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Conserved domains on  [gi|1009287433|ref|NP_001308349|]
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rho GDP-dissociation inhibitor 2 [Homo sapiens]

Protein Classification

rho GDP-dissociation inhibitor( domain architecture ID 10489308)

rho GDP-dissociation inhibitor (Rho GDI) regulates the GDP/GTP exchange reaction of the rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


:

Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287433 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287433 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287433 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287433 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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