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Conserved domains on  [gi|1011858337|ref|WP_062676723|]
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lysozyme [Enterobacter cloacae]

Protein Classification

lysozyme( domain architecture ID 10091405)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins; similar to Salmonella virus P22 endolysin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-148 3.16e-75

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 220.08  E-value: 3.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGGTrTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVS 91
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGD-TITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1011858337  92 FAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFL 148
Cdd:cd00737    80 FAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-148 3.16e-75

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 220.08  E-value: 3.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGGTrTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVS 91
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGD-TITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1011858337  92 FAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFL 148
Cdd:cd00737    80 FAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
12-149 4.99e-70

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 207.39  E-value: 4.99e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGgtRTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVS 91
Cdd:COG3772     8 GLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPG--DTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDALVS 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011858337  92 FAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFLS 149
Cdd:COG3772    86 FAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLG 143
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 33-140 4.28e-21

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 82.02  E-value: 4.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  33 IPTIGYGLVENPIPPGgtRTITAEAAEQLLRDDLQRFEHEVNNMLTVE-VTQNQFDALVSFAFNLGPANLKSSTLLRKVN 111
Cdd:pfam00959   1 YWTIGIGHNGKDVSPH--PRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGN 78

                          90       100
                  ....*....|....*....|....*....
gi 1011858337 112 SGDVNGAADEFLKWNHAgGQVLAGLTARR 140
Cdd:pfam00959  79 IGQWIKACSAIWKSLKA-GKVYNGLVNRR 106
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 15-121 1.36e-04

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 40.51  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  15 LIKQYEGLRLTTYKDAVGIPTIGYG--LVENPIP-----------------PGGtrTITAEAAEQLLRDDLQRFEHEVNN 75
Cdd:PHA02596  178 MLRRDEGIRLKVYWDSEGYPTIGIGhlIIREKTRdmaqinkllskqvgrevTGG--RITAEEASKLFARDLAKVQRDISR 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011858337  76 MLTVEVTQNQFD-----ALVSFAFNLGPANL-KSSTLLRKVNSGDVNGAADE 121
Cdd:PHA02596  256 HSKVGPVYNKLNrsrqmALENMAFQMGVGGVaKFKNMLAAMLAGDWKKAYDA 307
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-148 3.16e-75

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 220.08  E-value: 3.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGGTrTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVS 91
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGD-TITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1011858337  92 FAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFL 148
Cdd:cd00737    80 FAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
12-149 4.99e-70

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 207.39  E-value: 4.99e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGgtRTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVS 91
Cdd:COG3772     8 GLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPG--DTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDALVS 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011858337  92 FAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFLS 149
Cdd:COG3772    86 FAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLG 143
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 13-148 1.02e-47

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 150.79  E-value: 1.02e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  13 IALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGgtRTITAEAAEQLLRDDLQRFEHEVNNMLTVEVTQNQFDALVSF 92
Cdd:cd16900     9 AALVGPWEGLRLTAYRDPVGVWTVCYGHTGGDVKPG--MRYTPAECDALLAKDLQEAAAAVDRCVKVPLPDPQRAALASF 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1011858337  93 AFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTLFL 148
Cdd:cd16900    87 AYNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGRVLRGLVNRREAERALCL 142
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 12-146 2.19e-41

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 134.66  E-value: 2.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  12 GIALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPpgGTRTITAEAAEQLLRDdLQRFEHEVN-NMLTVEVTQNQFDALV 90
Cdd:cd16901     6 GLELIANAEGCRRDPYKCPAGVPTIGIGSTHGVKP--GDRYTDEQAAKRLAKD-IKKAERCVNrCFNGVPLPQGEFDAYV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1011858337  91 SFAFNLGPANLKSSTLLRKVNSGDVNGAADEFLKWNHAGGQVLAGLTARRNAEKTL 146
Cdd:cd16901    83 SFAFNVGCGAFCKSTIYKKLQAGDYAAACNQLPRWVYAGGKVLPGLVTRRQKERAL 138
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 33-140 4.28e-21

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 82.02  E-value: 4.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  33 IPTIGYGLVENPIPPGgtRTITAEAAEQLLRDDLQRFEHEVNNMLTVE-VTQNQFDALVSFAFNLGPANLKSSTLLRKVN 111
Cdd:pfam00959   1 YWTIGIGHNGKDVSPH--PRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGN 78

                          90       100
                  ....*....|....*....|....*....
gi 1011858337 112 SGDVNGAADEFLKWNHAgGQVLAGLTARR 140
Cdd:pfam00959  79 IGQWIKACSAIWKSLKA-GKVYNGLVNRR 106
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 13-127 5.11e-16

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 70.10  E-value: 5.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  13 IALIKQYEGLRLTTYKDAVGIPTIGYGLVENPIPPGGTR-TITAEAAEQLLRDDLQRFEHEVNNMLTV-----EVTQNQF 86
Cdd:cd00735     3 REMLRQDEGYRLKAYKDTEGYPTIGIGHLIGKKGASLTNgTITKDEAEALFEQDVDRAVRDMLRNPKLapvyaQLNAARR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1011858337  87 DALVSFAFNLGPANL-KSSTLLRKVNSGDVNGAADEFL--KWNH 127
Cdd:cd00735    83 MALINMAFQMGVGGLaKFKNMLAAIKAGDWEEAADGMLnsLWAK 126
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 15-121 1.36e-04

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 40.51  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011858337  15 LIKQYEGLRLTTYKDAVGIPTIGYG--LVENPIP-----------------PGGtrTITAEAAEQLLRDDLQRFEHEVNN 75
Cdd:PHA02596  178 MLRRDEGIRLKVYWDSEGYPTIGIGhlIIREKTRdmaqinkllskqvgrevTGG--RITAEEASKLFARDLAKVQRDISR 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011858337  76 MLTVEVTQNQFD-----ALVSFAFNLGPANL-KSSTLLRKVNSGDVNGAADE 121
Cdd:PHA02596  256 HSKVGPVYNKLNrsrqmALENMAFQMGVGGVaKFKNMLAAMLAGDWKKAYDA 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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