|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
5-448 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 557.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 5 LSLNQLAQLLslqdNGDISFSPDSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNyssn 84
Cdd:COG0770 3 LTLAEIAEAT----GGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPAD---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 85 IPVFLVHNTLETYQQLAHWWRNQFTIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHDS 164
Cdd:COG0770 75 LPLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 165 AVIEMGMRGRGEIALLAQITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVwQG 244
Cdd:COG0770 155 AVLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERA-KA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 245 EKITYGFS-GGDIVGELLDLT------TLRVNG--LDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSG 314
Cdd:COG0770 234 RVLTFGLSeDADVRAEDIELDedgtrfTLHTPGgeLEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLaAFQPVKG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 315 RAKRYQLEPDILLLDETYNAGLESMLAALDLLKATPG-QRHIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLvdD 393
Cdd:COG0770 314 RLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGgGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTV--G 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1002987647 394 PEAKFIAESATGVNCECFQTHADLINRLKEVIDSGDRILCKASHSVGLNRVVEEL 448
Cdd:COG0770 392 ELARAIAEAAGGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
35-448 |
5.85e-160 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 458.27 E-value: 5.85e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 35 TDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNYSsnIPVFLVHNTLETYQQLAHWWRNQFTIPVIA 114
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNG--LPQILVDDTLEALQALARAKRAKFSGKVIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 115 ITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHDSAVIEMGMRGRGEIALLAQITQPTIAVITNV 194
Cdd:TIGR01143 79 ITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 195 GTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVWQGEKITYGFSGGDIVGELLDLTTLRVNGLDF- 273
Cdd:TIGR01143 159 GPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEGGDFVAKDISYSALGSTSFTLv 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 274 --------NLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK-VNLPSGRAkRYQLEPDILLLDETYNAGLESMLAALD 344
Cdd:TIGR01143 239 apggefevSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAeLKLVKGRF-EVQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 345 LLKATPGQRhIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLVDDPeakFIAESATGVNCECFQTHADLINRLKEV 424
Cdd:TIGR01143 318 ALARFPGKK-ILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEA---AVIYDSFGKQGKHFADKDELLAFLKTL 393
|
410 420
....*....|....*....|....
gi 1002987647 425 IDSGDRILCKASHSVGLNRVVEEL 448
Cdd:TIGR01143 394 VRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-449 |
1.44e-109 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 345.54 E-value: 1.44e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 27 DSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSvnySSNIPVFLVHNTLETYQQLAHWWRN 106
Cdd:PRK11929 523 LPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVA---DVDLPQIVVDDTRAALGRLATAWRA 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 107 QFTIPVIAITGSVGKTTTKELIASVLATR---GKVHKTLANYNNEIGVPKTLLELDETHDSAVIEMGMRGRGEIALLAQI 183
Cdd:PRK11929 600 RFSLPVVAITGSNGKTTTKEMIAAILAAWqgeDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAI 679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 184 TQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVWQGEKITYGFS-GGDIVGELL- 261
Cdd:PRK11929 680 AAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQpGADVYAEKIa 759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 262 -DLTTLRVNGLDFN-----------LPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSGRAKRYQLEPDILLL 328
Cdd:PRK11929 760 kDISVGEAGGTRCQvvtpagsaevyLPLIGEHNLRNALAAIACALAAGASLKQIRAGLeRFQPVAGRMQRRRLSCGTRII 839
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 329 DETYNAGLESMLAALDLLKATPGQRHIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLVDDpeAKFIAESATGVNC 408
Cdd:PRK11929 840 DDTYNANPDSMRAAIDVLAELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEA--ARDAAAAFGAGAR 917
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1002987647 409 ECFQTHADLINRLKEVIDSGDRILCKASHSVGLNRVVEELI 449
Cdd:PRK11929 918 GVCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
115-293 |
1.69e-49 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 167.48 E-value: 1.69e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 115 ITGSVGKTTTKELIASVLATRGKVHKTLA--------NYNNEIGVPKTLLEL-DETHDSAVIEMGMRGRGEiALLAQITQ 185
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 186 PTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKR--VWQGEKITYGFSGGDIV------ 257
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKlkKAGVRVITYGIEGEADLraanie 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1002987647 258 ----GELLDLTTLRVNGLDFNLPLSGRHQALNFMAALAVA 293
Cdd:pfam08245 160 lssdGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
104-336 |
8.67e-10 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 60.42 E-value: 8.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 104 WRNQFTIPVIAITGSVGKTTTKELIASVLATRGKV-HKTLANYNNEIGV--------PKTLLEL--------DETHDSAV 166
Cdd:NF033197 86 KYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPASILNAlelaeeigIDDYGFLI 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 167 IE--MGMRGRGEiallaqitqptIAVITNVGTAH-IGRlGSEAAIAeAKCELLAESPSSSIAVLNydhpllTETAKRVWQ 243
Cdd:NF033197 166 FEvsLGGTGAGD-----------VGIITNILEDYpIAG-GKRSASA-AKLQSLKNAKVGSINVAD------LGIYINGKN 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 244 GEKITygfsggDIVGELLDLTTLRVNGLDFNLPLS----GRHQALNFMAALAVAKILGIDWTSLQEGIK-VNLPSGRAKR 318
Cdd:NF033197 227 KLVIT------VAGVEILSKYPLRFKYGNTEFEFNpllfGPHYRENSLFAIEAALNLGVDPEDIISALKgFKGLPGRMAV 300
|
250
....*....|....*...
gi 1002987647 319 YQLEpDILLLDETyNAGL 336
Cdd:NF033197 301 KKEG-GVVIVDNI-NPGL 316
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
5-448 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 557.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 5 LSLNQLAQLLslqdNGDISFSPDSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNyssn 84
Cdd:COG0770 3 LTLAEIAEAT----GGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPAD---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 85 IPVFLVHNTLETYQQLAHWWRNQFTIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHDS 164
Cdd:COG0770 75 LPLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 165 AVIEMGMRGRGEIALLAQITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVwQG 244
Cdd:COG0770 155 AVLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERA-KA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 245 EKITYGFS-GGDIVGELLDLT------TLRVNG--LDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSG 314
Cdd:COG0770 234 RVLTFGLSeDADVRAEDIELDedgtrfTLHTPGgeLEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLaAFQPVKG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 315 RAKRYQLEPDILLLDETYNAGLESMLAALDLLKATPG-QRHIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLvdD 393
Cdd:COG0770 314 RLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGgGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTV--G 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1002987647 394 PEAKFIAESATGVNCECFQTHADLINRLKEVIDSGDRILCKASHSVGLNRVVEEL 448
Cdd:COG0770 392 ELARAIAEAAGGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
35-448 |
5.85e-160 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 458.27 E-value: 5.85e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 35 TDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNYSsnIPVFLVHNTLETYQQLAHWWRNQFTIPVIA 114
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNG--LPQILVDDTLEALQALARAKRAKFSGKVIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 115 ITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHDSAVIEMGMRGRGEIALLAQITQPTIAVITNV 194
Cdd:TIGR01143 79 ITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 195 GTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVWQGEKITYGFSGGDIVGELLDLTTLRVNGLDF- 273
Cdd:TIGR01143 159 GPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEGGDFVAKDISYSALGSTSFTLv 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 274 --------NLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK-VNLPSGRAkRYQLEPDILLLDETYNAGLESMLAALD 344
Cdd:TIGR01143 239 apggefevSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAeLKLVKGRF-EVQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 345 LLKATPGQRhIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLVDDPeakFIAESATGVNCECFQTHADLINRLKEV 424
Cdd:TIGR01143 318 ALARFPGKK-ILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEA---AVIYDSFGKQGKHFADKDELLAFLKTL 393
|
410 420
....*....|....*....|....
gi 1002987647 425 IDSGDRILCKASHSVGLNRVVEEL 448
Cdd:TIGR01143 394 VRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-449 |
1.44e-109 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 345.54 E-value: 1.44e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 27 DSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSvnySSNIPVFLVHNTLETYQQLAHWWRN 106
Cdd:PRK11929 523 LPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVA---DVDLPQIVVDDTRAALGRLATAWRA 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 107 QFTIPVIAITGSVGKTTTKELIASVLATR---GKVHKTLANYNNEIGVPKTLLELDETHDSAVIEMGMRGRGEIALLAQI 183
Cdd:PRK11929 600 RFSLPVVAITGSNGKTTTKEMIAAILAAWqgeDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAI 679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 184 TQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVWQGEKITYGFS-GGDIVGELL- 261
Cdd:PRK11929 680 AAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQpGADVYAEKIa 759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 262 -DLTTLRVNGLDFN-----------LPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSGRAKRYQLEPDILLL 328
Cdd:PRK11929 760 kDISVGEAGGTRCQvvtpagsaevyLPLIGEHNLRNALAAIACALAAGASLKQIRAGLeRFQPVAGRMQRRRLSCGTRII 839
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 329 DETYNAGLESMLAALDLLKATPGQRHIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLFVLVDDpeAKFIAESATGVNC 408
Cdd:PRK11929 840 DDTYNANPDSMRAAIDVLAELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEA--ARDAAAAFGAGAR 917
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1002987647 409 ECFQTHADLINRLKEVIDSGDRILCKASHSVGLNRVVEELI 449
Cdd:PRK11929 918 GVCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
4-448 |
5.57e-91 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 283.46 E-value: 5.57e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 4 HLSLNQLAQLLSLQDNGDisfspDSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNyss 83
Cdd:PRK10773 3 SVTLSQLADILNGELQGA-----DITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDID--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 84 nIPVFLVHNTLETYQQLAHWWRNQFTIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHD 163
Cdd:PRK10773 75 -LPQLVVKDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 164 SAVIEMGMRGRGEIALLAQITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYD-----HPLLTETA 238
Cdd:PRK10773 154 YAVIELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADsndwlNWQSVIGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 239 KRVWQ---GEKITYGFSGGDI-VGELLDLTTLR--VNGLDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIKvNLP 312
Cdd:PRK10773 234 KTVWRfspNAANSVDFTATNIhVTSHGTEFTLHtpTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLA-NLK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 313 S--GRAKRYQLEPDILLLDETYNAGLESMLAALDLLKATPGQRhIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRlfVL 390
Cdd:PRK10773 313 AvpGRLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYR-VMVVGDMAELGAESEACHRQVGEAAKAAGIDK--VL 389
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 391 VDDPEAKFIAEsATGVNcECFQTHADLINRLKEVIDSGDRI--LCKASHSVGLNRVVEEL 448
Cdd:PRK10773 390 SVGKLSHAISE-ASGVG-EHFADKTALIARLKALLAEHQVItiLVKGSRSAAMEEVVRAL 447
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
20-388 |
1.30e-74 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 241.60 E-value: 1.30e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 20 GDISFSPDSLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNYSSNIPVFLVHNTLETYQQ 99
Cdd:PRK14093 18 ATRSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFAADAPLLVVDDVLAALRD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 100 LAHWWRNQFTIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDETHDSAVIEMGMRGRGEIAL 179
Cdd:PRK14093 98 LGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 180 LAQITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPL---LTETAKRVWQGEKITYGfSGGDI 256
Cdd:PRK14093 178 LVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQfdrLAASARAAGIARIVSFG-ADEKA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 257 VGELLDL------TTLRVNGLD----FNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSGRAKRYQLE--- 322
Cdd:PRK14093 257 DARLLDValhadcSAVHADILGhdvtYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALsQVQPAAGRGVRHTLEvgg 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002987647 323 PDILLLDETYNAGLESMLAALDLLKATP--GQ-RHIAVLGTMKELGSFSEQLHRQVGERVQKLGIDRLF 388
Cdd:PRK14093 337 GEATLIDESYNANPASMAAALGVLGRAPvgPQgRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVF 405
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
5-448 |
2.51e-57 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 202.50 E-value: 2.51e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 5 LSLNQLAQLLSLQDNGDisfsPDSLVSGINTDSRSIE--SGQAFLALKGDNFNGHDFIDMAIEKGAATLIVD-QPVSVNY 81
Cdd:PRK11930 3 YTLESISGILGAEGLGD----KDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSeEKHPEES 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 82 SSNIPVFLVHNTLETYQQLAHWWRNQFTIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIGVPKTLLELDET 161
Cdd:PRK11930 79 YPDANFLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 162 HDSAVIEMGMRGRGEIALLAQITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESpSSSIAVLNYDhPLLTETAKRV 241
Cdd:PRK11930 159 HELGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFKDC-DVIIYNGDNE-LISSCITKSN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 242 WQGEKITYGFSG------GDIVGELLDLTTLRVNGLD----FNLPLSGRHQALNFMAALAVAKILGIDWTSLQEgikvnl 311
Cdd:PRK11930 237 LTLKLISWSRKDpeaplyIPFVEKKEDHTVISYTYKGedfhFEIPFIDDASIENLIHCIAVLLYLGYSADQIQE------ 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 312 psgRAKRYQLEP----------DILLLDETYNAGLESMLAALDLL-KATPGQRHIAVLGTMKELGSFSEQLHRQVGERVQ 380
Cdd:PRK11930 311 ---RMARLEPVAmrlevkeginNCTLINDSYNSDLQSLDIALDFLnRRSQSKKKTLILSDILQSGQSPEELYRKVAQLIS 387
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 381 KLGIDRLFVLvddpEAKFIAESA--TGVNCECFQTHADLINRLKEVIDSGDRILCKASHSVGLNRVVEEL 448
Cdd:PRK11930 388 KRGIDRLIGI----GEEISSEASkfEGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
115-293 |
1.69e-49 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 167.48 E-value: 1.69e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 115 ITGSVGKTTTKELIASVLATRGKVHKTLA--------NYNNEIGVPKTLLEL-DETHDSAVIEMGMRGRGEiALLAQITQ 185
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 186 PTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKR--VWQGEKITYGFSGGDIV------ 257
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKlkKAGVRVITYGIEGEADLraanie 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1002987647 258 ----GELLDLTTLRVNGLDFNLPLSGRHQALNFMAALAVA 293
Cdd:pfam08245 160 lssdGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
32-359 |
1.43e-35 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 137.13 E-value: 1.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 32 GINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVnYSSNIPVFLVHNTLETYQQLAHWWRNQFTIP 111
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGAL-LAAGVPVIVVPDPRAALALLAAAFYGHPSQK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 112 --VIAITGSVGKTTTKELIASVLATRGkvHK-----TLanynnEIGVPKTLLELDETHDSAvIEM-----GMRGRG---- 175
Cdd:COG0769 80 lkLIGVTGTNGKTTTTYLLAQILRALG--KKtgligTV-----GNGIGGELIPSSLTTPEA-LDLqrllaEMVDAGvthv 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 176 --E---IAL----LAQItQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHP----LLTETAKRVW 242
Cdd:COG0769 152 vmEvssHALdqgrVDGV-RFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPygrrLAAAAPARVI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 243 qgekiTYGFSGG-DIVGELLDLT------TLRVNG--LDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLP 312
Cdd:COG0769 231 -----TYGLKADaDLRATDIELSadgtrfTLVTPGgeVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALeKLKGV 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1002987647 313 SGRAKRYQLEPDILLLDE---TYNAgLESMLAAldlLKATPGQRHIAVLG 359
Cdd:COG0769 306 PGRMERVDGGQGPTVIVDyahTPDA-LENVLEA---LRPHTKGRLIVVFG 351
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
30-359 |
9.37e-26 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 109.33 E-value: 9.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 30 VSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVnYSSNIPVFLVHNTLETYQQLA-----HWW 104
Cdd:TIGR01085 4 VTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDF-YVAPVPVIIVPDLRHALSSLAaafygHPS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 105 RNqftIPVIAITGSVGKTTTKELIASVLATRGKVHKTLANYNNEIG------------------VPKTLLELDETH-DSA 165
Cdd:TIGR01085 83 KK---LKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGgndliknpaalttpealtLQSTLAEMVEAGaQYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 166 VIEMgmrgrGEIALLAQITQPT---IAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVW 242
Cdd:TIGR01085 160 VMEV-----SSHALAQGRVRGVrfdAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 243 QgeKITYGFSGGDIVGELLDL----TTLRVNGLDFNL-----------PLSGRHQALNFMAALAVAK-ILGIDWTSLQEG 306
Cdd:TIGR01085 235 K--DITVSAITQPADGRAQDIkitdSGYSFEGQQFTFetpageghlhtPLIGRFNVYNLLAALATLLhLGGIDLEDIVAA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1002987647 307 I-KVNLPSGRAKRYQLEPDIL-LLDetYNAGLESMLAALDLLKATPGQRHIAVLG 359
Cdd:TIGR01085 313 LeKFRGVPGRMELVDGGQKFLvIVD--YAHTPDALEKALRTLRKHKDGRLIVVFG 365
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
30-359 |
9.77e-26 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 109.07 E-value: 9.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 30 VSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNysSNIPVFLVHNTLETYQQLAHWW--RNQ 107
Cdd:PRK00139 15 ITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAG--TGVPVIIVPDLRKALALLAAAFygHPS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 108 FTIPVIAITGSVGKTTTKELIASVLATRGkvHK-----TLANYNNEIGVPKTL-----LELDETHDSAViEMGMRgrgei 177
Cdd:PRK00139 93 DKLKLIGVTGTNGKTTTAYLLAQILRLLG--EKtaligTLGNGIGGELIPSGLttpdaLDLQRLLAELV-DAGVT----- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 178 AL--------LAQ----ITQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAEspSSSIAVLNYDHPLLTETAKRVWqge 245
Cdd:PRK00139 165 YAamevsshaLDQgrvdGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSE--LGLAAVINADDEVGRRLLALPD--- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 246 KITYGFSGGDIVGELLDLT----TLRVNGlDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGI-KVNLPSGRAKRYQ 320
Cdd:PRK00139 240 AYAVSMAGADLRATDVEYTdsgqTFTLVT-EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALaKLQGVPGRMERVD 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1002987647 321 LEPDILLL-D--ETYNAgLESMLAAldlLKATPGQRHIAVLG 359
Cdd:PRK00139 319 AGQGPLVIvDyaHTPDA-LEKVLEA---LRPHAKGRLICVFG 356
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
111-308 |
4.04e-23 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 101.31 E-value: 4.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 111 PVIAITGSVGKTTTKELIASVLATRGKvhKTLA--NynneIGVPktLLEL---DETHDSAVIE------MGMRGrgeial 179
Cdd:COG0771 106 PIIAITGTNGKTTTTTLIGHILKAAGL--RVAVggN----IGTP--LLDLllePEPPDVYVLElssfqlETTPS------ 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 180 laqiTQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVwQGEKIT----------Y 249
Cdd:COG0771 172 ----LRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEA-KARVVPfslkepleggA 246
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1002987647 250 GFSGGDIVGELLDLTTLRVNgldfNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK 308
Cdd:COG0771 247 GLEDGKLVDRASGEELLPVD----DLRLPGRHNLENALAALAAARALGVPPEAIREALR 301
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
28-359 |
7.45e-20 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 92.84 E-value: 7.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 28 SLVSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNYSSNIPVFL-VHNTLETYQQLAHWWRN 106
Cdd:PRK11929 27 AATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADALVLpVADLRKALGELAARWYG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 107 QFTIP--VIAITGSVGKTTTKELIASVLATRGKVHKTLANYNN-----EIGVPKTLLELDETH-----------DSAVIE 168
Cdd:PRK11929 107 RPSEQlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLTTPDAIILHrilarmraagaDAVAME 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 169 MGMRG--RGEIALLAQITqptiAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHP-------LLTETAK 239
Cdd:PRK11929 187 ASSHGleQGRLDGLRIAV----AGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPaaarllaALPRGLK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 240 RVWQGEKITYGFSGGDIVGELLDLT-TLRVN--GLDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIKVNLP-SGR 315
Cdd:PRK11929 263 VGYSPQNAGADVQARDLRATAHGQVfTLATPdgSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPvPGR 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1002987647 316 AKRYQLEPDI----LLLD--ETYNAgLESMLAALDLLKATPGQRHIAVLG 359
Cdd:PRK11929 343 MERVGPTAGAqgplVVVDyaHTPDA-LAKALTALRPVAQARNGRLVCVFG 391
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
112-308 |
3.46e-18 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 86.27 E-value: 3.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 112 VIAITGSVGKTTTKELIASVLAtrgkvhktlanynnEIGVPKTLL---ELDETHDSAVIemgmrGRGEI----------A 178
Cdd:COG0773 106 SIAVAGTHGKTTTTSMLAHILE--------------EAGLDPTFLiggILNNFGTNARL-----GDGDYfvaeadesdgS 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 179 LLAqiTQPTIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVWQgEKITYGFS-GGDIV 257
Cdd:COG0773 167 FLH--YSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGR-PVITYGFSeDADYR 243
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 258 GELLDLT------TLRVNG---LDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK 308
Cdd:COG0773 244 AENIRIDgggstfDVLRRGeelGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALA 303
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
111-308 |
2.63e-16 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 80.46 E-value: 2.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 111 PVIAITGSVGKTTTKELIASVLATRGKvhKTLANYNneIGVPKTLLELDETHDSAVIEM----GMRGRGEIallaqitqP 186
Cdd:TIGR01087 103 PVVAITGTNGKTTTTSLLYHLLKAAGL--KAFLGGN--IGTPALEVLDQEGAELYVLELssfqLETTESLR--------P 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 187 TIAVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVwQGEKITYgFSGGDIVGELLDLT-- 264
Cdd:TIGR01087 171 EIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKS-KAQVIWF-SVEKDAERGLCIRDgg 248
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1002987647 265 -TLRVNGLDFNLPlsGRHQALNFMAALAVAKILGIDWTSLQEGIK 308
Cdd:TIGR01087 249 lYLKPNDLEGSLL--GLHNAENILAAIALAKSLGLNLEAILEALR 291
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
111-308 |
2.95e-14 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 74.24 E-value: 2.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 111 PVIAITGSVGKTTTKELIASVLATRGKvhKTLANYNneIGVP--KTLLELDEtHDSAVIEMGMRGRGEIALLAqitqPTI 188
Cdd:PRK14106 109 PIVAITGTNGKTTTTTLLGEIFKNAGR--KTLVAGN--IGYPliDAVEEYGE-DDIIVAEVSSFQLETIKEFK----PKV 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 189 AVITNVGTAHIGRLGSEAAIAEAKCELLAESPSSSIAVLNYDHPLLTETAKRVwQGEKIT----------YGFSGGDIVG 258
Cdd:PRK14106 180 GCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKA-KARVIFfsrkslleegVFVKNGKIVI 258
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1002987647 259 ELLDLTT--LRVNgldfNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK 308
Cdd:PRK14106 259 SLGGKEEevIDID----EIFIPGEHNLENALAATAAAYLLGISPDVIANTLK 306
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
165-433 |
3.20e-13 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 70.90 E-value: 3.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 165 AVIEMGMRGRgeiaLLA-QITQPTIAVITNVGTAHIGRLGSE-AAIAEAKCE--------LLAESPSSSIAVLnydhpll 234
Cdd:COG0285 137 AVLEVGLGGR----LDAtNVIDPLVSVITSIGLDHTDFLGDTlEEIAREKAGiikpgvpvVTGDQQPEALEVI------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 235 TETAKRV-----WQGEKITYGFSGGDivgeLLDLTTLRVNGLDFNLPLSGRHQALNFMAALAVAKIL-----GIDWTSLQ 304
Cdd:COG0285 206 EERAAELgaplyRAGRDFSVEEREGA----VFSYQGPGGEYEDLPLPLLGAHQAENAALALAALEALrelglPISEEAIR 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 305 EGI-KVNLPsGRAKRYQLEPDIlLLDETYN-AGLESMLAALDLLKatPGQRHIAVLGTM--KELGSFSEQLHRQVgervq 380
Cdd:COG0285 282 EGLaNARWP-GRLEVLSRGPLV-ILDGAHNpAGARALAETLKELF--PFRKLHLVFGMLadKDIEGMLAALAPLA----- 352
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1002987647 381 klgiDRLFVL-VDDP---EAKFIAESAT--GVNCECFQTHADLINRLKEVIDSGDRILC 433
Cdd:COG0285 353 ----DEVIVTtPPSPralDAEELAEAARelGLRVEVAPDVEEALEAALELADPDDLILV 407
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
106-308 |
2.48e-11 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 65.95 E-value: 2.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 106 NQFTIPVIAITGSVGKTTTKELIASVLATRGK----------------VHKT-LANYNNeigvPKTLLeLDETHDSAVIE 168
Cdd:PRK14016 476 DDGRIPIVAVTGTNGKTTTTRLIAHILKLSGKrvgmtttdgvyidgrlIDKGdCTGPKS----ARRVL-MNPDVEAAVLE 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 169 MgmrGRGEI---AL---LAQitqptIAVITNVGTAHIGRLG--SEAAIAEAKcELLAESPSSS-IAVLNYDHPLLTETAK 239
Cdd:PRK14016 551 T---ARGGIlreGLaydRCD-----VGVVTNIGEDHLGLGGinTLEDLAKVK-RVVVEAVKPDgYAVLNADDPMVAAMAE 621
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 240 RVwQGEKITYGFS--------------------GGDIV---GElldlTTLRVNGLDfNLPLS--GR--HQALNFMAALAV 292
Cdd:PRK14016 622 RC-KGKVIFFSMDpdnpviaehraqggravyveGDYIVlaeGG----WEIRIISLA-DIPLTlgGKagFNIENALAAIAA 695
|
250
....*....|....*.
gi 1002987647 293 AKILGIDWTSLQEGIK 308
Cdd:PRK14016 696 AWALGIDIELIRAGLR 711
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
30-105 |
2.56e-10 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 56.47 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 30 VSGINTDSRSIESGQAFLALKGDNFNGHDFIDMAIEKGAATLIVDQPVSVNYSSNI-------PVFLVHNTLETYQQLAH 102
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNISPDNPeleaakvPGIPVIDRREALAELAA 81
|
...
gi 1002987647 103 WWR 105
Cdd:pfam01225 82 AFY 84
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
104-336 |
8.67e-10 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 60.42 E-value: 8.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 104 WRNQFTIPVIAITGSVGKTTTKELIASVLATRGKV-HKTLANYNNEIGV--------PKTLLEL--------DETHDSAV 166
Cdd:NF033197 86 KYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPASILNAlelaeeigIDDYGFLI 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 167 IE--MGMRGRGEiallaqitqptIAVITNVGTAH-IGRlGSEAAIAeAKCELLAESPSSSIAVLNydhpllTETAKRVWQ 243
Cdd:NF033197 166 FEvsLGGTGAGD-----------VGIITNILEDYpIAG-GKRSASA-AKLQSLKNAKVGSINVAD------LGIYINGKN 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 244 GEKITygfsggDIVGELLDLTTLRVNGLDFNLPLS----GRHQALNFMAALAVAKILGIDWTSLQEGIK-VNLPSGRAKR 318
Cdd:NF033197 227 KLVIT------VAGVEILSKYPLRFKYGNTEFEFNpllfGPHYRENSLFAIEAALNLGVDPEDIISALKgFKGLPGRMAV 300
|
250
....*....|....*...
gi 1002987647 319 YQLEpDILLLDETyNAGL 336
Cdd:NF033197 301 KKEG-GVVIVDNI-NPGL 316
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
30-137 |
7.20e-09 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 57.74 E-value: 7.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 30 VSGINTDSRSIESGQAFLAlKGDNFNgHDFIDMAIEKGAATLIVDqpvsVNYSSNIPVFLVHNTLETYQQLAHWW----R 105
Cdd:PRK14022 34 FDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLKLYVSE----KDYEVGIPQVIVPDIKKAMSLIAMEFydnpQ 107
|
90 100 110
....*....|....*....|....*....|..
gi 1002987647 106 NQFTIpvIAITGSVGKTTTKELIASVLATRGK 137
Cdd:PRK14022 108 HKLKL--LAFTGTKGKTTAAYFAYHILKQLHK 137
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
314-396 |
1.22e-06 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 46.18 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 314 GRAKRYQLEPDILLLDEtYNAGLESMLAALDLLKATPGQRHIAVLGTMKELGsfsEQLHRQVGeRVQKLGIDRLFVLVDD 393
Cdd:pfam02875 3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRLILVFGGMGDRD---AEFHALLG-RLAAALADVVILTGDY 77
|
...
gi 1002987647 394 PEA 396
Cdd:pfam02875 78 PRA 80
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
113-308 |
8.71e-06 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 48.27 E-value: 8.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 113 IAITGSVGKTTTKELIASVLATRGK-----VHKTLANY-NNEIGVPKTLL-ELDETHDSaviemgmrgrgeialLAQITq 185
Cdd:PRK14573 107 ILVSGSHGKTTVSSLITAIFQEAKKdpsyaIGGLNQEGlNGYSGSSEYFVaEADESDGS---------------LKHYT- 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987647 186 PTIAVITNVGTAHIGRL-GSEAAIAEAKCELLAESPSSSIAVLNYDHPLLtetaKRVWQGekITYGFSGG---DIVG--- 258
Cdd:PRK14573 171 PEFSVITNIDNEHLSNFeGDRELLLASIQDFARKVQQINKCFYNGDCPRL----KGCLQG--HSYGFSSScdlHILSyyq 244
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1002987647 259 ----ELLDLTTLRVNGLDFNLPLSGRHQALNFMAALAVAKILGIDWTSLQEGIK 308
Cdd:PRK14573 245 egwrSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALK 298
|
|
| |
