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Conserved domains on  [gi|1008856410|gb|KYK38959|]
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hypothetical protein AYK18_00390 [Theionarchaea archaeon DG-70]

Protein Classification

protein-L-isoaspartate O-methyltransferase family protein( domain architecture ID 11457531)

protein-L-isoaspartate O-methyltransferase family protein may catalyze the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

CATH:  3.55.20.10
EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091|GO:0036211
PubMed:  35462043|20564550|35462043|9253175
SCOP:  4000666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 7-206 2.09e-90

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 263.49  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   7 VDALKRYGyIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSGY 86
Cdd:COG2518     1 VQQLRPRG-VTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  87 NGALLAEIVGeeHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKVQG 165
Cdd:COG2518    80 QAAVLARLAG--RVYSVERDPELAERARERLAALGYDnVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGG 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008856410 166 LIICPVGSKYWyQELEVVRKTEQGnVETTHHGGCAFVPLIG 206
Cdd:COG2518   158 RLVAPVGEGGV-QRLVLITRTGDG-FERESLFEVRFVPLRG 196
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 7-206 2.09e-90

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 263.49  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   7 VDALKRYGyIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSGY 86
Cdd:COG2518     1 VQQLRPRG-VTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  87 NGALLAEIVGeeHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKVQG 165
Cdd:COG2518    80 QAAVLARLAG--RVYSVERDPELAERARERLAALGYDnVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGG 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008856410 166 LIICPVGSKYWyQELEVVRKTEQGnVETTHHGGCAFVPLIG 206
Cdd:COG2518   158 RLVAPVGEGGV-QRLVLITRTGDG-FERESLFEVRFVPLRG 196
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
3-210 2.29e-85

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 251.28  E-value: 2.29e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   3 WETLVDALKRYGyIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGC 82
Cdd:PRK00312    9 FARLVLRLRAEG-ILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPGDRVLEIGT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  83 GSGYNGALLAEIVgeEHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQI 161
Cdd:PRK00312   88 GSGYQAAVLAHLV--RRVFSVERIKTLQWEAKRRLKQLGLHnVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLEQL 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1008856410 162 KVQGLIICPVGSKyWYQELEVVRKTEqGNVETTHHGGCAFVPLIGKEGF 210
Cdd:PRK00312  166 KEGGILVAPVGGE-EQQLLTRVRKRG-GRFEREVLEEVRFVPLVKGELA 212
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
1-204 8.21e-74

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 221.86  E-value: 8.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   1 MNWETLVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEI 80
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  81 GCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWV 158
Cdd:pfam01135  81 GSGSGYLTACFARMVGEVgRVVSIEHIPELVEIARRNLEKLGLEnVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALI 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1008856410 159 DQIKVQGLIICPVGSKYwYQELEVVRKTEQGNVETTHHGGCAFVPL 204
Cdd:pfam01135 161 DQLKEGGRLVIPVGPNG-NQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 6-210 1.36e-63

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 196.20  E-value: 1.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   6 LVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSG 85
Cdd:TIGR00080  10 LIDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKVLEIGTGSG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  86 YNGALLAEIVGEEH-VITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKV 163
Cdd:TIGR00080  90 YQAAVLAEIVGRDGlVVSIERIPELAEKAERRLRKLGLDnVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKE 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1008856410 164 QGLIICPVGskywyQELEVVRKTEQGNVETTHH--GGCAFVPLIGKEGF 210
Cdd:TIGR00080 170 GGILVMPVG-----EYLQVLKRAEKRGGEIIIKdvEPVAFVPLVGGEGF 213
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 76-162 4.10e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  76 DILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDG-TLGYPECAPYDRIISTAAAPKI 153
Cdd:cd02440     1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKAAAALLADnVEVLKGDAeELPPEADESFDVIISDPPLHHL 79


                  ....*....
gi 1008856410 154 PQPWVDQIK 162
Cdd:cd02440    80 VEDLARFLE 88
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 7-206 2.09e-90

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 263.49  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   7 VDALKRYGyIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSGY 86
Cdd:COG2518     1 VQQLRPRG-VTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  87 NGALLAEIVGeeHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKVQG 165
Cdd:COG2518    80 QAAVLARLAG--RVYSVERDPELAERARERLAALGYDnVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGG 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008856410 166 LIICPVGSKYWyQELEVVRKTEQGnVETTHHGGCAFVPLIG 206
Cdd:COG2518   158 RLVAPVGEGGV-QRLVLITRTGDG-FERESLFEVRFVPLRG 196
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
3-210 2.29e-85

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 251.28  E-value: 2.29e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   3 WETLVDALKRYGyIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGC 82
Cdd:PRK00312    9 FARLVLRLRAEG-ILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPGDRVLEIGT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  83 GSGYNGALLAEIVgeEHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQI 161
Cdd:PRK00312   88 GSGYQAAVLAHLV--RRVFSVERIKTLQWEAKRRLKQLGLHnVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLEQL 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1008856410 162 KVQGLIICPVGSKyWYQELEVVRKTEqGNVETTHHGGCAFVPLIGKEGF 210
Cdd:PRK00312  166 KEGGILVAPVGGE-EQQLLTRVRKRG-GRFEREVLEEVRFVPLVKGELA 212
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 6-210 1.76e-81

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 241.46  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   6 LVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSG 85
Cdd:PRK13942    9 VIEELIREGYIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLDLKEGMKVLEIGTGSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  86 YNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGY-HVKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKV 163
Cdd:PRK13942   89 YHAAVVAEIVGKSgKVVTIERIPELAEKAKKTLKKLGYdNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPKPLIEQLKD 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1008856410 164 QGLIICPVGSkyWYQELEVVRKTEqGNVETTHHGGCAFVPLIGKEGF 210
Cdd:PRK13942  169 GGIMVIPVGS--YSQELIRVEKDN-GKIIKKKLGEVAFVPLIGKNGF 212
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
1-204 8.21e-74

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 221.86  E-value: 8.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   1 MNWETLVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEI 80
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  81 GCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWV 158
Cdd:pfam01135  81 GSGSGYLTACFARMVGEVgRVVSIEHIPELVEIARRNLEKLGLEnVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALI 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1008856410 159 DQIKVQGLIICPVGSKYwYQELEVVRKTEQGNVETTHHGGCAFVPL 204
Cdd:pfam01135 161 DQLKEGGRLVIPVGPNG-NQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 6-210 1.36e-63

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 196.20  E-value: 1.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   6 LVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSG 85
Cdd:TIGR00080  10 LIDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKVLEIGTGSG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  86 YNGALLAEIVGEEH-VITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKV 163
Cdd:TIGR00080  90 YQAAVLAEIVGRDGlVVSIERIPELAEKAERRLRKLGLDnVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKE 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1008856410 164 QGLIICPVGskywyQELEVVRKTEQGNVETTHH--GGCAFVPLIGKEGF 210
Cdd:TIGR00080 170 GGILVMPVG-----EYLQVLKRAEKRGGEIIIKdvEPVAFVPLVGGEGF 213
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 6-204 8.73e-49

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 158.05  E-value: 8.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   6 LVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYSDTPLPILCGQTISAPSMIAIMLEVAQLEKGLDILEIGCGSG 85
Cdd:PRK13944    5 LVEELVREGIIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPRPGMKILEVGTGSG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  86 YNGALLAEIVGEEHVI-TIERIPELAEWGKKNLEAAGYH--VKVVVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIK 162
Cdd:PRK13944   85 YQAAVCAEAIERRGKVyTVEIVKELAIYAAQNIERLGYWgvVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSALVRQLK 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1008856410 163 VQGLIICPVgSKYWYQELEVVRKTEQGnVETTHHGGCAFVPL 204
Cdd:PRK13944  165 DGGVLVIPV-EEGVGQVLYKVVKRGEK-VEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 4-171 6.32e-47

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 158.68  E-value: 6.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   4 ETLVDALKRYGYIKSPEVEAAFQNVDREKFVLPEYKNRAYS-DTPLPI------LCGQTISAPSMIAIMLEVAQLEKGLD 76
Cdd:TIGR04364   6 AALVDELREDGVIRSPRVEAAFRTVPRHLFAPGAPLEKAYAaNRAVVTkrdedgRALSSVSAPHIQAMMLEQAGVEPGMR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  77 ILEIGCGsGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYH-VKVVVEDGTLGYPECAPYDRIISTAAAPKIP 154
Cdd:TIGR04364  86 VLEIGSG-GYNAALLAELVGPSgEVTTVDIDEDVTDRARACLAAAGYPqVTVVLADAEAGVPELAPYDRIIVTVGAWDIP 164

                         170
                  ....*....|....*..
gi 1008856410 155 QPWVDQIKVQGLIICPV 171
Cdd:TIGR04364 165 PAWLDQLAPGGRLVVPL 181
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 6-189 2.30e-43

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 148.66  E-value: 2.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   6 LVDALKRYGYIKSPEVEAAFQNVDREKFV------LP----------------EYKNRAYSDTPLPILCGQTI------- 56
Cdd:TIGR04188   1 LAARLAAAGVLTDPAWREAVEAVPRHLFLpgfftqLPdgrgwrpvtadrpdpdEWLALVYSDETLVTQLDGDLaadaagg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  57 ----------SAPSMIAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGEEHVITIERIPELAEWGKKNLEAAGYHVKV 126
Cdd:TIGR04188  81 pvtgrptsssTQPSLVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYAPTV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1008856410 127 VVEDGTLGYPECAPYDRIISTAAAPKIPQPWVDQIKVQGLIICPVGSKYWYQELEVVRKTEQG 189
Cdd:TIGR04188 161 VTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSGWLYGGGLVRLTVDDDG 223
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 4-174 6.09e-29

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 109.94  E-value: 6.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410   4 ETLVDALKRYGYikSPEVEAAFQNVDREKFVLPEYK-NRAYSDTPLPILCGQ----TISAPSMIAIMLEVAQLEKGLDIL 78
Cdd:PRK13943    8 EKLFWILKKYGI--SDHIAKAFLEVPREEFLTKSYPlSYVYEDIVLVSYDDGeeysTSSQPSLMALFMEWVGLDKGMRVL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  79 EIGCGSGYNGALLAEIVGEEH-VITIERIPELAEWGKKNLEAAGY-HVKVVVEDGTLGYPECAPYDRIISTAAAPKIPQP 156
Cdd:PRK13943   86 EIGGGTGYNAAVMSRVVGEKGlVVSVEYSRKICEIAKRNVRRLGIeNVIFVCGDGYYGVPEFAPYDVIFVTVGVDEVPET 165

                         170
                  ....*....|....*...
gi 1008856410 157 WVDQIKVQGLIICPVGSK 174
Cdd:PRK13943  166 WFTQLKEGGRVIVPINLK 183
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 60-162 2.96e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 60.94  E-value: 2.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  60 SMIAIMLEVaqlEKGLDILEIGCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYH--VKVVVEDGTLGYP 136
Cdd:COG2519    81 GYIIARLDI---FPGARVLEAGTGSGALTLALARAVGPEgKVYSYERREDFAEIARKNLERFGLPdnVELKLGDIREGID 157

                          90       100
                  ....*....|....*....|....*...
gi 1008856410 137 EcAPYDRIIStaaapKIPQPW--VDQIK 162
Cdd:COG2519   158 E-GDVDAVFL-----DMPDPWeaLEAVA 179
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-156 2.09e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.54  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  65 MLEVAQLEKGLDILEIGCGSGYNGALLAEIVGeeHVITIERIPELAEWGKKNLEAAGYHVKVVVEDGT-LGYPEcAPYDR 143
Cdd:COG2226    14 LLAALGLRPGARVLDLGCGTGRLALALAERGA--RVTGVDISPEMLELARERAAEAGLNVEFVVGDAEdLPFPD-GSFDL 90

                          90
                  ....*....|...
gi 1008856410 144 IISTAAAPKIPQP 156
Cdd:COG2226    91 VISSFVLHHLPDP 103
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 77-149 5.24e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.49  E-value: 5.24e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1008856410  77 ILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAGYHVKVVVEDGT-LGYPEcAPYDRIISTAA 149
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEdLPFPD-GSFDLVVSSGV 72
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 61-146 1.16e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 52.24  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  61 MIAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAG--YHVKVVVEDGTlGYPEC 138
Cdd:COG2230    39 KLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARERAAEAGlaDRVEVRLADYR-DLPAD 116


                  ....*...
gi 1008856410 139 APYDRIIS 146
Cdd:COG2230   117 GQFDAIVS 124
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 77-126 2.13e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 51.72  E-value: 2.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1008856410  77 ILEIGCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYHVKV 126
Cdd:COG4122    20 ILEIGTGTGYSTLWLARALPDDgRLTTIEIDPERAAIARENFARAGLADRI 70
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 58-147 2.70e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  58 APSMIAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAGY-HVKVVVED--GTLG 134
Cdd:COG0500    11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKAGLgNVEFLVADlaELDP 89

                          90
                  ....*....|...
gi 1008856410 135 YPEcAPYDRIIST 147
Cdd:COG0500    90 LPA-ESFDLVVAF 101
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 76-162 4.10e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  76 DILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAGYH-VKVVVEDG-TLGYPECAPYDRIISTAAAPKI 153
Cdd:cd02440     1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKAAAALLADnVEVLKGDAeELPPEADESFDVIISDPPLHHL 79


                  ....*....
gi 1008856410 154 PQPWVDQIK 162
Cdd:cd02440    80 VEDLARFLE 88
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 56-140 7.97e-06

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 43.47  E-value: 7.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  56 ISAPSMIAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGEEHVITIERIPELAEWGKKNLEAAGYHVKVVVEDGTlgy 135
Cdd:TIGR02469   2 MTKREVRALTLAKLRLRPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVSNIVIVEGDA--- 78


                  ....*
gi 1008856410 136 PECAP 140
Cdd:TIGR02469  79 PEAPE 83
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
77-149 1.71e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 42.12  E-value: 1.71e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1008856410  77 ILEIGCGSGYNGALLAEIVGEEHVITIERIPELAEWGKKNLEaagyHVKVVVED-GTLGYPEcaPYDRIISTAA 149
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP----NVRFVVADlRDLDPPE--PFDLVVSNAA 72
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 69-168 3.41e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.93  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  69 AQLEKGLDILEIGCGSGYNGALLAEiVGeEHVITIERIPELAEWGKKNleAAGYHVKVVVEDGT-LGYPEcAPYDRIIST 147
Cdd:COG2227    20 RLLPAGGRVLDVGCGTGRLALALAR-RG-ADVTGVDISPEALEIARER--AAELNVDFVQGDLEdLPLED-GSFDLVICS 94

                          90       100
                  ....*....|....*....|....*..
gi 1008856410 148 AAAPKIPQPW------VDQIKVQGLII 168
Cdd:COG2227    95 EVLEHLPDPAallrelARLLKPGGLLL 121
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 71-130 3.56e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.40  E-value: 3.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1008856410  71 LEKGLDILEIGCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGY-HVKVVVED 130
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNaEVVGIDISEEAIEKARENAQKLGFdNVEFEQGD 62
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 63-146 8.29e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 41.71  E-value: 8.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  63 AIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGEEHVITI---ERIPELAewgKKNLEAAGY-HVKVVVEDGTLGYPEc 138
Cdd:COG2813    39 RLLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVdvnARAVELA---RANAAANGLeNVEVLWSDGLSGVPD- 114


                  ....*...
gi 1008856410 139 APYDRIIS 146
Cdd:COG2813   115 GSFDLILS 122
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
77-146 1.11e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.56  E-value: 1.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1008856410  77 ILEIGCGSGYNgALLAEIVGEEHVITIERIPELAEWGKKNLEAAGYH--VKVVVEDGT-LGYPEcaPYDRIIS 146
Cdd:COG4076    39 VLDIGTGSGLL-SMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdrITVINADATdLDLPE--KADVIIS 108
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
59-132 3.22e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 40.27  E-value: 3.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1008856410  59 PSMIAIMLEVAQLEKGLD---ILEIGCGSGYNgALLAEIVGEEHVITIERIPELAEWGKKNLEAAGYHVKVVVEDGT 132
Cdd:COG2263    28 AELAAELLHLAYLRGDIEgktVLDLGCGTGML-AIGAALLGAKKVVGVDIDPEALEIARENAERLGVRVDFIRADVT 103
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 78-149 5.17e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.03  E-value: 5.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1008856410  78 LEIGCGSGYNGALLAEIVgeEHVITIERIPELAEWGKKNLEAAGyhVKVVVEDGT-LGYPEcAPYDRIISTAA 149
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG--ARVTGVDISPEMLELAREKAPREG--LTFVVGDAEdLPFPD-NSFDLVLSSEV 68
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 62-149 5.67e-04

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.00  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  62 IAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGeEHVITIERIPELAEWGKKNLEAAGYHVKVVVEdgTLGYPECA-P 140
Cdd:pfam02353  50 LDLILDKLGLKPGMTLLDIGCGWGGLMRRAAERYD-VNVVGLTLSKNQYKLARKRVAAEGLARKVEVL--LQDYRDFDeP 126


                  ....*....
gi 1008856410 141 YDRIISTAA 149
Cdd:pfam02353 127 FDRIVSVGM 135
PRK08317 PRK08317
hypothetical protein; Provisional
 66-156 5.71e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.53  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  66 LEVAQLEKGLDILEIGCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYHVKVVVEDGT-LGYPECApYDR 143
Cdd:PRK08317   12 FELLAVQPGDRVLDVGCGPGNDARELARRVGPEgRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADgLPFPDGS-FDA 90

                          90
                  ....*....|...
gi 1008856410 144 IISTAAAPKIPQP 156
Cdd:PRK08317   91 VRSDRVLQHLEDP 103
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
61-147 5.75e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.21  E-value: 5.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  61 MIAIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGeeHVITIERIPE-LAEWGKKNLeaagyHVKVVVED-GTLGYPEc 138
Cdd:COG4976    34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGY--RLTGVDLSEEmLAKAREKGV-----YDRLLVADlADLAEPD- 105


                  ....*....
gi 1008856410 139 APYDRIIST 147
Cdd:COG4976   106 GRFDLIVAA 114
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
67-130 6.20e-04

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.50  E-value: 6.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1008856410  67 EVAQLEKGLDILEIGCGsgyNGAL---LAEIVGeeHVITIERIPELAEWGKKNLEAAGyHVKVVVED 130
Cdd:PRK14896   23 EYAEDTDGDPVLEIGPG---KGALtdeLAKRAK--KVYAIELDPRLAEFLRDDEIAAG-NVEIIEGD 83
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 69-146 9.36e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.97  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  69 AQLEKGLDILEIGCGSGYNGALLAEIVGEEHVITIERIPELAEWGKKNLEAAGYHVKV-VVEDGTLGYPECAP---YDRI 144
Cdd:COG4123    33 APVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRItVIHGDLKEFAAELPpgsFDLV 112


                  ..
gi 1008856410 145 IS 146
Cdd:COG4123   113 VS 114
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 59-130 1.29e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 38.57  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008856410  59 PSMIAIMLEVAQLEKGLDILEIGCGsgyNGAL---LAEIVGeeHVITIERIPELAEWGKKNLEAAGyHVKVVVED 130
Cdd:COG0030    23 PNIIRRIVDAAGITPGDTVLEIGPG---LGALtraLLERAA--RVTAVEIDRRLAAILRETFAAYP-NLTVIEGD 91
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 63-131 4.52e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 36.70  E-value: 4.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  63 AIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGEE-HVITIERIPELAEWGKKNLEAAGYHVKVVVEDG 131
Cdd:PRK00377   30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETgKVYAVDKDEKAINLTRRNAEKFGVLNNIVLIKG 99
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 59-130 9.13e-03

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 36.05  E-value: 9.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1008856410  59 PSMIAIMLEVAQLEKGLDILEIGCGSGYngalLAEIVGE--EHVITIERIPELAEWGKKNLEAAGyHVKVVVED 130
Cdd:TIGR00755  15 ENVIRKIVEAANIQEGDRVLEIGPGLGA----LTEPLLKraKKVTAIEIDPRLAERLRKLLSLYN-NLEIIEGD 83
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 63-146 9.25e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 35.64  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008856410  63 AIMLEVAQLEKGLDILEIGCGSGYNGALLAEIVGEEHVITIE---RIPELAewgKKNLEAAGYH-VKVVVEDGTLGYPEc 138
Cdd:pfam05175  21 RLLLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDinaRALESA---RENLAANGLEnGEVVASDVYSGVED- 96


                  ....*...
gi 1008856410 139 APYDRIIS 146
Cdd:pfam05175  97 GKFDLIIS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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