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Conserved domains on  [gi|1002246314|ref|XP_015627328|]
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U2 small nuclear ribonucleoprotein A' [Oryza sativa Japonica Group]

Protein Classification

U2 small nuclear ribonucleoprotein A'( domain architecture ID 12169332)

U2 small nuclear ribonucleoprotein A' (SNRPA1) is involved in pre-mRNA splicing as a component of the spliceosome

Gene Symbol:  SNRPA1
Gene Ontology:  GO:0005515|GO:0000398|GO:0030620
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
1-174 3.12e-99

Leucine-rich repeat;


:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 288.20  E-value: 3.12e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   1 MVRLTADLIWKSPHFFNAVKDRELDIRGNKIPIIENLGATEDQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRIN 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPVRERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  81 PNLGEFLPKLHTLVLTNNRLTNLAEIDPLASLPKLQFLSLLDNTVTKQPDYRLYVIHKLKHLRLLDFKKVKQQERIAAAQ 160
Cdd:pfam14580  81 EGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160

                         170
                  ....*....|....
gi 1002246314 161 KFHSKEAEEEAKKV 174
Cdd:pfam14580 161 MFRSKQGKQLAKEI 174
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
1-174 3.12e-99

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 288.20  E-value: 3.12e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   1 MVRLTADLIWKSPHFFNAVKDRELDIRGNKIPIIENLGATEDQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRIN 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPVRERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  81 PNLGEFLPKLHTLVLTNNRLTNLAEIDPLASLPKLQFLSLLDNTVTKQPDYRLYVIHKLKHLRLLDFKKVKQQERIAAAQ 160
Cdd:pfam14580  81 EGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160

                         170
                  ....*....|....
gi 1002246314 161 KFHSKEAEEEAKKV 174
Cdd:pfam14580 161 MFRSKQGKQLAKEI 174
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-146 9.90e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 9.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   1 MVRLTADLIWKSPHFFNAVKDRELDIRGNKI----PIIENLgateDQFDTIDLSDNEIVKL-ENFPYLNRLGTLLVNNNR 75
Cdd:COG4886    95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLtdlpEELANL----TNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002246314  76 ITRINPNLGEfLPKLHTLVLTNNRLTNLAEidPLASLPKLQFLSLLDNTVTKQPDyrlyVIHKLKHLRLLD 146
Cdd:COG4886   171 LTDLPEELGN-LTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 28-155 3.37e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  28 GNKIPIIENLGATEdQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRIN-----PNLGE----------------- 85
Cdd:cd21340    33 DNKITKIENLEFLT-NLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEglenlTNLEElhienqrlppgekltfd 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  86 ----------------------------FLPKLHTLVLTNNRLTNLAEI-DPLASLPKLQFLSLLDNTVTKQPDYRLYVI 136
Cdd:cd21340   112 prslaalsnslrvlnisgnnidsleplaPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKPKYRDKII 191

                         170
                  ....*....|....*....
gi 1002246314 137 HKLKHLRLLDFKKVKQQER 155
Cdd:cd21340   192 LASKSLEVLDGKEITDTER 210
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
1-174 3.12e-99

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 288.20  E-value: 3.12e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   1 MVRLTADLIWKSPHFFNAVKDRELDIRGNKIPIIENLGATEDQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRIN 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPVRERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  81 PNLGEFLPKLHTLVLTNNRLTNLAEIDPLASLPKLQFLSLLDNTVTKQPDYRLYVIHKLKHLRLLDFKKVKQQERIAAAQ 160
Cdd:pfam14580  81 EGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160

                         170
                  ....*....|....
gi 1002246314 161 KFHSKEAEEEAKKV 174
Cdd:pfam14580 161 MFRSKQGKQLAKEI 174
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-146 9.90e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 9.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   1 MVRLTADLIWKSPHFFNAVKDRELDIRGNKI----PIIENLgateDQFDTIDLSDNEIVKL-ENFPYLNRLGTLLVNNNR 75
Cdd:COG4886    95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLtdlpEELANL----TNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQ 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002246314  76 ITRINPNLGEfLPKLHTLVLTNNRLTNLAEidPLASLPKLQFLSLLDNTVTKQPDyrlyVIHKLKHLRLLD 146
Cdd:COG4886   171 LTDLPEELGN-LTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 28-155 3.37e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  28 GNKIPIIENLGATEdQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRIN-----PNLGE----------------- 85
Cdd:cd21340    33 DNKITKIENLEFLT-NLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEglenlTNLEElhienqrlppgekltfd 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  86 ----------------------------FLPKLHTLVLTNNRLTNLAEI-DPLASLPKLQFLSLLDNTVTKQPDYRLYVI 136
Cdd:cd21340   112 prslaalsnslrvlnisgnnidsleplaPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKPKYRDKII 191

                         170
                  ....*....|....*....
gi 1002246314 137 HKLKHLRLLDFKKVKQQER 155
Cdd:cd21340   192 LASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-149 7.85e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  22 RELDIRGNKIPIIENLGATEDQFDTIDLSDNEIVKL-ENFPYLNRLGTLLVNNNRITRINPNLGEfLPKLHTLVLTNNRL 100
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQL 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1002246314 101 TNLAEidpLASLPKLQFLSLLDNTVTKQPDyrlyvIHKLKHLRLLDFKK 149
Cdd:COG4886   241 TDLPE---LGNLTNLEELDLSNNQLTDLPP-----LANLTNLKTLDLSN 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-251 3.82e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 3.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  22 RELDIRGNKI----PIIENLgateDQFDTIDLSDNEIVKL-ENFPYLNRLGTLLVNNNRITRInPNLGEfLPKLHTLVLT 96
Cdd:COG4886   185 KELDLSNNQItdlpEPLGNL----TNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDL-PELGN-LTNLEELDLS 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314  97 NNRLTnlaEIDPLASLPKLQFLSLLDNTVTKQPDYRLYVIHKLKHLRLLDFKKVKQQERIAAAQKFHSKEAEEEAKKVPA 176
Cdd:COG4886   259 NNQLT---DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002246314 177 KTFTPGQVVDAQDTTMEEQGPKVVAPTPEQITAIKAAIVNSQTLEEVARLEKALSTGQIPAEFAIPKPDANMADA 251
Cdd:COG4886   336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-146 2.33e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002246314   4 LTADLIWKSPHFFNAVKDRELDIRGNKIPIIENLGATEDQFDTIDLSDNEIVKLENFPYLNRLGTLLVNNNRITRINPNL 83
Cdd:COG4886    53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002246314  84 GEfLPKLHTLVLTNNRLTNLAEidPLASLPKLQFLSLLDNTVTKQPDyrlyVIHKLKHLRLLD 146
Cdd:COG4886   133 AN-LTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPE----ELGNLTNLKELD 188
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-123 1.94e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002246314  49 LSDNEIVKLENFPYLNRLGTLLVNNNRITRInPNLgEFLPKLHTLVLTNNRLTnlaEIDPLASLPKLQFLSLLDN 123
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENL-EFLTNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
65-123 2.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002246314  65 RLGTLLVNNNRITRINPNLGEFLPKLHTLVLTNNRLTNLAEIDpLASLPKLQFLSLLDN 123
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
46-100 2.81e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 2.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002246314  46 TIDLSDNEIVKL--ENFPYLNRLGTLLVNNNRITRINPNLGEFLPKLHTLVLTNNRL 100
Cdd:pfam13855   5 SLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-124 1.40e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1002246314  88 PKLHTLVLTNNRLTNlaeIDPLASLPKLQFLSLLDNT 124
Cdd:pfam12799   1 PNLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
88-146 1.35e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002246314  88 PKLHTLVLTNNRLTNLaEIDPLASLPKLQFLSLLDNTVTkqpDYRLYVIHKLKHLRLLD 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSL-DDGAFKGLSNLKVLDLSNNLLT---TLSPGAFSGLPSLRYLD 55
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 65-111 4.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 4.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1002246314  65 RLGTLLVNNNRITRINPnlGEFLPKLHTLVLTNNrlTNLAEIDPLAS 111
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN--NKITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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