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Conserved domains on  [gi|1002286831|ref|XP_015647718|]
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protein CHROMATIN REMODELING 35 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 12785252)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 425-620 4.61e-70

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18007:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 239  Bit Score: 232.57  E-value: 4.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVG-----DKPGGCILAHAPGSGKTFMLISFIQSFLAKYPS-ARPLVVLPKGILGTWKREFQRWQ 498
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGtdvgsDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWEDEFKKWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 499 VED-IPLYDFYSVKADKRTEQ-LEVLKSWEARMSILFLGYKQFSRIICGDG-DGNIAAACRDRLLM-VPNLLILDEGHTP 574
Cdd:cd18007    81 PPDlRPLLVLVSLSASKRADArLRKINKWHKEGGVLLIGYELFRNLASNATtDPRLKQEFIAALLDpGPDLLVLDEGHRL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18007   161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYL 206
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 424-912 1.20e-60

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 219.71  E-value: 1.20e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNlvGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWqVEDIP 503
Cdd:COG0553   241 TLRPYQLEGAAWLLFL--RRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKF-APGLR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSvkADKRTEQLEVLKswearmsilflgykQFSRIICgdgdgNIAAACRDR--LLMVP-NLLILDEGHTPRNRETD 580
Cdd:COG0553   318 VLVLDG--TRERAKGANPFE--------------DADLVIT-----SYGLLRRDIelLAAVDwDLVILDEAQHIKNPATK 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 581 VLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLkmessrpiarrimsqvaisgiRSLKgvhdsAFTESVEDTL 660
Cdd:COG0553   377 RAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL---------------------GSLK-----AFRERFARPI 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 661 LNDDnftrkSHVIRSLRELTKDVLH-YYKGDILDELPGLVDFSVFLKLSTKQKEIvhkieaYEKFKRSAvgtalyihpcL 739
Cdd:COG0553   431 EKGD-----EEALERLRRLLRPFLLrRTKEDVLKDLPEKTEETLYVELTPEQRAL------YEAVLEYL----------R 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 740 SEISEGDAADRATNLTDAT------------VDSLIESIIIKDGvKAKFFFNILSLANSAGEKLLAFSQYILPMKFLERL 807
Cdd:COG0553   490 RELEGAEGIRRRGLILAALtrlrqicshpalLLEEGAELSGRSA-KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEER 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 808 LVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFGSIKACGEGISLVGASRVIILDVHLNPSVTRQAIGRAF 887
Cdd:COG0553   569 LEER-----GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAH 643

                         490       500
                  ....*....|....*....|....*
gi 1002286831 888 RPGQQKKVFVYRLVAADSPEVKFHE 912
Cdd:COG0553   644 RIGQTRDVQVYKLVAEGTIEEKILE 668
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 425-620 4.61e-70

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 232.57  E-value: 4.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVG-----DKPGGCILAHAPGSGKTFMLISFIQSFLAKYPS-ARPLVVLPKGILGTWKREFQRWQ 498
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGtdvgsDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWEDEFKKWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 499 VED-IPLYDFYSVKADKRTEQ-LEVLKSWEARMSILFLGYKQFSRIICGDG-DGNIAAACRDRLLM-VPNLLILDEGHTP 574
Cdd:cd18007    81 PPDlRPLLVLVSLSASKRADArLRKINKWHKEGGVLLIGYELFRNLASNATtDPRLKQEFIAALLDpGPDLLVLDEGHRL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18007   161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYL 206
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 424-912 1.20e-60

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 219.71  E-value: 1.20e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNlvGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWqVEDIP 503
Cdd:COG0553   241 TLRPYQLEGAAWLLFL--RRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKF-APGLR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSvkADKRTEQLEVLKswearmsilflgykQFSRIICgdgdgNIAAACRDR--LLMVP-NLLILDEGHTPRNRETD 580
Cdd:COG0553   318 VLVLDG--TRERAKGANPFE--------------DADLVIT-----SYGLLRRDIelLAAVDwDLVILDEAQHIKNPATK 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 581 VLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLkmessrpiarrimsqvaisgiRSLKgvhdsAFTESVEDTL 660
Cdd:COG0553   377 RAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL---------------------GSLK-----AFRERFARPI 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 661 LNDDnftrkSHVIRSLRELTKDVLH-YYKGDILDELPGLVDFSVFLKLSTKQKEIvhkieaYEKFKRSAvgtalyihpcL 739
Cdd:COG0553   431 EKGD-----EEALERLRRLLRPFLLrRTKEDVLKDLPEKTEETLYVELTPEQRAL------YEAVLEYL----------R 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 740 SEISEGDAADRATNLTDAT------------VDSLIESIIIKDGvKAKFFFNILSLANSAGEKLLAFSQYILPMKFLERL 807
Cdd:COG0553   490 RELEGAEGIRRRGLILAALtrlrqicshpalLLEEGAELSGRSA-KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEER 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 808 LVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFGSIKACGEGISLVGASRVIILDVHLNPSVTRQAIGRAF 887
Cdd:COG0553   569 LEER-----GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAH 643

                         490       500
                  ....*....|....*....|....*
gi 1002286831 888 RPGQQKKVFVYRLVAADSPEVKFHE 912
Cdd:COG0553   644 RIGQTRDVQVYKLVAEGTIEEKILE 668
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 773-901 9.64e-36

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 131.83  E-value: 9.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 773 KAKFFFNILSLANSAGEKLLAFSQYILPMKFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFGSI 852
Cdd:cd18793    12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-----GIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1002286831 853 KACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPGQQKKVFVYRLV 901
Cdd:cd18793    87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 428-617 3.83e-18

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 85.81  E-value: 3.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 428 HQLEGFSFLVKNLVGDKPGgCILAHAPGSGKTFMLISFIQSFLAKYPSARP--LVVLPKGILGTWKREFQRWQVED-IPL 504
Cdd:pfam00176   1 YQIEGVNWMLSLENNLGRG-GILADEMGLGKTLQTISLLLYLKHVDKNWGGptLIVVPLSLLHNWMNEFERWVSPPaLRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDFYSVKADKRTEQLEVLKSWEArmSILFLGYKQFSRIicgdgdgniaaacRDRLLMV-PNLLILDEGHTPRNRETDVLA 583
Cdd:pfam00176  80 VVLHGNKRPQERWKNDPNFLADF--DVVITTYETLRKH-------------KELLKKVhWHRIVLDEGHRLKNSKSKLSK 144

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:pfam00176 145 ALKSLKTRNRWILTGTPLQNNLEELWALLNFLRP 178
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 424-952 4.21e-17

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 86.78  E-value: 4.21e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  424 QMRPHQLEGFSFLVKnLVGDKPGGcILAHAPGSGKTFMLISFIqSFLAKYP--SARPLVVLPKGILGTWKREFQRWqVED 501
Cdd:PLN03142   169 KMRDYQLAGLNWLIR-LYENGING-ILADEMGLGKTLQTISLL-GYLHEYRgiTGPHMVVAPKSTLGNWMNEIRRF-CPV 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  502 IPLYDFYSvKADKRTEQLE----------VLKSWEarMSIL-FLGYKQFS-RIIcgdgdgniaaacrdrllmvpnllILD 569
Cdd:PLN03142   245 LRAVKFHG-NPEERAHQREellvagkfdvCVTSFE--MAIKeKTALKRFSwRYI-----------------------IID 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  570 EGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKflkmessrpiarrimsqvaisgIRSLKGVHD 649
Cdd:PLN03142   299 EAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPE----------------------IFSSAETFD 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  650 SAFTESVEdtllNDdnftrKSHVIRSLRELTKD-VLHYYKGDILDELPGLVDFSVFLKLSTKQKE----IVHK-IEAYEK 723
Cdd:PLN03142   357 EWFQISGE----ND-----QQEVVQQLHKVLRPfLLRRLKSDVEKGLPPKKETILKVGMSQMQKQyykaLLQKdLDVVNA 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  724 F--KRSAVGTALYIHPCLSEISEGDAADRATNLTdaTVDSLIESiiikdGVKAKFFFNILSLANSAGEKLLAFSQYILPM 801
Cdd:PLN03142   428 GgeRKRLLNIAMQLRKCCNHPYLFQGAEPGPPYT--TGEHLVEN-----SGKMVLLDKLLPKLKERDSRVLIFSQMTRLL 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  802 KFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFG-SIKACGEGISLVGASRVIILDVHLNPSVTR 880
Cdd:PLN03142   501 DILEDYLMYR-----GYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLlSTRAGGLGINLATADIVILYDSDWNPQVDL 575

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002286831  881 QAIGRAFRPGQQKKVFVYRLVAADSPEVKFHETAFKKEVIPKLWFEWSELctTEDFKLNQvdiddseDELLE 952
Cdd:PLN03142   576 QAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRL--AEQKTVNK-------DELLQ 638
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 773-890 2.20e-16

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 75.71  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 773 KAKFFFNILSLANsaGEKLLAFSQYIlpmkflERLLVKRLGWHVGKEIFMISGDTSADDREVAMDQFNNSaDAKVLFgSI 852
Cdd:pfam00271   2 KLEALLELLKKER--GGKVLIFSQTK------KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-AT 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1002286831 853 KACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPG 890
Cdd:pfam00271  72 DVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
802-890 3.85e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 68.39  E-value: 3.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  802 KFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSaDAKVLFGSiKACGEGISLVGASRVIILDVHLNPSVTRQ 881
Cdd:smart00490   1 EELAELLKEL-----GIKVARLHGGLSQEEREEILDKFNNG-KIKVLVAT-DVAERGLDLPGVDLVIIYDLPWSPASYIQ 73


                   ....*....
gi 1002286831  882 AIGRAFRPG 890
Cdd:smart00490  74 RIGRAGRAG 82
DEXDc smart00487
DEAD-like helicases superfamily;
417-603 7.79e-14

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 71.37  E-value: 7.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  417 IHPRHAKQMRPHQLEGFSFLVKNLvgdkpGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLP-KGILGTWKREFQ 495
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-----RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  496 RWqVEDIPLYDFYSVKADKRTEQLEVLKSweARMSILFLGYKQFSRIIcgdgdgniaaacRDRLLMVPN--LLILDEGH- 572
Cdd:smart00487  76 KL-GPSLGLKVVGLYGGDSKREQLRKLES--GKTDILVTTPGRLLDLL------------ENDKLSLSNvdLVILDEAHr 140

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1002286831  573 -TPRNRETDVLASLKRV-QTPRKVVLSGTLFQN 603
Cdd:smart00487 141 lLDGGFGDQLEKLLKLLpKNVQLLLLSATPPEE 173
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 425-620 4.61e-70

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 232.57  E-value: 4.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVG-----DKPGGCILAHAPGSGKTFMLISFIQSFLAKYPS-ARPLVVLPKGILGTWKREFQRWQ 498
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGtdvgsDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWEDEFKKWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 499 VED-IPLYDFYSVKADKRTEQ-LEVLKSWEARMSILFLGYKQFSRIICGDG-DGNIAAACRDRLLM-VPNLLILDEGHTP 574
Cdd:cd18007    81 PPDlRPLLVLVSLSASKRADArLRKINKWHKEGGVLLIGYELFRNLASNATtDPRLKQEFIAALLDpGPDLLVLDEGHRL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18007   161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYL 206
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 424-912 1.20e-60

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 219.71  E-value: 1.20e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNlvGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWqVEDIP 503
Cdd:COG0553   241 TLRPYQLEGAAWLLFL--RRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKF-APGLR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSvkADKRTEQLEVLKswearmsilflgykQFSRIICgdgdgNIAAACRDR--LLMVP-NLLILDEGHTPRNRETD 580
Cdd:COG0553   318 VLVLDG--TRERAKGANPFE--------------DADLVIT-----SYGLLRRDIelLAAVDwDLVILDEAQHIKNPATK 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 581 VLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLkmessrpiarrimsqvaisgiRSLKgvhdsAFTESVEDTL 660
Cdd:COG0553   377 RAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL---------------------GSLK-----AFRERFARPI 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 661 LNDDnftrkSHVIRSLRELTKDVLH-YYKGDILDELPGLVDFSVFLKLSTKQKEIvhkieaYEKFKRSAvgtalyihpcL 739
Cdd:COG0553   431 EKGD-----EEALERLRRLLRPFLLrRTKEDVLKDLPEKTEETLYVELTPEQRAL------YEAVLEYL----------R 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 740 SEISEGDAADRATNLTDAT------------VDSLIESIIIKDGvKAKFFFNILSLANSAGEKLLAFSQYILPMKFLERL 807
Cdd:COG0553   490 RELEGAEGIRRRGLILAALtrlrqicshpalLLEEGAELSGRSA-KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEER 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 808 LVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFGSIKACGEGISLVGASRVIILDVHLNPSVTRQAIGRAF 887
Cdd:COG0553   569 LEER-----GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAH 643

                         490       500
                  ....*....|....*....|....*
gi 1002286831 888 RPGQQKKVFVYRLVAADSPEVKFHE 912
Cdd:COG0553   644 RIGQTRDVQVYKLVAEGTIEEKILE 668
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 773-901 9.64e-36

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 131.83  E-value: 9.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 773 KAKFFFNILSLANSAGEKLLAFSQYILPMKFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFGSI 852
Cdd:cd18793    12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-----GIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1002286831 853 KACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPGQQKKVFVYRLV 901
Cdd:cd18793    87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 425-620 2.30e-30

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 119.92  E-value: 2.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLV-------GDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRW 497
Cdd:cd18069     1 LKPHQIGGIRFLYDNIIeslerykGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 498 --QVEDIPLYDFYSVK-------ADKRTEQLEVLKSWEARMSILFLGYKQFsriicgdgdgniaaacrdRLLMVPNLLIL 568
Cdd:cd18069    81 lpPPEALPNVRPRPFKvfilndeHKTTAARAKVIEDWVKDGGVLLMGYEMF------------------RLRPGPDVVIC 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002286831 569 DEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18069   143 DEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFL 194
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 425-620 2.64e-30

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 118.05  E-value: 2.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLvgDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWqVEDIP 503
Cdd:cd17919     1 LRPYQLEGLNFLLELY--ENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPvLVVCPLSVLENWEREFEKW-TPDLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSvkaDKRTEQLEVLKSWEARMSILFLGYKQFSRiicgdgdgNIAAACRDRllmvPNLLILDEGHTPRNRETDVLA 583
Cdd:cd17919    78 VVVYHG---SQRERAQIRAKEKLDKFDVVLTTYETLRR--------DKASLRKFR----WDLVVVDEAHRLKNPKSQLSK 142

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd17919   143 ALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 425-630 1.16e-27

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 112.38  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKP---GGCILAHAPGSGKTFMLISFI-----QSFLAKYPSARPLVVLPKGILGTWKREFQR 496
Cdd:cd18004     1 LRPHQREGVQFLYDCLTGRRGyggGGAILADEMGLGKTLQAIALVwtllkQGPYGKPTAKKALIVCPSSLVGNWKAEFDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 497 W-QVEDIplyDFYSVKADKRTEQLEVLKSWEA-RMSILFLGYKQFSRIIcgdgdGNIAAAcrdrllMVPNLLILDEGHTP 574
Cdd:cd18004    81 WlGLRRI---KVVTADGNAKDVKASLDFFSSAsTYPVLIISYETLRRHA-----EKLSKK------ISIDLLICDEGHRL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP-------KFLKMeSSRPIAR 630
Cdd:cd18004   147 KNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPgilgslaSFRKV-FEEPILR 208
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 425-620 2.59e-26

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 108.82  E-value: 2.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFL-------VKNlVGDKPG-GCILAHAPGSGKTFMLISFIQSFLA---KYPSARPLVVLPKGILGTWKRE 493
Cdd:cd18068     1 LKPHQVDGVQFMwdcccesLKK-TKKSPGsGCILAHCMGLGKTLQVVTFLHTVLLcekLENFSRVLVVCPLNTVLNWLNE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 494 FQRWQV-----EDIPLYDFYSVKaDKRTEQLEvLKSWEARMSILFLGYKQFsRIICGDGDGNIAAACRDRLLMV-----P 563
Cdd:cd18068    80 FEKWQEglkdeEKIEVNELATYK-RPQERSYK-LQRWQEEGGVMIIGYDMY-RILAQERNVKSREKLKEIFNKAlvdpgP 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002286831 564 NLLILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18068   157 DFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLL 213
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 425-630 1.15e-21

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 94.91  E-value: 1.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKPG---GCILAHAPGSGKTFMLISFIQSFLAKYPSA------RPLVVLPKGILGTWKREFQ 495
Cdd:cd18066     1 LRPHQREGIEFLYECVMGMRVNerfGAILADEMGLGKTLQCISLIWTLLRQGPYGgkpvikRALIVTPGSLVKNWKKEFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 496 RW-QVEDIPLYdfySVKADKRTEqlEVLKSweARMSILFLGYKQFSRiicgdgdgNIAAACRDRLlmvpNLLILDEGHTP 574
Cdd:cd18066    81 KWlGSERIKVF---TVDQDHKVE--EFIAS--PLYSVLIISYEMLLR--------SLDQISKLNF----DLVICDEGHRL 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS------RPIAR 630
Cdd:cd18066   142 KNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTyrkvyeEPIVR 203
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 425-620 1.52e-21

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 94.84  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKPG---GCILAHAPGSGKTFMLISFIQSFLAKYPSARP-----LVVLPKGILGTWKREFQR 496
Cdd:cd18067     1 LRPHQREGVKFLYRCVTGRRIRgshGCIMADEMGLGKTLQCITLMWTLLRQSPQCKPeidkaIVVSPSSLVKNWANELGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 497 WQVEDI-PLydfySVKADKRTEQLEVLKSW----EARMS--ILFLGYKQFSRIICGDGDGNIAaacrdrllmvpnLLILD 569
Cdd:cd18067    81 WLGGRLqPL----AIDGGSKKEIDRKLVQWasqqGRRVStpVLIISYETFRLHVEVLQKGEVG------------LVICD 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002286831 570 EGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18067   145 EGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGIL 195
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 425-617 2.64e-21

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 93.98  E-value: 2.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLvgDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP---------------------LVVLP 483
Cdd:cd18005     1 LRDYQREGVEFMYDLY--KNGRGGILGDDMGLGKTVQVIAFLAAVLGKTGTRRDrennrprfkkkppassakkpvLIVAP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 484 KGILGTWKREFQRWQvedipLYDFYSVKADKRTEQLEV-LKSweARMSILFLGYKQFSRiicgdgdgniaaaCRDRLLMV 562
Cdd:cd18005    79 LSVLYNWKDELDTWG-----HFEVGVYHGSRKDDELEGrLKA--GRLEVVVTTYDTLRR-------------CIDSLNSI 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1002286831 563 P-NLLILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18005   139 NwSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVP 194
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 427-630 5.72e-20

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 89.74  E-value: 5.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 427 PHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVeDIPLYD 506
Cdd:cd18001     3 PHQREGVAWLWSLHDGGK--GGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTP-GLRVKV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 507 FYSVKADKRTEQLEVLKSweaRMSILFLGY-------KQFSRIicgDGDGNiaaacrdrllmVPNLLILDEGHTPRNRET 579
Cdd:cd18001    80 FHGTSKKERERNLERIQR---GGGVLLTTYgmvlsntEQLSAD---DHDEF-----------KWDYVILDEGHKIKNSKT 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002286831 580 DVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL-------KMESSRPIAR 630
Cdd:cd18001   143 KSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSLlgtrktfKMEFENPITR 200
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 425-618 6.11e-19

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 86.53  E-value: 6.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRW------ 497
Cdd:cd17995     1 LRDYQLEGVNWLLFNWYNRR--NCILADEMGLGKTIQSIAFLEHLYQVEGIRGPfLVIAPLSTIPNWQREFETWtdmnvv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 498 ----QVED---IPLYDFYSVKADKRTeqlevlKSWEARMSILFLGYKQfsrIICGDGD-GNIAAACrdrllmvpnlLILD 569
Cdd:cd17995    79 vyhgSGESrqiIQQYEMYFKDAQGRK------KKGVYKFDVLITTYEM---VIADAEElRKIPWRV----------VVVD 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1002286831 570 EGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPK 618
Cdd:cd17995   140 EAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPE 188
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 428-617 3.83e-18

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 85.81  E-value: 3.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 428 HQLEGFSFLVKNLVGDKPGgCILAHAPGSGKTFMLISFIQSFLAKYPSARP--LVVLPKGILGTWKREFQRWQVED-IPL 504
Cdd:pfam00176   1 YQIEGVNWMLSLENNLGRG-GILADEMGLGKTLQTISLLLYLKHVDKNWGGptLIVVPLSLLHNWMNEFERWVSPPaLRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDFYSVKADKRTEQLEVLKSWEArmSILFLGYKQFSRIicgdgdgniaaacRDRLLMV-PNLLILDEGHTPRNRETDVLA 583
Cdd:pfam00176  80 VVLHGNKRPQERWKNDPNFLADF--DVVITTYETLRKH-------------KELLKKVhWHRIVLDEGHRLKNSKSKLSK 144

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:pfam00176 145 ALKSLKTRNRWILTGTPLQNNLEELWALLNFLRP 178
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 425-625 1.15e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 83.16  E-value: 1.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVEDIPL 504
Cdd:cd18059     1 LREYQLEGVNWLLFNWYNTR--NCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YdfYSVKADKRTEQLEVLKSWEARMSILFLGYKQFSRIICGDgdgNIAAACRDrLLMVP-NLLILDEGHTPRNRETDVLA 583
Cdd:cd18059    79 Y--HGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFE---MILTDCPE-LRNIPwRCVVIDEAHRLKNRNCKLLE 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS 625
Cdd:cd18059   153 GLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETT 194
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 424-620 3.92e-17

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 81.46  E-value: 3.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVK----NLvgdkpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQv 499
Cdd:cd18012     4 TLRPYQKEGFNWLSFlrhyGL------GGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFA- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 500 ediPLYDFYSVKADKRTEQLE--------VLKSWE-ARMSILFLGYKQFsriicgdgdgniaaacrdrllmvpNLLILDE 570
Cdd:cd18012    77 ---PELKVLVIHGTKRKREKLraledydlVITSYGlLRRDIELLKEVKF------------------------HYLVLDE 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1002286831 571 GHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18012   130 AQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLL 179
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 424-952 4.21e-17

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 86.78  E-value: 4.21e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  424 QMRPHQLEGFSFLVKnLVGDKPGGcILAHAPGSGKTFMLISFIqSFLAKYP--SARPLVVLPKGILGTWKREFQRWqVED 501
Cdd:PLN03142   169 KMRDYQLAGLNWLIR-LYENGING-ILADEMGLGKTLQTISLL-GYLHEYRgiTGPHMVVAPKSTLGNWMNEIRRF-CPV 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  502 IPLYDFYSvKADKRTEQLE----------VLKSWEarMSIL-FLGYKQFS-RIIcgdgdgniaaacrdrllmvpnllILD 569
Cdd:PLN03142   245 LRAVKFHG-NPEERAHQREellvagkfdvCVTSFE--MAIKeKTALKRFSwRYI-----------------------IID 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  570 EGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKflkmessrpiarrimsqvaisgIRSLKGVHD 649
Cdd:PLN03142   299 EAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPE----------------------IFSSAETFD 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  650 SAFTESVEdtllNDdnftrKSHVIRSLRELTKD-VLHYYKGDILDELPGLVDFSVFLKLSTKQKE----IVHK-IEAYEK 723
Cdd:PLN03142   357 EWFQISGE----ND-----QQEVVQQLHKVLRPfLLRRLKSDVEKGLPPKKETILKVGMSQMQKQyykaLLQKdLDVVNA 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  724 F--KRSAVGTALYIHPCLSEISEGDAADRATNLTdaTVDSLIESiiikdGVKAKFFFNILSLANSAGEKLLAFSQYILPM 801
Cdd:PLN03142   428 GgeRKRLLNIAMQLRKCCNHPYLFQGAEPGPPYT--TGEHLVEN-----SGKMVLLDKLLPKLKERDSRVLIFSQMTRLL 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  802 KFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSADAKVLFG-SIKACGEGISLVGASRVIILDVHLNPSVTR 880
Cdd:PLN03142   501 DILEDYLMYR-----GYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLlSTRAGGLGINLATADIVILYDSDWNPQVDL 575

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002286831  881 QAIGRAFRPGQQKKVFVYRLVAADSPEVKFHETAFKKEVIPKLWFEWSELctTEDFKLNQvdiddseDELLE 952
Cdd:PLN03142   576 QAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRL--AEQKTVNK-------DELLQ 638
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 773-890 2.20e-16

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 75.71  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 773 KAKFFFNILSLANsaGEKLLAFSQYIlpmkflERLLVKRLGWHVGKEIFMISGDTSADDREVAMDQFNNSaDAKVLFgSI 852
Cdd:pfam00271   2 KLEALLELLKKER--GGKVLIFSQTK------KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-AT 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1002286831 853 KACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPG 890
Cdd:pfam00271  72 DVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 427-620 6.66e-16

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 76.98  E-value: 6.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 427 PHQLEGFSFLVKnLVGDKPGGcILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRW--QVEDIP 503
Cdd:cd18000     3 KYQQTGVQWLWE-LHCQRVGG-ILGDEMGLGKTIQIIAFLAALHHSKLGLGPsLIVCPATVLKQWVKEFHRWwpPFRVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSVKADKRTEQLEVLKSWEARMS-----ILFLGYKQFsRIICgdgdgniaaacrdrLLMVPNL---LILDEGHTPR 575
Cdd:cd18000    81 LHSSGSGTGSEEKLGSIERKSQLIRKVvgdggILITTYEGF-RKHK--------------DLLLNHNwqyVILDEGHKIR 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1002286831 576 NRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFL 620
Cdd:cd18000   146 NPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 425-617 1.15e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 77.02  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVEDIPL 504
Cdd:cd18060     1 LREYQLEGVNWLLFNWYNRQ--NCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDfYSVKADKRTEQLEVL-KSWEARmsiLFLGYKQFSRIICGDGdgNIAAACRDRLLMVPNLLILDEGHTPRNRETDVLA 583
Cdd:cd18060    79 YH-GSLASRQMIQQYEMYcKDSRGR---LIPGAYKFDALITTFE--MILSDCPELREIEWRCVIIDEAHRLKNRNCKLLD 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18060   153 SLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEP 186
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 425-625 1.50e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 77.00  E-value: 1.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVEDIPL 504
Cdd:cd18058     1 LREYQLEGMNWLLFNWYNRK--NCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWTEMNAIV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDFYSVkADKRTEQLEVLksWEARMSILFLGYKQFSRIICGDGdgNIAAACRDRLLMVPNLLILDEGHTPRNRETDVLAS 584
Cdd:cd18058    79 YHGSQI-SRQMIQQYEMY--YRDEQGNPLSGIFKFQVVITTFE--MILADCPELKKINWSCVIIDEAHRLKNRNCKLLEG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1002286831 585 LKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS 625
Cdd:cd18058   154 LKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETT 194
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 424-617 1.97e-14

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 73.96  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKnLVGDKPGGcILAHAPGSGKTFMLISFIqSFLAKYPSARP-LVVLPKGILGTWKREFQRWqVEDI 502
Cdd:cd18009     3 VMRPYQLEGMEWLRM-LWENGING-ILADEMGLGKTIQTIALL-AHLRERGVWGPfLVIAPLSTLPNWVNEFARF-TPSV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 503 PLYDFYSVKADKRTEQLEVLKSWEARM--SILFLGYKqfsriicgdgdgnIAAACRDRLLMVP-NLLILDEGHTPRNRET 579
Cdd:cd18009    79 PVLLYHGTKEERERLRKKIMKREGTLQdfPVVVTSYE-------------IAMRDRKALQHYAwKYLIVDEGHRLKNLNC 145

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1002286831 580 DVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18009   146 RLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLP 183
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 425-625 2.19e-14

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 73.50  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVEDIPL 504
Cdd:cd18061     1 LREYQLEGLNWLLFNWYNRR--NCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWTDLNVVV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDfYSVKADKRTEQLEV-LKSWEARmsiLFLGYKQFSRIICGDGdgNIAAACRDRLLMVPNLLILDEGHTPRNRETDVLA 583
Cdd:cd18061    79 YH-GSLISRQMIQQYEMyFRDSQGR---IIRGAYRFQAIITTFE--MILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLE 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1002286831 584 SLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS 625
Cdd:cd18061   153 GLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSEST 194
HELICc smart00490
helicase superfamily c-terminal domain;
802-890 3.85e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 68.39  E-value: 3.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  802 KFLERLLVKRlgwhvGKEIFMISGDTSADDREVAMDQFNNSaDAKVLFGSiKACGEGISLVGASRVIILDVHLNPSVTRQ 881
Cdd:smart00490   1 EELAELLKEL-----GIKVARLHGGLSQEEREEILDKFNNG-KIKVLVAT-DVAERGLDLPGVDLVIIYDLPWSPASYIQ 73


                   ....*....
gi 1002286831  882 AIGRAFRPG 890
Cdd:smart00490  74 RIGRAGRAG 82
DEXDc smart00487
DEAD-like helicases superfamily;
417-603 7.79e-14

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 71.37  E-value: 7.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  417 IHPRHAKQMRPHQLEGFSFLVKNLvgdkpGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLP-KGILGTWKREFQ 495
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-----RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831  496 RWqVEDIPLYDFYSVKADKRTEQLEVLKSweARMSILFLGYKQFSRIIcgdgdgniaaacRDRLLMVPN--LLILDEGH- 572
Cdd:smart00487  76 KL-GPSLGLKVVGLYGGDSKREQLRKLES--GKTDILVTTPGRLLDLL------------ENDKLSLSNvdLVILDEAHr 140

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1002286831  573 -TPRNRETDVLASLKRV-QTPRKVVLSGTLFQN 603
Cdd:smart00487 141 lLDGGFGDQLEKLLKLLpKNVQLLLLSATPPEE 173
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 425-630 2.34e-13

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 70.16  E-value: 2.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNLVGDKpgGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVL-PKGILGTWKREFQRWQvediP 503
Cdd:cd18006     1 LRPYQLEGVNWLLQCRAEQH--GCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLcPLSVLDNWKEELNRFA----P 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSVKADK--RTEQLEVLKSwEARMSILFLGYKqfsrIICGDGD--GNIAAACrdrllmvpnlLILDEGHTPRNRET 579
Cdd:cd18006    75 DLSVITYMGDKekRLDLQQDIKS-TNRFHVLLTTYE----ICLKDASflKSFPWAS----------LVVDEAHRLKNQNS 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002286831 580 DVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP-KFLKMESSRPIAR 630
Cdd:cd18006   140 LLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPnVFPKDKLDDFIKA 191
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 425-618 4.75e-13

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 68.57  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLvkNLVGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRW----QVE 500
Cdd:cd17998     1 LKDYQLIGLNWL--NLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWcpslKVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 501 diPLYDFYSVKADKRTEQLEVLKSWEarmsILFLGYkqfsriicgdgdgNIAAACRD--RLLMVPNL--LILDEGHTPRN 576
Cdd:cd17998    79 --PYYGSQEERKHLRYDILKGLEDFD----VIVTTY-------------NLATSNPDdrSFFKRLKLnyVVYDEGHMLKN 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1002286831 577 RETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPK 618
Cdd:cd17998   140 MTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 426-621 4.09e-12

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 66.93  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 426 RPHQLEGFSFLVknlvgdkPGGCILAHAPGSGKTFMLISFIQS------------------FLAKYPSARPLVVLPKGIL 487
Cdd:cd18008     2 LPYQKQGLAWML-------PRGGILADEMGLGKTIQALALILAtrpqdpkipeeleenssdPKKLYLSKTTLIVVPLSLL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 488 GTWKREFQR-WQVEDIPLYDFYSVKADKRTEQLE----VLKSWearmSILFLGYKQFSRIICGDGDGNIAAACRD----R 558
Cdd:cd18008    75 SQWKDEIEKhTKPGSLKVYVYHGSKRIKSIEELSdydiVITTY----GTLASEFPKNKKGGGRDSKEKEASPLHRirwyR 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002286831 559 llmvpnlLILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILdlvrpKFLK 621
Cdd:cd18008   151 -------VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLL-----RFLR 201
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 425-617 3.90e-11

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 63.46  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKnlvgDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGILGTWKREFQRWQVEDIPL 504
Cdd:cd18011     1 PLPHQIDAVLRALR----KPPVRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQDKFGLPFLI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 505 YDFysvkADKRTEQLEVLKSWEAR----MSILFLGYKqfsriicGDGDGNIAAACRDrllmvpnLLILDEGH-------T 573
Cdd:cd18011    77 LDR----ETAAQLRRLIGNPFEEFpiviVSLDLLKRS-------EERRGLLLSEEWD-------LVVVDEAHklrnsggG 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002286831 574 PRNRETDVLASLKRvQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18011   139 KETKRYKLGRLLAK-RARHVLLLTATPHNGKEEDFRALLSLLDP 181
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 425-629 6.62e-11

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 63.52  E-value: 6.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEG---FSFLVK-NLVGdkpggcILAHAPGSGKTFMLISFIQSFLAKYPS-----ARP-LVVLPKGILGTWKREF 494
Cdd:cd17999     1 LRPYQQEGinwLAFLNKyNLHG------ILCDDMGLGKTLQTLCILASDHHKRANsfnseNLPsLVVCPPTLVGHWVAEI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 495 QRW---QVEDIPLYDFYSVKADKRTEQLE----VLKSWE-ARMSILFLGYKQFsriicgdgdgniaaacrdrllmvpNLL 566
Cdd:cd17999    75 KKYfpnAFLKPLAYVGPPQERRRLREQGEkhnvIVASYDvLRNDIEVLTKIEW------------------------NYC 130

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002286831 567 ILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMES------SRPIA 629
Cdd:cd17999   131 VLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKqfqrrfLKPIL 199
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 424-621 7.36e-11

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 63.16  E-value: 7.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVkNLVGDKPGGcILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRW--QVE 500
Cdd:cd17996     3 TLKEYQLKGLQWMV-SLYNNNLNG-ILADEMGLGKTIQTISLITYLMEKKKNNGPyLVIVPLSTLSNWVSEFEKWapSVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 501 DIplydFYSVKADKRTEQLEVLKSweARMSILFLGYKQfsrIIcgdgdgniaaacRDRLLMVP---NLLILDEGHTPRNR 577
Cdd:cd17996    81 KI----VYKGTPDVRKKLQSQIRA--GKFNVLLTTYEY---II------------KDKPLLSKikwKYMIIDEGHRMKNA 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1002286831 578 ETDVLASLKR-VQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLK 621
Cdd:cd17996   140 QSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFK 184
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 424-624 1.16e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 62.72  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNLVgdKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQVE-D 501
Cdd:cd18054    20 ELRDYQLEGLNWLAHSWC--KNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPfLLVVPLSTLTSWQREFEIWAPEiN 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 502 IPLY--DFYSVKADKRTEQLEVlKSWEARMSILFLGYKqfsrIICGDGD--GNIAAAcrdrllmvpnLLILDEGHTPRNR 577
Cdd:cd18054    98 VVVYigDLMSRNTIREYEWIHS-QTKRLKFNALITTYE----ILLKDKTvlGSINWA----------FLGVDEAHRLKND 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1002286831 578 ETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKflKMES 624
Cdd:cd18054   163 DSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE--KFEF 207
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 427-631 2.24e-10

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 61.45  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 427 PHQLEGFSFLVKnlvgdKPGGCILAHAPGSGKTfmlisfIQS--FLAKYPSARP-LVVLPKGILGTWKREFQRWqVEDIP 503
Cdd:cd18010     3 PFQREGVCFALR-----RGGRVLIADEMGLGKT------VQAiaIAAYYREEWPlLIVCPSSLRLTWADEIERW-LPSLP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSVKADKrteqlEVLKSWEARMSIlfLGYKQFSRiicgdgdgniaaaCRDRLLMVP-NLLILDEGHTPRNRE---T 579
Cdd:cd18010    71 PDDIQVIVKSK-----DGLRDGDAKVVI--VSYDLLRR-------------LEKQLLARKfKVVICDESHYLKNSKakrT 130

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002286831 580 DVLASLKRvQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFlkMESSRPIARR 631
Cdd:cd18010   131 KAALPLLK-RAKRVILLSGTPALSRPIELFTQLDALDPKL--FGRFHDFGRR 179
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 424-619 4.87e-10

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 60.41  E-value: 4.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVkNLVGDKPGGcILAHAPGSGKTFMLISFIqSFLAKYPS-ARP-LVVLPKGILGTWKREFQRWqved 501
Cdd:cd17997     3 TMRDYQIRGLNWLI-SLFENGING-ILADEMGLGKTLQTISLL-GYLKHYKNiNGPhLIIVPKSTLDNWMREFKRW---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 502 IPLYDFYSVKADKRtEQLEVLK--SWEARMSILFLGYKQFSRiicgdgdgNIAAACRDRLlmvpNLLILDEGHTPRNRET 579
Cdd:cd17997    76 CPSLRVVVLIGDKE-ERADIIRdvLLPGKFDVCITSYEMVIK--------EKTVLKKFNW----RYIIIDEAHRIKNEKS 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1002286831 580 DVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKF 619
Cdd:cd17997   143 KLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDV 182
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 424-619 5.09e-10

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 60.45  E-value: 5.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNLVgdKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRW----- 497
Cdd:cd17993     1 ELRDYQLTGLNWLAHSWC--KGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPfLVVVPLSTMPAWQREFAKWapdmn 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 498 ---------QVEDIPLYDFYsvkadkrTEQLEVLKswearMSILFLGYKqfsrIICGDGD--GNIAAACrdrllmvpnlL 566
Cdd:cd17993    79 vivylgdikSRDTIREYEFY-------FSQTKKLK-----FNVLLTTYE----IILKDKAflGSIKWQY----------L 132

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002286831 567 ILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP-KF 619
Cdd:cd17993   133 AVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPgKF 186
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 424-618 8.37e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 60.06  E-value: 8.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVKNLVgdKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQvedi 502
Cdd:cd18053    20 ELRDYQLNGLNWLAHSWC--KGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPfLLVVPLSTLTSWQREIQTWA---- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 503 PLYDFYSVKADKRTEQLEVLKSW------EARMSILFLGYKqfsrIICGDGD--GNIAAAcrdrllmvpnLLILDEGHTP 574
Cdd:cd18053    94 PQMNAVVYLGDINSRNMIRTHEWmhpqtkRLKFNILLTTYE----ILLKDKSflGGLNWA----------FIGVDEAHRL 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002286831 575 RNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRPK 618
Cdd:cd18053   160 KNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE 203
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 425-648 9.85e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 60.08  E-value: 9.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLvkNLVGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQVedip 503
Cdd:cd18057     1 LHPYQLEGLNWL--RFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPyLVSAPLSTIINWEREFEMWAP---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 lyDFYSVKADKRTEQLEVL----------------------KSWEARMSILFLGYKQFSriICGDGDGNIAAACrdrllm 561
Cdd:cd18057    75 --DFYVVTYTGDKESRSVIrenefsfednairsgkkvfrmkKEAQIKFHVLLTSYELIT--IDQAILGSIEWAC------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 562 vpnlLILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP-KFLKMESSRPIARRIMSQVAISG 640
Cdd:cd18057   145 ----LVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPeRFNNLEGFLEEFADISKEDQIKK 220


                  ....*...
gi 1002286831 641 IRSLKGVH 648
Cdd:cd18057   221 LHDLLGPH 228
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
422-953 3.56e-09

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 60.42  E-value: 3.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 422 AKQMRPHQLEGFSFLVKNLVGDKPGGCILAhAPGSGKTFMLISFIQSFLAKYPSarpLVVLP-KGILGTWKREFQRWqve 500
Cdd:COG1061    78 SFELRPYQQEALEALLAALERGGGRGLVVA-PTGTGKTVLALALAAELLRGKRV---LVLVPrRELLEQWAEELRRF--- 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 501 diplydfysvkadkRTEQLEVLKSWEARMSILFLGYKQFSRiicgdgdgniaAACRDRLLMVPNLLILDEGH---TPRNR 577
Cdd:COG1061   151 --------------LGDPLAGGGKKDSDAPITVATYQSLAR-----------RAHLDELGDRFGLVIIDEAHhagAPSYR 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 578 ETdvlasLKRVQTPRKVVLSGTLFqnhvsevfnildlvRpkflkmESSRPIArrimsqvaisgIRSLKGVhdsAFTESVE 657
Cdd:COG1061   206 RI-----LEAFPAAYRLGLTATPF--------------R------SDGREIL-----------LFLFDGI---VYEYSLK 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 658 DtlLNDDNFTRKSHVIRSLRELTKDVLHYykgDILDElpglvdfSVFLKLSTKQKEIVHKIEAYEKfkrsavgtalyihp 737
Cdd:COG1061   247 E--AIEDGYLAPPEYYGIRVDLTDERAEY---DALSE-------RLREALAADAERKDKILRELLR-------------- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 738 clseisegdaadratnltdatvdsliesiiikdgvkakfffnilslANSAGEKLLAFSQYILPMKFLERLLVKRlgwhvG 817
Cdd:COG1061   301 ----------------------------------------------EHPDDRKTLVFCSSVDHAEALAELLNEA-----G 329

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 818 KEIFMISGDTSADDREVAMDQFNNSaDAKVLFgSIKACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPGQQKKVF- 896
Cdd:COG1061   330 IRAAVVTGDTPKKEREEILEAFRDG-ELRILV-TVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDAl 407

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002286831 897 VYRLVAADSPEVKFHETAFKKEVIPKLWFEWSELCTTEDFKLNQVDIDDSEDELLEA 953
Cdd:COG1061   408 VYDFVGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEE 464
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 425-625 3.60e-09

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 58.54  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVkNLVGDKPGGcILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQVEDIP 503
Cdd:cd18063    24 LKHYQLQGLEWMV-SLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRLNGPyLIIVPLSTLSNWTYEFDKWAPSVVK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYdfYSVKADKRTEQLEVLKSweARMSILFLGYKQFSRiicgdgDGNIAAACRDRLLMVpnllilDEGHTPRNRETDVLA 583
Cdd:cd18063   102 IS--YKGTPAMRRSLVPQLRS--GKFNVLLTTYEYIIK------DKHILAKIRWKYMIV------DEGHRMKNHHCKLTQ 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1002286831 584 SLK-RVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS 625
Cdd:cd18063   166 VLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCST 208
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 424-625 5.03e-09

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 58.13  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 424 QMRPHQLEGFSFLVkNLVGDKPGGcILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQVEDI 502
Cdd:cd18062    23 VLKQYQIKGLEWLV-SLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRINGPfLIIVPLSTLSNWVYEFDKWAPSVV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 503 PLYdfYSVKADKRTEQLEVLKSweARMSILFLGYKQFSRiicgdgDGNIAAACRDRLLMVpnllilDEGHTPRNRETDVL 582
Cdd:cd18062   101 KVS--YKGSPAARRAFVPQLRS--GKFNVLLTTYEYIIK------DKQILAKIRWKYMIV------DEGHRMKNHHCKLT 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002286831 583 ASLK-RVQTPRKVVLSGTLFQNHVSEVFNILDLVRPKFLKMESS 625
Cdd:cd18062   165 QVLNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCST 208
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 425-624 8.03e-08

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 53.60  E-value: 8.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLvkNLVGDKPGGCILAHAPGSGKTFMLISFIQSFLAKYPSARP-LVVLPKGILGTWKREFQRWQvediP 503
Cdd:cd17994     1 LHPYQLEGLNWL--RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPfLVSAPLSTIINWEREFEMWA----P 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 lyDFYSVkadKRTEQLEVLKSWEarmsilflgykqfsrIICGDGD--GNIAAACrdrllmvpnlLILDEGHTPRNRETDV 581
Cdd:cd17994    75 --DFYVV---TYVGDHVLLTSYE---------------LISIDQAilGSIDWAV----------LVVDEAHRLKNNQSKF 124

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002286831 582 LASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP-KFLKMES 624
Cdd:cd17994   125 FRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPeRFNNLQG 168
ResIII pfam04851
Type III restriction enzyme, res subunit;
423-572 8.10e-08

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 52.67  E-value: 8.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 423 KQMRPHQLEGFSFLVKNLVGDKPGGCIlAHAPGSGKTFMLISFIQSFLAKYPSARPLVVLP-KGILGTWKREFQRWQVED 501
Cdd:pfam04851   2 LELRPYQIEAIENLLESIKNGQKRGLI-VMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLLEQALEEFKKFLPNY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002286831 502 IPLYDFYSVKADKRteqlevlksWEARMSILFLGYKQFSRIICGDGDGNIAAAcrdrllmvPNLLILDEGH 572
Cdd:pfam04851  81 VEIGEIISGDKKDE---------SVDDNKIVVTTIQSLYKALELASLELLPDF--------FDVIIIDEAH 134
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 419-617 9.95e-08

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 54.29  E-value: 9.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 419 PRHAK--QMRPHQLEGFSFLVkNLVGDKPGGcILAHAPGSGKTFMLISFIqSFLAKYPS--ARPLVVLPKGILGTWKREF 494
Cdd:cd18064     8 PSYVKwgKLRDYQVRGLNWLI-SLYENGING-ILADEMGLGKTLQTISLL-GYMKHYRNipGPHMVLVPKSTLHNWMAEF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 495 QRWqvedIPLYDFYSVKADKrteqlevlkswEARMSilflgykqFSRIICGDGDGNIAAACRDRLLMVPNL--------L 566
Cdd:cd18064    85 KRW----VPTLRAVCLIGDK-----------DQRAA--------FVRDVLLPGEWDVCVTSYEMLIKEKSVfkkfnwryL 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002286831 567 ILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18064   142 VIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP 192
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 425-600 2.47e-06

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 48.07  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLVKNlVGDKPGgcILAHAPGSGKTFMLISFIqsflAKYPSARPLVVLP-KGILGTWKREFQRWqVEDIP 503
Cdd:cd17926     1 LRPYQEEALEAWLAH-KNNRRG--ILVLPTGSGKTLTALALI----AYLKELRTLIVVPtDALLDQWKERFEDF-LGDSS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 504 LYDFYSVKADKRTEQLEVLKSWEARMSILFLGYKQFSRiicgdgdgniaaacrdrllmvPNLLILDEGHT---PRNREtd 580
Cdd:cd17926    73 IGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQ---------------------FGLLIVDEAHHlpaKTFSE-- 129

                         170       180
                  ....*....|....*....|
gi 1002286831 581 vlaSLKRVQTPRKVVLSGTL 600
Cdd:cd17926   130 ---ILKELNAKYRLGLTATP 146
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 425-617 3.53e-06

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 49.27  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 425 MRPHQLEGFSFLV----KNLVGdkpggcILAHAPGSGKTFMLISFIqSFLAKY-----PSarpLVVLPKGILGTWKREFQ 495
Cdd:cd18003     1 LREYQHIGLDWLAtlyeKNLNG------ILADEMGLGKTIQTIALL-AHLACEkgnwgPH---LIVVPTSVMLNWEMEFK 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 496 RWqvedIPLYDFYSVKADKRtEQLEVLKSWEARMS--ILFLGYKQFSRiicgdgdgNIAAACRDRLlmvpNLLILDEGHT 573
Cdd:cd18003    71 RW----CPGFKILTYYGSAK-ERKLKRQGWMKPNSfhVCITSYQLVVQ--------DHQVFKRKKW----KYLILDEAHN 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002286831 574 PRNRETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVRP 617
Cdd:cd18003   134 IKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMP 177
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 447-623 6.97e-06

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 48.62  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 447 GCILAHAPGSGKTFMLISFIQSflakypsARPLVVLPKGILGTWKREFQRWQVEDIplYDFYSVKADKRTEQLEVLkswe 526
Cdd:cd18071    50 GGILADDMGLGKTLTTISLILA-------NFTLIVCPLSVLSNWETQFEEHVKPGQ--LKVYTYHGGERNRDPKLL---- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 527 ARMSILFLGYKQFSRIICGDGDGNIAAacrdrllMVPNLLILDEGHTPRNRETDVLASLKRVQTPRKVVLSGTLFQNHVS 606
Cdd:cd18071   117 SKYDIVLTTYNTLASDFGAKGDSPLHT-------INWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPK 189

                         170
                  ....*....|....*..
gi 1002286831 607 EVFNILdlvrpKFLKME 623
Cdd:cd18071   190 DLGSLL-----SFLHLK 201
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 444-616 2.92e-05

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 46.70  E-value: 2.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 444 KPGGCILAHAPGSGKTFMLISFIqsfLAK--------------------------YPSARPLVVLPKGILGTWKREFQ-R 496
Cdd:cd18072    19 KPRGGILADDMGLGKTLTMIALI---LAQkntqnrkeeekekalteweskkdstlVPSAGTLVVCPASLVHQWKNEVEsR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 497 WQVEDIPLYDFYSVKADKRTEQLevlksweARMSILFLGYKQFSRIICGDGDGNIAAACrdrLLMVPNLLILDEGHTPRN 576
Cdd:cd18072    96 VASNKLRVCLYHGPNRERIGEVL-------RDYDIVITTYSLVAKEIPTYKEESRSSPL---FRIAWARIILDEAHNIKN 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1002286831 577 RETDVLASLKRVQTPRKVVLSGTLFQNHVSEVFNILDLVR 616
Cdd:cd18072   166 PKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
 788-901 3.07e-04

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 42.24  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 788 GEKLLAFSQYilpmKFLERLLVKRLGwhvgkeIFMISGDTSADDREVAMDQFNNSAdAKVLFGSiKACGEGISLVGASRV 867
Cdd:cd18789    49 GDKIIVFTDN----VEALYRYAKRLL------KPFITGETPQSEREEILQNFREGE-YNTLVVS-KVGDEGIDLPEANVA 116

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1002286831 868 IILDVHLNPsvTRQAI---GRAFRPGQQ--KKVFVYRLV 901
Cdd:cd18789   117 IQISGHGGS--RRQEAqrlGRILRPKKGggKNAFFYSLV 153
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 846-898 9.87e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 38.84  E-value: 9.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1002286831 846 KVLFGSiKACGEGISLVGASRVIILDVHLNPSVTRQAIGRAFRPGQQKKVFVY 898
Cdd:cd18785    24 EILVAT-NVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 554-610 2.84e-03

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 39.65  E-value: 2.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002286831 554 ACRDRLLMVPNLLILDEGHTpRNRETDVL-ASLKRVQTPRK---------VVLSGTLFQNHVSEVFN 610
Cdd:cd17978   106 AIGDPLLSKYSVIILDEAHE-RTVHTDVLfGLVKSAQRRRKeqklsplkvIIMSATLDADLFSEYFN 171
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 447-599 7.19e-03

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 38.15  E-value: 7.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 447 GCILAHAPGSGKTFM-LISFIQSFLAKYPSArpLVVLP-KGILGTWKREFQRWQVEDIP---LYDFYSVKadkrteqlEV 521
Cdd:cd00046     3 NVLITAPTGSGKTLAaLLAALLLLLKKGKKV--LVLVPtKALALQTAERLRELFGPGIRvavLVGGSSAE--------ER 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002286831 522 LKSWEARMSILFLGYKQFSRiicgdgdgNIAAACRDRLLMVpNLLILDEGH--------TPRNRETDVLASLKRVQTprk 593
Cdd:cd00046    73 EKNKLGDADIIIATPDMLLN--------LLLREDRLFLKDL-KLIIVDEAHallidsrgALILDLAVRKAGLKNAQV--- 140


                  ....*.
gi 1002286831 594 VVLSGT 599
Cdd:cd00046   141 ILLSAT 146
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 425-497 8.71e-03

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 38.87  E-value: 8.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002286831 425 MRPHQLegfsfLVKNLVGDKPGGCILAhAPGSGKTFMLISFIQSFLAKYPSARPLVVLPKGIL-GTWKREFQRW 497
Cdd:cd18013     1 PHPYQK-----VAINFIIEHPYCGLFL-DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVArSTWPDEVEKW 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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