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ribonucleotide-reductase, large subunit [Alcelaphine gammaherpesvirus 1]
Protein Classification
glycyl radical enzyme family protein ( domain architecture ID 1562547 )
glycyl radical enzyme family protein such as ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL), which have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
List of domain hits
Name
Accession
Description
Interval
E-value
RNR_PFL super family
cl38938 Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
95-731
6.69e-168
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
TIGR02506 :Pssm-ID: 476821 [Multi-domain]
Cd Length: 617
Bit Score: 498.06
E-value: 6.69e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 95 A K RF Y DT Y V LR T A D - G SC YES VSHCF MR I A A fctvqvltnsalkitilylgrd K L FKDL P CSPTMDLF I Y F FSP LS HQLV 173
Cdd:TIGR02506 4 L K EL Y NR Y L LR N A A t G AI YES PQEAY MR V A M ---------------------- G L ASLE P KDTRLADA I R F YDL LS RLKI 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 174 CC ATP IMRS AG LRDAN L A SCFL INPDLS T e KSTTTALLQELTM L LSAKS G V G C N V T ---------- SFGVDE K C I QSCVG 243
Cdd:TIGR02506 62 SP ATP TLFN AG TPRGQ L S SCFL LDVTDD T - LESIYKAIDDVAQ L SKHGG G I G L N L T klraigspir GTNNAS K G I IPFLK 140
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 244 L IN S Q VE FF N DQNP RP VSV A A Y M EVWH SQ I Q EFL AV K LP -- ENPS RC ASIYQ GL C IP K LF FEKFI ED pg QN WYLF K P EKS 321
Cdd:TIGR02506 141 L LD S S VE AV N QGGK RP GAA A V Y L EVWH PD I E EFL DL K KN ng DERR RC DNLFY GL W IP D LF MKRVE ED -- KD WYLF S P YDV 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 322 GN L AN LYG D EF RS EYERL VG --- IGCYADAIPIKS LM FL I IN T IIK TG S PYI IY K E A C N E H HWKNME G C AI ASA NLC A E V 398
Cdd:TIGR02506 219 PG L YG LYG E EF EE EYERL EK dve ARKKIRKVSARD LM KD I LR T RVE TG R PYI LF K D A V N K H NPFKTG G G AI KMS NLC T E I 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 399 I Q Y ---- PGADVST CNLA N V C L PMC l V TVSNDSH S P LE K tycgnviesqavsgvgfsmpilha AV EV AV FLVNCA I - AGG 473
Cdd:TIGR02506 299 T Q P tdds HKGETAV CNLA S V N L ANF - V MEDKFDF S E LE D ------------------------ AV RI AV RFLDNV I d LQN 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 474 KCVT P GMERG QR E RS M GIGV H GL A DV F A EM G YS Y LD E R A AR L DVE IFE NM Y FR A V K T S NNICRLG G gr PF E G WGE SK LRH 553
Cdd:TIGR02506 354 YPTA P AAKSN QR R RS I GIGV M GL H DV L A KL G LP Y DS E E A RD L NDR IFE AI Y YY A I K A S AELAKEK G -- PF P G FSG SK YAK 431
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 554 G FF H WQG WE DVNLSIPIT ----- E WE K L SR R CISS G VY NSQ FI ALMPT VG SS L LTG FS ES YY P Y F A NI SS K VSSKE E VMK 628
Cdd:TIGR02506 432 G WL H PDT WE KTIDPKTSM aptee D WE A L RE R IKEY G LR NSQ LT ALMPT AS SS Q LTG VT ES IE P V F S NI FT K KTLSG E FLI 511
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 PN MTFWNRVSKED L DTVRFFS ------ G DVALFPEPLKEKYSLFLS A FDYCA E KQLAR A RL R AP FVDQS Q S HSFH L K EE n 702
Cdd:TIGR02506 512 PN KYLMKELEELG L WDADRRG divenv G SPQPIAAIPETLKYKYKT A YELDQ E ALIDM A AD R QK FVDQS I S LNLF L T EE - 590
650 660
....*....|....*....|....*....
gi 10140983 703 v V S A RF L KD L I L SGYTL GLKT i MYYC KVK 731
Cdd:TIGR02506 591 - V T A KD L LK L L L LAWKK GLKT - MYYC RSR 617
Name
Accession
Description
Interval
E-value
NrdE_NrdA
TIGR02506 ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...
95-731
6.69e-168
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain]
Cd Length: 617
Bit Score: 498.06
E-value: 6.69e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 95 A K RF Y DT Y V LR T A D - G SC YES VSHCF MR I A A fctvqvltnsalkitilylgrd K L FKDL P CSPTMDLF I Y F FSP LS HQLV 173
Cdd:TIGR02506 4 L K EL Y NR Y L LR N A A t G AI YES PQEAY MR V A M ---------------------- G L ASLE P KDTRLADA I R F YDL LS RLKI 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 174 CC ATP IMRS AG LRDAN L A SCFL INPDLS T e KSTTTALLQELTM L LSAKS G V G C N V T ---------- SFGVDE K C I QSCVG 243
Cdd:TIGR02506 62 SP ATP TLFN AG TPRGQ L S SCFL LDVTDD T - LESIYKAIDDVAQ L SKHGG G I G L N L T klraigspir GTNNAS K G I IPFLK 140
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 244 L IN S Q VE FF N DQNP RP VSV A A Y M EVWH SQ I Q EFL AV K LP -- ENPS RC ASIYQ GL C IP K LF FEKFI ED pg QN WYLF K P EKS 321
Cdd:TIGR02506 141 L LD S S VE AV N QGGK RP GAA A V Y L EVWH PD I E EFL DL K KN ng DERR RC DNLFY GL W IP D LF MKRVE ED -- KD WYLF S P YDV 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 322 GN L AN LYG D EF RS EYERL VG --- IGCYADAIPIKS LM FL I IN T IIK TG S PYI IY K E A C N E H HWKNME G C AI ASA NLC A E V 398
Cdd:TIGR02506 219 PG L YG LYG E EF EE EYERL EK dve ARKKIRKVSARD LM KD I LR T RVE TG R PYI LF K D A V N K H NPFKTG G G AI KMS NLC T E I 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 399 I Q Y ---- PGADVST CNLA N V C L PMC l V TVSNDSH S P LE K tycgnviesqavsgvgfsmpilha AV EV AV FLVNCA I - AGG 473
Cdd:TIGR02506 299 T Q P tdds HKGETAV CNLA S V N L ANF - V MEDKFDF S E LE D ------------------------ AV RI AV RFLDNV I d LQN 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 474 KCVT P GMERG QR E RS M GIGV H GL A DV F A EM G YS Y LD E R A AR L DVE IFE NM Y FR A V K T S NNICRLG G gr PF E G WGE SK LRH 553
Cdd:TIGR02506 354 YPTA P AAKSN QR R RS I GIGV M GL H DV L A KL G LP Y DS E E A RD L NDR IFE AI Y YY A I K A S AELAKEK G -- PF P G FSG SK YAK 431
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 554 G FF H WQG WE DVNLSIPIT ----- E WE K L SR R CISS G VY NSQ FI ALMPT VG SS L LTG FS ES YY P Y F A NI SS K VSSKE E VMK 628
Cdd:TIGR02506 432 G WL H PDT WE KTIDPKTSM aptee D WE A L RE R IKEY G LR NSQ LT ALMPT AS SS Q LTG VT ES IE P V F S NI FT K KTLSG E FLI 511
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 PN MTFWNRVSKED L DTVRFFS ------ G DVALFPEPLKEKYSLFLS A FDYCA E KQLAR A RL R AP FVDQS Q S HSFH L K EE n 702
Cdd:TIGR02506 512 PN KYLMKELEELG L WDADRRG divenv G SPQPIAAIPETLKYKYKT A YELDQ E ALIDM A AD R QK FVDQS I S LNLF L T EE - 590
650 660
....*....|....*....|....*....
gi 10140983 703 v V S A RF L KD L I L SGYTL GLKT i MYYC KVK 731
Cdd:TIGR02506 591 - V T A KD L LK L L L LAWKK GLKT - MYYC RSR 617
Ribonuc_red_lgC
pfam02867 Ribonucleotide reductase, barrel domain;
191-727
6.18e-128
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain]
Cd Length: 487
Bit Score: 390.41
E-value: 6.18e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 191 A SCFL INPDL S TEKSTT T al L Q E LTM L LSAKS G V G C N VT ---------- SF G VDEKCIQSCVG L INSQVEFF N DQNP R PV 260
Cdd:pfam02867 1 S SCFL LSVED S LDSIYD T -- L K E AAL L SKGGG G I G L N LS klrakgspir GT G GASSGVVPFLK L FDDSARYV N QGGK R RG 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 261 SV A A Y M EVWH SQ I Q EFL AV K LPE -- NPS R CASIYQ G LCI P K LF F E KFIE D pg QN W Y LF K P EKSGN L AN LYG D EF RS E - YE 337
Cdd:pfam02867 79 AA A V Y L EVWH PD I E EFL DL K KNN gd EEV R ARNLNL G VWV P D LF M E RVEA D -- ED W T LF S P REAPD L ED LYG E EF EK E y YE 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 338 R LVGI G CYADAIPIKS L M F L I INTI I K TG S PYI IY K E A C N EHHW k NMEGCA I A S A NLC A E VI Q YP - GADVST CNLA NVC L 416
Cdd:pfam02867 157 R EENE G IRKKTVKARE L W F K I AKSQ I E TG Y PYI LF K D A V N RKNP - QKHLGT I K S S NLC T E IV Q PT s PSEIAV CNLA SIN L 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 417 PMC lvt V SNDSHSPL EK tycgnviesqavsgvgfsmpi L HAA V EV AV FLVNCA I AGGKCVT P GME R G - Q R E R SM G I GV H G 495
Cdd:pfam02867 236 AKF --- V EFGGTFDF EK --------------------- L REV V KL AV RALDNV I DINDYPV P EAR R S n K R H R PI G L GV M G 291
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 496 LAD VF A EM G YS Y LD E R A AR L DVE IFE N MY FR A V K T S NNICRLG G gr PF E G WGE SK LRH G FFHWQGWE ---- DVNL S IPIT 571
Cdd:pfam02867 292 LAD AL A KL G IP Y DS E E A RD L NDK IFE T MY YY A L K A S SELAKEK G -- PF P G FEG SK YSK G ILQFDKYV ktdf APKA S KTRE 369
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 572 E WE K L SRRCISS G VY NSQ FI A LM PT VGS S LLT G FS ES YY P Y F A N IS S KVSSK EE VMK pnmtfwnrvskedldtvrffsgd 651
Cdd:pfam02867 370 D WE E L REDIKKY G LR NSQ LT A IA PT GSI S QIA G AT ES IE P I F S N VY S RKVLS EE TKE ----------------------- 426
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10140983 652 valfpeplkekys LFLS A F D YCAEKQLAR A RL R A PFVDQS Q S HSFH L KEE nv VSARF LK D L I L SGYT LGLKTI M YY 727
Cdd:pfam02867 427 ------------- YYKT A Y D IDQKAHIDM A AA R Q PFVDQS I S KTLF L PND -- ATTSD LK S L Y L YAWK LGLKTI Y YY 487
NrdA
COG0209 Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...
40-727
7.14e-62
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain]
Cd Length: 665
Bit Score: 220.44
E-value: 7.14e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 40 K ATKTVTEYIEKFADVL EE NVL -- R F L QDNA E M L ELC I YMYE - QLPA Y kavksrgi LSA K RF YD T Y V L RTA DG SCY E SVS 116
Cdd:COG0209 4 K EALGQYKSFSEKIKYV EE GLY de R L L EEDL E E L AAA I DPER d RFFS Y -------- NAL K TL YD R Y L L KDE DG KPL E TPQ 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 117 HC FMR I A afctvqvltnsalkiti LY L GRDKLFK D lpcsp TMDLFIY F FSP LS HQLVCC ATP IMRS AG LRDAN L A SCF LI 196
Cdd:COG0209 76 DL FMR V A ----------------- MG L AAAEKPE D ----- REEWAKE F YDL LS SLRFLP ATP TLFN AG TPRGQ L S SCF VL 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 197 NPDL S T E --- KSTTT A llqelt M LLS a KS -- GVG C N VT --------------- S F G V dekciqsc V G --- LINSQVEFF N 253
Cdd:COG0209 134 PVED S L E sif DALKD A ------ A LLS - KS gg GVG F N FS rlrpkgspikgtggv S S G P -------- V P fmk VFDDAAVAV N 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 254 DQNP R PVSVAA Y ME VWH SQ I Q EFL AV K L -- PENPS R CASIYQGLC IP K LF F E KFI ED pg QN W Y LF K P EKSGN L AN LYG D E 331
Cdd:COG0209 199 QGGK R RGANMV Y LR VWH PD I E EFL DL K K nn GDERR R LHNFNISVW IP D LF M E AVE ED -- ED W T LF S P REVPD L YG LYG E E 276
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 332 F RSE YE RLVGI G CYADA I PIKS L MFL I INTIIK TG S P Y I IY K EAC N EHH wk NMEGCA - I A S A NLC A E VIQY P - GADVST C 409
Cdd:COG0209 277 F EEA YE EYEAD G RVYKT I KARE L WRK I LESAWE TG E P G I LF K DTI N RRN -- PLPHLG v I H S S NLC G E IPLL P y ESEDAS C 354
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 410 NL ANVC L PMCLVTVSN D SHS p LE K T ycgnviesqavsgvgfsmpilhaa V EV AV - FL V N caiaggkc V ------- T P GM E 481
Cdd:COG0209 355 NL GSIN L AKFVKDGEF D WEK - LE E T ------------------------ V RT AV r FL D N -------- V idindyp V P EI E 401
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 482 RG - Q R E R SM G I GV H GLAD VF A EM G YS Y LD E R A AR L DV EI F E NMYFR A V K T S NNICRLG G gr P F EGWGE SK LRH G FFHWQG 560
Cdd:COG0209 402 KA n R R H R PI G L GV M GLAD AL A KL G IP Y DS E E A RE L AD EI M E FINYY A Y K A S AELAKER G -- A F PAFEG SK YAK G ILPFDK 479
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 561 WE D VN L SIPITE W EK L SRRCISS G VY NS QFI A LM PT v G S - SL LT G FSESYY P Y F ANISSK - V SSKE E VMKP N -------- 630
Cdd:COG0209 480 YL D DL L IPTTLD W DA L REDIKKH G LR NS TLT A IA PT - G T i SL IA G TTSGIE P I F SLVYVR k V LDGG E FTVV N pylvralk 558
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 631 - MTF W NRVSK E DLDT vrff S G D V ALFP E PLK E KYS L FLS A FDYCA E KQLARARL R APF VDQ SQ S HSFH L KEE nv VSARF L 709
Cdd:COG0209 559 e LGL W DEELV E KIKE ---- D G S V QDID E LPE E LKE L YVT A YEIDP E WHIDMQAA R QKH VDQ AI S KTLN L PND -- ATVED L 632
730
....*....|....*...
gi 10140983 710 KD L I L SGYT LGLK T I M YY 727
Cdd:COG0209 633 AE L Y L LAWK LGLK G I Y YY 650
PLN02437
PLN02437 ribonucleoside--diphosphate reductase large subunit
176-779
8.94e-61
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain]
Cd Length: 813
Bit Score: 220.00
E-value: 8.94e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 176 A T P IMRS AG LRDAN L A SCFLI N - P D L S T E KSTT T al L Q E LTMLLSAKS G V G CN V TSFGVDEKC I QSCV G LI N SQ V --- EF 251
Cdd:PLN02437 201 A S P TLFN AG TPRPQ L S SCFLI C m K D D S I E GIYD T -- L K E CAVISKSAG G I G LS V HNIRATGSY I RGTN G TS N GI V pml RV 278
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 252 FND Q -------- NP R PVSV A A Y M E V WH SQ I Q EFL av K L PE N ---- PS R CASIYQG L C IP K LF F E K f IEDP G Q n W Y LF K P E 319
Cdd:PLN02437 279 FND T aryvdqgg GK R KGAF A I Y L E P WH AD I F EFL -- D L RK N hgke EH R ARDLFYA L W IP D LF M E R - VQSN G D - W S LF C P N 354
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 320 KSGN LA NLY G D EF RSE Y ERLVGI G CYADAIPIKS L M F L I INTI I K TG S PY IIY K EA CN EHHWKNME G c A I A S A NLC A E V I 399
Cdd:PLN02437 355 EAPG LA DCW G E EF ERL Y TKYERE G KAKKVVQAQQ L W F A I LESQ I E TG T PY MLF K DS CN RKSNQQNL G - T I K S S NLC T E I I 433
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 400 Q Y PGAD - VST CNLA NVC LP MCLVT -- V SND SH SP lektycg NVIE S QAVSGVG F SMPI L HAAVE V AVFLV N CA I AGGKCV 476
Cdd:PLN02437 434 E Y TSPT e TAV CNLA SIA LP RFVRE kg V PLE SH PS ------- KLVG S LGSKNRY F DFEK L AEVTA V VTRNL N KI I DVNYYP 506
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 477 TPGME R GQ - R E R SM GIGV H GLAD V F AEM G YSYLDER A AR L DVE IFE NM Y FR A V K T S NNICRLG G gr P F E GWGE S KLRH G F 555
Cdd:PLN02437 507 VETAR R SN m R H R PI GIGV Q GLAD A F ILL G MPFDSPE A QQ L NKD IFE TI Y YH A L K A S SELAARE G -- P Y E TYAG S PVSK G I 584
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 556 FHWQG W e D V nls I P IT -- E W EK L SRRCISS GV Y NS QFI A L MPT VGS S LLT G FS E SYY PY FA NI - S SK V S S K E E V MK ---- 628
Cdd:PLN02437 585 LQPDM W - G V --- T P SG rw D W AA L REMISKN GV R NS LLV A P MPT AST S QIL G NN E CFE PY TS NI y S RR V L S G E F V VV nkhl 660
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 ---- PN M TF W NRVS K EDL ---- DT V R ffsg DVALF P EP LK EK Y --------- S L FLS A F D ycaekqlararl R APFV DQS 691
Cdd:PLN02437 661 lhdl TE M GL W TPTL K NKI iaen GS V Q ---- KIPEI P DD LK AI Y ktvweikqr T L VDM A A D ------------ R GCYI DQS 724
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 692 QS HSF H LKEE N VVS arf L KD L ILSGYTL GLKT I MYY ck VKKQSTMSSFQCLR D Q ---- NKSEMTGNDQGVEP E SYIKCTA 767
Cdd:PLN02437 725 QS LNI H MDQP N FGK --- L TS L HFYAWSK GLKT G MYY -- LRSRAAADAIKFTV D T aslk PSATGVAAPEEEDV E TKMAQMV 799
650
....*....|..
gi 10140983 768 AGGETS E A CL H C 779
Cdd:PLN02437 800 CSLDNR E E CL A C 811
RNR_I
cd01679 Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
158-728
2.54e-51
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain]
Cd Length: 460
Bit Score: 186.21
E-value: 2.54e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 158 MDLFIY F FSP LS H Q LVCC ATP IMRS AG LRDAN L A SCFL INP D L S T E --- KSTTTA llqelt ML LS AKS - G V G C N VTSF -- 231
Cdd:cd01679 17 LEWAKE F YDL LS K Q RFTP ATP TLFN AG TPRGQ L S SCFL LTV D D S L E siy DTIKEC ------ AQ LS KIG g G I G L N LSNI ra 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 232 ------ G VDEKC i QSCVG --- L I N SQVEFFNDQNP R PVSV A A Y M E V WH SQ I Q EFL AV K LPENP -- S R CASIYQ G LC IP K L 300
Cdd:cd01679 91 tgspir G TNGAS - NGVIP flk L L N DTARYVDQGGQ R KGAG A V Y L E I WH PD I E EFL DL K KNNGD er R R ARDLFY G VW IP D L 169
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 301 F F E KFIE D pgqnwylfkpeksgnlanlygdefrseyerlvgigcyadaipiks L MFL I INTIIK TG S PYI IY K EA CN EHH 380
Cdd:cd01679 170 F M E RVER D --------------------------------------------- L WRK I LESQFE TG Y PYI LF K DT CN RKN 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 381 WKNME G c A I A S A NLC A E VI Q Y ------- PG A D VS t CNLA NVC L pmclvtvsndshsplektyc GN VIESQA vsgvgfsmp 453
Cdd:cd01679 205 PQKHL G - T I K S S NLC T E IL Q P tspsede PG E D AV - CNLA SIN L -------------------- GN FVTFEK --------- 253
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 454 i L HAA V EV AV FLVNCA I AGGKCVT P GME R G - Q R E R SM G I GV H GL A D VF A EMGYS Y LD E R A AR L DVE IFE NMYFR A V K T S N 532
Cdd:cd01679 254 - L EEV V KL AV RALDNV I DLNYYPV P EAK R S n M R H R AI G L GV M GL H D YL A LLRIP Y ES E E A LD L NDR IFE TINYY A L K A S C 332
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 533 NICR lgggrpfegwgeskl RH G ffhwqgwedvnlsipiteweklsrrciss G VY NS QFI A LM PT VGS S LLT G FSE S YY P Y 612
Cdd:cd01679 333 ELAK --------------- ER G ----------------------------- G LR NS LLL A IA PT ASI S QIL G ATP S IE P I 368
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 613 FA NI SSKVSSKE E VMKP N mtfwnrvsk ED L dtvrffsgdvalfp E PLKEK Y S L FLS A FDYCAEKQLAR A RL R APFV DQ S Q 692
Cdd:cd01679 369 TS NI YVRRVLSG E FPVV N --------- PH L -------------- E KDLWE Y G L YKT A YEIDQRWLIDL A AD R QKHI DQ G Q 425
570 580 590
....*....|....*....|....*....|....*.
gi 10140983 693 S HSFH L KEE nv VSA R F L KD L ILSGYTL GLKT I m YY C 728
Cdd:cd01679 426 S LNLF L TPP -- ATT R D L NS L YFYAWKK GLKT L - YY L 458
Name
Accession
Description
Interval
E-value
NrdE_NrdA
TIGR02506 ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...
95-731
6.69e-168
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain]
Cd Length: 617
Bit Score: 498.06
E-value: 6.69e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 95 A K RF Y DT Y V LR T A D - G SC YES VSHCF MR I A A fctvqvltnsalkitilylgrd K L FKDL P CSPTMDLF I Y F FSP LS HQLV 173
Cdd:TIGR02506 4 L K EL Y NR Y L LR N A A t G AI YES PQEAY MR V A M ---------------------- G L ASLE P KDTRLADA I R F YDL LS RLKI 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 174 CC ATP IMRS AG LRDAN L A SCFL INPDLS T e KSTTTALLQELTM L LSAKS G V G C N V T ---------- SFGVDE K C I QSCVG 243
Cdd:TIGR02506 62 SP ATP TLFN AG TPRGQ L S SCFL LDVTDD T - LESIYKAIDDVAQ L SKHGG G I G L N L T klraigspir GTNNAS K G I IPFLK 140
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 244 L IN S Q VE FF N DQNP RP VSV A A Y M EVWH SQ I Q EFL AV K LP -- ENPS RC ASIYQ GL C IP K LF FEKFI ED pg QN WYLF K P EKS 321
Cdd:TIGR02506 141 L LD S S VE AV N QGGK RP GAA A V Y L EVWH PD I E EFL DL K KN ng DERR RC DNLFY GL W IP D LF MKRVE ED -- KD WYLF S P YDV 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 322 GN L AN LYG D EF RS EYERL VG --- IGCYADAIPIKS LM FL I IN T IIK TG S PYI IY K E A C N E H HWKNME G C AI ASA NLC A E V 398
Cdd:TIGR02506 219 PG L YG LYG E EF EE EYERL EK dve ARKKIRKVSARD LM KD I LR T RVE TG R PYI LF K D A V N K H NPFKTG G G AI KMS NLC T E I 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 399 I Q Y ---- PGADVST CNLA N V C L PMC l V TVSNDSH S P LE K tycgnviesqavsgvgfsmpilha AV EV AV FLVNCA I - AGG 473
Cdd:TIGR02506 299 T Q P tdds HKGETAV CNLA S V N L ANF - V MEDKFDF S E LE D ------------------------ AV RI AV RFLDNV I d LQN 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 474 KCVT P GMERG QR E RS M GIGV H GL A DV F A EM G YS Y LD E R A AR L DVE IFE NM Y FR A V K T S NNICRLG G gr PF E G WGE SK LRH 553
Cdd:TIGR02506 354 YPTA P AAKSN QR R RS I GIGV M GL H DV L A KL G LP Y DS E E A RD L NDR IFE AI Y YY A I K A S AELAKEK G -- PF P G FSG SK YAK 431
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 554 G FF H WQG WE DVNLSIPIT ----- E WE K L SR R CISS G VY NSQ FI ALMPT VG SS L LTG FS ES YY P Y F A NI SS K VSSKE E VMK 628
Cdd:TIGR02506 432 G WL H PDT WE KTIDPKTSM aptee D WE A L RE R IKEY G LR NSQ LT ALMPT AS SS Q LTG VT ES IE P V F S NI FT K KTLSG E FLI 511
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 PN MTFWNRVSKED L DTVRFFS ------ G DVALFPEPLKEKYSLFLS A FDYCA E KQLAR A RL R AP FVDQS Q S HSFH L K EE n 702
Cdd:TIGR02506 512 PN KYLMKELEELG L WDADRRG divenv G SPQPIAAIPETLKYKYKT A YELDQ E ALIDM A AD R QK FVDQS I S LNLF L T EE - 590
650 660
....*....|....*....|....*....
gi 10140983 703 v V S A RF L KD L I L SGYTL GLKT i MYYC KVK 731
Cdd:TIGR02506 591 - V T A KD L LK L L L LAWKK GLKT - MYYC RSR 617
Ribonuc_red_lgC
pfam02867 Ribonucleotide reductase, barrel domain;
191-727
6.18e-128
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain]
Cd Length: 487
Bit Score: 390.41
E-value: 6.18e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 191 A SCFL INPDL S TEKSTT T al L Q E LTM L LSAKS G V G C N VT ---------- SF G VDEKCIQSCVG L INSQVEFF N DQNP R PV 260
Cdd:pfam02867 1 S SCFL LSVED S LDSIYD T -- L K E AAL L SKGGG G I G L N LS klrakgspir GT G GASSGVVPFLK L FDDSARYV N QGGK R RG 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 261 SV A A Y M EVWH SQ I Q EFL AV K LPE -- NPS R CASIYQ G LCI P K LF F E KFIE D pg QN W Y LF K P EKSGN L AN LYG D EF RS E - YE 337
Cdd:pfam02867 79 AA A V Y L EVWH PD I E EFL DL K KNN gd EEV R ARNLNL G VWV P D LF M E RVEA D -- ED W T LF S P REAPD L ED LYG E EF EK E y YE 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 338 R LVGI G CYADAIPIKS L M F L I INTI I K TG S PYI IY K E A C N EHHW k NMEGCA I A S A NLC A E VI Q YP - GADVST CNLA NVC L 416
Cdd:pfam02867 157 R EENE G IRKKTVKARE L W F K I AKSQ I E TG Y PYI LF K D A V N RKNP - QKHLGT I K S S NLC T E IV Q PT s PSEIAV CNLA SIN L 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 417 PMC lvt V SNDSHSPL EK tycgnviesqavsgvgfsmpi L HAA V EV AV FLVNCA I AGGKCVT P GME R G - Q R E R SM G I GV H G 495
Cdd:pfam02867 236 AKF --- V EFGGTFDF EK --------------------- L REV V KL AV RALDNV I DINDYPV P EAR R S n K R H R PI G L GV M G 291
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 496 LAD VF A EM G YS Y LD E R A AR L DVE IFE N MY FR A V K T S NNICRLG G gr PF E G WGE SK LRH G FFHWQGWE ---- DVNL S IPIT 571
Cdd:pfam02867 292 LAD AL A KL G IP Y DS E E A RD L NDK IFE T MY YY A L K A S SELAKEK G -- PF P G FEG SK YSK G ILQFDKYV ktdf APKA S KTRE 369
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 572 E WE K L SRRCISS G VY NSQ FI A LM PT VGS S LLT G FS ES YY P Y F A N IS S KVSSK EE VMK pnmtfwnrvskedldtvrffsgd 651
Cdd:pfam02867 370 D WE E L REDIKKY G LR NSQ LT A IA PT GSI S QIA G AT ES IE P I F S N VY S RKVLS EE TKE ----------------------- 426
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10140983 652 valfpeplkekys LFLS A F D YCAEKQLAR A RL R A PFVDQS Q S HSFH L KEE nv VSARF LK D L I L SGYT LGLKTI M YY 727
Cdd:pfam02867 427 ------------- YYKT A Y D IDQKAHIDM A AA R Q PFVDQS I S KTLF L PND -- ATTSD LK S L Y L YAWK LGLKTI Y YY 487
NrdA
COG0209 Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...
40-727
7.14e-62
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain]
Cd Length: 665
Bit Score: 220.44
E-value: 7.14e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 40 K ATKTVTEYIEKFADVL EE NVL -- R F L QDNA E M L ELC I YMYE - QLPA Y kavksrgi LSA K RF YD T Y V L RTA DG SCY E SVS 116
Cdd:COG0209 4 K EALGQYKSFSEKIKYV EE GLY de R L L EEDL E E L AAA I DPER d RFFS Y -------- NAL K TL YD R Y L L KDE DG KPL E TPQ 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 117 HC FMR I A afctvqvltnsalkiti LY L GRDKLFK D lpcsp TMDLFIY F FSP LS HQLVCC ATP IMRS AG LRDAN L A SCF LI 196
Cdd:COG0209 76 DL FMR V A ----------------- MG L AAAEKPE D ----- REEWAKE F YDL LS SLRFLP ATP TLFN AG TPRGQ L S SCF VL 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 197 NPDL S T E --- KSTTT A llqelt M LLS a KS -- GVG C N VT --------------- S F G V dekciqsc V G --- LINSQVEFF N 253
Cdd:COG0209 134 PVED S L E sif DALKD A ------ A LLS - KS gg GVG F N FS rlrpkgspikgtggv S S G P -------- V P fmk VFDDAAVAV N 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 254 DQNP R PVSVAA Y ME VWH SQ I Q EFL AV K L -- PENPS R CASIYQGLC IP K LF F E KFI ED pg QN W Y LF K P EKSGN L AN LYG D E 331
Cdd:COG0209 199 QGGK R RGANMV Y LR VWH PD I E EFL DL K K nn GDERR R LHNFNISVW IP D LF M E AVE ED -- ED W T LF S P REVPD L YG LYG E E 276
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 332 F RSE YE RLVGI G CYADA I PIKS L MFL I INTIIK TG S P Y I IY K EAC N EHH wk NMEGCA - I A S A NLC A E VIQY P - GADVST C 409
Cdd:COG0209 277 F EEA YE EYEAD G RVYKT I KARE L WRK I LESAWE TG E P G I LF K DTI N RRN -- PLPHLG v I H S S NLC G E IPLL P y ESEDAS C 354
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 410 NL ANVC L PMCLVTVSN D SHS p LE K T ycgnviesqavsgvgfsmpilhaa V EV AV - FL V N caiaggkc V ------- T P GM E 481
Cdd:COG0209 355 NL GSIN L AKFVKDGEF D WEK - LE E T ------------------------ V RT AV r FL D N -------- V idindyp V P EI E 401
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 482 RG - Q R E R SM G I GV H GLAD VF A EM G YS Y LD E R A AR L DV EI F E NMYFR A V K T S NNICRLG G gr P F EGWGE SK LRH G FFHWQG 560
Cdd:COG0209 402 KA n R R H R PI G L GV M GLAD AL A KL G IP Y DS E E A RE L AD EI M E FINYY A Y K A S AELAKER G -- A F PAFEG SK YAK G ILPFDK 479
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 561 WE D VN L SIPITE W EK L SRRCISS G VY NS QFI A LM PT v G S - SL LT G FSESYY P Y F ANISSK - V SSKE E VMKP N -------- 630
Cdd:COG0209 480 YL D DL L IPTTLD W DA L REDIKKH G LR NS TLT A IA PT - G T i SL IA G TTSGIE P I F SLVYVR k V LDGG E FTVV N pylvralk 558
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 631 - MTF W NRVSK E DLDT vrff S G D V ALFP E PLK E KYS L FLS A FDYCA E KQLARARL R APF VDQ SQ S HSFH L KEE nv VSARF L 709
Cdd:COG0209 559 e LGL W DEELV E KIKE ---- D G S V QDID E LPE E LKE L YVT A YEIDP E WHIDMQAA R QKH VDQ AI S KTLN L PND -- ATVED L 632
730
....*....|....*...
gi 10140983 710 KD L I L SGYT LGLK T I M YY 727
Cdd:COG0209 633 AE L Y L LAWK LGLK G I Y YY 650
PLN02437
PLN02437 ribonucleoside--diphosphate reductase large subunit
176-779
8.94e-61
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain]
Cd Length: 813
Bit Score: 220.00
E-value: 8.94e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 176 A T P IMRS AG LRDAN L A SCFLI N - P D L S T E KSTT T al L Q E LTMLLSAKS G V G CN V TSFGVDEKC I QSCV G LI N SQ V --- EF 251
Cdd:PLN02437 201 A S P TLFN AG TPRPQ L S SCFLI C m K D D S I E GIYD T -- L K E CAVISKSAG G I G LS V HNIRATGSY I RGTN G TS N GI V pml RV 278
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 252 FND Q -------- NP R PVSV A A Y M E V WH SQ I Q EFL av K L PE N ---- PS R CASIYQG L C IP K LF F E K f IEDP G Q n W Y LF K P E 319
Cdd:PLN02437 279 FND T aryvdqgg GK R KGAF A I Y L E P WH AD I F EFL -- D L RK N hgke EH R ARDLFYA L W IP D LF M E R - VQSN G D - W S LF C P N 354
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 320 KSGN LA NLY G D EF RSE Y ERLVGI G CYADAIPIKS L M F L I INTI I K TG S PY IIY K EA CN EHHWKNME G c A I A S A NLC A E V I 399
Cdd:PLN02437 355 EAPG LA DCW G E EF ERL Y TKYERE G KAKKVVQAQQ L W F A I LESQ I E TG T PY MLF K DS CN RKSNQQNL G - T I K S S NLC T E I I 433
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 400 Q Y PGAD - VST CNLA NVC LP MCLVT -- V SND SH SP lektycg NVIE S QAVSGVG F SMPI L HAAVE V AVFLV N CA I AGGKCV 476
Cdd:PLN02437 434 E Y TSPT e TAV CNLA SIA LP RFVRE kg V PLE SH PS ------- KLVG S LGSKNRY F DFEK L AEVTA V VTRNL N KI I DVNYYP 506
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 477 TPGME R GQ - R E R SM GIGV H GLAD V F AEM G YSYLDER A AR L DVE IFE NM Y FR A V K T S NNICRLG G gr P F E GWGE S KLRH G F 555
Cdd:PLN02437 507 VETAR R SN m R H R PI GIGV Q GLAD A F ILL G MPFDSPE A QQ L NKD IFE TI Y YH A L K A S SELAARE G -- P Y E TYAG S PVSK G I 584
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 556 FHWQG W e D V nls I P IT -- E W EK L SRRCISS GV Y NS QFI A L MPT VGS S LLT G FS E SYY PY FA NI - S SK V S S K E E V MK ---- 628
Cdd:PLN02437 585 LQPDM W - G V --- T P SG rw D W AA L REMISKN GV R NS LLV A P MPT AST S QIL G NN E CFE PY TS NI y S RR V L S G E F V VV nkhl 660
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 ---- PN M TF W NRVS K EDL ---- DT V R ffsg DVALF P EP LK EK Y --------- S L FLS A F D ycaekqlararl R APFV DQS 691
Cdd:PLN02437 661 lhdl TE M GL W TPTL K NKI iaen GS V Q ---- KIPEI P DD LK AI Y ktvweikqr T L VDM A A D ------------ R GCYI DQS 724
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 692 QS HSF H LKEE N VVS arf L KD L ILSGYTL GLKT I MYY ck VKKQSTMSSFQCLR D Q ---- NKSEMTGNDQGVEP E SYIKCTA 767
Cdd:PLN02437 725 QS LNI H MDQP N FGK --- L TS L HFYAWSK GLKT G MYY -- LRSRAAADAIKFTV D T aslk PSATGVAAPEEEDV E TKMAQMV 799
650
....*....|..
gi 10140983 768 AGGETS E A CL H C 779
Cdd:PLN02437 800 CSLDNR E E CL A C 811
RNR_I
cd01679 Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
158-728
2.54e-51
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain]
Cd Length: 460
Bit Score: 186.21
E-value: 2.54e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 158 MDLFIY F FSP LS H Q LVCC ATP IMRS AG LRDAN L A SCFL INP D L S T E --- KSTTTA llqelt ML LS AKS - G V G C N VTSF -- 231
Cdd:cd01679 17 LEWAKE F YDL LS K Q RFTP ATP TLFN AG TPRGQ L S SCFL LTV D D S L E siy DTIKEC ------ AQ LS KIG g G I G L N LSNI ra 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 232 ------ G VDEKC i QSCVG --- L I N SQVEFFNDQNP R PVSV A A Y M E V WH SQ I Q EFL AV K LPENP -- S R CASIYQ G LC IP K L 300
Cdd:cd01679 91 tgspir G TNGAS - NGVIP flk L L N DTARYVDQGGQ R KGAG A V Y L E I WH PD I E EFL DL K KNNGD er R R ARDLFY G VW IP D L 169
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 301 F F E KFIE D pgqnwylfkpeksgnlanlygdefrseyerlvgigcyadaipiks L MFL I INTIIK TG S PYI IY K EA CN EHH 380
Cdd:cd01679 170 F M E RVER D --------------------------------------------- L WRK I LESQFE TG Y PYI LF K DT CN RKN 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 381 WKNME G c A I A S A NLC A E VI Q Y ------- PG A D VS t CNLA NVC L pmclvtvsndshsplektyc GN VIESQA vsgvgfsmp 453
Cdd:cd01679 205 PQKHL G - T I K S S NLC T E IL Q P tspsede PG E D AV - CNLA SIN L -------------------- GN FVTFEK --------- 253
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 454 i L HAA V EV AV FLVNCA I AGGKCVT P GME R G - Q R E R SM G I GV H GL A D VF A EMGYS Y LD E R A AR L DVE IFE NMYFR A V K T S N 532
Cdd:cd01679 254 - L EEV V KL AV RALDNV I DLNYYPV P EAK R S n M R H R AI G L GV M GL H D YL A LLRIP Y ES E E A LD L NDR IFE TINYY A L K A S C 332
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 533 NICR lgggrpfegwgeskl RH G ffhwqgwedvnlsipiteweklsrrciss G VY NS QFI A LM PT VGS S LLT G FSE S YY P Y 612
Cdd:cd01679 333 ELAK --------------- ER G ----------------------------- G LR NS LLL A IA PT ASI S QIL G ATP S IE P I 368
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 613 FA NI SSKVSSKE E VMKP N mtfwnrvsk ED L dtvrffsgdvalfp E PLKEK Y S L FLS A FDYCAEKQLAR A RL R APFV DQ S Q 692
Cdd:cd01679 369 TS NI YVRRVLSG E FPVV N --------- PH L -------------- E KDLWE Y G L YKT A YEIDQRWLIDL A AD R QKHI DQ G Q 425
570 580 590
....*....|....*....|....*....|....*.
gi 10140983 693 S HSFH L KEE nv VSA R F L KD L ILSGYTL GLKT I m YY C 728
Cdd:cd01679 426 S LNLF L TPP -- ATT R D L NS L YFYAWKK GLKT L - YY L 458
PRK12364
PRK12364 ribonucleoside-diphosphate reductase subunit alpha;
2-733
3.72e-32
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain]
Cd Length: 842
Bit Score: 134.11
E-value: 3.72e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 2 A SA E A T P Q QQI D qlkvnag W DM ksn I K A G LL HHE e ME KK AT K TVTEY - I EK F A D --- V L E E NV L -- RFLQDN --- A E ML E 72
Cdd:PRK12364 155 A AV E L T T Q EAP D ------- W EF --- I A A R LL MLQ - FS KK LG K SLEKL g I HS F Y D kik Y L T E EG L yg SYILEH ysr E E IE E 223
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 73 LCIYMYEQ --- L PA Y KAVK srgi L SA KR fydt YV L RT ADGSCY ES VSHC F MR IA afctvqvl TNS A LKITILYL G RD K L F 149
Cdd:PRK12364 224 AAGFIDPE rdk L FT Y SGLD ---- L LL KR ---- YV I RT HSHEPL ES PQEM F LG IA -------- LHL A MPEKQDRM G WV K R F 287
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 150 K D L pcsptmdlfiyffsp LS HQL V CC ATP IMRS A GLRDAN L A SCF LIN - PD l S TE --- K S TTT allqe LTMLLSAKS G V G 225
Cdd:PRK12364 288 Y D M --------------- LS KLK V TM ATP TLSN A RKPFHQ L S SCF IDT v PD - S LD giy R S IDN ----- FAQVSKFGG G M G 346
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 226 C --- N V TSF G VDEKCI Q SCV G LINSQVEFF ND Q ------- NP R PVS VA A Y ME VWH SQ I Q EFL AVKLPENPS R CAS -- IYQ 293
Cdd:PRK12364 347 L yfg K V RAV G SNIRGF Q GVA G GVIRWIKLA ND T avavdql GM R QGA VA V Y LD VWH KD I P EFL QLRTNNGDD R MKA hd VFP 426
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 294 GL C I P K LF FEKFIE D PG Q N WYLF K P E ----- K SGN L ANL YG D E FRSE Y ER lvgig C YA DA ------ IPIK S L MF LI INTI 362
Cdd:PRK12364 427 AV C Y P D LF WKMVRD D IN Q S WYLF C P H eiltv K GYA L EDY YG E E WEKR Y LD ----- C VN DA riskrs IPIK D L VR LI LKSA 501
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 363 IK TG S P YIIYKEAC N EHHWKNME G c A I ASA NLC A E VI Q ------------------------- Y PG a D VST CNLA NVC L - 416
Cdd:PRK12364 502 VE TG T P FTFNRDTV N RANPNKHK G - M I YCS NLC T E IA Q nmsaietvsteietedgdtvvvttt R PG - D FVV CNLA SLS L g 579
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 417 -- PM clvtvs N D SHSPL E KTYCG ----- NVI E sqavsg VG F s M P ILH A AVE vavflvncaiaggkcvtpgmer GQ R E RS M 489
Cdd:PRK12364 580 ni DL ------ E D EEELE E VVRTV vrald NVI D ------ LN F - Y P VPY A QIT ---------------------- NK R Y RS I 624
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 490 G I GV H G LADVF A EM G YSYLD E RAARLDVEI FE NMYFR A V K T S NN I CRLG G GRP - FEG -- W -- G E sklrhg F F HWQ G WED v 564
Cdd:PRK12364 625 G L GV S G YHHAL A KN G IRWES E EHLEFADRV FE RINYA A I K A S ME I AKEK G AYG y FEG sd W qt G A ------ Y F RKR G YTS - 697
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 565 nlsipi T EW EK L S R RCISS G VY N SQFI A LM PT VGS S LLT G FSESYY P ---- YF anissk VSS K EEVMK P nmtfwn RV S ke 640
Cdd:PRK12364 698 ------ E EW QR L A R EVAEN G MR N AYLL A VA PT SST S IIA G TTAGVD P vmkr YF ------ LEE K KGALM P ------ RV A -- 757
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 641 dldtvrffsgdvalf PE PLKEKYS L FLS A FDYCAEKQLAR A RL R APFV DQ S QS HSFHLKE E nv VSA R FLK DL I L SGYTL G 720
Cdd:PRK12364 758 --------------- PE LSDKTFW L YKN A HLIDQKWSIRA A GV R QRHI DQ A QS VNLYITN E -- FTM R QVL DL Y L LAWEE G 820
810
....*....|...
gi 10140983 721 L KTI m YY CKV K KQ 733
Cdd:PRK12364 821 V KTI - YY VRS K SL 832
PRK06539
PRK06539 ribonucleoside-diphosphate reductase subunit alpha;
102-736
9.38e-32
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain]
Cd Length: 822
Bit Score: 132.74
E-value: 9.38e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 102 Y VL R TAD G SCY E SVSHCF MRIA AFCTV -- QVL T N SAL K itilylgrdklfkdlpcsptmdlfiy F FSPL S HQLVCC A TPI 179
Cdd:PRK06539 160 Y GI R ARN G DAL E VPQYFW MRIA MGLSL ne DDP T S SAL A -------------------------- F YEKM S KLEYLA A GST 213
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 180 MRS AG LRDAN L AS CF LINPDLST E KSTT T al LQELTM L LSAKS G V G CN V TSFGVDEKC I Q S CVGLINSQVE F FN -- D QNP 257
Cdd:PRK06539 214 LVN AG TPYPQ L SN CF VMEMQDDI E HIAK T -- TRDVMW L TKGTG G I G LS V SKLRAQGSP I R S NNTTSTGPIP F MH ti D SVL 291
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 258 R P VS -------- VAA YME V WH SQIQ EFL AVKL ---- P ENPS R C A S iy QGLC I PKL F FEKFIE D pg QN WYLF K P EKSGN L A 325
Cdd:PRK06539 292 R A VS rggkkfga LCF YME N WH MDFP EFL DLRQ nsgd P YRRT R T A N -- TAVW I SDE F MKRVQN D -- ED WYLF D P LETPD L N 367
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 326 N LYG DE F RSE Y ERL V GI gcy A D A IP I K sl MF ---------- L I INTIIK T GS P YIIY K EAC N EHHWK N ME G c A I ASA NLC 395
Cdd:PRK06539 368 E LYG KA F SKR Y AQY V EQ --- A E A GR I R -- MF kritareqfr A I LMSLQT T SH P WLTW K DTI N NRALN N NT G - T I HLS NLC 441
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 396 A E VIQYPGA D - VS T CNLA NVC L PMC L VTVSN D s HSP LE KT ycgnvi ESQ AV SGVGFSMP I LHAA V EV A V F lvncaiaggk 474
Cdd:PRK06539 442 T E ICLPQDR D n VS V CNLA SIN L SRH L ADGEL D - WAQ LE ES ------ TRL AV RQLDNLID I TASS V KE A D F ---------- 504
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 475 cvtpgme RG Q RE R SM G I GV H G LA D VFAEM GYSY LD E R A AR L DVE I F E NMYFR A VKT S NNICRLG G GR P - FEG WGE S K lrh 553
Cdd:PRK06539 505 ------- SN Q QN R AI G L GV M G FT D MVERL GYSY ES E E A YD L IDR I M E HISYA A IDE S ADLAAER G AY P n FEG SRW S R --- 574
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 554 G FFHWQGWE -- DVNLSI P IT ------- E W EK L s R RCISS G VY N SQFI A LM PT VGSS L LT G FSESYY P Y F AN I S S KVS S KE 624
Cdd:PRK06539 575 G MVPVDSIA ll EADRGV P VD vnrttrl D W DA L - R AKVRG G MR N ATLM A IA PT ASIG L VA G TTPGLD P Q F SQ I F S RST S SG 653
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 625 EVMKP N --------- MTF W NR V SK E D L DT vrff S GD --- V A LF P EPL K EK Y -- S LF LS AFDYC ae KQL ARA R lra PF VDQ 690
Cdd:PRK06539 654 KFLEV N rnlvadlke LGL W ET V RE E I L RS ---- Q GD iqe I A AI P DEI K AL Y rt S FQ LS PYAFL -- EVA ARA Q --- KW VDQ 724
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 10140983 691 SQ S HSFH L KEENVVS arf LK D LILSGYTL G L KT i M YY CKV K ----- K QST M 736
Cdd:PRK06539 725 AI S RNMY L ESRDIGD --- MM D IYTAAWEM G V KT - T YY LHM K prhta E QST V 771
PRK12365
PRK12365 ribonucleoside-diphosphate reductase subunit alpha;
162-759
1.25e-31
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain]
Cd Length: 1046
Bit Score: 132.76
E-value: 1.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 162 I Y F FSP LS HQLVCC ATP IMRSA G L R DAN L A SC F L -- INP DL stek STTTALLQELT ML LSAKS G V G CNV T SFGVDEKC I Q 239
Cdd:PRK12365 426 I T F YNL LS TFRYTP ATP TLFNS G M R HSQ L S SC Y L st VQD DL ---- VHIYKVISDNA ML SKWAG G I G NDW T AVRATGAL I K 501
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 240 SCV G LINSQVE F F ---------- N DQNP R PVS V AA Y M EVWH SQIQE FL AVK -- LPENPS R CAS I YQGLC IP K LFF EK f IE 307
Cdd:PRK12365 502 GTN G KSQGVIP F I kvandtavav N QGGK R KGA V CV Y L EVWH LDYED FL ELR kn TGDERR R THD I NTASW IP D LFF KR - LQ 580
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 308 DP G q N W Y LF K P EKSGN L ANL YG D EF R --- S EYER L V GI G --- C Y a DAIPIKS L MFLIINTIIK TG S P YIIY K EAC N EHHW 381
Cdd:PRK12365 581 QK G - T W T LF S P DDVPG L HEA YG E EF E kly E EYER K V DT G eir L Y - KKVEAED L WRKMLSMLYE TG H P WMTF K DPS N IRSA 658
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 382 KNME G c AIASA NLC A E V - IQYPGADVST CNL ANVC L pmclvtvsndshsp L E KTYCGNVI E SQAVSGVGFSMP IL HAAVE 460
Cdd:PRK12365 659 QDHK G - VVRCS NLC T E I l LNCSETETAV CNL GSIN L -------------- V E HIVNDGLD E EKLSETISIAIR IL DNVID 723
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 461 VAVF lvncaiaggkcvt P GM E RGQ --- RE R SM G I GV H G LA D VFAEMGY SY LDER A ARLDVEIF E NMYFR A VKT S NNICRL 537
Cdd:PRK12365 724 INFY ------------- P TK E AKE anl AH R AI G L GV M G FQ D ALYKLNI SY ASQE A VEFADYSS E LIAYY A ILA S SLLAKE 790
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 538 G G gr PFEGWGE SK LRH G FF --------- HWQ G WEDVNLSIPI - TE WE KLSRRCISS G VY NSQ FI A LM PT VGS S LLT G FSE 607
Cdd:PRK12365 791 R G -- TYSSYKG SK WDR G YL pidtiellk EYR G EANLLMDTSS r KD WE PVRSLIKEY G MR NSQ LM A IA PT ATI S NII G VTQ 868
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 608 S YY P YFANISS K VSSKE E VMK PN MTFWNRVS K ------ ED LD TVRF F S G --- DVALF P EP LK E kys L FL S AF DYCA E KQL 678
Cdd:PRK12365 869 S IE P TYKHLFV K SNLSG E FTI PN VYLIEKLK K lgiwda DM LD DLKY F D G sll EIERI P DH LK K --- I FL T AF EIEP E WII 945
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 679 AR A RL R APFV D QS QS HSFH L K E EN vvs ARF L KDLI L SGYTL GLKT IM Y yck VKKQSTM S SFQCLR D Q NK semtgnd Q G VE 758
Cdd:PRK12365 946 EC A SR R QKWI D MG QS LNLY L A E PD --- GKK L SNMY L TAWKK GLKT TY Y --- LRSSAAT S VEKSFV D I NK ------- R G IQ 1012
.
gi 10140983 759 P 759
Cdd:PRK12365 1013 P 1013
PRK09209
PRK09209 ribonucleoside-diphosphate reductase subunit alpha;
100-726
2.69e-27
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain]
Cd Length: 761
Bit Score: 118.29
E-value: 2.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 100 D T Y VLRTA D GSC YE SVSHCFMR IA AF ctvqvltnsalkitilylgrdk L FKDL P CSPT M D L FIYFFSP LS HQLVCC ATP I 179
Cdd:PRK09209 166 D R Y LATDS D RNV YE LPQERWLT IA LY ---------------------- L MQNE P RERR M Q L VKEAYWA LS NLYMTV ATP T 223
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 180 MRS AG LRDAN L A SCF LINP D L S T ---- EKS T TT A LL qeltmlls A K S G V G CNV ----- T S F G V D EKCIQSCVG ------- 243
Cdd:PRK09209 224 LAN AG KVGGQ L S SCF IDTV D D S L qgiy DSN T DV A RV -------- S K H G G G VGA ylgkv R S R G S D IRGFKGVSS gvipwik 295
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 244 - L I N SQ V EF fn DQ - NP R PVSV A A Y ME VWH SQ I QE FL AVK L PENPS R -- CASIYQ G L CIP K LF F E K f I E DP G q N WYLF K P - 318
Cdd:PRK09209 296 q L N N TA V SV -- DQ l GQ R KGAI A V Y LD VWH KD I ES FL DLR L NNGDE R lr AHDVFT G V CIP D LF M E A - V E RR G - D WYLF D P h 371
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 319 --- EKS G - N L ANL Y GDE ----- FR SE YE R lvgig C Y AD ------ AIPIKSL M FL I INTIIK TG S P YII Y KEAC N EHHWKN 383
Cdd:PRK09209 372 evk KVM G w Y L EDF Y DEK kgdgs FR EK YE E ----- C V AD erlsrk TVKAIDI M KR I MVSQLE TG N P FMF Y RDEV N RMNPNK 446
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 384 M EG c A I A S A NLC A E VI Q --------------------- Y PG a D VST CNL ANVC L PM clv T V SN D SHS --- P LEKTYCG NV 439
Cdd:PRK09209 447 H EG - M I Y S S NLC T E IM Q nmsptvmiqeiisggqivitk Q PG - D FVV CNL SSIN L GR --- A V TA D VLE rli P IQVRMLD NV 521
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 440 I ESQ avsgvgf SM P ILH A A vevavf LV N caiaggkcvtpgmerg Q RE R SM G I G VH G LADVF A EM G YSYLD E R A ARLDV E I 519
Cdd:PRK09209 522 I DLN ------- QL P VPQ A T ------ IT N ---------------- Q KY R AI G L G TF G WHHLL A LK G IAWES E E A VQYAD E L 572
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 520 F E NMYFRAVKT S NNICRLG G GR P - F E G -- W -- GE sklrhg F F HWQ G WED vnlsipi TE W EK L SRRCISS GV Y N SQFI A LM 594
Cdd:PRK09209 573 Y E RINYLTIQA S MELAKEK G AY P v F K G sd W qt GE ------ Y F ERR G YNS ------- PQ W DE L AAQVAEN GV R N AYLM A VA 639
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 595 P TVGSSLLT G FSE S YY P YF anis S KVSSK E evm K PNMTFWNRVSKED LDT VRFFSGDVAL fpep LKEKY S L flsafdyca 674
Cdd:PRK09209 640 P NMSTAQIA G STA S ID P IY ---- S AFYYE E --- K KDYRRPVTAPDLS LDT WPYYEKGAYK ---- VDQFW S I --------- 699
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 10140983 675 e K Q L A R arl R APF VDQS Q S HS F HLK ee NVVS A RF L K DL ILSGYTL GLKT IM Y 726
Cdd:PRK09209 700 - R Q N A A --- R QRH VDQS I S FN F YVP -- STIR A SE L L DL HMTAWKE GLKT TY Y 745
PRK07088
PRK07088 ribonucleoside-diphosphate reductase subunit alpha;
164-734
1.42e-25
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain]
Cd Length: 764
Bit Score: 112.98
E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 164 F FSP LS HQLVCC ATP IMRS AG LRDAN L A SCF LINP D LSTE ks TTTALL Q ELTMLLSAKSGV G C --- NVTSFGVDEKCIQS 240
Cdd:PRK07088 210 F YDL LS ELKATV ATP TLSN AG TPFYQ L S SCF ISVV D DNLW -- SIYDVN Q KFAQVSKHGGAL G I ytg KIRALNSEIRGFKN 287
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 241 CV G LINSQVEFF ND Q ------- NP R PVSV A AYMEV WH SQ I Q EFL AV K LPENPS R -- CAS I YQ G LCI P K LF FEKFIED pg Q 311
Cdd:PRK07088 288 AS G GVIPWIKLY ND T aiavdql GK R KGGA A ITLDI WH KD I P EFL DL K TNNGDD R rk AHD I FP G VSY P D LF MKRLEKR -- E 365
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 312 NW Y LF K P E ----- K SGN L ANL Y GD E F R S E YERLV g IG C YA D ------ AI P IKSL M FL I INTIIK TG S P Y I IYKEAC N EHH 380
Cdd:PRK07088 366 NW S LF D P H eikkv K GYS L EDY Y DE E D R K E FTKKY - LE C EE D tniprr TV P VLDI M KK I MKSAVE TG T P F I FFRDTV N KAN 444
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 381 w K N MEGCA I A S A NLC A E VI Q ypgadvstc N LANVC L PMCLVTVS N DSHSPLE K TYC G NVIESQAV S G V -- GFSMPI L HAA 458
Cdd:PRK07088 445 - P N KHKGM I Y S S NLC H E IA Q --------- N MSESE L LEEEIIDE N GYYEVVQ K IKA G DMVTCNLN S I V lg NVDDEE L EEV 514
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 459 VEVAVFLVNCA I AGGKCVT P GM E - RGQRE R SM G I G VH G LADVF A EMGYSYLDERAARLDVE I F E NMYFR A V K T S NNICRL 537
Cdd:PRK07088 515 IPTQIRMLDNV I SLNYYPV P EA E i TSDKY R AI G L G TS G YHHML A NNKIRWESDEHIKFADK I Y E EIAYY A I K A S MELAKE 594
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 538 G G GR P - F E G -- W GES K lrhg F F HWQ G WED vnlsipi TE W E KL SRRCISS G VY N SQFI A LM PT VGS S LLTGFSESYY P Y F A 614
Cdd:PRK07088 595 K G SY P a F K G se W ETG K ---- Y F ERR G YNS ------- ER W K KL KEEIKKY G MR N GYIT A VA PT GST S NIANTTAGID P V F K 663
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 615 N -- ISS K VS S KEEVMK P NM --- T FW NRVSKEDL D T vrffsgdvalfpeplkekyslflsaf DYCAEKQLA R A R lrap FV D 689
Cdd:PRK07088 664 R ff MEE K KG S FTPKTA P DL nee N FW YYKEAHTI D Q -------------------------- QWSIKACGV R Q R ---- HI D 713
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 10140983 690 Q S QS HSFHLKE E nv VS A RFLKD L ILSGYTL G L KTI M Y yck V KKQ S 734
Cdd:PRK07088 714 Q A QS FNLYITP E -- YK A KQILN L YIEAWKQ G V KTI Y Y --- V RNK S 753
PRK08447
PRK08447 ribonucleoside-diphosphate reductase subunit alpha;
93-726
3.71e-21
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain]
Cd Length: 789
Bit Score: 99.03
E-value: 3.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 93 L SA K RF YD T Y VLRTADGSCY E SVS H C FM R IA A F ctvqv L TNSA L K itil YLGRD K L F K D L pcsptmdlfiyffsp L S HQL 172
Cdd:PRK08447 140 L GI K TL YD R Y LIKDRNNNPI E LPQ H M FM A IA M F ----- L AQNE L D ---- PQKWA K K F Y D V --------------- I S KFE 195
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 173 V CC ATP IMRS A GLRDAN L A SC FL inpdlste K ST TTAL ------ LQ E LTM L LSAKS G V G --- CN V TSF G VDEKCIQSCV G 243
Cdd:PRK08447 196 V ML ATP TLSN A RTTRHQ L S SC YI -------- G ST PDNI egifds YK E MAL L SKYGG G I G wdw SK V RAM G SYIDGHKNAA G 267
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 244 ------ L I NSQVEFFN DQ - NP R PVSV A A Y M E V WH SQ I QE F LAVKLP -- E NPS R CASIYQG L C I PK LF FEKFI ED pg QN W Y 314
Cdd:PRK08447 268 giipfl K I TNDIAIAV DQ l GT R KGAI A V Y L E P WH MD I SD F IDLRKN sg E ERR R AHDLFPA L W I ND LF MKRVE ED -- AM W T 345
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 315 LF K P EKSGN L AN LYG D EF RS --- EYE RLVG I gc YADA I PI K S L MFL I INTIIK TG S P YIIY K EAC N EHHWKNME G c A I A S 391
Cdd:PRK08447 346 LF D P YECKD L TE LYG E EF EK ryl EYE KDEK I -- IKEY I NA K E L WKK I LTNYFE TG L P FLCF K DNA N RANPNAHA G - I I R S 422
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 392 A NLC A E VI Q --------------------------------------------------------- YPGADVST CNLA NV 414
Cdd:PRK08447 423 S NLC T E IF Q ntapnhykikiefedgsieffeeeelvtvdsgitkkakkitsldslkgkkiyiveke KKDGKTAV CNLA SI 502
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 415 C L PMCLVTVSNDSHS P LEKTYCG NVI E sqavsg VG F s M P il HAA V EVA vflvncaiaggkcvtpgmer GQRE R SM G I GV H 494
Cdd:PRK08447 503 N L SKINTKEDIERVV P IAIRMLD NVI D ------ LN F - Y P -- NRK V KAT -------------------- NLKS R AI G L GV M 553
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 495 G L A DVF AE MGYSY - LD E RAARL D v EI F E NMYFR A VKT S N N ICRLG G GR P - FEG WGE SK ---------------- L R H G F F 556
Cdd:PRK08447 554 G E A QML AE HKIAW g SK E HLEKI D - EI M E QISYN A IDA S S N LALEK G VY P d FEG SNW SK gifpidkaneeakklv E R G G L F 632
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 557 HWQ gwedvnlsipi TE WE K L SRRCISS G VY N SQFI A LM PT VGS S L L T G FSESYY P ------ YFA N I S SKVS skee V MK PN 630
Cdd:PRK08447 633 DSA ----------- CD WE G L REKVKKD G MR N GYLM A IA PT SSI S I L V G TTQTIE P vykrkw FEE N L S GLIP ---- V VV PN 697
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 631 MT fwnrvsked LD T VRFFS gdvalfpeplkekyslfl S A F D YCAEKQLAR A RL R APFV DQ S QS HSFH L KEEN v V S ARF L K 710
Cdd:PRK08447 698 LS --------- PE T WQYYT ------------------ P A Y D LDQKDLIKA A AV R QKWI DQ G QS LNIF L SLDK - A S GKY L N 749
730
....*....|....*.
gi 10140983 711 DLILSGYT LGLK TIM Y 726
Cdd:PRK08447 750 EIYTLAWK LGLK STY Y 765
NrdJ_Z
TIGR02504 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ...
164-727
1.99e-18
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain]
Cd Length: 575
Bit Score: 89.69
E-value: 1.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 164 F FSPLSHQLVCCAT P I - M RSA G L R DAN L AS CF LINPDL S T E ks TTTAL L Q E LTMLLSAKS GVG C N V t S FGVDEKCIQ S CV 242
Cdd:TIGR02504 49 F YDLMVNLGFIPNS P T l M NAG G T R LGQ L SA CF VLPVED S M E -- DIFEA L K E AALIFKRGG GVG Y N F - S TLRPKGDLV S GT 125
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 243 G LIN S - Q V E F FN -- D QNPRP V SV ----- A A Y M --- E VWH SQ I Q EF LAV K LP E NPSRCAS I yq GLCIPKL F F E KFIE D pg Q 311
Cdd:TIGR02504 126 G GVA S g P V S F MR vf D SAAGV V KQ ggtrr G A Q M gil D VWH PD I E EF IEA K AK E GKLQNFN I -- SVGVTDE F M E AVEN D -- E 201
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 312 NWY L FK P E ksgnlanlygdefrseyerlvg I G C Y A d AIPIKS L MFL I INTII K TGS P YIIYKEAC N EH H w KNME G CA I AS 391
Cdd:TIGR02504 202 EYE L RN P R ---------------------- T G E Y K - EVDARE L WDK I VESAW K SAE P GVLFIDTI N KW H - TCPY G GR I NA 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 392 A N L C A E viq Y P GADVST CNL ANVC L p MCL V tvsndshsplektycgnvi ESQAVSGVG F SMPI L HAA V EV A V - FL V N c A I 470
Cdd:TIGR02504 258 T N P C G E --- Q P LLPYES CNL GSIN L - AKF V ------------------- KNDFGDEAS F DFER L REV V RL A T r FL D N - V I 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 471 AGGKCVT P G - M E RGQRE R SM G I G VH GLAD VFAEM G YS Y LD E R A AR L DV E IF E NMYFR A VKT S NNICRLG G gr P F EGWGE S 549
Cdd:TIGR02504 314 DINVFPL P E i A E NTKKT R RI G L G IM GLAD LLIKL G IP Y DS E E A RE L AE E VM E FIADA A YRA S AELAKER G -- A F PLYDA S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 550 K LRH G FFHWQ gwedvnl S IP ITEWEKLSRRCISS G VY N S Q FIALM PT VGS SL LT G F S ESYY P Y FA NISSKVSSKEEVMK - 628
Cdd:TIGR02504 392 K YPM G RAMGA ------- R IP SALPAEIREAIRKY G IR N A Q LTTIA PT GTI SL IA G T S SGIE P V FA LVYFRNVTVGGELL e 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 629 P N MTFWNR ----- VSKEDLDTVRFFS G D V ALF P E P l K E KYSL F LS A F D YCA E kql ARARLR A --- P F VD Q S Q S HSFHLKE 700
Cdd:TIGR02504 465 V N PLVELA lrelg YYSDEIVKYVDEK G T V EGA P G P - E E LPKV F VT A M D ISP E --- DHVLMQ A aiq P W VD S S I S KTINMPS 540
570 580
....*....|....*....|....*..
gi 10140983 701 E nv VSARFL K DLI L SGYT LGLK T I MY Y 727
Cdd:TIGR02504 541 D -- ATVEDV K AVY L EAWK LGLK G I TV Y 565
nrdA
PHA02572 ribonucleoside-diphosphate reductase subunit alpha; Provisional
95-726
1.00e-15
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain]
Cd Length: 753
Bit Score: 81.30
E-value: 1.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 95 A KRFYDT Y VLRTAD - G SC YE SVSHCF M R IA A fctvqvltnsalkitilylgrd K L FK D L P CSPTMDLF I Y F FSPL S HQLV 173
Cdd:PHA02572 146 A MQLKEK Y LVQDRS t G EI YE TPQFAY M L IA M ---------------------- A L HQ D E P KEDRLEHV I R F YNAV S TRKI 203
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 174 CCA TPIM rs AG L R DA -- NLA SC FL I NPD -- L STEKS T TT A LLQ eltm LL S AKS G V G C N VTSF - GVDE K CIQSC V --- G L I 245
Cdd:PHA02572 204 SLP TPIM -- AG V R TP tr QFS SC VV I ESG ds L DSINK T AM A IVK ---- YI S KRA G I G I N AGMI r AEGS K IRGGE V rht G V I 277
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 246 ------ NSQ V EFFNDQNP R PVSVA AY MEV WH SQIQEF L AV K ---- LP EN ps R CASIYQ G LC I PK L FF E K FI ED pg QNWY L 315
Cdd:PHA02572 278 pfwkhf QTA V KSCSQGGI R GGAAT AY YPI WH LEVEDL L VL K nnkg VE EN -- R IRHLDY G VQ I ND L MY E R FI KN -- DYIT L 353
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 316 F K P - EKS G N L ANL Y G --- D E FR SE YE R L V gigcy A D A - IPI K ----- S L MF L IINTIIK TG SP YI IYKEA CN E H H - W K N m 384
Cdd:PHA02572 354 F S P h DVG G E L YDA Y F adq D R FR EL YE A L E ----- K D P s VRK K rikaq E L FL L LLKERSE TG RI YI MFIDH CN N H S p F K D - 427
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 385 egc A I ASA NLC A E v I QY P GADVSTCNLAN --- V C LPMCL V TVSNDSHSPL E K tycgnv IESQ AV SG vgfsmpi L HAAVEV 461
Cdd:PHA02572 428 --- P I RQS NLC C E - I AL P TKPLNHIDGEG eia L C TLSAI V LGNFEDQDEI E E ------ LAEV AV RA ------- L DNLLDY 490
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 462 AVFL V NC A IAGG K cvtpgmergqr E RS M G I GV HGL A DVF A EMGY SY l DERA A R L DV E I FE NMYFRAV K T SN NICRLG G gr 541
Cdd:PHA02572 491 QDYP V PA A LKAK K ----------- R RS L G V GV TNY A HYL A KNFA SY - EDAN A D L VH E L FE RLQYYLI K A SN KLAKEK G -- 556
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 542 PF E GWGES K LRH G FF -- H W QG w ED V NLSIP --- ITE WE K L SRRCISS G VY NS QFI ALMP TVG SS LLTGFSESYY P YFANI 616
Cdd:PHA02572 557 AC E YFSDT K YSR G EL pi D W YK - KK V DELVA pky NCD WE S L REDLKKY G IR NS TLS ALMP CES SS QVSNSTNGIE P PRGPV 635
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 617 S S K v S SKE EVMK --- PN M tfwnrvskedldtvrffsgdvalfp E P LK EK Y S L FLSAFDYCAEKQ L ARARLRAP FVDQ SQ S 693
Cdd:PHA02572 636 S I K - K SKE GPFN qvv PN V ------------------------- E T LK DL Y D L LWDLAKKGNKGY L TQVAIMQK FVDQ AI S 689
650 660 670
....*....|....*....|....*....|....*...
gi 10140983 694 HSFHLKE EN ----- V VSARF L K DL i L SG Y TL G L KT IM Y 726
Cdd:PHA02572 690 ANTSYDP EN ypngk V PMSVM L D DL - L YF Y YY G G KT LY Y 726
PRK07207
PRK07207 ribonucleoside-diphosphate reductase subunit alpha;
262-727
1.99e-15
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain]
Cd Length: 965
Bit Score: 80.78
E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 262 V A AY M E V WH SQ I Q EFL av K L PE N PS ---- R CASIYQGLC IP K LF FEKFI ED pg QN W Y LF K P EKSGN L AN L Y G DE F R --- S 334
Cdd:PRK07207 451 V C AY L E T WH LD I E EFL -- E L RK N TG ddrr R THDMNTANW IP D LF MKRVM ED -- GE W T LF S P SEVPD L HD L F G KA F E eay T 526
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 335 E YE RLVGI G -- CYADA IP IKS L MFLIINTIIK TG S P Y I IY K EA CN EHHWKNME G c AIA S A NLC A E VIQYPGA D - VST CNL 411
Cdd:PRK07207 527 A YE AKAAR G ei KLFKK IP AVD L WRKMLSMLFE TG H P W I TF K DP CN LRSPQQHV G - VVH S S NLC T E ITLNTSD D e IAV CNL 605
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 412 AN V C L PMCLVTVSNDS H SP L EK T ycgnviesqavsg V GFS M PI L HAAVEVAVFL V NC A iaggkcvtpgme R GQ -- R E R SM 489
Cdd:PRK07207 606 GS V N L VAHIKDGAKLD H EK L KR T ------------- V STA M RM L DNVIDINYYA V PK A ------------ R NS nl R H R PV 660
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 490 G I G VH G LA D VFAEMGYS Y LDER A ARLDVEIF E NMYFR A VKT S NNICRLG G GRP - F EG -- W GESK L ----------- R H G F 555
Cdd:PRK07207 661 G L G IM G FQ D ALYLLRIP Y ASDE A VEFADRSM E AVSYY A IWA S TELAEER G RYS s Y EG sl W SRGI L pidslkllaea R G G Y 740
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 556 F hwqgwe D V NL S IPI t E W EK L SR R CISS G VY NS QFI A LM PT VGS S LLT G F S E S YY P YFA N IS -- S KV S SKEE V MK P NMT - 632
Cdd:PRK07207 741 L ------ E V DR S STL - D W DA L RA R IKKH G MR NS NCM A IA PT ATI S NII G V S Q S IE P TYQ N LY vk S NL S GEFT V VN P YLV r 813
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 633 ------ F W NR V SKE DL dtv RF F S G DVALF --- P EP LK EK Y S lfl S AF D ---- YCA E kql A RA R l R APFV DQ S QS HSFHLK 699
Cdd:PRK07207 814 dlkarg L W DE V MVN DL --- KY F D G SLQRI dri P AD LK AL Y A --- T AF E vdpr WLV E --- A AS R - R QKWI DQ A QS LNLYMA 883
490 500
....*....|....*....|....*...
gi 10140983 700 E env V S ARF L KDLILSGYTL GLKT i M YY 727
Cdd:PRK07207 884 G --- A S GKK L DETYKLAWLR GLKT - T YY 907
Ribonuc_red_lgN
pfam00317 Ribonucleotide reductase, all-alpha domain;
90-186
3.55e-15
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain]
Cd Length: 75
Bit Score: 70.73
E-value: 3.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 90 RGI L S AK RFY D T Y V L RTA DG SCY E SVSHC FMR I A AFCTVQV L TNSA lkitilylgrdklfkdlpcspt MD L FIY F FSP LS 169
Cdd:pfam00317 1 LTY L G AK VLE D R Y L L KDE DG ELL E TPQDM FMR V A LALAGAE L EEDR ---------------------- LE L AEE F YDL LS 58
90
....*....|....*..
gi 10140983 170 HQLVCC ATP IMRS AG LR 186
Cdd:pfam00317 59 SLKFLP ATP TLMN AG TP 75
PRK09102
PRK09102 ribonucleoside-diphosphate reductase subunit alpha;
164-731
7.97e-15
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain]
Cd Length: 601
Bit Score: 78.08
E-value: 7.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 164 F F S P lshqlvcc ATP IMRSA G LRDANLA SCFL INPDL S T E K st TTALLQ E LTM L LSAKS G V G C --- NV T S F G VDEKCIQS 240
Cdd:PRK09102 70 W F M P -------- ATP VLSNG G TDRGLPI SCFL NYVED S L E G -- IVNTWN E NVW L AKRGG G I G S ywg NV R S I G EPIRNNGK 139
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 241 CV G L I ------ N S QVEFFNDQNP R PV S V A A Y MEVW H SQ I Q EFL AVKL P - EN P S R - CASIYQ G L C IPKL F F E KFIE dp G QN 312
Cdd:PRK09102 140 SS G I I pfikvm D S LTLAISQGSL R RG S F A V Y LDIE H PE I E EFL DIRK P t GD P N R k ALNLHH G V C VTDE F M E AVED -- G DE 217
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 313 W Y L FK P eksgnlanl YGDEFRSEYE rlvgigcy A DAIPI K slmfl I IN T I I K TG S PY IIYKEAC N EH --- HW K NM e G CAI 389
Cdd:PRK09102 218 W D L IS P --------- KDKSVIRTVK -------- A RDLWA K ----- I LE T R I E TG E PY LLFIDNV N RA lpe VY K DL - G LKV 274
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 390 ASA NLC A E VIQYP G A D VSTCNLAN VC lpm CL V tvsndshsplektycgnviesqavsgvgf S MPILH -------- A AV E V 461
Cdd:PRK09102 275 KAS NLC S E ITLPT G I D HLGEDRTA VC --- CL S ----------------------------- S LNLEY ydewkdtd A FI E D 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 462 AV - FL V N CA --- I AGGK cvt PG MER GQ ---- RERS M G I GV hgladvfae MG Y - SYL DER -------- A ARLDVE IF ENMY 524
Cdd:PRK09102 323 LM r FL D N VL qdf I DKAP --- DE MER AK ysam RERS V G L GV --------- MG F h SYL QSK mipfesvm A KQWNKK IF KHIR 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 525 FR A V K T S NNICRLG G GR P - FE G W G E sklrhgffhwqgwedvnlsipitewekl S RR cissgvy N S QFI A LM PT VGS S LLT 603
Cdd:PRK09102 391 EQ A D K A S KELAKEK G EC P d AA G Y G V ---------------------------- M RR ------- F S TKM A IA PT ASI S IIL 435
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 604 G - F S ESYY P YF AN I ------ SSKVSS K -------- EE VM K PNMTF W NRVSKED ldtvrffs G D V ALFPEPLK E KYSL F LS 668
Cdd:PRK09102 436 G n T S PGIE P IA AN Y ythktl KGSFTV K nkylekll EE KG K DTDEV W SSILTNE -------- G S V QHLDFLSE E EKDV F KT 507
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10140983 669 AF DYCAEKQLAR A RL R APFV DQ S QS HSFH L KEE nv V SA R F L KD L ILSGYTL G L K TI m YY CKV K 731
Cdd:PRK09102 508 AF EIDQRWIIEL A AD R QKYI DQ A QS LNLF L PAN -- V PK R D L NK L HFEAWKK G V K SL - YY QRS K 567
RNR_II_dimer
cd02888 Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ...
164-614
4.15e-12
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain]
Cd Length: 464
Bit Score: 69.19
E-value: 4.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 164 FF SP L SH Q LVCCAT P IMRS AG L - RDAN L AS CF LINPDLSTEKSTTT AL LQE l TMLLSAKS GVG cnv TS F GV -- DEKC I QS 240
Cdd:cd02888 4 FF YL L LS Q GFIPNS P TLMN AG T g ELGQ L SA CF VLPVEDDSIEGIFD AL KEA - ALIFKRGG GVG --- YN F SR lr PKGD I VK 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 241 CV G LIN S - Q V E F FN -- D QNPRPVSV ----- A A Y M --- E V W H SQ I Q EF LAV K LP E NPSRC asi Y Q GL ---- CIPKL F F E KF 305
Cdd:cd02888 80 ST G GVA S g P V S F MR vf D AATGVIKQ ggtrr G A N M gvl D V D H PD I E EF IDA K MK E EKTVV --- L Q NF nisv AVTDA F M E AV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 306 IE D pg QN W Y L FK P E ksgnlanlyg DEFRSEYE R lvgigcyad AI P IKS L MFL I INTIIKTGS P YIIYKEAC N E hh W KNME 385
Cdd:cd02888 157 EN D -- EP W E L RN P R ---------- EPDTGKVY R --------- TV P ARE L WDK I VEAAWDSAD P GVLFIDTI N R -- W NPLP 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 386 G CA - I ASA N L C A E viq Y P GADVST CNL ANV clpmclvtvs N dshsp L E K TY cgnvie SQAVS G VG F SMPI L HA AV EV AV - 463
Cdd:cd02888 214 G LG r I NAT N P C G E --- Q P LLPYES CNL GSI ---------- N ----- L S K FV ------ KNPFG G AS F DFER L RE AV RL AV r 269
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 464 FL V N c A I AGGKCVT P GMER - GQRE R SM G I GV H GLAD VFAEM G YS Y LD E R A AR L DVE I FENMYFR A VKT S NNICRLG G gr P 542
Cdd:cd02888 270 FL D N - V I DVNRYPL P EIAE e TKAT R RI G L GV M GLAD MLIKL G IP Y DS E E A RE L AER I MSFIRDA A YRA S AELAKER G -- P 346
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10140983 543 F EGWGE S KLRHGFFHWQGW E D vnlsipite WEKLSRRCISS G VY N SQFIALM PT VGS SL LT G F S ESYY P Y F A 614
Cdd:cd02888 347 F PLFDA S RYLMLKVIVNAK E L --------- PDDVLEEIEKY G IR N AHLTTIA PT GTI SL IA G T S SGIE P I F S 409
PRK08332
PRK08332 vitamin B12-dependent ribonucleotide reductase;
460-727
4.46e-07
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain]
Cd Length: 1740
Bit Score: 53.62
E-value: 4.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 460 E VA VF L V N c AI AGG K CVT P GMERGQR - E R SM G I G VH GLAD VFAEM G YS Y LD E RAARLDVEIF E NMY F R A V K T S NNICRLG 538
Cdd:PRK08332 1340 K VA KY L D N - AI DVN K FPL P EIDYNTK l T R RI G V G MM GLAD ALFKL G IP Y NS E EGFKFMRKVT E YLT F Y A Y K Y S VEAAKKR 1418
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 539 G GR P F --- EGWGESK L R - H GF F H WQG W edv NL S ipite W E KL SRRCISS GV Y N SQFIALM PT VGS S LLTGF S ESYY P Y FA 614
Cdd:PRK08332 1419 G TF P L yek TEYPKGE L P v E GF Y H PEI W --- NL P ----- W D KL VEEIKKY GV R N AMVTTCP PT GSV S MIADT S SGIE P I FA 1490
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 615 NISS K VSSKE E VMKPNMT F WNRV ------ S K E D L DTVRFFS G D V ALFP E PLKEKYSL F LS A F D - YCAEKQ LA R A RLRAPF 687
Cdd:PRK08332 1491 LVYK K SVTVG E FYYVDPV F EAEL kkrgly S E E L L KKISDNY G S V QGLE E IPEDMQRV F VT A L D i HWLDHI LA Q A NIQMWL 1570
250 260 270 280
....*....|....*....|....*....|....*....|
gi 10140983 688 V D q S Q S HSFHLKE E NV V SA rf L K DLI L SGYT LG L K TIMY Y 727
Cdd:PRK08332 1571 T D - S A S KTINMIN E AT V ED -- V K AAY L IAHF LG C K GVTV Y 1607
PRK09103
PRK09103 ribonucleoside-diphosphate reductase subunit alpha;
148-727
1.81e-06
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain]
Cd Length: 758
Bit Score: 51.53
E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 148 LF KDL P CSPTM D LFIY F FSPL S HQLVCCA TPIM rs A G L R DA -- NLA SC F LI NPD -- L STEKS T TT A LLQ eltm LL S AKS G 223
Cdd:PRK09103 177 LF SNY P KETRL D YVKR F YDAV S TFKISLP TPIM -- S G V R TP tr QFS SC V LI ECG ds L DSINA T SS A IVK ---- YV S QRA G 250
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 224 V G C N --- VTSF G VDEK -------- CI ---------- Q SC vglin SQ -- V effndqnp R PVSVAAYMEV WH SQIQEF L AV K 280
Cdd:PRK09103 251 I G I N agr IRAL G SPIR ggeafhtg CI pfykhfqtav K SC ----- SQ gg V -------- R GGAATLFYPI WH LEVESL L VL K 317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 281 ---- LP EN ps R CASIYQ G LC I P KL FFEKF I E dp G QNWY LF K P eks GNLAN LY g D E F --- RS E Y ERL vgigc Y ---- A D -- 347
Cdd:PRK09103 318 nnrg VE EN -- R VRHMDY G VQ I N KL MYQRL I K -- G GDIT LF S P --- SDVPG LY - D A F fad QD E F ERL ----- Y tkye Q D ds 384
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 348 ---- AIPIKS L MF L IINTIIK TG SP YI IYKEA CN E H HWKNMEGCAIASA NLC A E v I QY P GADVSTC N LA N VCLPM C LVTV 423
Cdd:PRK09103 385 irkk RVKAVE L FS L MMQERAS TG RI YI QNVDH CN T H SPFDPKVAPVRQS NLC L E - I AL P TKPLNDV N DE N GEIAL C TLSA 463
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 424 S N ---- D S HSP LE K tycgnv IESQ AV SG vgfsmpi L H A AVEVAVFLVNC A IA G G kcvtpg M E R gqre R SM GIGV HGL A DV 499
Cdd:PRK09103 464 F N lgai N S LDE LE E ------ LADL AV RA ------- L D A LLDYQDYPIPA A KR G A ------ M G R ---- R TL GIGV INF A YY 520
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 500 F A EM G YS Y L D ER A AR L DVEI FE NMYFRAV K T SN NICRLG G GR P F eg WG E SKLRH G FF --- HWQGWE D VNLSI P I - TE WE K 575
Cdd:PRK09103 521 L A KN G VR Y S D GS A NN L THKT FE AIQYYLL K A SN ELAKEQ G AC P W -- FN E TTYAQ G IL pid TYKKDL D AICNE P L h YD WE T 598
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 576 L SRRCISS G VY NS QFI ALMP TVG SS LLTGFSESYY P YFANI S S K v S SK EEVM K pnmtfwn R V SKE dldtvrffsgdvalf 655
Cdd:PRK09103 599 L REEIKTH G LR NS TLS ALMP SET SS QISNATNGIE P PRGYV S I K - A SK DGIL K ------- Q V VPD --------------- 655
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10140983 656 P E P LK EK Y S L FLSAFDYCAEK QL ar ARLRAP FVDQS Q S HSFHLK ---- EENV V SAR - F LKDL i L SG Y TL G L KT i M YY 727
Cdd:PRK09103 656 Y E R LK DA Y E L LWEMPNNDGYL QL -- VGIMQK FVDQS I S ANTNYD psrf PSGK V PMK q L LKDL - L TA Y KF G V KT - L YY 728
PRK08115
PRK08115 vitamin B12-dependent ribonucleotide reductase;
486-614
1.04e-04
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain]
Cd Length: 858
Bit Score: 45.99
E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10140983 486 ER SM G I GV H GL A D VFAEMGYS Y LD E RAAR L DVE IFE NMYFR A VK TS NNICRLG G GR PF - E G WG E --- S KLR HG F FH w Q G W 561
Cdd:PRK08115 545 ER RV G L GV M GL H D LLIYCETV Y GS E EGNQ L VDQ IFE TIATT A YR TS IELAKEK G SF PF l V G QT E eet A KLR EA F IN - T G Y 623
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 10140983 562 ED vnl SI P itew E KLSRRCISS G VY NS QFIALM PT VGSSLLT G F S ESYY PYF A 614
Cdd:PRK08115 624 MK --- KM P ---- E DIREDILKY G IR NS HLLTVA PT GSTGTMV G V S TGLE PYF S 669
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
