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Conserved domains on  [gi|1022943240|ref|NP_001311107|]
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zinc finger protein 33A isoform i [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-78 7.60e-36

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 7.60e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240   19 VSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEVIFRLQQGEEPW 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-806 8.41e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 8.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 430 CQKSDLTKHQRTHTGL----KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKS 503
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 504 YECNACGKTFYHKsllTRHQIIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHT 583
Cdd:COG5048    92 DLNSKSLPLSNSK---ASSSSLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 584 GEK-------PYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHK 656
Cdd:COG5048   160 NTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 657 SALI--------------------------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE- 697
Cdd:COG5048   239 SLLSqspsslsssdssssasesprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 698 -KPYECNE--CGKFFRHKSSLTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTF 765
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1022943240 766 SQKSNLIVHQRRHIGENLMNEMDIRNFQPQVSLHNASEYSH 806
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-523 2.59e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 149 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 217
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 218 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 277
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 278 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 356
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 357 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 423
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 424 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 492
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1022943240 493 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 523
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-78 7.60e-36

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 7.60e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240   19 VSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEVIFRLQQGEEPW 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 18-59 1.31e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 1.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1022943240  18 SVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVG 59
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 19-57 1.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.91  E-value: 1.76e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1022943240  19 VSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVS 57
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-806 8.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 8.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 430 CQKSDLTKHQRTHTGL----KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKS 503
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 504 YECNACGKTFYHKsllTRHQIIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHT 583
Cdd:COG5048    92 DLNSKSLPLSNSK---ASSSSLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 584 GEK-------PYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHK 656
Cdd:COG5048   160 NTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 657 SALI--------------------------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE- 697
Cdd:COG5048   239 SLLSqspsslsssdssssasesprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 698 -KPYECNE--CGKFFRHKSSLTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTF 765
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1022943240 766 SQKSNLIVHQRRHIGENLMNEMDIRNFQPQVSLHNASEYSH 806
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-523 2.59e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 149 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 217
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 218 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 277
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 278 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 356
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 357 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 423
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 424 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 492
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1022943240 493 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 523
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 3.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1022943240 378 NLTKHQRSHTGEKPFECNECGKAFSH 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 5.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.28e-04
                          10        20
                  ....*....|....*....|....*
gi 1022943240 462 HLKVHQRTHTGEKPFECLECGKSFS 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 362-410 8.90e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 8.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1022943240 362 KPFqCNECEKAFWDKSNLTKHQRSHTgekpFECNECGKAFSHKSALTLH 410
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-78 7.60e-36

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 129.25  E-value: 7.60e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240   19 VSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEVIFRLQQGEEPW 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 18-59 1.31e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 1.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1022943240  18 SVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVG 59
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 19-57 1.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.91  E-value: 1.76e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1022943240  19 VSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVS 57
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-806 8.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 8.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 430 CQKSDLTKHQRTHTGL----KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKS 503
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 504 YECNACGKTFYHKsllTRHQIIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHT 583
Cdd:COG5048    92 DLNSKSLPLSNSK---ASSSSLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 584 GEK-------PYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHK 656
Cdd:COG5048   160 NTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 657 SALI--------------------------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE- 697
Cdd:COG5048   239 SLLSqspsslsssdssssasesprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 698 -KPYECNE--CGKFFRHKSSLTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTF 765
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1022943240 766 SQKSNLIVHQRRHIGENLMNEMDIRNFQPQVSLHNASEYSH 806
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-681 3.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 336 FECNECGKAFWEKSHLTRHQRVHTGQKPFQCN--ECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRT 413
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 414 HTGE-KPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSFRVTS----------------------HLKVHQRTH 470
Cdd:COG5048   114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 471 TGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACG------------------------KTFYHKSLLTRHQIIH 526
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssaSESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 527 TGW-----------KPYECYECGKTFCLKSDLTVHQRT--HTGQ--KPFACPE--CGKFFSHKSTLSQHYRTHTGEKPYE 589
Cdd:COG5048   274 SPNesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 590 CHECGKIFYNKSYLTK-------HNRTHTGEKPYEC--NECGKAFYQKSQLTQHQRIHIGEKP--YKCNECGKAFCHKSA 658
Cdd:COG5048   354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|...
gi 1022943240 659 LIVHQRTHTQEKPYKCNECGKSF 681
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-523 2.59e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 149 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 217
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 218 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 277
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 278 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 356
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 357 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 423
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943240 424 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 492
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1022943240 493 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 523
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 3.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1022943240 378 NLTKHQRSHTGEKPFECNECGKAFSH 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 5.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.28e-04
                          10        20
                  ....*....|....*....|....*
gi 1022943240 462 HLKVHQRTHTGEKPFECLECGKSFS 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*
gi 1022943240 350 HLTRHQRVHTGQKPFQCNECEKAFW 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
742-767 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1022943240 742 ELAQHQRSHTGEKPYECNTCRKTFSQ 767
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
546-571 2.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1022943240 546 DLTVHQRTHTGQKPFACPECGKFFSH 571
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-627 2.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1022943240 602 YLTKHNRTHTGEKPYECNECGKAFYQ 627
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
631-653 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 631 LTQHQRIHIGEKPYKCNECGKAF 653
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
658-681 2.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.64e-03
                          10        20
                  ....*....|....*....|....
gi 1022943240 658 ALIVHQRTHTQEKPYKCNECGKSF 681
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 420-442 4.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.25e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 420 YQCNACGKTFCQKSDLTKHQRTH 442
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-457 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....
gi 1022943240 434 DLTKHQRTHTGLKPYECYECGKSF 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 644-666 4.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 644 YKCNECGKAFCHKSALIVHQRTH 666
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
575-597 5.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 575 LSQHYRTHTGEKPYECHECGKIF 597
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
687-711 6.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.15e-03
                          10        20
                  ....*....|....*....|....*
gi 1022943240 687 LIFHERKHTGEKPYECNECGKFFRH 711
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 392-414 6.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 392 FECNECGKAFSHKSALTLHQRTH 414
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-429 6.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|....
gi 1022943240 406 ALTLHQRTHTGEKPYQCNACGKTF 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 362-410 8.90e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 8.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1022943240 362 KPFqCNECEKAFWDKSNLTKHQRSHTgekpFECNECGKAFSHKSALTLH 410
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 616-638 9.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|...
gi 1022943240 616 YECNECGKAFYQKSQLTQHQRIH 638
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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