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Conserved domains on  [gi|1014097995|gb|KYS46735|]
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protein TolA [Escherichia coli]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11484310)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-384 1.51e-100

cell envelope integrity inner membrane protein TolA; Provisional


:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.51e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 161 KKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510  161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 241 AKAAAEKAAAAKAAAEA--DDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 318
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAevDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995 319 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 384
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-384 1.51e-100

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.51e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 161 KKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510  161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 241 AKAAAEKAAAAKAAAEA--DDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 318
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAevDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995 319 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 384
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-384 3.58e-40

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 145.37  E-value: 3.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELkqkqaeeaaaKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEE----------KQKQAEEAKAKQAAEAKAKAEAEAERKAKEEA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAAKAAAEKAAAA 251
Cdd:TIGR02794 149 AKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERK 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 252 KAAAEADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIK 331
Cdd:TIGR02794 229 ADEAELGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIR 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1014097995 332 LAPDGMLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 384
Cdd:TIGR02794 293 LAPDGTLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 290-382 4.56e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.17  E-value: 4.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 290 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 368
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 1014097995 369 QAVYEVFKNAPLDF 382
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-129 1.53e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1014097995  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-129 8.36e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 37.56  E-value: 8.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1014097995  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:cd16269   170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHL 239
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-384 1.51e-100

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.51e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 161 KKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510  161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 241 AKAAAEKAAAAKAAAEA--DDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 318
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAevDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995 319 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 384
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-384 3.58e-40

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 145.37  E-value: 3.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELkqkqaeeaaaKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEE----------KQKQAEEAKAKQAAEAKAKAEAEAERKAKEEA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAAKAAAEKAAAA 251
Cdd:TIGR02794 149 AKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERK 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 252 KAAAEADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIK 331
Cdd:TIGR02794 229 ADEAELGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIR 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1014097995 332 LAPDGMLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 384
Cdd:TIGR02794 293 LAPDGTLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 290-382 4.56e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.17  E-value: 4.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995 290 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 368
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 1014097995 369 QAVYEVFKNAPLDF 382
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
PTZ00121 PTZ00121
MAEBL; Provisional
 74-128 4.99e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 4.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995   74 AKRSDEQRKMKEQQAAEELREKQAAEQ-ERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:PTZ00121  1277 ARKADELKKAEEKKKADEAKKAEEKKKaDEAKKKAEEAKKADEAKKKAEEAKKKAD 1332
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-129 1.53e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1014097995  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-128 1.68e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1014097995  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-128 2.00e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.32  E-value: 2.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1014097995  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:pfam15709 359 EQRRLQQEQLERAEKMREELELEQQRRFEEIRlRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQE 426
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-127 3.04e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.55  E-value: 3.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995  62 EQYKRMQSQESSAKRSDEQRKMKE---QQAAEELREKQAAEQERLKQL-------EKERLAAQEQKKQAEEAAKQA 127
Cdd:pfam15709 433 QELQRKKQQEEAERAEAEKQRQKElemQLAEEQKRLMEMAEEERLEYQrqkqeaeEKARLEAEERRQKEEEAARLA 508
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 76-127 3.62e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 39.09  E-value: 3.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995  76 RSDEQ---RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAE-EAAKQA 127
Cdd:pfam07946 266 REEEIekiKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEkERKKEQ 321
PTZ00121 PTZ00121
MAEBL; Provisional
 61-128 3.69e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.69e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1014097995   61 VEQYKRMQSQESSAKRSDEQ-RKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:PTZ00121  1430 KKKADEAKKKAEEAKKADEAkKKAEEAKKAEEAKKKaeEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 60-127 5.59e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 38.78  E-value: 5.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1014097995   60 VVEQYKRMQSQESSAKRSDEQRKMKEQQAAEeLREKQAAEQERLKQLEKERLAA-QEQKKQAEEAAKQA 127
Cdd:PRK11448   158 LELQAREKAQSQALAEAQQQELVALEGLAAE-LEEKQQELEAQLEQLQEKAAETsQERKQKRKEITDQA 225
PTZ00121 PTZ00121
MAEBL; Provisional
 67-129 5.78e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 5.78e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995   67 MQSQESSAKRSDE-QRKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:PTZ00121  1410 LKKAAAAKKKADEaKKKAEEKKKADEAKKKaeEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 63-129 7.07e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.39  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  63 QYKRMQSQESSAKRSDEQRKMKEQQAAEE---------------LREKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQ 126
Cdd:pfam15709 436 QRKKQQEEAERAEAEKQRQKELEMQLAEEqkrlmemaeeerleyQRQKQEAEEKARLEAEERRQKEEEAARLAlEEAMKQ 515


                  ...
gi 1014097995 127 AEL 129
Cdd:pfam15709 516 AQE 518
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 78-126 7.70e-03

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 38.00  E-value: 7.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1014097995  78 DEQRKMKEQQAA-EELREKQAAEQERL------KQLEKERLAAQ--EQKKQAEEAAKQ 126
Cdd:pfam06098 153 EELANLREQQRAfEELRNAELAEVQRLeeqerrLREEKERRIAQqrEALKKEKETAEK 210
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-128 7.77e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 7.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014097995  62 EQYKRMQSQESSAKRSD---EQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG1196   281 LELEEAQAEEYELLAELarlEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 61-129 7.95e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 7.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995  61 VEQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQA---AEQERL---KQLEKERLaAQEQKKQAEEAAKQAEL 129
Cdd:pfam17380 296 MEQERLRQEKEEKAREVERRRKLEEAEKARQAEmDRQAaiyAEQERMameRERELERI-RQEERKRELERIRQEEI 370
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-129 8.36e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 37.56  E-value: 8.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1014097995  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:cd16269   170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHL 239
PTZ00121 PTZ00121
MAEBL; Provisional
 62-128 9.21e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.20  E-value: 9.21e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014097995   62 EQYKRMQSQESSA---KRSDEQRKMKEQQAAEELREKQAAEQ----ERLKQLEKERLA--AQEQKKQAEEAAKQAE 128
Cdd:PTZ00121  1610 EEAKKAEEAKIKAeelKKAEEEKKKVEQLKKKEAEEKKKAEElkkaEEENKIKAAEEAkkAEEDKKKAEEAKKAEE 1685
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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