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Conserved domains on  [gi|10092657|ref|NP_061326|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform a [Homo sapiens]

Protein Classification

complex I NDUFA12 subunit family protein( domain architecture ID 10523838)

complex I NDUFA12 subunit family protein similar to NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12), an accessory subunit that is not involved in catalysis of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 2.88e-42

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


:

Pssm-ID: 461542  Cd Length: 96  Bit Score: 135.42  E-value: 2.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657    37 TLVGEDKYGNKYYEDNK-QFFGRHRWVVYTTemngkntfWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 10092657   116 NVTGTPEQY--VPYSTTRKKIQEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 2.88e-42

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 135.42  E-value: 2.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657    37 TLVGEDKYGNKYYEDNK-QFFGRHRWVVYTTemngkntfWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 10092657   116 NVTGTPEQY--VPYSTTRKKIQEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 36-126 3.30e-24

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 90.69  E-value: 3.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657  36 GTLVGEDKYGNKYYE--DNKQFFGRHRWVVYttemNGKNtfwdvDGSMVPPEWHRWLHSMTDDPPTTKPLTARkfIW-TN 112
Cdd:COG3761  26 GEKVGEDEFGNRYYRtkDGKALGRERRWVIY----NGYA-----EASRVPPEWHGWLHHTTDEPPTEEPYPPR--PWeKP 94

                        90
                ....*....|....
gi 10092657 113 HKFNVTGTPEQYVP 126
Cdd:COG3761  95 HQPNLTGTPLAYRP 108
PRK08183 PRK08183
NADH:ubiquinone oxidoreductase subunit NDUFA12;
36-126 6.64e-23

NADH:ubiquinone oxidoreductase subunit NDUFA12;


Pssm-ID: 236176 [Multi-domain]  Cd Length: 133  Bit Score: 87.35  E-value: 6.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657   36 GTLVGEDKYGNKYY--EDNKQFFGR-HRWVVYttemNGKNtfwdvDGSMVPPEWHRWLHSMTDDPPTTKPLTARkfIW-T 111
Cdd:PRK08183  26 GERVGEDEFGNVYYrtKGGKPSDGReRRWVIY----NGYA-----EASRIPPEWHGWLHHTVDVPPTKEPYPPR--EWeK 94

                         90
                 ....*....|....*
gi 10092657  112 NHKFNVTGTPEQYVP 126
Cdd:PRK08183  95 PHQPNLTGTPLAYRP 109
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 2.88e-42

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 135.42  E-value: 2.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657    37 TLVGEDKYGNKYYEDNK-QFFGRHRWVVYTTemngkntfWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 10092657   116 NVTGTPEQY--VPYSTTRKKIQEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 36-126 3.30e-24

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 90.69  E-value: 3.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657  36 GTLVGEDKYGNKYYE--DNKQFFGRHRWVVYttemNGKNtfwdvDGSMVPPEWHRWLHSMTDDPPTTKPLTARkfIW-TN 112
Cdd:COG3761  26 GEKVGEDEFGNRYYRtkDGKALGRERRWVIY----NGYA-----EASRVPPEWHGWLHHTTDEPPTEEPYPPR--PWeKP 94

                        90
                ....*....|....
gi 10092657 113 HKFNVTGTPEQYVP 126
Cdd:COG3761  95 HQPNLTGTPLAYRP 108
PRK08183 PRK08183
NADH:ubiquinone oxidoreductase subunit NDUFA12;
36-126 6.64e-23

NADH:ubiquinone oxidoreductase subunit NDUFA12;


Pssm-ID: 236176 [Multi-domain]  Cd Length: 133  Bit Score: 87.35  E-value: 6.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657   36 GTLVGEDKYGNKYY--EDNKQFFGR-HRWVVYttemNGKNtfwdvDGSMVPPEWHRWLHSMTDDPPTTKPLTARkfIW-T 111
Cdd:PRK08183  26 GERVGEDEFGNVYYrtKGGKPSDGReRRWVIY----NGYA-----EASRIPPEWHGWLHHTVDVPPTKEPYPPR--EWeK 94

                         90
                 ....*....|....*
gi 10092657  112 NHKFNVTGTPEQYVP 126
Cdd:PRK08183  95 PHQPNLTGTPLAYRP 109
PLN03095 PLN03095
NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional
 34-140 1.78e-19

NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional


Pssm-ID: 215571  Cd Length: 115  Bit Score: 78.00  E-value: 1.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657   34 KVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYttemngKNTFwDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFiWTNH 113
Cdd:PLN03095   8 RAGRLVGEDEFGNKYYENPSYQSGRHRWVEY------ADKD-DYNASNIPPEWHGWLHYVNDEPGELEDRTAPRY-QLEF 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 10092657  114 KFNVTGTPEQYV---------PYSTTRKKIQEWIPP 140
Cdd:PLN03095  80 IAGGTTTGTQYMyhpkghflsKRPRNWKRYTPWSPP 115
PLN02732 PLN02732
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit
 6-142 3.26e-16

Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit


Pssm-ID: 215389  Cd Length: 159  Bit Score: 70.73  E-value: 3.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657    6 VLKRGLQQI--TGHGGLR------GYLRVF-----FRTNDAKVG-TLVGEDKYGNKYYED-NKQFFGRHRWVVYTTEMNg 70
Cdd:PLN02732   5 VVKSALEAIreKGLGGFLrmlreeGYLRCLadgnlLQTKIHNIGaTLVGVDKFGNKYYQKlGDTQYGRHRWVEYAEKSR- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092657   71 kntfwdVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTR---------KKIQEWIPPS 141
Cdd:PLN02732  84 ------YNASQVPAEWHGWLHFITDHTGDELLMLKPKRYGLEHKENFSGEGEEYIYHSKGHtlnpgqkdwTRYQSWQPTK 157


                 .
gi 10092657  142 T 142
Cdd:PLN02732 158 T 158
PRK06630 PRK06630
hypothetical protein; Provisional
 39-98 4.77e-06

hypothetical protein; Provisional


Pssm-ID: 168631  Cd Length: 99  Bit Score: 42.65  E-value: 4.77e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10092657   39 VGEDKYGNKYYED-NKQFFGRHRWVVYTTEMNgkntfwdvDGSMVPPEWHRWLHSMTDDPP 98
Cdd:PRK06630  16 VGEDEFLNQYYESrNIDYLGRPRRFVIYKNVN--------EPTKIPPSWHAWLHHLVNEIP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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