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Conserved domains on  [gi|100818170|ref|NP_852081|]
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rho GTPase-activating protein 11A [Mus musculus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138228)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 46-246 1.20e-110

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 340.22  E-value: 1.20e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFNSLPHSVVPEFGHIPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCDVAGLLKQFF 125
Cdd:cd04394    1 VFGVPLHSLPHSTVPEYGNVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 126 RELPEPVLPADLHEALFKAQQLG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLL 204
Cdd:cd04394   81 RELPEPLLPYDLHEALLKAQELPtDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 100818170 205 QTSEGHEKMSANTEKKLRLQAAVVQTFIDCASDIGRVPDFIL 246
Cdd:cd04394  161 QSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
 
Name Accession Description Interval E-value
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 46-246 1.20e-110

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 340.22  E-value: 1.20e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFNSLPHSVVPEFGHIPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCDVAGLLKQFF 125
Cdd:cd04394    1 VFGVPLHSLPHSTVPEYGNVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 126 RELPEPVLPADLHEALFKAQQLG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLL 204
Cdd:cd04394   81 RELPEPLLPYDLHEALLKAQELPtDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 100818170 205 QTSEGHEKMSANTEKKLRLQAAVVQTFIDCASDIGRVPDFIL 246
Cdd:cd04394  161 QSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 63-233 5.07e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 160.12  E-value: 5.07e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170    63 GHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEA---CLSSALPCDVAGLLKQFFRELPEPVLPADLH 138
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDpdlDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170   139 EALFKAQQLG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANT 217
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLKDI 160

                          170
                   ....*....|....*.
gi 100818170   218 ekklRLQAAVVQTFID 233
Cdd:smart00324 161 ----RHQNTVIEFLIE 172
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 66-207 4.33e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 136.52  E-value: 4.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170   66 PSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEaCLSSALPC----DVAGLLKQFFRELPEPVLPADLHEA 140
Cdd:pfam00620   1 PLIVRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGP-DVDLDLEEedvhVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 100818170  141 LFKAQQLGAEERNKATLLLSC-LMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTS 207
Cdd:pfam00620  80 FIEAAKLPDEEERLEALRELLrKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
 
Name Accession Description Interval E-value
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 46-246 1.20e-110

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 340.22  E-value: 1.20e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFNSLPHSVVPEFGHIPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCDVAGLLKQFF 125
Cdd:cd04394    1 VFGVPLHSLPHSTVPEYGNVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 126 RELPEPVLPADLHEALFKAQQLG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLL 204
Cdd:cd04394   81 RELPEPLLPYDLHEALLKAQELPtDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 100818170 205 QTSEGHEKMSANTEKKLRLQAAVVQTFIDCASDIGRVPDFIL 246
Cdd:cd04394  161 QSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 63-233 5.07e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 160.12  E-value: 5.07e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170    63 GHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEA---CLSSALPCDVAGLLKQFFRELPEPVLPADLH 138
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDpdlDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170   139 EALFKAQQLG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANT 217
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLKDI 160

                          170
                   ....*....|....*.
gi 100818170   218 ekklRLQAAVVQTFID 233
Cdd:smart00324 161 ----RHQNTVIEFLIE 172
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 66-233 1.69e-38

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 141.29  E-value: 1.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  66 PSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGE--ACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALF 142
Cdd:cd00159    1 PLIIEKCIEYLEKNgLNTEGIFRVSGSASKIEELKKKFDRGEdiDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 143 KA-QQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKkl 221
Cdd:cd00159   81 ELaKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDIKK-- 158

                        170
                 ....*....|..
gi 100818170 222 rlQAAVVQTFID 233
Cdd:cd00159  159 --LNEIVEFLIE 168
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 66-207 4.33e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 136.52  E-value: 4.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170   66 PSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEaCLSSALPC----DVAGLLKQFFRELPEPVLPADLHEA 140
Cdd:pfam00620   1 PLIVRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGP-DVDLDLEEedvhVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 100818170  141 LFKAQQLGAEERNKATLLLSC-LMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTS 207
Cdd:pfam00620  80 FIEAAKLPDEEERLEALRELLrKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 57-242 2.30e-29

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 116.39  E-value: 2.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  57 SVVPEFGHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGE--ACLSSALPCDVAGLLKQFFRELPEPVL 133
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIdvVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 134 PADLHEALFKAQQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRA-----------SENKMDSSNLAVIFAPN 202
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 100818170 203 LLQTSEGHEKMSANTEKKL---RLQAAVVQTFIDCASDIGRVP 242
Cdd:cd04376  161 LLHKQKSGEREFVQASLRIeesTAIINVVQTMIDNYEELFMVS 203
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 47-215 4.90e-28

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 112.05  E-value: 4.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLPHSVvPEFGHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPcDV---AGLLK 122
Cdd:cd04404    6 FGVSLQFLKEKN-PEQEPIPPVVRETVEYLQAHaLTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYE-DVhlpAVILK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 123 QFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPN 202
Cdd:cd04404   84 TFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPN 163

                        170
                 ....*....|...
gi 100818170 203 LLQTSEGHEKMSA 215
Cdd:cd04404  164 LLWAKDASMSLSA 176
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 45-213 1.17e-25

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 105.24  E-value: 1.17e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  45 KVFGVPFNSLPHSVVPEFGhIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEACLSS--ALPCDVAGLL 121
Cdd:cd04393    1 KVFGVPLQELQQAGQPENG-VPAVVRHIVEYLEQHgLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSkeADVCSAASLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 122 KQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLSCLMANPTVD--ILRYFFNFLKSVSLRASENKMDSSNLAVIF 199
Cdd:cd04393   80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNysLLKFLCHFLSNVASQHHENRMTAENLAAVF 159

                        170
                 ....*....|....
gi 100818170 200 APNLLQTSEGHEKM 213
Cdd:cd04393  160 GPDVFHVYTDVEDM 173
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 47-245 4.50e-24

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 101.29  E-value: 4.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSL--------PHSVVPEFGHIPSFLVDACASLKE-HIHTEGLFRKSGSVVRLKALKSKLD-QGEAC--LSSALP 114
Cdd:cd04397    1 FGVPLEILvekfgadsTLGVGPGKLRIPALIDDIISAMRQmDMSVEGVFRKNGNIRRLKELTEEIDkNPTEVpdLSKENP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 115 CDVAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATL-LLSCLMANPTVDILRYFFNFLKSVSLRA-----SEN 188
Cdd:cd04397   81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLhLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGS 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 100818170 189 KMDSSNLAVIFAPNLLQTseghEKMSANTEKKLRLQAAVVQTFIDCASDIGRVPDFI 245
Cdd:cd04397  161 KMDIHNLATVITPNILYS----KTDNPNTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 44-225 8.64e-24

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 100.57  E-value: 8.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  44 GKVFGVPF--------NSLPHSVVPEFGHIPSFLVDacaslkehihTEGLFRKSGSVVRLKALKSKLDQGEACL----SS 111
Cdd:cd04375    2 KNVFGVPLlvnlqrtgQPLPRSIQQAMRWLRNNALD----------QVGLFRKSGVKSRIQKLRSMIESSTDNVnydgQQ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 112 ALpcDVAGLLKQFFRELPEPVLPADLHE---ALFkaQQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASEN 188
Cdd:cd04375   72 AY--DVADMLKQYFRDLPEPLLTNKLSEtfiAIF--QYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQEN 147

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 100818170 189 KMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQA 225
Cdd:cd04375  148 QMTATNLAVCLAPSLFHLNTSRRENSSPARRMQRKKS 184
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 81-238 9.01e-24

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 99.68  E-value: 9.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  81 HTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCDV-AGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATL-- 157
Cdd:cd04402   32 STEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLlASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAELqr 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 158 LLScLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLqaavVQTFIDCASD 237
Cdd:cd04402  112 LLD-KLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPPASSELQNEDLKKVTSL----VQFLIENCQE 186


                 .
gi 100818170 238 I 238
Cdd:cd04402  187 I 187
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 47-232 6.93e-23

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 97.49  E-value: 6.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLPHSVvPEfgHIPsFLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGEAC--LSSALPCDVAGLLK 122
Cdd:cd04378    1 FGVDFSQVPRDF-PD--EVP-FIIKKCTSEIENraLGVQGIYRVSGSKARVEKLCQAFENGKDLveLSELSPHDISSVLK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 123 QFFRELPEPVLPADLHE---ALFKAQQLGAEERNKATLL------------LSCLMANPTVDILRYFFNFLKSVSLRASE 187
Cdd:cd04378   77 LFLRQLPEPLILFRLYNdfiALAKEIQRDTEEDKAPNTPievnriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFEE 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 100818170 188 NKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFI 232
Cdd:cd04378  157 NKMSPNNLGIVFGPTLIRPRPGDADVSLSSLVDYGYQARLVEFLI 201
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 67-204 1.10e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 97.14  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  67 SFLVDACAS-LKEH-IHTEGLFRKSGSVVRLKALKSKLDQGeaCLSSALP---CD---VAGLLKQFFRELPEPVLPADLH 138
Cdd:cd04386   21 ALPIEACVMcLLETgMNEEGLFRVGGGASKLKRLKAALDAG--TFSLPLDefySDphaVASALKSYLRELPDPLLTYNLY 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 100818170 139 EALFKAQQLGAEERNKATLLLSC-LMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLL 204
Cdd:cd04386   99 EDWVQAANKPDEDERLQAIWRILnKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLL 165
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 47-238 3.77e-21

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 92.08  E-value: 3.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSL---PHSVVPEfghipsfLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCD----- 116
Cdd:cd04398    1 FGVPLEDLilrEGDNVPN-------IVYQCIQAIENfgLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLISPEDyesdi 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 117 --VAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATL--LLSCLmANPTVDILRYFFNFLKSVSLRASENKMDS 192
Cdd:cd04398   74 hsVASLLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALhgLINDL-PDANYATLRALMFHLARIKEHESVNRMSV 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 100818170 193 SNLAVIFAPNLLQTSEGH-EKMSantekklrLQAAVVQTFIDCASDI 238
Cdd:cd04398  153 NNLAIIWGPTLMNAAPDNaADMS--------FQSRVIETLLDNAYQI 191
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 46-246 3.17e-20

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 90.10  E-value: 3.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFNSL---PHSVVPEFgHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLD----QGEACLSSALPCDV 117
Cdd:cd04391    1 LFGVPLSTLlerDQKKVPGS-KVPLIFQKLINKLEERgLETEGILRIPGSAQRVKFLCQELEakfyEGTFLWDQVKQHDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 118 AGLLKQFFRELPEPVLPADLHEALFKAQQL-GAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLA 196
Cdd:cd04391   80 ASLLKLFIRELPQPLLTVEYLPAFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 100818170 197 VIFAPNLLQTSEGHEKMSANTEKKLRLQAA---VVQTFIDCASDIGRVPDFIL 246
Cdd:cd04391  160 MIMAPNLFPPRGKHSKDNESLQEEVNMAAGcanIMRLLIRYQDLLWTVPSFLI 212
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 65-220 4.46e-20

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 88.90  E-value: 4.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  65 IPsFLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGEA----CLSSALPCDVAGLLKQFFRELPEPVLPADLH 138
Cdd:cd04385   15 IP-VIVDKCIDFITQhgLMSEGIYRKNGKNSSVKKLLEAFRKDARsvqlREGEYTVHDVADVLKRFLRDLPDPLLTSELH 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 139 EALFKAqqlgAEERNKATL------LLSCLmanPTVD--ILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTsEGH 210
Cdd:cd04385   94 AEWIEA----AELENKDERiarykeLIRRL---PPINraTLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQT-DEH 165

                        170
                 ....*....|
gi 100818170 211 EKMSANTEKK 220
Cdd:cd04385  166 SVGQTSHEVK 175
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 80-214 5.21e-20

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 88.63  E-value: 5.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  80 IHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALP-CD---VAGLLKQFFRELPEPVLPADLHEALFKAQQLG--AEERN 153
Cdd:cd04383   34 LQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNdHDinsVAGVLKLYFRGLENPLFPKERFEDLMSCVKLEnpTERVH 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 100818170 154 KATLLLSCLMAnPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMS 214
Cdd:cd04383  114 QIREILSTLPR-SVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLMPVPEGQDQVS 173
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 68-232 6.53e-19

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 85.65  E-value: 6.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  68 FLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQ-GE-ACLSSALPCDV---AGLLKQFFRELPEPVLPADLHEA 140
Cdd:cd04372   18 MVVDMCIREIEArgLQSEGLYRVSGFAEEIEDVKMAFDRdGEkADISATVYPDInviTGALKLYFRDLPIPVITYDTYPK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 141 LFKAQQLG-AEERNKAtlLLSCLMANPTV--DILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANt 217
Cdd:cd04372   98 FIDAAKISnPDERLEA--VHEALMLLPPAhyETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTLN- 174

                        170
                 ....*....|....*
gi 100818170 218 ekKLRLQAAVVQTFI 232
Cdd:cd04372  175 --DMRYQILIVQLLI 187
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 46-208 1.25e-18

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 85.14  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFNSLPHSVVPEfgHIPsFLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQG--EACLSSALPCD---VA 118
Cdd:cd04395    1 TFGVPLDDCPPSSENP--YVP-LIVEVCCNIVEArgLETVGIYRVPGNNAAISALQEELNRGgfDIDLQDPRWRDvnvVS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 119 GLLKQFFRELPEPVLPADLHEALFKAQQL-GAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAV 197
Cdd:cd04395   78 SLLKSFFRKLPEPLFTNELYPDFIEANRIeDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAI 157

                        170
                 ....*....|.
gi 100818170 198 IFAPNLLQTSE 208
Cdd:cd04395  158 VFGPTLVRTSD 168
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 76-251 1.50e-18

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 85.21  E-value: 1.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  76 LKEHIHTEGLFRKSGSVVRLKALKSKLDQGEAC-LSSA--LPCDVAGLLKQFFRELPEPVLP----------ADLHEALF 142
Cdd:cd04392   20 LEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLdLESGgfHAHDCATVLKGFLGELPEPLLThahypahlqiADLCQFDE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 143 KAQQLGAEERNK---ATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTseghEKMSAN--- 216
Cdd:cd04392  100 KGNKTSAPDKERlleALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICP----RNLTPEdlh 175

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 100818170 217 -TEKKLrlqAAVVQTFIDCASDIGRVPDFILEKIPA 251
Cdd:cd04392  176 eNAQKL---NSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 47-232 3.11e-18

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 83.64  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLphsvVPEFGHIPSFLvdacASLKEHI-----HTEGLFRKSGSVVRLKALKSKLDQG--EACLSSALPCDVAG 119
Cdd:cd04377    1 FGVSLSSL----TSEDRSVPLVL----EKLLEHIemhglYTEGIYRKSGSANKIKELRQGLDTDpdSVNLEDYPIHVITS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 120 LLKQFFRELPEPVLPADLHEALFKAQQL-GAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVI 198
Cdd:cd04377   73 VLKQWLRELPEPLMTFELYENFLRAMELeEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIV 152

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 100818170 199 FAPNLLQTSE-GHEKMSANTEKKlrlQAAVVQTFI 232
Cdd:cd04377  153 FAPCILRCPDtADPLQSLQDVSK---TTTCVETLI 184
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 77-217 7.63e-18

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 82.67  E-value: 7.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  77 KEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSAL-PCDV---AGLLKQFFRELPEPVLPADLHEALFKAQQLgAEER 152
Cdd:cd04387   29 RRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLsEMDVnaiAGTLKLYFRELPEPLFTDELYPNFAEGIAL-SDPV 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 100818170 153 NKATLLLSCLMANPTVDILRYFF--NFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANT 217
Cdd:cd04387  108 AKESCMLNLLLSLPDPNLVTFLFllHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNT 174
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 47-209 9.66e-18

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 82.56  E-value: 9.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLPHsvvpEFGHIPSFLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGEAC--LSSALPCDVAGLLK 122
Cdd:cd04408    1 FGVDFSQLPR----DFPEEVPFVVVRCTAEIENraLGVQGIYRISGSKARVEKLCQAFENGRDLvdLSGHSPHDITSVLK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 123 QFFRELPEPVLPADLHE---ALFKAQQLGAEERNKATLL----------LSCLMANPTVDILRYFFNFLKSVSLRASENK 189
Cdd:cd04408   77 HFLKELPEPVLPFQLYDdfiALAKELQRDSEKAAESPSIveniirslkeLLGRLPVSNYNTLRHLMAHLYRVAERFEDNK 156

                        170       180
                 ....*....|....*....|
gi 100818170 190 MDSSNLAVIFAPNLLQTSEG 209
Cdd:cd04408  157 MSPNNLGIVFGPTLLRPLVG 176
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 65-219 1.16e-17

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 82.05  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  65 IPSFLVDACASLKEHiHTEGLFRKSGSVVRLKALKSKLDQGEACLSSAL-PCDVAGLLKQFFRELPEPVLPADLHEALFK 143
Cdd:cd04389   24 ILTFLSEKVLALGGF-QTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLEdPHVPASLLKLWLRELEEPLIPDALYQQCIS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 144 AqqlgAEERNKATLLLSCLmanPTVD--ILRYFFNFLKSVSLRA--SENKMDSSNLAVIFAPNLLQ-TSEGHEKMSANTE 218
Cdd:cd04389  103 A----SEDPDKAVEIVQKL---PIINrlVLCYLINFLQVFAQPEnvAHTKMDVSNLAMVFAPNILRcTSDDPRVIFENTR 175


                 .
gi 100818170 219 K 219
Cdd:cd04389  176 K 176
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 65-203 3.42e-17

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 80.80  E-value: 3.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  65 IPSFLVDaCASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGE--ACLSSALPCDVAGLLKQFFRELPEPVLPADLHEA 140
Cdd:cd04382   17 IPALIVH-CVNEIEArgLTEEGLYRVSGSEREVKALKEKFLRGKtvPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKE 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 100818170 141 LFKAQQLGAEERNKATLLLS-CLMANPTVDILRYFFNFLKSVSlRASENKMDSSNLAVIFAPNL 203
Cdd:cd04382   96 FMEAAEILDEDNSRAALYQAiSELPQPNRDTLAFLILHLQRVA-QSPECKMDINNLARVFGPTI 158
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 61-217 1.77e-16

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 78.59  E-value: 1.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  61 EFGHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEAC-LSSALPCD---VAGLLKQFFRELPEPVLPA 135
Cdd:cd04403   12 ENSTVPKFVRLCIEAVEKRgLDVDGIYRVSGNLAVIQKLRFAVDHDEKLdLDDSKWEDihvITGALKLFFRELPEPLFPY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 136 DLHEALFKA-QQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMS 214
Cdd:cd04403   92 SLFNDFVAAiKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQETGNIA 171


                 ...
gi 100818170 215 ANT 217
Cdd:cd04403  172 VHM 174
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 46-205 7.25e-16

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 77.10  E-value: 7.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGvpfNSLPHSVVPE--FG-HIPSFLVDACAS-LKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEaclSSALPCD---- 116
Cdd:cd04390    2 VFG---QRLEDTVAYErkFGpRLVPILVEQCVDfIREHgLKEEGLFRLPGQANLVKQLQDAFDAGE---RPSFDSDtdvh 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 117 -VAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLS---CLMANPTVDILRYFFNFLKSVSLRASENKMDS 192
Cdd:cd04390   76 tVASLLKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMkqvSILPKVNYNLLSYICRFLDEVQSNSSVNKMSV 155

                        170
                 ....*....|...
gi 100818170 193 SNLAVIFAPNLLQ 205
Cdd:cd04390  156 QNLATVFGPNILR 168
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 47-205 7.62e-16

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 76.57  E-value: 7.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLPHSVVPefghIPSFLvdacASLKEHI-----HTEGLFRKSGSVVRLKALKSKLDQGEA--CLSSALPCDVAG 119
Cdd:cd04407    1 FGVRVGSLTSNKTS----VPIVL----EKLLEHVemhglYTEGIYRKSGSANRMKELHQLLQADPEnvKLENYPIHAITG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 120 LLKQFFRELPEPVLPADLHEALFKAQQLgAEERNKATLLLSCLMANPTVD---ILRYFFNFLKsVSLRASENKMDSSNLA 196
Cdd:cd04407   73 LLKQWLRELPEPLMTFAQYNDFLRAVEL-PEKQEQLQAIYRVLEQLPTANhntLERLIFHLVK-VALEEDVNRMSPNALA 150


                 ....*....
gi 100818170 197 VIFAPNLLQ 205
Cdd:cd04407  151 IVFAPCLLR 159
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 47-204 3.40e-15

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 74.80  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPfnsLPHSVVPEfGHIPSFLvDACASL--KEHIHTEGLFRKSGSVVRLKALKSKLDQ-GEACLSSA-LPCD-VAGLL 121
Cdd:cd04373    1 FGVP---LANVVTSE-KPIPIFL-EKCVEFieATGLETEGIYRVSGNKTHLDSLQKQFDQdHNLDLVSKdFTVNaVAGAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 122 KQFFRELPEPVLPADLHEALFKAQQLGAEERnKATLLLSCLMANPTV--DILRYFFNFLKSVSLRASENKMDSSNLAVIF 199
Cdd:cd04373   76 KSFFSELPDPLIPYSMHLELVEAAKINDREQ-RLHALKELLKKFPPEnfDVFKYVITHLNKVSQNSKVNLMTSENLSICF 154


                 ....*
gi 100818170 200 APNLL 204
Cdd:cd04373  155 WPTLM 159
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 46-238 3.13e-14

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 73.21  E-value: 3.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPF-NSLPHSVVP-----------EFGHIPSFLVDACASLKEH-IHTEGLFRKSGSVVRLKALKSKLDQGEACLSSA 112
Cdd:cd04396    1 VFGVSLeESLKYASVAisivdedgeqyVYGYIPVVVAKCGVYLKENaTEVEGIFRVAGSSKRIRELQLIFSTPPDYGKSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 113 LPC-----DVAGLLKQFFRELPEPVLPADLHEAL------FKAQQLGAEERNKATL------------LLSCLMANPTVD 169
Cdd:cd04396   81 DWDgytvhDAASVLRRYLNNLPEPLVPLDLYEEFrnplrkRPRILQYMKGRINEPLntdidqaikeyrDLITRLPNLNRQ 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 100818170 170 ILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLqTSEGHEKMSanteKKLRLQAAVVQTFIDCASDI 238
Cdd:cd04396  161 LLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGIL-SHPDHEMDP----KEYKLSRLVVEFLIEHQDKF 224
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 47-232 3.08e-13

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 69.84  E-value: 3.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  47 FGVPFNSLPHSVvPEfgHIPsFLVDACASLKEH--IHTEGLFRKSGSVVRLKALKSKLDQGEAC--LSSALPCDVAGLLK 122
Cdd:cd04409    1 FGADFAQVAKKS-PD--GIP-FIIKKCTSEIESraLCLKGIYRVNGAKSRVEKLCQAFENGKDLveLSELSPHDISNVLK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 123 QFFRELPEPVLPADLHEALF-------------KAQQLGAEER-NKATLLLSCL---------MANPTVDILRYFFNFLK 179
Cdd:cd04409   77 LYLRQLPEPLILFRLYNEFIglakesqhvnetqEAKKNSDKKWpNMCTELNRILlkskdllrqLPAPNYNTLQFLIVHLH 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 100818170 180 SVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFI 232
Cdd:cd04409  157 RVSEQAEENKMSASNLGIIFGPTLIRPRPTDATVSLSSLVDYPHQARLVELLI 209
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 46-203 3.92e-13

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 68.92  E-value: 3.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  46 VFGVPFN-SLPHSVVPEFGH-IPS-------FLvDACASLKEhihtEGLFRKSGSVVRLKALKSKLDQGEAC--LSSALP 114
Cdd:cd04400    1 IFGSPLEeAVELSSHKYNGRdLPSvvyrcieYL-DKNRAIYE----EGIFRLSGSASVIKQLKERFNTEYDVdlFSSSLY 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 115 CD---VAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLSCLMANPTV--DILRYFFNFLKSVSLRASENK 189
Cdd:cd04400   76 PDvhtVAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQAnyDLLYVLFSFLRKIIEHSDVNK 155

                        170
                 ....*....|....
gi 100818170 190 MDSSNLAVIFAPNL 203
Cdd:cd04400  156 MNLRNVCIVFSPTL 169
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 80-233 6.44e-13

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 68.57  E-value: 6.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  80 IHTEGLFRKSGSVVRL-KALKSKLDQGEAClssalPCDV------------AGLLKQFFRELPEPVLPADLHEALFKAQQ 146
Cdd:cd04374   44 INEQGLYRVVGVNSKVqKLLSLGLDPKTST-----PGDVdldnseweiktiTSALKTYLRNLPEPLMTYELHNDFINAAK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 147 LG-AEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEghEKMSANTEkkLRLQA 225
Cdd:cd04374  119 SEnLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE--ETVAAIMD--IKFQN 194


                 ....*...
gi 100818170 226 AVVQTFID 233
Cdd:cd04374  195 IVVEILIE 202
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 65-229 6.63e-11

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 62.52  E-value: 6.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  65 IPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKLDQG------EACLSSALPCdVAGLLKQFFRELPEPVLPADLH 138
Cdd:cd04384   18 VPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEqipdltKDVYIQDIHS-VSSLCKLYFRELPNPLLTYQLY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 139 EALFKAQQLGAEERNKATLLLSCL-MANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTS--EGHEKMSA 215
Cdd:cd04384   97 EKFSEAVSAASDEERLEKIHDVIQqLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKqiESACFSGT 176

                        170
                 ....*....|....
gi 100818170 216 NTEKKLRLQAAVVQ 229
Cdd:cd04384  177 AAFMEVRIQSVVVE 190
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 84-227 2.39e-10

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 61.33  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  84 GLFRKSGSVVRLKALKSKLDQGEA--CLSSALPCDV---AGLLKQFFRELPEPVLPADLHEALFKAQ--QLGAEERNKAT 156
Cdd:cd04379   38 GLYRLCGSAAKKKELRDAFERNSAavELSEELYPDInviTGVLKDYLRELPEPLITPQLYEMVLEALavALPNDVQTNTH 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 100818170 157 LLLSCLMANPTV--DILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAV 227
Cdd:cd04379  118 LTLSIIDCLPLSakATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFCSQEFSRYGISPTSKMAAVSTV 190
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 80-205 6.69e-10

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 59.63  E-value: 6.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  80 IHTEGLFRKSGSVVRLKALKSKLDQ--GEACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALFKAQQLgAEERNKATL 157
Cdd:cd04406   31 LYTEGIYRKSGSTNKIKELRQGLDTdaNSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGL-QERRETVRG 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 100818170 158 LLSCL--MANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQ 205
Cdd:cd04406  110 VYSVIdqLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILR 159
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 77-203 6.32e-08

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 53.59  E-value: 6.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  77 KEHIHTEGLFRKSGSVVRLKALKSKLDQGEA-CLSSALPCDVAGLLKQFFRELPEPVLPADL----HEAlfkAQQLGAEE 151
Cdd:cd04381   33 KHGMKCEGIYKVSGIKSKVDELKAAYNRRESpNLEEYEPPTVASLLKQYLRELPEPLLTKELmprfEEA---CGRPTEAE 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 100818170 152 RNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNL 203
Cdd:cd04381  110 REQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPTV 161
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 69-232 2.01e-07

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 52.73  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  69 LVDACASlkEHIHTEGLFRKSGSVVRLKALK----SKLDQGEACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALfkA 144
Cdd:cd04380   57 LVDYLYT--RGLAQEGLFEEPGLPSEPGELLaeirDALDTGSPFNSPGSAESVAEALLLFLESLPDPIIPYSLYERL--L 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170 145 QQLGAEERNKATlLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHekMSANTEKKLRLQ 224
Cdd:cd04380  133 EAVANNEEDKRQ-VIRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDPPRA--GGKERRAERDRK 209


                 ....*...
gi 100818170 225 AAVVQTFI 232
Cdd:cd04380  210 RAFIEQFL 217
RhoGAP_fMSB1 cd04401
RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 71-201 8.56e-03

RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal MSB1-like proteins. Msb1 was originally identified as a multicopy suppressor of temperature sensitive cdc42 mutation. Msb1 is a positive regulator of the Pkc1p-MAPK pathway and 1,3-beta-glucan synthesis, both pathways involve Rho1 regulation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239866  Cd Length: 198  Bit Score: 38.48  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  71 DACASLKEHIHTEGlfrKSGSVVRLKALKSkldqgeacLSSALPCDVAGLLKQFFRELPEPVLP-ADLHEAlFKAQqlga 149
Cdd:cd04401   38 DKVRSLINSFFPSQ---NGQLQGTAELLDE--------LRYADPHTLILVLKWIWSRLPGSKVIwWEVYEE-FKAR---- 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 100818170 150 EERNK------ATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAP 201
Cdd:cd04401  102 ERRSNypadafLDLLPQCLSSPAHASILYDFFDLLSSIAAHSSVNGMSGRKLSKMAGP 159
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 66-205 9.86e-03

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 38.32  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100818170  66 PSFLVdacaSLKEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPC---DVAGL---LKQFFRELPEPVLPADLHE 139
Cdd:cd04388   16 PPLLI----KLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCDAASVDLeqfDVAALadaLKRYLLDLPNPVIPAPVYS 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 100818170 140 ALFKAQQLGAEERNKATlLLSCLMANPTVD-----ILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQ 205
Cdd:cd04388   92 EMISRAQEVQSSDEYAQ-LLRKLIRSPNLPhqywlTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFR 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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