NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1002261477|ref|XP_015635099|]
View 

uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

SAM domain-containing protein( domain architecture ID 10175456)

SAM (sterile alpha motif) domain-containing protein may interact with proteins, RNAs and membrane lipids, and may play a role in protein homo- and/or hetero- dimerization/oligomerization

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 4-60 8.30e-08

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


:

Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 46.85  E-value: 8.30e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002261477   4 DWYAWLSAARLDQavayeYALVFSRNELEADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:cd09487     1 DVAEWLESLGLEQ-----YADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILR 52
 
Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 4-60 8.30e-08

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 46.85  E-value: 8.30e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002261477   4 DWYAWLSAARLDQavayeYALVFSRNELEADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:cd09487     1 DVAEWLESLGLEQ-----YADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILR 52
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
8-60 4.61e-04

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 37.25  E-value: 4.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002261477   8 WLSAARLDQavaYEYAlvFSRNELE-ADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:pfam07647  12 WLRSIGLEQ---YTDN--FRDQGITgAELLLRLTLEDLKRLGITSVGHRRKILK 60
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 7-60 3.32e-03

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 34.96  E-value: 3.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002261477    7 AWLSAARLDQavayeYALVFSRNELEADDLAY-FDHEFLHSMGVSVAKHRLEILK 60
Cdd:smart00454  11 DWLESIGLEQ-----YADNFRKNGIDGALLLLlTSEEDLKELGITKLGHRKKILK 60
 
Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 4-60 8.30e-08

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 46.85  E-value: 8.30e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002261477   4 DWYAWLSAARLDQavayeYALVFSRNELEADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:cd09487     1 DVAEWLESLGLEQ-----YADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILR 52
SAM_Ste50-like_fungal cd09533
SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or ...
 7-60 1.89e-06

SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or Ubc2 for Ustilago bypass of cyclase) subfamily is a putative protein-protein interaction domain. This group includes only fungal proteins. Basidiomycetes have an N-terminal SAM domain, central UBQ domain, and C-terminal SH3 domain, while Ascomycetes lack the SH3 domain. Ubc2 of Ustilago maydis is a major virulence and maize pathogenicity factor. It is required for filamentous growth (the budding haploid form of Ustilago maydis is a saprophyte, while filamentous dikaryotic form is a pathogen). Also the Ubc2 protein is involved in the pheromone-responsive morphogenesis via the MAP kinase cascade. The SAM domain is necessary for ubc2 function; deletion of SAM eliminates this function. A Lys-to-Glu mutation in the SAM domain of ubc2 gene induces temperature sensitivity.


Pssm-ID: 188932  Cd Length: 58  Bit Score: 43.46  E-value: 1.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002261477   7 AWLSAARLDQavayeYALVFSRNELEADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:cd09533     4 DWLSSLGLPQ-----YEDQFIENGITGDVLVALDHEDLKEMGITSVGHRLTILK 52
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
8-60 4.61e-04

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 37.25  E-value: 4.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002261477   8 WLSAARLDQavaYEYAlvFSRNELE-ADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:pfam07647  12 WLRSIGLEQ---YTDN--FRDQGITgAELLLRLTLEDLKRLGITSVGHRRKILK 60
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 7-60 3.32e-03

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 34.96  E-value: 3.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002261477    7 AWLSAARLDQavayeYALVFSRNELEADDLAY-FDHEFLHSMGVSVAKHRLEILK 60
Cdd:smart00454  11 DWLESIGLEQ-----YADNFRKNGIDGALLLLlTSEEDLKELGITKLGHRKKILK 60
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
 5-60 4.73e-03

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 34.20  E-value: 4.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1002261477   5 WYAWLSAARLDQAVAYEYALVFSRNELEADDLAYFDHEFLHSMGVSVAKHRLEILK 60
Cdd:cd09531     4 WIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH