nickel-dependent lactate racemase similar to Lactobacillus plantarum lactate racemization operon protein LarA that catalyzes the interconversion between the D- and L-isomers of lactate
nickel-dependent lactate racemase; LarA from Lactobacillus plantarum is a nickel-dependent ...
6-420
3.53e-171
nickel-dependent lactate racemase; LarA from Lactobacillus plantarum is a nickel-dependent lactate racemase and the founding member of a family of isomerases that depend on a nicotinic acid-derived nickel pincer cofactor. While it is not yet clear which homologs of LarA act preferentially on lactate, this model identifies one clade of architecurally similar proteins from among a broader set of LarA homologs. Note that the crystal structure 4NAR, on deposit at PDB but not associated with any publication, represents a protein from Thermotoga maritima that falls outside the scope of this family and that is annotated in PDB as a putative uronate isomerase.
Pssm-ID: 468049 Cd Length: 417 Bit Score: 485.47 E-value: 3.53e-171
Lactate racemase N-terminal domain; This is the N-terminal domain found in Lactate racemase ...
8-205
7.94e-80
Lactate racemase N-terminal domain; This is the N-terminal domain found in Lactate racemase enzymes EC:5.1.2.1. LarA is a nickel-dependent lactate racemase from the larA-E operon of Lactobacillus plantarum, whereas LarB, LarC and LarE are accessory proteins required for the incorporation of Ni in the lactate racemase apoprotein. LarA contains 18 beta-strands and 16 alpha-helices arranged in a novel fold composed of two domains of similar size. This entry represents the N-terminal domain of LarA and related proteins.
Pssm-ID: 401722 Cd Length: 204 Bit Score: 244.81 E-value: 7.94e-80
nickel-dependent lactate racemase; LarA from Lactobacillus plantarum is a nickel-dependent ...
6-420
3.53e-171
nickel-dependent lactate racemase; LarA from Lactobacillus plantarum is a nickel-dependent lactate racemase and the founding member of a family of isomerases that depend on a nicotinic acid-derived nickel pincer cofactor. While it is not yet clear which homologs of LarA act preferentially on lactate, this model identifies one clade of architecurally similar proteins from among a broader set of LarA homologs. Note that the crystal structure 4NAR, on deposit at PDB but not associated with any publication, represents a protein from Thermotoga maritima that falls outside the scope of this family and that is annotated in PDB as a putative uronate isomerase.
Pssm-ID: 468049 Cd Length: 417 Bit Score: 485.47 E-value: 3.53e-171
Lactate racemase N-terminal domain; This is the N-terminal domain found in Lactate racemase ...
8-205
7.94e-80
Lactate racemase N-terminal domain; This is the N-terminal domain found in Lactate racemase enzymes EC:5.1.2.1. LarA is a nickel-dependent lactate racemase from the larA-E operon of Lactobacillus plantarum, whereas LarB, LarC and LarE are accessory proteins required for the incorporation of Ni in the lactate racemase apoprotein. LarA contains 18 beta-strands and 16 alpha-helices arranged in a novel fold composed of two domains of similar size. This entry represents the N-terminal domain of LarA and related proteins.
Pssm-ID: 401722 Cd Length: 204 Bit Score: 244.81 E-value: 7.94e-80
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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