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Conserved domains on  [gi|1012274352|ref|XP_015984887|]
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mediator of RNA polymerase II transcription subunit 23 isoform X3 [Rousettus aegyptiacus]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1229 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2111.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352    1 MAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAR 80
Cdd:pfam11573   85 YAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALE 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352   81 EVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNS 156
Cdd:pfam11573  165 NVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSP 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  157 WKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMER 236
Cdd:pfam11573  245 WKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMER 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  237 SETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLP 316
Cdd:pfam11573  319 SETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLP 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  317 VMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--LQMN- 392
Cdd:pfam11573  397 ILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGs 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  393 DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKL 472
Cdd:pfam11573  477 DYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKF 552

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  473 AHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL 552
Cdd:pfam11573  553 AQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSL 632

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  553 AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQG 631
Cdd:pfam11573  633 ANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSE 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  632 TWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLF 711
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  712 LCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL 791
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCL 868

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  792 AMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQS 871
Cdd:pfam11573  869 ALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SN 944

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  872 PYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRKLVHA 951
Cdd:pfam11573  945 PYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSA 1024

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  952 IIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTC 1031
Cdd:pfam11573 1025 IIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTC 1104

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1032 VELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvGYPFR 1111
Cdd:pfam11573 1105 VELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFE 1183

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1112 LFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIE 1191
Cdd:pfam11573 1184 LFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLD 1263

                         1210      1220      1230
                   ....*....|....*....|....*....|....*...
gi 1012274352 1192 IGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1229
Cdd:pfam11573 1264 ITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1229 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2111.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352    1 MAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAR 80
Cdd:pfam11573   85 YAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALE 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352   81 EVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNS 156
Cdd:pfam11573  165 NVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSP 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  157 WKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMER 236
Cdd:pfam11573  245 WKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMER 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  237 SETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLP 316
Cdd:pfam11573  319 SETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLP 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  317 VMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--LQMN- 392
Cdd:pfam11573  397 ILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGs 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  393 DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKL 472
Cdd:pfam11573  477 DYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKF 552

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  473 AHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL 552
Cdd:pfam11573  553 AQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSL 632

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  553 AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQG 631
Cdd:pfam11573  633 ANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSE 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  632 TWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLF 711
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  712 LCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL 791
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCL 868

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  792 AMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQS 871
Cdd:pfam11573  869 ALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SN 944

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  872 PYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRKLVHA 951
Cdd:pfam11573  945 PYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSA 1024

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  952 IIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTC 1031
Cdd:pfam11573 1025 IIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTC 1104

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1032 VELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvGYPFR 1111
Cdd:pfam11573 1105 VELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFE 1183

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1112 LFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIE 1191
Cdd:pfam11573 1184 LFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLD 1263

                         1210      1220      1230
                   ....*....|....*....|....*....|....*...
gi 1012274352 1192 IGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1229
Cdd:pfam11573 1264 ITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1229 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2111.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352    1 MAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAR 80
Cdd:pfam11573   85 YAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQLRALE 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352   81 EVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNS 156
Cdd:pfam11573  165 NVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadHLTSP 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  157 WKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVYAMER 236
Cdd:pfam11573  245 WKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMICAMER 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  237 SETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLP 316
Cdd:pfam11573  319 SETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLP 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  317 VMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--LQMN- 392
Cdd:pfam11573  397 ILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGs 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  393 DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKL 472
Cdd:pfam11573  477 DYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKF 552

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  473 AHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL 552
Cdd:pfam11573  553 AQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSL 632

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  553 AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSDSIQG 631
Cdd:pfam11573  633 ANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTGTDSE 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  632 TWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLF 711
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  712 LCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL 791
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCL 868

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  792 AMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpvqiQS 871
Cdd:pfam11573  869 ALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS----SN 944

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  872 PYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRKLVHA 951
Cdd:pfam11573  945 PYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSA 1024

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352  952 IIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTC 1031
Cdd:pfam11573 1025 IIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTC 1104

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1032 VELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvGYPFR 1111
Cdd:pfam11573 1105 VELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFE 1183

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274352 1112 LFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIE 1191
Cdd:pfam11573 1184 LFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLD 1263

                         1210      1220      1230
                   ....*....|....*....|....*....|....*...
gi 1012274352 1192 IGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1229
Cdd:pfam11573 1264 ITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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