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Conserved domains on  [gi|1000232450]
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Chain B, Methylosome protein 50

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
102-330 2.22e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 102 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 181
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 182 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 261
Cdd:COG2319   253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 262 HSQCVTGLVFSPHSvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDHQV 330
Cdd:COG2319   329 HTGAVRSVAFSPDG-KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
102-330 2.22e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 102 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 181
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 182 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 261
Cdd:COG2319   253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 262 HSQCVTGLVFSPHSvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDHQV 330
Cdd:COG2319   329 HTGAVRSVAFSPDG-KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-327 9.78e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 9.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  88 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 166
Cdd:cd00200     9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 167 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 245
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 246 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASlSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPlNHSLLTTV 324
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSP-DGYLLASG 237


                  ...
gi 1000232450 325 GWD 327
Cdd:cd00200   238 SED 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 167-204 7.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1000232450  167 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 204
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
168-204 3.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1000232450 168 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 204
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
102-330 2.22e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 102 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 181
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 182 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 261
Cdd:COG2319   253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 262 HSQCVTGLVFSPHSvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDHQV 330
Cdd:COG2319   329 HTGAVRSVAFSPDG-KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-327 9.78e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 9.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  88 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 166
Cdd:cd00200     9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 167 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 245
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 246 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASlSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPlNHSLLTTV 324
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSP-DGYLLASG 237


                  ...
gi 1000232450 325 GWD 327
Cdd:cd00200   238 SED 240
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-290 1.43e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 1.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  88 EAGVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 166
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 167 VLSSYRAHAAQVTCVAASPhKDSVFLSCSEDNRILLWDTRCPKP-ASQIGCSAPgylPTSLAWHPQqSEVFVFGDENGTV 245
Cdd:cd00200   169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENG---VNSVAFSPD-GYLLASGSEDGTI 243

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1000232450 246 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAV 290
Cdd:cd00200   244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
54-330 1.50e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  54 ASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCkyEHD 133
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 134 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPhkDSVFL-SCSEDNRILLWDTRCPKPAS 212
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DGKTLaSGSADGTVRLWDLATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 213 QIgcSAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAVLD 292
Cdd:COG2319   157 TL--TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWD 232

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1000232450 293 -SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDHQV 330
Cdd:COG2319   233 lATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-334 2.02e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 2.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 130 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFlSCSEDNRILLWDTRCPK 209
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 210 PASQIGCSAPGylPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLA 289
Cdd:cd00200    85 CVRTLTGHTSY--VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1000232450 290 VLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVG------WDHQVVHHV 334
Cdd:cd00200   161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSdgtiklWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-204 1.68e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  99 ERGILVASDSGAVELWELDenetlivSKFCKYE---HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 175
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDLS-------TGKCLGTlrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261

                          90       100
                  ....*....|....*....|....*....
gi 1000232450 176 AQVTCVAASPHKdSVFLSCSEDNRILLWD 204
Cdd:cd00200   262 NSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
102-206 5.43e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 102 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 181
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                          90       100
                  ....*....|....*....|....*
gi 1000232450 182 AASPHkDSVFLSCSEDNRILLWDTR 206
Cdd:COG2319   379 AFSPD-GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-330 6.31e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 6.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 171 YRAHAAQVTCVAASPHKDsVFLSCSEDNRILLWDT-RCPKPASQIGCSAPGylpTSLAWHPqQSEVFVFGDENGTVSLVD 249
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLeTGELLRTLKGHTGPV---RDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 250 TKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPlNHSLLTTVGWDH 328
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSP-DGTFVASSSQDG 157


                  ..
gi 1000232450 329 QV 330
Cdd:cd00200   158 TI 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 167-204 7.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1000232450  167 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 204
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
166-273 2.17e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 166 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDENGTV 245
Cdd:COG3391    58 AGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATI---PVGGGPRGLAVDPDGGRLYVADSGNGRV 134

                          90       100
                  ....*....|....*....|....*...
gi 1000232450 246 SLVDTKSTSCVLSSAVHSQcVTGLVFSP 273
Cdd:COG3391   135 SVIDTATGKVVATIPVGAG-PHGIAVDP 161
WD40 pfam00400
WD domain, G-beta repeat;
168-204 3.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1000232450 168 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 204
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
83-273 6.35e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450  83 AGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 162
Cdd:COG3391    18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232450 163 AQQVVLSSYRAhAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDEN 242
Cdd:COG3391    98 ATGKVVATIPV-GGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI---PVGAGPHGIAVDPDGKRLYVANSGS 173

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1000232450 243 GTVSLV----DTKSTScVLSSAVHSQCVTGLVFSP 273
Cdd:COG3391   174 NTVSVIvsviDTATGK-VVATIPVGGGPVGVAVSP 207
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 96-162 5.11e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.36  E-value: 5.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1000232450  96 WVG----ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 162
Cdd:cd22857    85 FVGlhlfSGTLLTCTSKGSLRSTKLPDDSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDL 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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