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Conserved domains on  [gi|1012732565|gb|JAR27510|]
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hypothetical protein [Fundulus heteroclitus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1045-1324 1.85e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.85e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1045 SLGAFSNHTGPVHGLQIHD--GRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRC 1122
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT---YLASGSSDKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1123 YSIKSTKCLEQILL-PDRVLCLHIAW--HILYAGLASGSVVSHDLKTLKELDVLECHgPRGVSCLSTAQEGarRLLLVGS 1199
Cdd:cd00200     78 WDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSS 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1200 YDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVIL--GKVM 1275
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLL 234

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012732565 1276 VTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHKS--VIYTGCYDGSV 1324
Cdd:cd00200    235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
375-536 3.63e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  375 SNQGARAQPAQ----PEVASVRPESSNSSAQEDSEDKSGGPAPIRDVKAMLKEIRRALGVREPCRADREARRQTDNVQAA 450
Cdd:PRK12323   366 GQSGGGAGPATaaaaPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  451 ERSAES-----------REDAEQPAGAPAKTEHVAGSHGPPAHAGVSASAVAPFKQKQASFKKMQVINQEKNPQQMENAV 519
Cdd:PRK12323   446 GAPAPApapaaapaaaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525

                          170
                   ....*....|....*..
gi 1012732565  520 SSNDATSQEASDASTSA 536
Cdd:PRK12323   526 IPDPATADPDDAFETLA 542
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
816-1020 4.33e-03

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 41.12  E-value: 4.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  816 TNTFS-LGAASIL----SGASFPSSLQlsAATLAPDVPL-PRPASLTLPTVLVKQEALHPVSAGQASplflppavqpTAD 889
Cdd:PRK13108   260 TSTFVfIGAVVYIilapKGREAPGALR--GSEYVVDEALeREPAELAAAAVASAASAVGPVGPGEPN----------QPD 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  890 GSTSAHALPPESSSTQNEQETRDQLDHNDEQSSGFAEGTEENlSTEQEPAGDRSAdkrQKKASHEDDDGDSDSSVEVVNS 969
Cdd:PRK13108   328 DVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEA-DIEREQPGDLAG---QAPAAHQVDAEAASAAPEEPAA 403

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1012732565  970 NKSDVIDIVE-SECEESAERGAPARPEEPHASGSvevSAASTQTSQQCETER 1020
Cdd:PRK13108   404 LASEAHDETEpEVPEKAAPIPDPAKPDELAVAGP---GDDPAEPDGIRRQDD 452
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1045-1324 1.85e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.85e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1045 SLGAFSNHTGPVHGLQIHD--GRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRC 1122
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT---YLASGSSDKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1123 YSIKSTKCLEQILL-PDRVLCLHIAW--HILYAGLASGSVVSHDLKTLKELDVLECHgPRGVSCLSTAQEGarRLLLVGS 1199
Cdd:cd00200     78 WDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSS 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1200 YDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVIL--GKVM 1275
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLL 234

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012732565 1276 VTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHKS--VIYTGCYDGSV 1324
Cdd:cd00200    235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
1046-1325 3.37e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.37e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1046 LGAFSNHTGPVHGLQIH-DG-RLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSspanalP---RLYTGSSDHTI 1120
Cdd:COG2319    113 LRTLTGHTGAVRSVAFSpDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS------PdgkLLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1121 RCYSIKSTKCLEQILL-PDRVLCLhiAW----HILYAGLASGSVVSHDLKTLKELDVLECHGPrGVSCLSTAQEGarRLL 1195
Cdd:COG2319    187 RLWDLATGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDG--RLL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1196 LVGSYDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVI--L 1271
Cdd:COG2319    262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspD 341

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1012732565 1272 GKVMVTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHK--SVIYTGCYDGSVQ 1325
Cdd:COG2319    342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1082-1124 1.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.82e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1012732565  1082 TRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRCYS 1124
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK---YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1083-1124 5.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1012732565 1083 RECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRCYS 1124
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK---LLASGSDDGTVKVWD 39
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
375-536 3.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  375 SNQGARAQPAQ----PEVASVRPESSNSSAQEDSEDKSGGPAPIRDVKAMLKEIRRALGVREPCRADREARRQTDNVQAA 450
Cdd:PRK12323   366 GQSGGGAGPATaaaaPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  451 ERSAES-----------REDAEQPAGAPAKTEHVAGSHGPPAHAGVSASAVAPFKQKQASFKKMQVINQEKNPQQMENAV 519
Cdd:PRK12323   446 GAPAPApapaaapaaaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525

                          170
                   ....*....|....*..
gi 1012732565  520 SSNDATSQEASDASTSA 536
Cdd:PRK12323   526 IPDPATADPDDAFETLA 542
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 816-1020 4.33e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.12  E-value: 4.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  816 TNTFS-LGAASIL----SGASFPSSLQlsAATLAPDVPL-PRPASLTLPTVLVKQEALHPVSAGQASplflppavqpTAD 889
Cdd:PRK13108   260 TSTFVfIGAVVYIilapKGREAPGALR--GSEYVVDEALeREPAELAAAAVASAASAVGPVGPGEPN----------QPD 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  890 GSTSAHALPPESSSTQNEQETRDQLDHNDEQSSGFAEGTEENlSTEQEPAGDRSAdkrQKKASHEDDDGDSDSSVEVVNS 969
Cdd:PRK13108   328 DVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEA-DIEREQPGDLAG---QAPAAHQVDAEAASAAPEEPAA 403

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1012732565  970 NKSDVIDIVE-SECEESAERGAPARPEEPHASGSvevSAASTQTSQQCETER 1020
Cdd:PRK13108   404 LASEAHDETEpEVPEKAAPIPDPAKPDELAVAGP---GDDPAEPDGIRRQDD 452
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1045-1324 1.85e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.85e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1045 SLGAFSNHTGPVHGLQIHD--GRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRC 1122
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT---YLASGSSDKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1123 YSIKSTKCLEQILL-PDRVLCLHIAW--HILYAGLASGSVVSHDLKTLKELDVLECHgPRGVSCLSTAQEGarRLLLVGS 1199
Cdd:cd00200     78 WDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSS 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1200 YDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVIL--GKVM 1275
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLL 234

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012732565 1276 VTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHKS--VIYTGCYDGSV 1324
Cdd:cd00200    235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
1046-1325 3.37e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.37e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1046 LGAFSNHTGPVHGLQIH-DG-RLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSspanalP---RLYTGSSDHTI 1120
Cdd:COG2319    113 LRTLTGHTGAVRSVAFSpDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS------PdgkLLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1121 RCYSIKSTKCLEQILL-PDRVLCLhiAW----HILYAGLASGSVVSHDLKTLKELDVLECHGPrGVSCLSTAQEGarRLL 1195
Cdd:COG2319    187 RLWDLATGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDG--RLL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1196 LVGSYDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVI--L 1271
Cdd:COG2319    262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspD 341

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1012732565 1272 GKVMVTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHK--SVIYTGCYDGSVQ 1325
Cdd:COG2319    342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
1029-1325 5.51e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 5.51e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1029 TNDANQPAESAEEDEPSLGAFSNHTGPVHGLQIH--DGRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPAN 1106
Cdd:COG2319     54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1107 alpRLYTGSSDHTIRCYSIKSTKCLEQILLP-DRVLCLhiAW----HILYAGLASGSVVSHDLKTLKELDVLECHgPRGV 1181
Cdd:COG2319    134 ---TLASGSADGTVRLWDLATGKLLRTLTGHsGAVTSV--AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAV 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1182 SCLSTAQEGarRLLLVGSYDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYK 1259
Cdd:COG2319    208 RSVAFSPDG--KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLT 285

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1260 GHGHAVTSIVIL--GKVMVTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVH--KSVIYTGCYDGSVQ 1325
Cdd:COG2319    286 GHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
1046-1291 5.41e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 5.41e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1046 LGAFSNHTGPVHGLQIH-DGR-LYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRCY 1123
Cdd:COG2319    155 LRTLTGHSGAVTSVAFSpDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLW 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1124 SIKSTKCLeQILLPDRVLCLHIAWH----ILYAGLASGSVVSHDLKTLKELDVLEcHGPRGVSCLSTAQEGarRLLLVGS 1199
Cdd:COG2319    232 DLATGKLL-RTLTGHSGSVRSVAFSpdgrLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGS 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1200 YDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVIL--GKVM 1275
Cdd:COG2319    308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTL 387

                          250
                   ....*....|....*.
gi 1012732565 1276 VTACLDKLVRVYELQS 1291
Cdd:COG2319    388 ASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1063-1325 3.47e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 3.47e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1063 DGRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSSPAnalPRLYTGSSDHTIRCYSIKSTKCLEQIL-LPDRVL 1141
Cdd:COG2319     48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG---RLLASASADGTVRLWDLATGLLLRTLTgHTGAVR 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1142 ClhIAW----HILYAGLASGSVVSHDLKTLKELDVLECHgPRGVSCLSTAQEGarRLLLVGSYDSTISVRDAKSGLLLRT 1217
Cdd:COG2319    125 S--VAFspdgKTLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRT 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1218 LEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSIVIL--GKVMVTACLDKLVRVYELQSHD 1293
Cdd:COG2319    200 LTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGE 279

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1012732565 1294 RLQVYGGHSDMVMCMAVHK--SVIYTGCYDGSVQ 1325
Cdd:COG2319    280 LLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVR 313
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1041-1244 2.43e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.43e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1041 EDEPSLGAFSNHTGPVHGLQIHDGR--LYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVSsPANALprLYTGSSDH 1118
Cdd:cd00200     81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTF--VASSSQDG 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1119 TIRCYSIKSTKCLEQILLP-DRVLClhIAWHILYAGLASGSVVSH----DLKTLKELDVLECHgPRGVSCLSTAQEgaRR 1193
Cdd:cd00200    158 TIKLWDLRTGKCVATLTGHtGEVNS--VAFSPDGEKLLSSSSDGTiklwDLSTGKCLGTLRGH-ENGVNSVAFSPD--GY 232

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1012732565 1194 LLLVGSYDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSV 1244
Cdd:cd00200    233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1049-1168 2.39e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 2.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1049 FSNHTGPVHGLQIHD--GRLYTCSGDNTARAYSLLTRECEAVFEGHTNNVNCLLVsSPANALprLYTGSSDHTIRCYSIK 1126
Cdd:cd00200    173 LTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF-SPDGYL--LASGSEDGTIRVWDLR 249

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1012732565 1127 STKCLEQILLPD-RVLCLhiAWHILYAGLASGsvvSHDlKTLK 1168
Cdd:cd00200    250 TGECVQTLSGHTnSVTSL--AWSPDGKRLASG---SAD-GTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
1191-1325 1.09e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565 1191 ARRLLLVGSYDSTISVRDAKSGLLLRTLEGHTKTVLCMKVVND--LVFSGSSDTSVHAHNIHTGELVRIYKGHGHAVTSI 1268
Cdd:COG2319     47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1012732565 1269 VIL--GKVMVTACLDKLVRVYELQSHDRLQVYGGHSDMVMCMAVHK--SVIYTGCYDGSVQ 1325
Cdd:COG2319    127 AFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1082-1124 1.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.82e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1012732565  1082 TRECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRCYS 1124
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK---YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1251-1288 3.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1012732565  1251 TGELVRIYKGHGHAVTSIVIL--GKVMVTACLDKLVRVYE 1288
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1083-1124 5.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1012732565 1083 RECEAVFEGHTNNVNCLLVSSPANalpRLYTGSSDHTIRCYS 1124
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK---LLASGSDDGTVKVWD 39
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
375-536 3.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  375 SNQGARAQPAQ----PEVASVRPESSNSSAQEDSEDKSGGPAPIRDVKAMLKEIRRALGVREPCRADREARRQTDNVQAA 450
Cdd:PRK12323   366 GQSGGGAGPATaaaaPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  451 ERSAES-----------REDAEQPAGAPAKTEHVAGSHGPPAHAGVSASAVAPFKQKQASFKKMQVINQEKNPQQMENAV 519
Cdd:PRK12323   446 GAPAPApapaaapaaaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525

                          170
                   ....*....|....*..
gi 1012732565  520 SSNDATSQEASDASTSA 536
Cdd:PRK12323   526 IPDPATADPDDAFETLA 542
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 816-1020 4.33e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.12  E-value: 4.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  816 TNTFS-LGAASIL----SGASFPSSLQlsAATLAPDVPL-PRPASLTLPTVLVKQEALHPVSAGQASplflppavqpTAD 889
Cdd:PRK13108   260 TSTFVfIGAVVYIilapKGREAPGALR--GSEYVVDEALeREPAELAAAAVASAASAVGPVGPGEPN----------QPD 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012732565  890 GSTSAHALPPESSSTQNEQETRDQLDHNDEQSSGFAEGTEENlSTEQEPAGDRSAdkrQKKASHEDDDGDSDSSVEVVNS 969
Cdd:PRK13108   328 DVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEA-DIEREQPGDLAG---QAPAAHQVDAEAASAAPEEPAA 403

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1012732565  970 NKSDVIDIVE-SECEESAERGAPARPEEPHASGSvevSAASTQTSQQCETER 1020
Cdd:PRK13108   404 LASEAHDETEpEVPEKAAPIPDPAKPDELAVAGP---GDDPAEPDGIRRQDD 452
WD40 pfam00400
WD domain, G-beta repeat;
1252-1288 9.83e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 9.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1012732565 1252 GELVRIYKGHGHAVTSIVIL--GKVMVTACLDKLVRVYE 1288
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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