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Conserved domains on  [gi|375135897|ref|YP_004996547|]
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hypothetical protein BDGL_002279 [Acinetobacter pittii PHEA-2]

Protein Classification

RidA family protein( domain architecture ID 817)

RidA (reactive intermediate/imine deaminase A) family protein

PubMed:  25975565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_family super family cl10015
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 1-127 2.97e-81

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


The actual alignment was detected with superfamily member TIGR03610:

Pssm-ID: 447879  Cd Length: 127  Bit Score: 234.36  E-value: 2.97e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897    1 MSKQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI 80
Cdd:TIGR03610   1 MPKKVIIPAGTSKPLAPFVPGTLADGVVYVSGTLPFDKDNNVVHVGDAAAQTRHVLETIKSVIETAGGTMDDVTFNHIFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375135897   81 KDWADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIAHVG 127
Cdd:TIGR03610  81 RDWADYAAINEVYAEYFPGEKPARYCIQCGLVKPDALVEIASVAHIG 127
 
Name Accession Description Interval E-value
RutC TIGR03610
pyrimidine utilization protein C; This protein is observed in operons extremely similar to ...
 1-127 2.97e-81

pyrimidine utilization protein C; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the endoribonuclease L-PSP family defined by pfam01042.


Pssm-ID: 274677  Cd Length: 127  Bit Score: 234.36  E-value: 2.97e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897    1 MSKQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI 80
Cdd:TIGR03610   1 MPKKVIIPAGTSKPLAPFVPGTLADGVVYVSGTLPFDKDNNVVHVGDAAAQTRHVLETIKSVIETAGGTMDDVTFNHIFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375135897   81 KDWADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIAHVG 127
Cdd:TIGR03610  81 RDWADYAAINEVYAEYFPGEKPARYCIQCGLVKPDALVEIASVAHIG 127
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-125 1.08e-39

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 128.57  E-value: 1.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   13 APLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTV 92
Cdd:pfam01042   4 AAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNEV 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 375135897   93 YAEYFPSDK-PARFCIQCGLVKPDALIEIASIAH 125
Cdd:pfam01042  84 YAEYFDADKaPARSAVGVAALPLGALVEIEAIAV 117
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-127 3.80e-37

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 122.59  E-value: 3.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   1 MSKQVVIPEGtSAPLAPYVPATKADNIVYVSGTLAFDENNNVVcIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI 80
Cdd:COG0251    1 MTRELINPPA-PAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL-GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375135897  81 KDWADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIAHVG 127
Cdd:COG0251   79 TDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-124 1.32e-30

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 105.33  E-value: 1.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  18 YVPATKADNIVYVSGTLAFDENNNVVcIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTVYAEYF 97
Cdd:cd00448    1 YSQAVRVGNLVFVSGQIPLDPDGELV-PGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                         90       100
                 ....*....|....*....|....*...
gi 375135897  98 PSD-KPARFCIQCGLVKPDALIEIASIA 124
Cdd:cd00448   80 GEGpPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
3-124 1.59e-13

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 62.39  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   3 KQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCiGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKD 82
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIP-ADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 375135897  83 WADYTSVNTVYAEYFPSDK---PARFCIQCGLVKPDALIEIASIA 124
Cdd:PRK11401  81 LNDFATINEVYKQFFDEHQatyPTRSCVQVARLPKDVKLEIEAIA 125
 
Name Accession Description Interval E-value
RutC TIGR03610
pyrimidine utilization protein C; This protein is observed in operons extremely similar to ...
 1-127 2.97e-81

pyrimidine utilization protein C; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the endoribonuclease L-PSP family defined by pfam01042.


Pssm-ID: 274677  Cd Length: 127  Bit Score: 234.36  E-value: 2.97e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897    1 MSKQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI 80
Cdd:TIGR03610   1 MPKKVIIPAGTSKPLAPFVPGTLADGVVYVSGTLPFDKDNNVVHVGDAAAQTRHVLETIKSVIETAGGTMDDVTFNHIFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375135897   81 KDWADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIAHVG 127
Cdd:TIGR03610  81 RDWADYAAINEVYAEYFPGEKPARYCIQCGLVKPDALVEIASVAHIG 127
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-125 1.08e-39

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 128.57  E-value: 1.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   13 APLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTV 92
Cdd:pfam01042   4 AAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNEV 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 375135897   93 YAEYFPSDK-PARFCIQCGLVKPDALIEIASIAH 125
Cdd:pfam01042  84 YAEYFDADKaPARSAVGVAALPLGALVEIEAIAV 117
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-127 3.80e-37

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 122.59  E-value: 3.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   1 MSKQVVIPEGtSAPLAPYVPATKADNIVYVSGTLAFDENNNVVcIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI 80
Cdd:COG0251    1 MTRELINPPA-PAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL-GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375135897  81 KDWADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIAHVG 127
Cdd:COG0251   79 TDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-124 1.32e-30

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 105.33  E-value: 1.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  18 YVPATKADNIVYVSGTLAFDENNNVVcIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTVYAEYF 97
Cdd:cd00448    1 YSQAVRVGNLVFVSGQIPLDPDGELV-PGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                         90       100
                 ....*....|....*....|....*...
gi 375135897  98 PSD-KPARFCIQCGLVKPDALIEIASIA 124
Cdd:cd00448   80 GEGpPPARTAVGVAALPPGALVEIEAIA 107
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-124 1.32e-27

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 98.14  E-value: 1.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897    3 KQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKD 82
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 375135897   83 WADYTSVNTVYAEYFPSDKPARFCIQCGLVKPDALIEIASIA 124
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 14-124 4.38e-20

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 78.75  E-value: 4.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  14 PLAPYVPATKADNIVYVSGTLAFDENNNVVcIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTVY 93
Cdd:cd06154    9 EQAGYSRAVRVGNWVFVSGTTGYDYDGMVM-PGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAH 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 375135897  94 AEYFPSDKPARFCIQCGL-VKPDALIEIASIA 124
Cdd:cd06154   88 GEVFGDIRPAATMVVVSLlVDPEMLVEIEVTA 119
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 20-124 4.50e-18

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 73.34  E-value: 4.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  20 PATKADNIVYVSGTLAFDENnnvvciGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTVYAEYFPS 99
Cdd:cd06150    5 QAVVHNGTVYLAGQVADDTS------ADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWVPP 78

                         90       100
                 ....*....|....*....|....*.
gi 375135897 100 D-KPARFCIQCGLVKPDALIEIASIA 124
Cdd:cd06150   79 GhAPARACVEAKLADPGYLVEIVVTA 104
PRK11401 PRK11401
enamine/imine deaminase;
3-124 1.59e-13

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 62.39  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897   3 KQVVIPEGTSAPLAPYVPATKADNIVYVSGTLAFDENNNVVCiGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKD 82
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIP-ADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 375135897  83 WADYTSVNTVYAEYFPSDK---PARFCIQCGLVKPDALIEIASIA 124
Cdd:PRK11401  81 LNDFATINEVYKQFFDEHQatyPTRSCVQVARLPKDVKLEIEAIA 125
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 27-124 1.54e-12

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 59.58  E-value: 1.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  27 IVYVSGTLAFDeNNNVVCIGDAAGQTRHILETIKKVIETAGGTM-----DDVTFNSIFIKDWADYTSVNTVYAEYFPSDK 101
Cdd:cd06153   14 HLFISGTASIV-GHGTVHPGDVEAQTRETLENIEALLEAAGRGGgaqflADLLRLKVYLRDREDLPAVRAILAARLGPAV 92

                         90       100
                 ....*....|....*....|...
gi 375135897 102 PARFcIQCGLVKPDALIEIASIA 124
Cdd:cd06153   93 PAVF-LQADVCRPDLLVEIEAVA 114
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 22-111 2.44e-12

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 58.42  E-value: 2.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  22 TKADNIVYVSgtlafdennNVVCIG---DAAGQTRHILETIKKVIETAGGTMDDVTFNSIFIKDWADYTSVNTVYAEYFP 98
Cdd:cd06155    4 NRTGGLLWIS---------NVTASEsdeTVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFD 74

                         90
                 ....*....|....
gi 375135897  99 S-DKPARFCIQCGL 111
Cdd:cd06155   75 KpNPPSRVCVECGL 88
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 19-124 4.57e-12

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 58.49  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  19 VPATKAdnIVYVSGTLAFDEN-----NNVVCIGDAAGQTRHILETIKKVIETAGGTMDDVTFNSIFI------KDWADYT 87
Cdd:cd06151    7 VPAGAA--TIYLSGTVPAVVNasapkGSPARYGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGKMDFA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 375135897  88 SVNTVYAEYFPSD----KPARFCIQ-CGLVKPDALIEIASIA 124
Cdd:cd06151   85 GFMKAYRQFFGTAeqpnKPARSTLQvAGLVNPGWLVEIEVVA 126
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 18-126 2.81e-09

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 50.72  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375135897  18 YVPATKADNIVYVSGTLAFDENNNVvcIGDAAGQTRHILETIKKVIETAGGTMDD-VTFNSIFIKDWADYTSVNTVYAEY 96
Cdd:cd02198    3 YSPAVRVGDTLFVSGQVGSDADGSV--AEDFEAQFRLAFQNLGAVLEAAGCSFDDvVELTTFHVDMAAHLPAFAAVKDEY 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 375135897  97 FPSDKPARFCIQC-GLVKPDALIEIASIAHV 126
Cdd:cd02198   81 FKEPYPAWTAVGVaWLARPGLLVEIKVVAVR 111
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 6-38 2.38e-03

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 35.51  E-value: 2.38e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 375135897   6 VIPEgTSAPLAPYVPATKADNIVYVSGTLAFDE 38
Cdd:cd02199    5 ELPP-APAPVGNYVPAVRTGNLLYVSGQLPRVD 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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