPDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKT 520
Cdd:cd10278   397 YEPFEVNYTAGQPYVGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVDAKT 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026263879 521 GQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGG--AVPLWG------------GEVAKAVQHINQGGALWVFKL 583
Cdd:cd10278   477 GKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGwaGVGVAAglrdptaglgavGAFKDLPNYTQMGGTLYVFSL 553
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 74-582 2.88e-156

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 454.76  E-value: 2.88e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  74 AANVARLVPAFSASLGGEKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDG-IMPCCDVVNRGAAIY 152
Cdd:cd00216     1 ADNVFQLTPAWSFSTGDGGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwFEACCDLVNRGVAVW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 153 GDKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFTAAPMIVKGKVIYGNSGGEFGIVGKVEARDVNTGELIWSRPT 232
Cdd:cd00216    81 GGKVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 233 IEGHMGQLNGKDSTMTGKLNASWQGDQWKNGGGATWLGGTYDPDTNLIYMGTGNPAPWN--SHLRPGNNLYTSSTLAIDP 310
Cdd:cd00216   161 VMPDPNLLPGKDSTVTDRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWNwgGNRTPGDNLYTSSIVAVNA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 311 DTGEIKWHYQTTPHDGWDFDGVNEFIPFDM----DGRKLGAKADRNGYFFVLDRTNGKFVSANRFVsrtdwatgftkdgk 386
Cdd:cd00216   241 DTGEMKWQYQTTPHDAWDYDGDNTPVLADIkvkgKKVKVLFAPAKNGNFYVLDRRNGELVSARPLV-------------- 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 387 piydpakrppapsaekgasvfaapsflggknwmPMAYSQQTGMFYIPSNewgmdiwnepiaykkgaaylgagftikplnp 466
Cdd:cd00216   307 ---------------------------------PDSYDPDRELFYVPAN------------------------------- 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 467 dyiGVLRAMDPKTGKIAWEYKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTWEQDGEQ 546
Cdd:cd00216   323 ---GRIMALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDGEQ 399

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1026263879 547 YVAVMSGWGGAVPLWGGeVAKAVQHINQGGALWVFK 582
Cdd:cd00216   400 YVLIQAGGGGAFPLWGG-MADLTRGTQMGGTVVVYK 434
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 56-556 8.74e-83

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 270.99  E-value: 8.74e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  56 TYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGEKQRGQ-----EAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQY 130
Cdd:cd10280     3 AYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPDGnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELWRF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 131 D----ARLPDGIMPCcdvvnRGAAIYGDK---------IIFGTLDAHMVALNRKTGKVIW----------NKTLAPYDAG 187
Cdd:cd10280    83 DpkagADAAPGHQTC-----RGVSYWEDGaaaaacarrIFFGTGDARLIALDARTGKPCPdfgdngvvdlREGLGRVKPG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 188 -YSFTAAPMIVKGKVIYGNSGGEFGIV----GKVEARDVNTGELIWSRptiegHMGQLNGKDSTMTGklnaswqgDQWKN 262
Cdd:cd10280   158 fYSSTSPPTVYGDLVIVGSAVADNQAVdapsGVIRAFDVRTGKLVWAF-----DTIPPPGEAGPDTA--------GAWYT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 263 GGGA-TWLGGTYDPDTNLIYMGTGNPAP--WNSHlRPGNNLYTSSTLAIDPDTGEIKWHYQTTPHDGWDFDgvnefIP-- 337
Cdd:cd10280   225 RGGPnVWAGMSADEKLGLVYLPTGSATPdfYGGD-RPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYD-----LPaq 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 338 -----FDMDGRKLGA--KADRNGYFFVLDRTNGK------------------------------------FVSANRFVSR 374
Cdd:cd10280   299 ptlvdVPRDGKTVPAvaQPTKQGFVFVLDRRTGKplwpveerpvpqgdvpgertsptqpfptlpppfarqGLTEDDMWGA 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 375 TDWATGFTKD--GKPIYDPAKRPPapsAEKGASVFaaPSFLGGKNWMPMAYSQQTGMFYIPSNEWGMDIW------NEPI 446
Cdd:cd10280   379 TPFDQLACRIqfRSLRYEGLFTPP---SLDGTLIF--PGNDGGANWGGAAVDPERGILYVNSNRLPFVIQlvprapGDPA 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 447 AYKKGAAYLGAGFTIKPLNPDYIGV--------------------LRAMDPKTGKIAW-----EYKNKAPL--------- 492
Cdd:cd10280   454 GVAGGGEGGGGGGGPSPQAGTPYGVgrgrflsplglpcqappwgtLTAIDLNTGKILWqvplgTVPDLGPKgiplpiptg 533

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1026263879 493 ---WGGVLTTAGNLVFTG-TPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTWEQDGEQYVAVMSGWGG 556
Cdd:cd10280   534 tpnLGGPVVTAGGLVFIAaTQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHG 601
PQQ_membr_DH TIGR03074
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ...
 47-553 1.86e-47

membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.


Pssm-ID: 274418 [Multi-domain]  Cd Length: 764  Bit Score: 177.50  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  47 DAATPGDVLTYGMGPRAQRFSTLTQVNAANVARLVPAFSASLGGEKQRGQ------EAQPIVYDGVIYVTGSYSRLFAFD 120
Cdd:TIGR03074 131 PAVPAGDWAAYGRTQAGQRYSPLDQINPDNVGNLKVAWTYHTGDLKTPDDpgeatfQATPLKVGDTLYLCTPHNKVIALD 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 121 ARSGEELWQYDARLPDGIMP----CcdvvnRGAAIYGD------------------KIIFGTLDAHMVALNRKTGKV--- 175
Cdd:TIGR03074 211 AATGKEKWKFDPKLKTEADRqhqtC-----RGVSYYDApaaaagpagpaapadcarRIILPTSDARLIALDADTGKLced 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 176 --------IWNKTLAPYDAGYSFTAAPMIVKGKVIYGN------SGGEFGivGKVEARDVNTGELIW----SRPTIeghm 237
Cdd:TIGR03074 286 fgnngtvdLTAGMGPTPPGYYYPTSPPLVAGTTVVIGGrvadnySTDEPS--GVIRAFDVNTGALVWawdpGNPDP---- 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 238 gqlngkdstmTGKLNAswqGDQWKNGGGATWLGGTYDPDTNLIYMGTGNPAP--WNSHLRPGNNLYTSSTLAIDPDTGEI 315
Cdd:TIGR03074 360 ----------TAPPAP---GETYTRNSPNSWSVASYDEKLGLVYLPMGNQTPdqWGGDRTPADEKYSSSLVALDATTGKE 426

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 316 KWHYQTTPHDGWDFDGVNEFIPFDM---DGRKLGA--KADRNGYFFVLDRTNGK-FVSAN-RFVSRTDWATGFTKDGKPI 388
Cdd:TIGR03074 427 RWVFQTVHHDLWDMDVPAQPSLVDLpkaDGTTVPAlvAPTKQGQIYVLDRRTGEpIVPVEeVPVPQGAVPGERYSPTQPF 506

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 389 YDPAKRPPA-------------------------------PSAEKGASVFaaPSFLGGKNWMPMAYSQQTGMFYIPSNEW 437
Cdd:TIGR03074 507 SVLTFGPPTltesdmwgatpfdqlacriqfkslryeglytPPSEQGSLVF--PGNLGGFNWGGVAVDPTRQVMFVNPMRL 584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 438 G-------MDIWNEP------------IAYKKGAAY-------LGAgFTIKPLNPDYiGVLRAMDPKTGKIAWEYKNKA- 490
Cdd:TIGR03074 585 PfvsqlvpRAPGDEApsgakgkgtemgLNPNKGTPYavnmnpfLSP-LGIPCQAPPW-GYMAAIDLKTGKVVWQHPNGTv 662

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 491 ------------------PLWGGVLTTAGNLVF-TGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTW-EQDGEQYVAV 550
Cdd:TIGR03074 663 rdtgpmgipmplpipigvPTLGGPLATAGGLVFiGATQDNYLRAYDLSTGKELWEARLPAGGQATPMTYmGKDGKQYVVI 742


                  ...
gi 1026263879 551 MSG 553
Cdd:TIGR03074 743 VAG 745
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 100-319 1.22e-16

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 81.61  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQydARLPDGImpccdvVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNK 179
Cdd:cd10276    76 PAVGNGKIFVGTESGYLYALDAKDGSELWR--TEVSDSQ------LLSPPTYADGKIYVGTGDGRLYYCNAETGKVVWNR 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 180 TLAPYDAGYSFTAAPMIVKGKVIYGNSGgefgivGKVEARDVNTGELIWSRPTIEGH-MGQLNGK-DSTMTGKLN----- 252
Cdd:cd10276   148 TSTAPELSLRGGAAPVGAYDVVFVGDGN------GTVVALNTGTGVDIWEFSVSEPRgRTELPRMiDSSVTYVVVggyly 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 253 -ASWQGDQWKngggatwlggtYDPDTNLIY------MGTGNPAPWNSHLRPGNNlyTSSTLAIDPDTGEIKWHY 319
Cdd:cd10276   222 sTSYQGYLVA-----------LDFESGQFLwsrkasGGTSTSTDANGRVYVGDG--EGSLYCLDASTGDELWSQ 282
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 69-366 8.28e-16

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 79.47  E-value: 8.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  69 LTQVNAAnvARLVPAFSASLGGEKQRGQEA-QPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPdgimpccdvVNR 147
Cdd:COG1520    23 LPEFEPS--VKVKQLWSASVGDGVGKGYSRlAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP---------LSG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 148 GAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTL------AP-YDAG-----------YSF------------------- 190
Cdd:COG1520    92 GVGADGGLVVVGTEDGEVIALDADDGEELWRARLssevlaAPaVAGGrvvvrtgdgrvYALdaatgerlwsyqrpvpalt 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 191 ---TAAPMIVKGKVIYGNSGgefgivGKVEARDVNTGELIW--------------------SRPTIEGHM-------GQL 240
Cdd:COG1520   172 lrgTSSPVIVGGAVLVGFAN------GKLVALDLANGQPLWeqrvaqprgrtelerlvdvdGTPVVDGGVvyavayqGRL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 241 NGKDSTmTGKLnaswqgdQWKNGggatwLGGTYDPDTNliymgtgnpapwnshlrpGNNLYTSST----LAIDPDTGEIK 316
Cdd:COG1520   246 AALDLR-SGRV-------LWSRD-----LSSYTGLAVD------------------GNNLYVTDDdgrvWALDRRNGAEL 294

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1026263879 317 WhyqttphdgwdfdgVNEfipfDMDGRKLGAKA---------DRNGYFFVLDRTNGKFV 366
Cdd:COG1520   295 W--------------KQD----ALLYRGLTAPVvlgdyvvvgDFEGYLHWLSRDDGSLV 335
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 100-240 1.91e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 75.90  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMpccdVVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNK 179
Cdd:pfam13360  69 PLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEA 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026263879 180 TLA------PYDAGYSFTAAPMIVKGKVIYGNSGGEFGivgkveARDVNTGELIWSRPtIEGHMGQL 240
Cdd:pfam13360 145 PLAaprgtnELERLVDITGTPVVAGGRVFASAYQGRLV------AFDAATGRRLWTRE-ISGPNGPI 204
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 83-367 5.71e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 67.65  E-value: 5.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  83 AFSASLG-GEKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPdgimpccdvVNRGAAIYGDKIIFGTL 161
Cdd:TIGR03300  43 VWSASVGdGVGHYYLRLQPAVAGGKVYAADADGTVAALDAETGKRLWRVDLDER---------LSGGVGADGGLVFVGTE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 162 DAHMVALNRKTGKVIWNKTLapydaGYSFTAAPMIVKGKVIYGNSGgefgivGKVEARDVNTGELIW------------- 228
Cdd:TIGR03300 114 KGEVIALDAEDGKELWRAKL-----SSEVLSPPLVANGLVVVRTND------GRLTALDAATGERLWtysrvtppltlrg 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 229 -SRPTIEG---HMGQLNGKDST---MTGKLnaSWQGdQWKNGGGATWLGGTYDPDtnliymgtGNPapwnshLRPGNNLY 301
Cdd:TIGR03300 183 sASPVIADggvLVGFAGGKLVAldlQTGQP--LWEQ-RVALPKGRTELERLVDVD--------GDP------VVDGGQVY 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 302 TSS----TLAIDPDTGEIKWH----------------YQTTPHD---GWDF-DGVNEFIPFDMDGRKLGAKA-------- 349
Cdd:TIGR03300 246 AVSyqgrVAALDLRSGRVLWKrdassyqgpavddnrlYVTDADGvvvALDRrSGSELWKNDELKYRQLTAPAvlggylvv 325

                         330
                  ....*....|....*....
gi 1026263879 350 -DRNGYFFVLDRTNGKFVS 367
Cdd:TIGR03300 326 gDFEGYLHWLDRDDGSFVA 344
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 466-539 7.68e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 67.26  E-value: 7.68e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 466 PDYIGVLRAMDPKTGKIAWEYKNKAPLWGGVlTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVT 539
Cdd:TIGR03300  71 ADADGTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPLV 143
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 470-553 4.35e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 64.83  E-value: 4.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAPLWGGVlTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTweqdGEQYVA 549
Cdd:COG1520    67 GRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPAV----AGGRVV 141


                  ....
gi 1026263879 550 VMSG 553
Cdd:COG1520   142 VRTG 145
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 98-229 3.19e-10

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 60.49  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  98 AQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMPCCDVVNRGAA--IYGDKIIFGTLDAHMVALNRKTGKV 175
Cdd:pfam13360 112 GSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVDITGTpvVAGGRVFASAYQGRLVAFDAATGRR 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1026263879 176 IWNKTLAPYDagysftaaPMIVKGKVIYGNSGGefgivGKVEARDVNTGELIWS 229
Cdd:pfam13360 192 LWTREISGPN--------GPILDGDLLYVVSDD-----GELYALDRATGAVVWK 232
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 81-231 1.25e-09

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 60.33  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  81 VPAFSASLGGEKQRGQ---E--AQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMpccdvvnRGAA---IY 152
Cdd:TIGR03300 117 VIALDAEDGKELWRAKlssEvlSPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTPPLTL-------RGSAspvIA 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 153 GDKIIFGTLDAHMVALNRKTGKVIWNKTLApYDAGYS-------FTAAPMIVKGKViygnsggeFGIV--GKVEARDVNT 223
Cdd:TIGR03300 190 DGGVLVGFAGGKLVALDLQTGQPLWEQRVA-LPKGRTelerlvdVDGDPVVDGGQV--------YAVSyqGRVAALDLRS 260


                  ....*...
gi 1026263879 224 GELIWSRP 231
Cdd:TIGR03300 261 GRVLWKRD 268
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 100-229 1.49e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 60.33  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMPccdvVNRGAAIYG------DKIIFGTLDAHMVALNRKTG 173
Cdd:PRK11138   65 PAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS----KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1026263879 174 KVIWNKTlapydAGYSFTAAPMIVKGKVIYGNSGgefgivGKVEARDVNTGELIWS 229
Cdd:PRK11138  141 EVAWQTK-----VAGEALSRPVVSDGLVLVHTSN------GMLQALNESDGAVKWT 185
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 470-553 1.84e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 58.18  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAPLWGGVlTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPvtwEQDGEQYVA 549
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP---LVAGGRVFV 78


                  ....
gi 1026263879 550 VMSG 553
Cdd:pfam13360  79 VAGD 82
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 466-539 4.12e-09

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 58.50  E-value: 4.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1026263879 466 PDYIGVLRAMDPKTGKIAWEYK-NKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVT 539
Cdd:cd10276    44 ADANGQVSAFNATTGKIIWETSlSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPT 118
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 114-317 1.07e-08

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 55.87  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 114 SRLFAFDARSGEELWQYDARLPdgimpccdvVNRGAAIYGDKIIFGTLDAHMVALNRKTGKVIWNKTL------APY--- 184
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETG---------LGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLsgevlgAPLvag 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 185 ------DAGYSFTA-------------------------APMIVKGKVIYGNSGgefgivGKVEARDVNTGELIWSRPTI 233
Cdd:pfam13360  74 grvfvvAGDGSLIAldaadgrrlwsyqrsgeplalrssgSPAVVGDTVVAGFSS------GKLVALDPATGKVRWEAPLA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 234 EGH-------MGQLNGKDSTMTGKLNASwqgdqwkNGGGATwlgGTYDPDTNLIYMgTGNPAPWNSHLRPGNNLYTSST- 305
Cdd:pfam13360 148 APRgtnelerLVDITGTPVVAGGRVFAS-------AYQGRL---VAFDAATGRRLW-TREISGPNGPILDGDLLYVVSDd 216

                         250
                  ....*....|....*
gi 1026263879 306 ---LAIDPDTGEIKW 317
Cdd:pfam13360 217 gelYALDRATGAVVW 231
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 470-579 4.00e-08

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 55.71  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWE----------YKNKAPLWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQELWK------------- 526
Cdd:PRK11138   79 GLVKALDADTGKEIWSvdlsekdgwfSKNKSALLSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQtkvagealsrpvv 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026263879 527 ------FNTGSGVV-------GSPV-TWEQD-------GEQYVAVMSG---WGGAvplwGGEVAKAVqhINQGGALW 579
Cdd:PRK11138  159 sdglvlVHTSNGMLqalnesdGAVKwTVNLDvpsltlrGESAPATAFGgaiVGGD----NGRVSAVL--MEQGQLIW 229
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 85-538 1.05e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 54.26  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  85 SASLGGEKQRGQEAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDarLPDGIMpccdvVNRGAAIYGDKIIFGTLDAH 164
Cdd:cd10276    19 SKSVGNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETS--LSGKGF-----LGGTPAVGNGKIFVGTESGY 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 165 MVALNRKTGKVIWNKTLAPYdagySFTAAPMIVKGKVIYGNSGGefgivgKVEARDVNTGELIWSRPtieghmgqlngkD 244
Cdd:cd10276    92 LYALDAKDGSELWRTEVSDS----QLLSPPTYADGKIYVGTGDG------RLYYCNAETGKVVWNRT------------S 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 245 STMTGKLnaswqgdqwknGGGATWLGgtydpdTNLIYMGTGNpapwNSHLrpgnnlytsstLAIDPDTGEIKWhyqttph 324
Cdd:cd10276   150 TAPELSL-----------RGGAAPVG------AYDVVFVGDG----NGTV-----------VALNTGTGVDIW------- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 325 dgwDFDGVNEFipfdmdGRKLGAKADRngyffvldrtngkfvsanrfVSRTdwatgftkdgkpiydpakrppapsaekga 404
Cdd:cd10276   191 ---EFSVSEPR------GRTELPRMID--------------------SSVT----------------------------- 212

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 405 svfaapsflggknwmpmaYSQQTGMFYIpsnewgmdiwnepiaykkgAAYLGAGFtikplnpdyigvlrAMDPKTGKIAW 484
Cdd:cd10276   213 ------------------YVVVGGYLYS-------------------TSYQGYLV--------------ALDFESGQFLW 241

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1026263879 485 EYKNKAplWGGVLTTAGNLVFTGTPEGYLKAFDAKTGQELWKFN-TGSGVVGSPV 538
Cdd:cd10276   242 SRKASG--GTSTSTDANGRVYVGDGEGSLYCLDASTGDELWSQTvLLGRVLSSPA 294
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 502-537 1.79e-07

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 47.57  E-value: 1.79e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1026263879 502 NLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSP 537
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 470-525 1.26e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 50.97  E-value: 1.26e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAP---LWG-GVLTTAGNLVFTGTPEGYLKAFDAKTGQELW 525
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPaltLRGtSSPVIVGGAVLVGFANGKLVALDLANGQPLW 206
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 470-550 5.57e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 48.78  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAP---LWG-GVLTTAGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSG-----------VV 534
Cdd:TIGR03300 155 GRLTALDAATGERLWTYSRVTPpltLRGsASPVIADGGVLVGFAGGKLVALDLQTGQPLWEQRVALPkgrtelerlvdVD 234

                          90
                  ....*....|....*.
gi 1026263879 535 GSPVTweqDGEQYVAV 550
Cdd:TIGR03300 235 GDPVV---DGGQVYAV 247
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 100-208 8.86e-06

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 48.10  E-value: 8.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDgimpccdvVNRGAAIY-GDKIIFGTL-DAHMVALNRKTGKViw 177
Cdd:cd10276   252 STDANGRVYVGDGEGSLYCLDASTGDELWSQTVLLGR--------VLSSPAIYvGVYIYVTDNaEGYLYCLKDNDGLT-- 321

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1026263879 178 NKTLAPYDAGYSfTAAPMIVKGKVIYGNSGG 208
Cdd:cd10276   322 VARVEVDYSQYI-LQGPAVSDGWLYYGTDDG 351
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 97-177 4.78e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 45.09  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  97 EAQPIVYDGVIYVTGSYSRLFAFDARSGEELWqydARLPDGIMpccdvvnrGAAIYGDKIIFGTLDAHMVALNRKTGKVI 176
Cdd:pfam13360 162 TGTPVVAGGRVFASAYQGRLVAFDAATGRRLW---TREISGPN--------GPILDGDLLYVVSDDGELYALDRATGAVV 230


                  .
gi 1026263879 177 W 177
Cdd:pfam13360 231 W 231
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 470-525 6.71e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 44.70  E-value: 6.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAPLwGGVLTTAGNLVFTGTPEGYLKAFDAKTGQELW 525
Cdd:pfam13360  43 GQLVALDAATGKLLWRQTLSGEV-LGAPLVAGGRVFVVAGDGSLIALDAADGRRLW 97
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 71-230 7.21e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 45.31  E-value: 7.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879  71 QVNAANVARLVPAFSASLGGEKQrgqeAQPIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMpccdvvnRG-- 148
Cdd:PRK11138  131 QVYALNAEDGEVAWQTKVAGEAL----SRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVPSLTL-------RGes 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 149 --AAIYGdKIIFGTLDAHMVALNRKTGKVIWNKTLAPYDAGYSFT------AAPMIVkGKVIYGnsggeFGIVGKVEARD 220
Cdd:PRK11138  200 apATAFG-GAIVGGDNGRVSAVLMEQGQLIWQQRISQPTGATEIDrlvdvdTTPVVV-GGVVYA-----LAYNGNLVALD 272

                         170
                  ....*....|
gi 1026263879 221 VNTGELIWSR 230
Cdd:PRK11138  273 LRSGQIVWKR 282
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 100-208 1.45e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 44.42  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYDARLpdgimpccdvvNRG---AAIYGDKIIFGTLDAHMVALNRKTGKVI 176
Cdd:COG1520   267 LAVDGNNLYVTDDDGRVWALDRRNGAELWKQDALL-----------YRGltaPVVLGDYVVVGDFEGYLHWLSRDDGSLV 335

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1026263879 177 WNKTLapydAGYSFTAAPMIVKGKVI-YGNSGG 208
Cdd:COG1520   336 ARLRV----DGSGIRAAPVVVGDTLYvQTRDGT 364
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 470-525 1.55e-04

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 43.55  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 470 GVLRAMDPKTGKIAWEYKNKAPLW----GGVLTTAGNLVFTGTPEGYLKAFDAKTGQELW 525
Cdd:pfam13360  83 GSLIALDAADGRRLWSYQRSGEPLalrsSGSPAVVGDTVVAGFSSGKLVALDPATGKVRW 142
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 470-529 3.12e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 43.26  E-value: 3.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1026263879 470 GVLRAMDPKTGKIAWeyknKAPLWGGVLTT---AGNLVFTGTPEGYLKAFDAKTGQELWKFNT 529
Cdd:COG1520   107 GEVIALDADDGEELW----RARLSSEVLAApavAGGRVVVRTGDGRVYALDAATGERLWSYQR 165
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 481-553 3.94e-04

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 43.09  E-value: 3.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026263879 481 KIAWEYKNKAPLWGGVLTT---AGNLVFTGTPEGYLKAFDAKTGQELWKFNT-GSGVVGSPVTWEqDGEQYVAVMSG 553
Cdd:cd10276    15 EVLWSKSVGNGGMAGIDLTpvvAGDMVYAADANGQVSAFNATTGKIIWETSLsGKGFLGGTPAVG-NGKIFVGTESG 90
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 500-550 4.10e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 42.88  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1026263879 500 AGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTweqdGEQYVAV 550
Cdd:COG1520    56 AGDRVYAADADGRVAALDAATGKELWRVDLGEPLSGGVGA----DGGLVVV 102
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 499-528 4.37e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.90  E-value: 4.37e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1026263879  499 TAGNLVFTGTPEGYLKAFDAKTGQELWKFN 528
Cdd:smart00564   4 LSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 100-131 4.87e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.51  E-value: 4.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1026263879  100 PIVYDGVIYVTGSYSRLFAFDARSGEELWQYD 131
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 104-231 6.26e-04

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 42.09  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 104 DGVIYVTGSYSRLFAFDARSGE--------ELWQYDARLPDGIMPCCDVVNrgaAIYGDKIIFGTLDAHMVALNRKTGKV 175
Cdd:cd09213    93 DDVVVVGSKRTSVFALDAKTGKiiktyradGLPSTGGSDSDGNSTPGPDEL---QEEEELLYIGRTDYVLQAIDPRSGKE 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1026263879 176 IWNKTLAPYDAGYSFTAAPMIVK-GKVIYGNSGG-EFGIVGKVEARDVNTGELIWSRP 231
Cdd:cd09213   170 LWNVTYGEYEALTLDADELGTSSsSSPLSASFRIsENEPVPAVYLLGLQGGKSLWEHL 227
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 105-140 4.20e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 35.25  E-value: 4.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1026263879 105 GVIYVTGSYSRLFAFDARSGEELWQYDARLPDGIMP 140
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 101-202 8.04e-03

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 38.76  E-value: 8.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026263879 101 IVYDGVIYVTGSYSRLFAFDARSGEELWQYDarlpdgimpccDVVNR---GAAIYGDKIIFGTLDAHMVALNRKTGKVIw 177
Cdd:PRK11138  291 AVDGGRIYLVDQNDRVYALDTRGGVELWSQS-----------DLLHRlltAPVLYNGYLVVGDSEGYLHWINREDGRFV- 358

                          90       100
                  ....*....|....*....|....*.
gi 1026263879 178 nktlAPYDAGYS-FTAAPMIVKGKVI 202
Cdd:PRK11138  359 ----AQQKVDSSgFLSEPVVADDKLL 380
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 500-550 8.47e-03

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 38.76  E-value: 8.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1026263879 500 AGNLVFTGTPEGYLKAFDAKTGQELWKFNTGSGVVGSPVTweqdGEQYVAV 550
Cdd:TIGR03300  64 AGGKVYAADADGTVAALDAETGKRLWRVDLDERLSGGVGA----DGGLVFV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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