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Conserved domains on  [gi|1002248158|ref|XP_015628255|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-391 2.29e-81

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.84  E-value: 2.29e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  59 AFRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTAT 138
Cdd:COG2319    73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 139 RTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIW 218
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 219 DPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSM 298
Cdd:COG2319   232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 299 DQKLIIWDLG-RQSIRCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIV 377
Cdd:COG2319   309 DGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         330
                  ....*....|....
gi 1002248158 378 SVSTDGSALIFDIS 391
Cdd:COG2319   389 SGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-391 2.29e-81

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.84  E-value: 2.29e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  59 AFRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTAT 138
Cdd:COG2319    73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 139 RTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIW 218
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 219 DPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSM 298
Cdd:COG2319   232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 299 DQKLIIWDLG-RQSIRCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIV 377
Cdd:COG2319   309 DGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         330
                  ....*....|....
gi 1002248158 378 SVSTDGSALIFDIS 391
Cdd:COG2319   389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-389 2.32e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 230.30  E-value: 2.32e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 102 ELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHN 181
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 182 AILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWDPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVC 261
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 262 VVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDLGRQSIRCTCN-HDEGVTSLAWLGPSRFVASGCID 340
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002248158 341 GMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFD 389
Cdd:cd00200   241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 78-262 1.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  78 SLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSS-DGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWLK 156
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 157 WHPRGHLIIAGSEDCNLWMWNADHNAI-LNTFAGHSSTVTCGDFTpDGKLICTGSDDASLRIWDPRTAQS------RHVV 229
Cdd:PLN00181  626 PSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSF 704

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1002248158 230 RGHGyHTDGLTCLSVtSDSQtIVSGSKDNSVCV 262
Cdd:PLN00181  705 MGHT-NVKNFVGLSV-SDGY-IATGSETNEVFV 734
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 287-367 3.04e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.04  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 287 SPSYNWVATGSMDQKLIIWDLGRQSI--RCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVV 364
Cdd:pfam12894   4 CPTMDLIALATEDGELLLHRLNWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83


                  ...
gi 1002248158 365 QSL 367
Cdd:pfam12894  84 TCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 4.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002248158   96 SAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWN 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-391 2.29e-81

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.84  E-value: 2.29e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  59 AFRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTAT 138
Cdd:COG2319    73 TLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 139 RTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIW 218
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 219 DPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSM 298
Cdd:COG2319   232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 299 DQKLIIWDLG-RQSIRCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIV 377
Cdd:COG2319   309 DGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         330
                  ....*....|....
gi 1002248158 378 SVSTDGSALIFDIS 391
Cdd:COG2319   389 SGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
59-391 1.35e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.50  E-value: 1.35e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  59 AFRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTAT 138
Cdd:COG2319    31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 139 RTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIW 218
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 219 DPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSM 298
Cdd:COG2319   190 DLATGKLLRTLTG---HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 299 DQKLIIWDL-GRQSIRCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIV 377
Cdd:COG2319   267 DGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                         330
                  ....*....|....
gi 1002248158 378 SVSTDGSALIFDIS 391
Cdd:COG2319   347 SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-389 2.32e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 230.30  E-value: 2.32e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 102 ELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHN 181
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 182 AILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWDPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVC 261
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 262 VVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDLGRQSIRCTCN-HDEGVTSLAWLGPSRFVASGCID 340
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002248158 341 GMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFD 389
Cdd:cd00200   241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-347 3.21e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.20  E-value: 3.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  60 FRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATR 139
Cdd:cd00200     5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 140 TLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWD 219
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 220 PRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSMD 299
Cdd:cd00200   164 LRTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002248158 300 QKLIIWDLGRQSIRCTC-NHDEGVTSLAWLGPSRFVASGCIDGMVRIWD 347
Cdd:cd00200   241 GTIRVWDLRTGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
76-391 1.67e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.92  E-value: 1.67e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  76 DASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWL 155
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 156 KWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWDPRTAQSRHVVRGhgyH 235
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---H 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 236 TDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDLGRQSIRCT 315
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002248158 316 CN-HDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFDIS 391
Cdd:COG2319   242 LTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-306 1.14e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 1.14e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  50 DMQEDDSQYAFRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDG 129
Cdd:cd00200    37 DLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDK 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 130 RINVWNTATRTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTG 209
Cdd:cd00200   116 TIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 210 SDDASLRIWDPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPS 289
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                         250
                  ....*....|....*..
gi 1002248158 290 YNWVATGSMDQKLIIWD 306
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
114-391 4.20e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 4.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 114 AFSSDGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSST 193
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 194 VTCGDFTPDGKLICTGSDDASLRIWDPRTAQSRHVVRGhgyHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGS 273
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 274 LDGHTGSIECVGISPSYNWVATGSMDQKLIIWDLGRQSIRCTCN-HDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGE 352
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1002248158 353 CVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFDIS 391
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-394 1.71e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 1.71e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 186 TFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWDPRTAQSRHVVRGHgyhTDGLTCLSVTSDSQTIVSGSKDNSVCVVNI 265
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 266 NSGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDL--GRQSIRCTCnHDEGVTSLAWLGPSRFVASGCIDGMV 343
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVetGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002248158 344 RIWDSLSGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFDISMFK 394
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
60-267 4.39e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.86  E-value: 4.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  60 FRAHTDEIFAVACSPtDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATR 139
Cdd:COG2319   200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 140 TLQGTLEGSGSGFEWLKWHPRGHLIIAGSEDCNLWMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWD 219
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1002248158 220 PRTAQSRHVVRGHgyhTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINS 267
Cdd:COG2319   359 LATGELLRTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 271-394 3.13e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 271 VGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDL-GRQSIRCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSL 349
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLeTGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1002248158 350 SGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFDISMFK 394
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 78-262 1.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  78 SLVASGGKDDRGFLWKIGSAEDVLELAGHTDTVCTVAFSS-DGNLLASGSFDGRINVWNTATRTLQGTLEGSGSGFEWLK 156
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 157 WHPRGHLIIAGSEDCNLWMWNADHNAI-LNTFAGHSSTVTCGDFTpDGKLICTGSDDASLRIWDPRTAQS------RHVV 229
Cdd:PLN00181  626 PSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSF 704

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1002248158 230 RGHGyHTDGLTCLSVtSDSQtIVSGSKDNSVCV 262
Cdd:PLN00181  705 MGHT-NVKNFVGLSV-SDGY-IATGSETNEVFV 734
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 102-307 4.26e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 102 ELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWNTATRTLQG------TLEGSG-SGFEWLKWHPRGHLIIAGSE-DCNL 173
Cdd:PLN00181  478 DLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGrdihypVVELASrSKLSGICWNSYIKSQVASSNfEGVV 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 174 WMWNADHNAILNTFAGHSSTVTCGDF-TPDGKLICTGSDDASLRIWDPRTAQSRHVVRGHGyhtdGLTCLSVTSDS-QTI 251
Cdd:PLN00181  558 QVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKA----NICCVQFPSESgRSL 633

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002248158 252 VSGSKDNSVCVVNINSGQV-VGSLDGHTGSIECVGISPSYNWVATgSMDQKLIIWDL 307
Cdd:PLN00181  634 AFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 287-367 3.04e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.04  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 287 SPSYNWVATGSMDQKLIIWDLGRQSI--RCTCNHDEGVTSLAWLGPSRFVASGCIDGMVRIWDSLSGECVRAFAGHGDVV 364
Cdd:pfam12894   4 CPTMDLIALATEDGELLLHRLNWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83


                  ...
gi 1002248158 365 QSL 367
Cdd:pfam12894  84 TCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 4.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002248158   96 SAEDVLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWN 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-219 5.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1002248158  184 LNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWD 219
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
100-135 7.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 7.70e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002248158 100 VLELAGHTDTVCTVAFSSDGNLLASGSFDGRINVWN 135
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
184-219 1.04e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.04e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002248158 184 LNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWD 219
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 267-306 1.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002248158  267 SGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWD 306
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 190-390 3.39e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.53  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 190 HSSTVTCGDFTPDGKLICTGSDDASLRIWD----------PRTAQS-------------RHVVRGhgyHTDGLTCLSVTS 246
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEvlrgrssekrSRNTQTefprkdhviaetpFHILCG---HDDIITCLYVSV 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 247 DSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGS-IECVGISPSYNWVATGSMDQKLIIWDL-GRQSIRCTCNHDEGVTS 324
Cdd:pfam20426 200 ELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCpLSKLVASRHGRIVLYADDDLSLHLYSInGKHIASSESNGRLNCIE 279

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002248158 325 LAWLGpsRFVASGCIDG--MVRIWDSLsgECVRAFAGHGDVVQSLAVSADgNSIVSVSTDGSALIFDI 390
Cdd:pfam20426 280 LSSCG--EFLVCAGDQGqiVVRSMNSL--EVVRRYNGIGKIITSLTVTPE-ECFLAGTKDGSLLVYSI 342
WD40 pfam00400
WD domain, G-beta repeat;
268-306 3.56e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002248158 268 GQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWD 306
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 239-384 1.31e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 239 LTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVVGSLDGHTGSIECVGISPSYNWVATGSMDQKLIIWDL--GRQSIRCTC 316
Cdd:pfam20426  85 FATLQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrGRSSEKRSR 164

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002248158 317 NHDegvtslawlgpSRFVASGCIdgmvriwdsLSGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGS 384
Cdd:pfam20426 165 NTQ-----------TEFPRKDHV---------IAETPFHILCGHDDIITCLYVSVELDIVISGSKDGT 212
PTZ00421 PTZ00421
coronin; Provisional
 103-269 1.66e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 103 LAGHTDTVCTVAFSS-DGNLLASGSFDGRINVWNTATRTLQGT-------LEGSGSGFEWLKWHPRGHLIIAGS-EDCNL 173
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLASAgADMVV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 174 WMWNADHNAILNTFAGHSSTVTCGDFTPDGKLICTGSDDASLRIWDPRtaqSRHVVRGHGYHTDGltclsvtsDSQTIVS 253
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR---DGTIVSSVEAHASA--------KSQRCLW 219

                         170
                  ....*....|....*.
gi 1002248158 254 GSKDNSVCVVNINSGQ 269
Cdd:PTZ00421  220 AKRKDLIITLGCSKSQ 235
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 61-284 2.25e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158  61 RAHTDEIFAVACSPTDASLVASGGKDDRGFLWKIGSAEDVLELAGHTDtVCTVAFSSD-GNLLASGSFDGRINVWNTATR 139
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNP 650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 140 TLQ-GTLEGSGSGFEWLKWHPRGHLiIAGSEDCNLWMWNADHNAI------LNTFAGHSSTVTCGDFTPDGKLICTGSDD 212
Cdd:PLN00181  651 KLPlCTMIGHSKTVSYVRFVDSSTL-VSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSET 729

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002248158 213 ASLRIWdpRTAQSRHVVRGHGYHTDGLTCLSVTSDSQTIvsgskdNSVCVVNINSGQVVGSLDGHTGSIECV 284
Cdd:PLN00181  730 NEVFVY--HKAFPMPVLSYKFKTIDPVSGLEVDDASQFI------SSVCWRGQSSTLVAANSTGNIKILEMV 793
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 350-389 1.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002248158  350 SGECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFD 389
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 318-347 2.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.19e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1002248158  318 HDEGVTSLAWLGPSRFVASGCIDGMVRIWD 347
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
318-347 2.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.87e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1002248158 318 HDEGVTSLAWLGPSRFVASGCIDGMVRIWD 347
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
351-389 8.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 8.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002248158 351 GECVRAFAGHGDVVQSLAVSADGNSIVSVSTDGSALIFD 389
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 194-310 1.75e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248158 194 VTCGDF--TPDGKLICTGSDDASLRIWDPRtAQSRHVVRGhGYHTDGLTCLSVTSDSQTIVSGSKDNSVCVVNINSGQVV 271
Cdd:cd22857   181 VTDLTFlsKDDHRKIVTGTGYHQVRLYDTR-AQRRPVVSV-DFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLL 258

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1002248158 272 GSLDGHTG-SIECVGISPSYNWVATGSMDQKLIIWDL-GRQ 310
Cdd:cd22857   259 GCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTeTRQ 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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