![](files/infoQ.gif)
MoxR-like ATPase [Acinetobacter pittii PHEA-2]
AAA family ATPase( domain architecture ID 11431245)
AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | |||||
MoxR | COG0714 | MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
1-267 | 7.27e-65 | |||||
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis : Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 204.63 E-value: 7.27e-65
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
MoxR | COG0714 | MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
1-267 | 7.27e-65 | |||||
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 204.63 E-value: 7.27e-65
|
|||||||||
AAA | cd00009 | The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
21-185 | 1.42e-12 | |||||
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases. Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 64.09 E-value: 1.42e-12
|
|||||||||
AAA | pfam00004 | ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
34-185 | 2.50e-12 | |||||
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 62.61 E-value: 2.50e-12
|
|||||||||
AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
32-186 | 4.21e-09 | |||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 54.30 E-value: 4.21e-09
|
|||||||||
hflB | PRK10733 | ATP-dependent zinc metalloprotease FtsH; |
25-206 | 2.04e-04 | |||||
ATP-dependent zinc metalloprotease FtsH; Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 42.71 E-value: 2.04e-04
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
MoxR | COG0714 | MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
1-267 | 7.27e-65 | |||||
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 204.63 E-value: 7.27e-65
|
|||||||||
SpoVK | COG0464 | AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
34-201 | 1.40e-12 | |||||
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 67.24 E-value: 1.40e-12
|
|||||||||
AAA | cd00009 | The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
21-185 | 1.42e-12 | |||||
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases. Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 64.09 E-value: 1.42e-12
|
|||||||||
AAA | pfam00004 | ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
34-185 | 2.50e-12 | |||||
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 62.61 E-value: 2.50e-12
|
|||||||||
COG1223 | COG1223 | Predicted ATPase, AAA+ superfamily [General function prediction only]; |
34-195 | 1.15e-10 | |||||
Predicted ATPase, AAA+ superfamily [General function prediction only]; Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 60.28 E-value: 1.15e-10
|
|||||||||
RecA-like_protease | cd19481 | proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
16-176 | 6.05e-10 | |||||
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 56.91 E-value: 6.05e-10
|
|||||||||
AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
32-186 | 4.21e-09 | |||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 54.30 E-value: 4.21e-09
|
|||||||||
AAA_5 | pfam07728 | AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
33-177 | 1.76e-08 | |||||
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 51.91 E-value: 1.76e-08
|
|||||||||
RPT1 | COG1222 | ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ... |
38-197 | 1.48e-07 | |||||
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 51.93 E-value: 1.48e-07
|
|||||||||
RecA-like_ClpB_Hsp104-like | cd19499 | Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ... |
23-176 | 6.99e-06 | |||||
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410907 [Multi-domain] Cd Length: 178 Bit Score: 45.63 E-value: 6.99e-06
|
|||||||||
AAA_2 | pfam07724 | AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ... |
35-139 | 9.16e-06 | |||||
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400187 [Multi-domain] Cd Length: 168 Bit Score: 44.88 E-value: 9.16e-06
|
|||||||||
RecA-like_ATAD1 | cd19520 | ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ... |
31-176 | 3.27e-05 | |||||
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410928 [Multi-domain] Cd Length: 166 Bit Score: 43.18 E-value: 3.27e-05
|
|||||||||
RecA-like_CDC48_NLV2_r1-like | cd19503 | first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ... |
32-123 | 7.43e-05 | |||||
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 42.28 E-value: 7.43e-05
|
|||||||||
hflB | PRK10733 | ATP-dependent zinc metalloprotease FtsH; |
25-206 | 2.04e-04 | |||||
ATP-dependent zinc metalloprotease FtsH; Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 42.71 E-value: 2.04e-04
|
|||||||||
ruvB | PRK00080 | Holliday junction branch migration DNA helicase RuvB; |
12-122 | 2.96e-04 | |||||
Holliday junction branch migration DNA helicase RuvB; Pssm-ID: 234619 [Multi-domain] Cd Length: 328 Bit Score: 41.65 E-value: 2.96e-04
|
|||||||||
clpA | PRK11034 | ATP-dependent Clp protease ATP-binding subunit; Provisional |
10-156 | 3.12e-04 | |||||
ATP-dependent Clp protease ATP-binding subunit; Provisional Pssm-ID: 236828 [Multi-domain] Cd Length: 758 Bit Score: 42.13 E-value: 3.12e-04
|
|||||||||
AcoR | COG3284 | Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription]; |
25-54 | 9.81e-04 | |||||
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription]; Pssm-ID: 442514 [Multi-domain] Cd Length: 625 Bit Score: 40.27 E-value: 9.81e-04
|
|||||||||
DEXXQc_UPF1 | cd18039 | DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
23-45 | 2.52e-03 | |||||
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 38.38 E-value: 2.52e-03
|
|||||||||
TIP49 | pfam06068 | TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ... |
24-58 | 2.54e-03 | |||||
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases. Pssm-ID: 399217 [Multi-domain] Cd Length: 347 Bit Score: 38.83 E-value: 2.54e-03
|
|||||||||
CDC6 | COG1474 | Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; |
34-137 | 2.71e-03 | |||||
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; Pssm-ID: 441083 [Multi-domain] Cd Length: 389 Bit Score: 38.68 E-value: 2.71e-03
|
|||||||||
Fap7 | COG1936 | Broad-specificity NMP kinase [Nucleotide transport and metabolism]; |
34-86 | 2.96e-03 | |||||
Broad-specificity NMP kinase [Nucleotide transport and metabolism]; Pssm-ID: 441539 [Multi-domain] Cd Length: 173 Bit Score: 37.49 E-value: 2.96e-03
|
|||||||||
PRK13342 | PRK13342 | recombination factor protein RarA; Reviewed |
38-122 | 4.82e-03 | |||||
recombination factor protein RarA; Reviewed Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 38.14 E-value: 4.82e-03
|
|||||||||
RecA-like_PEX1_r2 | cd19526 | second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ... |
30-61 | 8.23e-03 | |||||
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410934 [Multi-domain] Cd Length: 158 Bit Score: 36.25 E-value: 8.23e-03
|
|||||||||
PspF | COG1221 | Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ... |
16-49 | 9.16e-03 | |||||
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms]; Pssm-ID: 440834 [Multi-domain] Cd Length: 835 Bit Score: 37.39 E-value: 9.16e-03
|
|||||||||
Blast search parameters | ||||
|