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Conserved domains on  [gi|1020738753|ref|NP_001310295|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform 2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 28-233 4.09e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467712  Cd Length: 206  Bit Score: 419.15  E-value: 4.09e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 107
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 108 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 187
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738753 188 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 28-233 4.09e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 419.15  E-value: 4.09e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 107
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 108 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 187
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738753 188 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 23-238 6.84e-72

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 220.17  E-value: 6.84e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  23 EFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPN 95
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  96 TTVILTAFKPHDLRWLLELLMGDKINT----NGFWKKPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHP 171
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738753 172 TTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 238
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 28-233 4.09e-151

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 419.15  E-value: 4.09e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 107
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 108 LRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 187
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738753 188 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 28-233 7.36e-117

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 332.33  E-value: 7.36e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 107
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 108 LRWLLELLMGDKINTN-GFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFpkNQKPKHPTTGIIAITLAFYICH 186
Cdd:cd23967    81 LLWLQAVIKGKKPNGKgGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1020738753 187 EVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 28-231 1.17e-82

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 245.73  E-value: 1.17e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDP-IHNDPNTTVILTAFKPH 106
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 107 DLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKvfpKNQKPKHPTTGIIAITLAFYICH 186
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738753 187 EVHLAGFKY-NFSDLKSPLHYYGNATMSLMnKNAYHNVTAEQLFLK 231
Cdd:cd23982   158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSM-ANSGHNLNAEAQAIQ 202
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 23-238 6.84e-72

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 220.17  E-value: 6.84e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  23 EFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPN 95
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  96 TTVILTAFKPHDLRWLLELLMGDKINT----NGFWKKPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHP 171
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738753 172 TTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 238
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 28-231 7.72e-69

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 210.75  E-value: 7.72e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHD 107
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 108 LRWLLELLMGDKI---NTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKvfPKN----QKPKHPTTGIIAITL 180
Cdd:cd23983    81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPE--PQSrlwgWDKNVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1020738753 181 AFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLK 231
Cdd:cd23983   159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLK 209
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 29-233 1.70e-62

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 194.37  E-value: 1.70e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDL 108
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 109 RWLLELLMGDKIN-TNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHE 187
Cdd:cd23981    82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1020738753 188 VHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23981   162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 32-233 6.55e-39

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 133.64  E-value: 6.55e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  32 CVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV---------FSDPIHNDPNTTVILTA 102
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrgprcGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 103 FKPHDLRWLLELlmgdkintngFWKKPALNLIYKPYQIRILDPFIirtAAYELLHFPKVFPKNqkpkHPTTGIIAITLAF 182
Cdd:cd19952    81 AAAADFKRLKRR----------KKRHDNAVLLLTDPAPDLLSYVR---KRLEKLGLKSFFGGN----APSSGLLAVLLAL 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1020738753 183 YICHEVHLAGF-KYNFSDLKSPLHYYGNATMSLMNKnaYHNVTAEQLFLKDI 233
Cdd:cd19952   144 QLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEGTA--VHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 28-226 1.23e-34

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 125.45  E-value: 1.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF-SDPIH--NDPNTTVILTAFK 104
Cdd:cd23964    81 RCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHnSLLKHvpQDKDTKYLFIPFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 105 PHDLRWLLELLMGDKINT---NGFWKKPALNLIYKPYQIRILDPFIIRtaayellHFPKVFPKNQKPKHPTTGIIAITLA 181
Cdd:cd23964   161 IRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATNVRLLHPDFIR-------YLFNRWLNSSTSYRPTTGALMLLTA 233

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1020738753 182 FYICHEVHLAGFKYnfsDLKSPLHYYGNATMSLMNKNAYHNVTAE 226
Cdd:cd23964   234 LHTCDQVSVYGFGY---DPRFSLHYYDKTFVKFTVFYANHDFTNE 275
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 19-236 4.74e-32

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 118.15  E-value: 4.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  19 DLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVfsdpIHNDPNTTV 98
Cdd:cd23966    67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  99 ILTAFKPHDLRWLLELLmgdkinTNGfwkkpalNLIYKPYQIRildPFI--IRTAAyELLH--FPKVFPKNQKPKH---P 171
Cdd:cd23966   143 VLVPFKVLDLQWLISAL------TTG-------EITRTYTPVK---RFIkaDKDKV-LVINpaFIKYVHDNWTEHHgryP 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1020738753 172 TTGIIAITLAFYICHEVHLAGF---KYNFSDlksplHYY-GNATMSLMNKNAYHNVTAEQlflkDIIEK 236
Cdd:cd23966   206 STGFLALIFALHICDEVSVFGFgadSKGNWH-----HYWeKNRSAGAFRKTGVHDADFES----DIIKK 265
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 19-225 4.99e-26

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 102.65  E-value: 4.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  19 DLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSdpihNDPNTTV 98
Cdd:cd23980    71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRE----LAQNVSM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  99 ILTAFKPHDLRWLLELLMGDKINTNgFWKKPALNLIYKPyQIRILDPFIIRTaayellhfpkVFPK--NQKPKHPTTGII 176
Cdd:cd23980   147 ILVPFKTLDLEWVISATTTGTISHT-YVPVPRKIKVKKE-KILIYHPAFIKY----------VFDRwlQGHGRYPSTGIL 214

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738753 177 AITLAFYICHEVHLAGFKynfSDLKSPLHYY--GNATMSLMNKNAYH------NVTA 225
Cdd:cd23980   215 SVIFSLHVCDEVDLYGFG---ADSKGNWHHYweNNPSAGAFRKTGVHdgdfesNVTT 268
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 6-232 5.20e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 102.34  E-value: 5.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753   6 EYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 85
Cdd:cd23963    40 KTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  86 FSdpIHNDPNTTVILTAFKpHDLRWLLE-LLMGDKintngFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVF-- 162
Cdd:cd23963   120 KR--RYNSLKKNRDRDKFL-NRLKEYNGsILWYPK-----FSFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQkf 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020738753 163 -PKNQKPKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLKS---PLHYYGNATMSLMNKNayHNVTAEQLFLKD 232
Cdd:cd23963   192 wKRRGLEKRPSTGLYLVSLALTFCDEIHLYGF-WPFPtDPNGrpvPYHYYDDLSPSTKNKV--HNMPEEFKLLRE 263
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 30-233 1.27e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 101.19  E-value: 1.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNttviltafkphDLR 109
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQILSKPEFNFLTD-----------PLY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 110 WLLELLMGDKINTNG----FWKKPALNLI--YKPYQIR-------ILDP-FIIRtaAYELLHfpKVFPKNQKPKHPTTGI 175
Cdd:cd23968   115 RNVTLLVWDPSSYNVnlekWYKKPDFDFFpnYIKYRRRhpeepfyLIDPrFLWR--LWDILQ--EYTPEKIKPNPPSSGF 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020738753 176 IAITLAFYICHEVHLagfkYNF--SDLKSPL-HYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23968   191 IGIVLMLHLCDWVDV----YEYvpSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 21-207 4.60e-22

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 91.86  E-value: 4.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  21 FDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPihndPNTTVIL 100
Cdd:cd23979    72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP----ANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 101 TAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIrildpfiirtaaYELLHFPKVFPK--NQKPKHPTTGIIAI 178
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQIRFTYAPVKQFLRVDKDKVQI------------YNPAFFKYIHDRwtEHHGRYPSTGMLVL 215

                         170       180
                  ....*....|....*....|....*....
gi 1020738753 179 TLAFYICHEVHLAGFKynfSDLKSPLHYY 207
Cdd:cd23979   216 FFALHVCDEVNVYGFG---ADSRGNWHHY 241
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 29-208 1.56e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 83.83  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLF-YP--ESVFSDPIHNDPN----TTVILt 101
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGtrapTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 102 afkphdlrWLLEllmgDKINTNGFWKKPALNLIYKPYqiRILDPFIIRTAAYEllHFPKVFpKNQ--KPKHPT-----TG 174
Cdd:cd23965    80 --------WGPE----TKMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPEKMD--YADELF-EKEtgKSRIKSgtwlsTG 142

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1020738753 175 IIAITLAFYICHEVHLAGF---KY--NFSDLKSPLHYYG 208
Cdd:cd23965   143 WFTMLLALDVCDEIKVYGMvpeNYcrEHPNSKVPYHYYE 181
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 30-233 4.80e-19

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 83.35  E-value: 4.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPEsVFSDPIHNDPNTT----VILTAFKP 105
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ-ILTNPNHHFIDSSlykdVILVAWDP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 106 HDLrwllellmgdKINTNGFWKKPALNLI--YKPYQIRILD-PFIIRTAAYeLLHFPKVFPKNQK----PKHPTTGIIAI 178
Cdd:cd23986   129 APY----------SANLHKWYKKPDYNLFtpYVQYRKRNPNqPFYILHPKF-IWQLWDIIQENTQekiqPNPPSSGFIGI 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020738753 179 TLAFYICHEVHLagFKYNFSDLKSPL-HYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23986   198 LIMMSMCREVHV--YEYIPSVRQTDLcHYHERYYDAACTLGAYHPLLYEKLLIQRM 251
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 24-231 2.21e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 82.06  E-value: 2.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  24 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPeSVFsDPIHNDPNTTVILTAF 103
Cdd:cd23970    63 FQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-SIL-EKYYNNLLTIQDRNNF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 104 KpHDLRWLlellmGDKIntngFWkKPALNLIYKPYQIRILDPFIIrtaayELLHFPKV---FP-------------KNQK 167
Cdd:cd23970   141 F-LSLKKL-----DGAI----LW-IPAFFFHTSATVTRTLVDFFV-----EHRGQLKVqlaWPgnimqhvnrywktKHLS 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1020738753 168 PKHPTTGIIAITLAFYICHEVHLAGFkYNFSDLKS----PLHYYGN-ATMSLMNKNAYHNVTAEQLFLK 231
Cdd:cd23970   205 PKRLSTGILMYTLASAICEEIHLYGF-WPFGFDPTgtplPYHYYDKkGTKFTTKWQESHQLPAEFVLLY 272
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 29-207 9.00e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 80.57  E-value: 9.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSD------------PIHNDpnT 96
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSlmilqkrgfkniPQDKD--I 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  97 TVILTAFKPHDLRWLLELLMGDKINTNGFWK---KPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTT 173
Cdd:cd23973   161 KYILFPEGPRDYQWLEALLKNKTIPSGAYYGrrpRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTT 240

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1020738753 174 GIIAITLAFYICHEVHLAGFKYNfSDLKSPLHYY 207
Cdd:cd23973   241 GAFLLLTALHLCDTVSAYGFITE-DYRKYPDHYY 273
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 30-217 1.90e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 79.00  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFypesvfsdpihndpNTTVILTAFK----P 105
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTM--------------NPSVIPHAYGdlvnA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 106 HDLRWLLELL--MGDKIntngFWkKPALNLIYKPYQIRILDPFI------IRTA--AYELLHFPKVFPKNQK--PKHPTT 173
Cdd:cd23969   131 TDKEKFVERLrqLGDSI----LW-IPAFVSKGGEEHVQWTNEIIlkhklnVKTAypPLRLNHAIRGYWLTTKfrIKRPST 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1020738753 174 GIIAITLAFYICHEVHLAGFkYNFS-DLK-SPL--HYYGNATMSLMNK 217
Cdd:cd23969   206 GLLMYTLATRFCDEIHLYGF-YPFSeDGNgRAVkyHYYDNRKYLTTAR 252
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 28-244 2.98e-17

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.60  E-value: 2.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  28 PCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLF------YPESVF-SDPIHNDPnttvIL 100
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFlKDSLYNEG----IL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 101 TAFKP---HDlrwllellmgdkiNTNGFWKKPALNlIYKPYQ-IRILDPfiirTAAYELLHfPKV-----------FPKN 165
Cdd:cd23985   120 IVWDPapyHS-------------DIPEWYKNPDYN-FFENYKtYRRLNP----NQPFYILH-PQMqwelwdiiqenSPEE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 166 QKPKHPTTGIIAITLAFYICHEVHLagfkYNF--SDLKSPL-HYYGNATMSLMNKNAYHNVtaeqLFlkdiiEKNLVINL 242
Cdd:cd23985   181 IQPNPPSSGMLGIILMMTLCDQVDV----YEFlpSKRKTDVcHYYQKFFDRACTMGAYHPL----LY-----EKNLVKHL 247


                  ..
gi 1020738753 243 TQ 244
Cdd:cd23985   248 NQ 249
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 24-209 1.57e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 71.13  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  24 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPvLGHEEEVGRRTTF-------------RLFYPESVFSDPI 90
Cdd:cd23971    59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLvtanpsilrekfhNLKKRRRPFVERM 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  91 HNDPNTTVILTAFKPHdlrwllellmgdkINTngfwkKPALNLIYkpyqirILDPFIIRTAAYeLLHfPK------VFPK 164
Cdd:cd23971   138 KVYGNALLLLPAFSYT-------------SNT-----EPSLRALY------TLEDFGSPQKVL-FFN-PEylrnlsRYWK 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1020738753 165 NQ--KPKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLKS---PLHYYGN 209
Cdd:cd23971   192 SKglKARRLSTGLMLVSAALELCENVHLYGF-WPFStDLDGnpiSHHYYDN 241
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 20-214 3.39e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 70.55  E-value: 3.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  20 LFDEFD----NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF-------SD 88
Cdd:cd23974    71 MFDWWDrpngRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMnslrayaGV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  89 PIHNDPNTTVILTAFKP-HDLRWLL-----ELLMGDKINTNGfwKKPAL----NLiyKPYQIRILDPFIIRTAAYELLHF 158
Cdd:cd23974   151 GFNGPPQSKETRYIFLPdHDRDYLLvkaalTHTPIDRGRDKS--KRPSKyfgkDV--TAEKFKIYHPDFIRYLRNRFLWS 226

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020738753 159 PKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGF------KYN---FSDLKSPLHYYGNATMSL 214
Cdd:cd23974   227 PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpdygKYSdhyYDKTYHKVVFYANHDLRL 291
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 30-233 7.19e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.50  E-value: 7.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPesvfsdpihndpntTVILTAFKphDL- 108
Cdd:cd23987    65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP--------------SVVQRAFE--DLv 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 109 --RWLLELLMG-DKINTNGFWkKPALNLIYKPYQIRILDPFII------RTA--AYELLHFPKVFPKNQKP--KHPTTGI 175
Cdd:cd23987   129 neTWKEKFLQRlQSLNGSILW-IPAFMAKGGEERVEWVNDLILkhhinvRTAypSLRLLHAVRGYWLTNKVhiKRPTTGL 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020738753 176 IAITLAFYICHEVHLAGF-KYNFSDLKSPL--HYYGNATMSLMNKNAYHNVTAEQLFLKDI 233
Cdd:cd23987   208 LMYTLATRFCNRIHLYGFwPFPRDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKNL 268
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 30-209 4.88e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 64.09  E-value: 4.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLG-HEEEVGRRTTFRLFYPESV-------------FSDPIHNDPN 95
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIterfhklekwrrpFYEVLQVYEN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  96 TTVILTAFkpHDLRwllellmgdkiNTN-GFWKKPALNLIYKPYQIRILDP-FIIRTAAYELLhfpkvfpKNQKPKHPTT 173
Cdd:cd23990   145 ASVVLPAF--YNTR-----------NTDvSIRVKYVLDDFESQQAVYYFHPqYLLNVSRFWLR-------QGVRAKRISS 204

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1020738753 174 GIIAITLAFYICHEVHLAG---FKYNFSDLKSPLHYYGN 209
Cdd:cd23990   205 GLMLVTAALELCEEVHLYGfwaFPMNPSGIFITHHYYDN 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 29-207 1.40e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 62.18  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVF------SDPIHNDPNTTVIlta 102
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYrvlrrpQEFLNRTPETTLI--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 103 fkphdlrwllellmgdkintngFW------KKPALNLIYKPYQ-----IRILDPFIIrtAAYELLHFPKVFP----KNQK 167
Cdd:cd23978    78 ----------------------FWgppnkmQKDGKSNLFRIIQrasmtFPNMSAFVV--SPRRMRQFDDLFRgetgRDRK 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1020738753 168 PKHP--TTGIIAITLAFYICHEVHLAGF-KYNF-----SDLKSPLHYY 207
Cdd:cd23978   134 KSHSwlSTGWFTMVIAVELCDNVHVYGMvPPNYcskrpTPKKMPYHYY 181
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 20-214 1.52e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.92  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  20 LFDEFDNIP-CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPI-------H 91
Cdd:cd23972    72 LFFPRDTPGkCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLIsywnlgfT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  92 NDPNTTVILTAFKPHDLR---WLLELLMGDKInTNGFWK--KPA--LNLIYKPYQIRILDPFIIRtaaYELLHFPKVFPK 164
Cdd:cd23972   152 RTPQGQDLQYIFIPSDIRdyvMLRSAILGVPV-PEGLDKgdRPHkyFGPEASAKKFKLLHPDFIS---YLTDRFLKSKLL 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1020738753 165 NQKPKH---PTTGIIAITLAFYICHEVHLAGF---KYN-FSD-----LKSPLHYYGNATMSL 214
Cdd:cd23972   228 NTHYGHlymPSTGALMLLTALHTCDQVSAYGFitsNYWkFSDhyyerKKKPLVFYANHDMLL 289
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 29-207 1.55e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.87  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV---FSDPIH--NDPNTTVILTAF 103
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYffKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 104 KPHDLRwllelLMGDKINTNgFWKKPALNliYKPYQIRIldpfiirTAAYELLHFPKVFPKN------QKPKHPTTGIIA 177
Cdd:cd23975    81 PFRNMR-----KDGKGIVYN-MLKKAVES--YPQAKIYV-------TTEKRMSYCDTVFKKEtgkdrvQSGSYLSTGWFT 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1020738753 178 ITLAFYICHEVHLAGF---KYNFSD--LKSPLHYY 207
Cdd:cd23975   146 LILAMDACYGIHVYGMindTYCKTEgyRKVPYHYY 180
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 30-228 1.65e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 62.66  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  30 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYP------------ESVFSDPIH-----N 92
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPsvvqrafggfrnESDREKFVHrlsmlN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  93 DpnTTVILTAF-----KPHdLRWLLELLMGDKINTNGFWkkPALNLIYKpyqIRildpfiirtaAYELlhfpkvfpKNQK 167
Cdd:cd23988   145 D--SVLWIPAFmvkggEKH-VEWVNALILKNKLKVRTAY--PSLRLIHA---VR----------GYWL--------TNKV 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 168 P-KHPTTGIIAITLAFYICHEVHLAGF------------KYN-FSDLKspLHYYGNAT---MSLMNK--NAYHNVTAEQL 228
Cdd:cd23988   199 NiKRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHyYDDLK--YRYFSNAGphrMPLEFKtlNVLHNRGALKL 276
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 29-85 1.61e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 59.10  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 85
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSV 57
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 27-230 1.67e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 53.68  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753  27 IPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVL-GHEEEVGRRTTFRLFYPeSVFSDPIHN-DPNTTVILTAFK 104
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANP-SIIDKRFQNlLWSRKSFVESMK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738753 105 PHDLRWLLELLMGDKINTN-GFWKKPALNLIYKPYQIRILDPFIIRTAAyellhfpkVFPKNQ--KPKHPTTGIIAITLA 181
Cdd:cd23989   140 VYGRSYIYMPAFSMKTGTDpSLRVYYTLADVGANQTVLFANPNFLRNVG--------KFWKSKgvHAKRLSTGLFLVSAA 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1020738753 182 FYICHEVHLAGFkYNFS-DL-KSPL--HYYGNatmsLMNKNAYHNVTAEQLFL 230
Cdd:cd23989   212 LGLCEEVTIYGF-WPFSvDLdERTIshHYYDN----VLPDSGFHAMPEEFLQL 259
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 24-75 9.03e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 51.68  E-value: 9.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1020738753  24 FDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHE-EEVGRRT 75
Cdd:cd23991    59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKT 111
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 29-85 7.08e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.71  E-value: 7.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020738753  29 CKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV 85
Cdd:cd23976    15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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