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Conserved domains on  [gi|1002877445|gb|AMN92252|]
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mitochondrial association factor 1 [Toxoplasma gondii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAF1-ALBA4_C cd21101
C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; ...
 169-432 4.48e-153

C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; Mitochondria play a role in the regulation of the innate immune response. Host mitochondria are recruited to the membranes that surround certain intracellular bacteria and parasites during infection, a phenomenon termed host mitochondrial association (HMA). In Toxoplasma gondii, HMA is driven by a gene family that encodes mitochondrial association factor 1 (MAF1) proteins. MAF1 is the parasite protein needed to recruit host mitochondria to the Toxoplasma-containing vacuole during infection. The T. gondii MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA; these fall into two broad groups designated MAF1a and MAF1b based on residue percent identity. MAF1b paralogs, but not MAF1a paralogs, have been shown to be responsible for the HMA phenotype. This family also includes Plasmodium yeolii ALBA4 which has been shown to modulate its stage-specific interactions and the fates of specific mRNAs during the parasite's growth and transmission, acting to regulate the development of the parasite's transmission stages.


:

Pssm-ID: 411045  Cd Length: 264  Bit Score: 434.25  E-value: 4.48e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 169 CLRDTKVTFFGPSGRQHGFTPLYDPSPNKRVATVDAGANALFIGGGGLNGQFAKTLLEEAEKNGIRLTSVALSEHSQRIQ 248
Cdd:cd21101     1 CLGSTIVPFFGPSHHTDGFTPLYDPAPNKRVATVDAGDNALFIGGGGINGAFAKTLLEEAEKNGIRLTHGELSDHSQRIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 249 QSLLRRAVKSPGKLVELDTGVASPVFARSFGFVPVVPGLMWKESKVGANVGVTFIHILKPEVTPYGNLNNNVMMYTVAPC 328
Cdd:cd21101    81 KELLRRAVKEPGKLVELDTGSVSPVFARSFPFVPVVPGLMWNESKVGSNVGVTFIHILKPEVTPHGNLNNMVMMYTVAPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 329 GAAPDTTYSLAYKTTIAGVIGAAAAYNDTPAGQQYPVQGLRLPLLRGGIFRRNRSLESIGRANAEGTSLAITQYGPNFEL 408
Cdd:cd21101   161 GNAPDVEYSLAYKTTIEGVIGAAAAYNGTPKGEEYPVQGLRLPLLGGGIFRRHRSLESIGRANAEGTSLAITRYGPSFEL 240

                         250       260
                  ....*....|....*....|....
gi 1002877445 409 QYMYDPSNAALHGLQEAESTYLAS 432
Cdd:cd21101   241 QFMYDPSNAALHGLQETESTYLFS 264
 
Name Accession Description Interval E-value
MAF1-ALBA4_C cd21101
C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; ...
 169-432 4.48e-153

C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; Mitochondria play a role in the regulation of the innate immune response. Host mitochondria are recruited to the membranes that surround certain intracellular bacteria and parasites during infection, a phenomenon termed host mitochondrial association (HMA). In Toxoplasma gondii, HMA is driven by a gene family that encodes mitochondrial association factor 1 (MAF1) proteins. MAF1 is the parasite protein needed to recruit host mitochondria to the Toxoplasma-containing vacuole during infection. The T. gondii MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA; these fall into two broad groups designated MAF1a and MAF1b based on residue percent identity. MAF1b paralogs, but not MAF1a paralogs, have been shown to be responsible for the HMA phenotype. This family also includes Plasmodium yeolii ALBA4 which has been shown to modulate its stage-specific interactions and the fates of specific mRNAs during the parasite's growth and transmission, acting to regulate the development of the parasite's transmission stages.


Pssm-ID: 411045  Cd Length: 264  Bit Score: 434.25  E-value: 4.48e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 169 CLRDTKVTFFGPSGRQHGFTPLYDPSPNKRVATVDAGANALFIGGGGLNGQFAKTLLEEAEKNGIRLTSVALSEHSQRIQ 248
Cdd:cd21101     1 CLGSTIVPFFGPSHHTDGFTPLYDPAPNKRVATVDAGDNALFIGGGGINGAFAKTLLEEAEKNGIRLTHGELSDHSQRIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 249 QSLLRRAVKSPGKLVELDTGVASPVFARSFGFVPVVPGLMWKESKVGANVGVTFIHILKPEVTPYGNLNNNVMMYTVAPC 328
Cdd:cd21101    81 KELLRRAVKEPGKLVELDTGSVSPVFARSFPFVPVVPGLMWNESKVGSNVGVTFIHILKPEVTPHGNLNNMVMMYTVAPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 329 GAAPDTTYSLAYKTTIAGVIGAAAAYNDTPAGQQYPVQGLRLPLLRGGIFRRNRSLESIGRANAEGTSLAITQYGPNFEL 408
Cdd:cd21101   161 GNAPDVEYSLAYKTTIEGVIGAAAAYNGTPKGEEYPVQGLRLPLLGGGIFRRHRSLESIGRANAEGTSLAITRYGPSFEL 240

                         250       260
                  ....*....|....*....|....
gi 1002877445 409 QYMYDPSNAALHGLQEAESTYLAS 432
Cdd:cd21101   241 QFMYDPSNAALHGLQETESTYLFS 264
 
Name Accession Description Interval E-value
MAF1-ALBA4_C cd21101
C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; ...
 169-432 4.48e-153

C-terminal domain of mitochondrial association factor 1 (MAF1), Alba4, and related proteins; Mitochondria play a role in the regulation of the innate immune response. Host mitochondria are recruited to the membranes that surround certain intracellular bacteria and parasites during infection, a phenomenon termed host mitochondrial association (HMA). In Toxoplasma gondii, HMA is driven by a gene family that encodes mitochondrial association factor 1 (MAF1) proteins. MAF1 is the parasite protein needed to recruit host mitochondria to the Toxoplasma-containing vacuole during infection. The T. gondii MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA; these fall into two broad groups designated MAF1a and MAF1b based on residue percent identity. MAF1b paralogs, but not MAF1a paralogs, have been shown to be responsible for the HMA phenotype. This family also includes Plasmodium yeolii ALBA4 which has been shown to modulate its stage-specific interactions and the fates of specific mRNAs during the parasite's growth and transmission, acting to regulate the development of the parasite's transmission stages.


Pssm-ID: 411045  Cd Length: 264  Bit Score: 434.25  E-value: 4.48e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 169 CLRDTKVTFFGPSGRQHGFTPLYDPSPNKRVATVDAGANALFIGGGGLNGQFAKTLLEEAEKNGIRLTSVALSEHSQRIQ 248
Cdd:cd21101     1 CLGSTIVPFFGPSHHTDGFTPLYDPAPNKRVATVDAGDNALFIGGGGINGAFAKTLLEEAEKNGIRLTHGELSDHSQRIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 249 QSLLRRAVKSPGKLVELDTGVASPVFARSFGFVPVVPGLMWKESKVGANVGVTFIHILKPEVTPYGNLNNNVMMYTVAPC 328
Cdd:cd21101    81 KELLRRAVKEPGKLVELDTGSVSPVFARSFPFVPVVPGLMWNESKVGSNVGVTFIHILKPEVTPHGNLNNMVMMYTVAPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002877445 329 GAAPDTTYSLAYKTTIAGVIGAAAAYNDTPAGQQYPVQGLRLPLLRGGIFRRNRSLESIGRANAEGTSLAITQYGPNFEL 408
Cdd:cd21101   161 GNAPDVEYSLAYKTTIEGVIGAAAAYNGTPKGEEYPVQGLRLPLLGGGIFRRHRSLESIGRANAEGTSLAITRYGPSFEL 240

                         250       260
                  ....*....|....*....|....
gi 1002877445 409 QYMYDPSNAALHGLQEAESTYLAS 432
Cdd:cd21101   241 QFMYDPSNAALHGLQETESTYLFS 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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