DNA repair protein REV1 isoform 6 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
PolY_Rev1 | cd01701 | DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
1-301 | 2.67e-167 | |||||
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. : Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 486.82 E-value: 2.67e-167
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Rev1_C | cd12145 | C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis ... |
634-727 | 1.88e-42 | |||||
C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis (TLS) polymerase; TLS is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. The C-terminal domain modeled here is essential for TLS and has been shown to mediate interactions with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7), as well as with the RIRs (Rev1-interacting regions) of polymerases kappa, iota, and eta. Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. : Pssm-ID: 213388 Cd Length: 94 Bit Score: 148.96 E-value: 1.88e-42
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
482-517 | 1.60e-15 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. : Pssm-ID: 412037 Cd Length: 36 Bit Score: 70.72 E-value: 1.60e-15
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
406-439 | 3.86e-12 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. : Pssm-ID: 412037 Cd Length: 36 Bit Score: 61.09 E-value: 3.86e-12
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Name | Accession | Description | Interval | E-value | |||||
PolY_Rev1 | cd01701 | DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
1-301 | 2.67e-167 | |||||
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 486.82 E-value: 2.67e-167
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DinP | COG0389 | Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
6-298 | 3.06e-70 | |||||
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair]; Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 232.73 E-value: 3.06e-70
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PRK02406 | PRK02406 | DNA polymerase IV; Validated |
4-234 | 2.89e-59 | |||||
DNA polymerase IV; Validated Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 203.81 E-value: 2.89e-59
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Rev1_C | cd12145 | C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis ... |
634-727 | 1.88e-42 | |||||
C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis (TLS) polymerase; TLS is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. The C-terminal domain modeled here is essential for TLS and has been shown to mediate interactions with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7), as well as with the RIRs (Rev1-interacting regions) of polymerases kappa, iota, and eta. Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. Pssm-ID: 213388 Cd Length: 94 Bit Score: 148.96 E-value: 1.88e-42
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IMS | pfam00817 | impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
4-99 | 2.47e-26 | |||||
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 104.96 E-value: 2.47e-26
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REV1_C | pfam16727 | DNA repair protein REV1 C-terminal domain; This is the C-terminal domain of DNA repair protein ... |
644-725 | 3.00e-17 | |||||
DNA repair protein REV1 C-terminal domain; This is the C-terminal domain of DNA repair protein REV1. It interacts with REV7, POLN, POLK and POLI. Pssm-ID: 465248 Cd Length: 91 Bit Score: 77.27 E-value: 3.00e-17
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
482-517 | 1.60e-15 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. Pssm-ID: 412037 Cd Length: 36 Bit Score: 70.72 E-value: 1.60e-15
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
406-439 | 3.86e-12 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. Pssm-ID: 412037 Cd Length: 36 Bit Score: 61.09 E-value: 3.86e-12
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UBM | pfam14377 | Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
488-519 | 4.24e-03 | |||||
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM). Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 35.17 E-value: 4.24e-03
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Name | Accession | Description | Interval | E-value | |||||
PolY_Rev1 | cd01701 | DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
1-301 | 2.67e-167 | |||||
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 486.82 E-value: 2.67e-167
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PolY_Pol_IV_kappa | cd03586 | DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-301 | 9.47e-74 | |||||
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases. Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 242.04 E-value: 9.47e-74
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DinP | COG0389 | Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
6-298 | 3.06e-70 | |||||
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair]; Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 232.73 E-value: 3.06e-70
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PRK02406 | PRK02406 | DNA polymerase IV; Validated |
4-234 | 2.89e-59 | |||||
DNA polymerase IV; Validated Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 203.81 E-value: 2.89e-59
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Rev1_C | cd12145 | C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis ... |
634-727 | 1.88e-42 | |||||
C-terminal domain of the Y-family polymerase Rev1; Rev1 is a eukaryotic translesion synthesis (TLS) polymerase; TLS is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. The C-terminal domain modeled here is essential for TLS and has been shown to mediate interactions with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7), as well as with the RIRs (Rev1-interacting regions) of polymerases kappa, iota, and eta. Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment. Pssm-ID: 213388 Cd Length: 94 Bit Score: 148.96 E-value: 1.88e-42
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PRK03348 | PRK03348 | DNA polymerase IV; Provisional |
1-273 | 2.78e-42 | |||||
DNA polymerase IV; Provisional Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 159.71 E-value: 2.78e-42
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PolY | cd00424 | Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
5-232 | 1.40e-39 | |||||
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention. Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 149.43 E-value: 1.40e-39
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PRK02794 | PRK02794 | DNA polymerase IV; Provisional |
1-278 | 1.57e-37 | |||||
DNA polymerase IV; Provisional Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 145.46 E-value: 1.57e-37
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PRK03103 | PRK03103 | DNA polymerase IV; Reviewed |
6-303 | 2.23e-37 | |||||
DNA polymerase IV; Reviewed Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 144.76 E-value: 2.23e-37
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PRK14133 | PRK14133 | DNA polymerase IV; Provisional |
6-251 | 1.22e-34 | |||||
DNA polymerase IV; Provisional Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 135.23 E-value: 1.22e-34
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PRK01810 | PRK01810 | DNA polymerase IV; Validated |
1-281 | 3.39e-33 | |||||
DNA polymerase IV; Validated Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 132.46 E-value: 3.39e-33
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PRK03858 | PRK03858 | DNA polymerase IV; Validated |
4-268 | 1.66e-31 | |||||
DNA polymerase IV; Validated Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 127.41 E-value: 1.66e-31
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PRK03352 | PRK03352 | DNA polymerase IV; Validated |
10-234 | 1.19e-27 | |||||
DNA polymerase IV; Validated Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 114.73 E-value: 1.19e-27
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IMS | pfam00817 | impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
4-99 | 2.47e-26 | |||||
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 104.96 E-value: 2.47e-26
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PRK01216 | PRK01216 | DNA polymerase IV; Validated |
6-188 | 1.60e-24 | |||||
DNA polymerase IV; Validated Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 105.64 E-value: 1.60e-24
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PolY_Pol_V_umuC | cd01700 | umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
6-234 | 5.78e-24 | |||||
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage. Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 103.78 E-value: 5.78e-24
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PolY_Pol_eta | cd01702 | DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-283 | 2.31e-22 | |||||
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA. Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 99.31 E-value: 2.31e-22
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IMS_C | pfam11799 | impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
186-305 | 1.27e-20 | |||||
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 87.23 E-value: 1.27e-20
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PTZ00205 | PTZ00205 | DNA polymerase kappa; Provisional |
8-234 | 4.23e-19 | |||||
DNA polymerase kappa; Provisional Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 91.62 E-value: 4.23e-19
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PolY_like | cd03468 | DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
1-233 | 3.37e-18 | |||||
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention. Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 86.67 E-value: 3.37e-18
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PolY_Pol_iota | cd01703 | DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-239 | 3.87e-18 | |||||
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides. Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 87.14 E-value: 3.87e-18
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REV1_C | pfam16727 | DNA repair protein REV1 C-terminal domain; This is the C-terminal domain of DNA repair protein ... |
644-725 | 3.00e-17 | |||||
DNA repair protein REV1 C-terminal domain; This is the C-terminal domain of DNA repair protein REV1. It interacts with REV7, POLN, POLK and POLI. Pssm-ID: 465248 Cd Length: 91 Bit Score: 77.27 E-value: 3.00e-17
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
482-517 | 1.60e-15 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. Pssm-ID: 412037 Cd Length: 36 Bit Score: 70.72 E-value: 1.60e-15
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Rev1_UBM2 | cd19318 | Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
406-439 | 3.86e-12 | |||||
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen. Pssm-ID: 412037 Cd Length: 36 Bit Score: 61.09 E-value: 3.86e-12
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umuC | PRK03609 | translesion error-prone DNA polymerase V subunit UmuC; |
23-200 | 1.05e-05 | |||||
translesion error-prone DNA polymerase V subunit UmuC; Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 48.61 E-value: 1.05e-05
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IMS_HHH | pfam11798 | IMS family HHH motif; These proteins are involved in UV protection, eg. |
111-142 | 1.58e-03 | |||||
IMS family HHH motif; These proteins are involved in UV protection, eg. Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.61 E-value: 1.58e-03
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UBM | pfam14377 | Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
488-519 | 4.24e-03 | |||||
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM). Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 35.17 E-value: 4.24e-03
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Blast search parameters | ||||
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