NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|66805061|ref|XP_636263|]
View 

succinate-CoA ligase [Dictyostelium discoideum AX4]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-313 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 558.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    1 MISAGMIARNFGKRFFSTKPSVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHL--DLPVFNTVKE 78
Cdd:PTZ00187   3 GAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   79 AKEATGANATVIYVPPPHAAAAIKEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQNKTRLIGPNCPGIIKPGECKIGIM 158
Cdd:PTZ00187  83 AKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  159 PGHIHKPGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEA 238
Cdd:PTZ00187 163 PGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEA 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66805061  239 AQWLIDNPTDKPVVSFIAGLSAPPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKMNEKK 313
Cdd:PTZ00187 243 AEWIKNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-313 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 558.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    1 MISAGMIARNFGKRFFSTKPSVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHL--DLPVFNTVKE 78
Cdd:PTZ00187   3 GAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   79 AKEATGANATVIYVPPPHAAAAIKEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQNKTRLIGPNCPGIIKPGECKIGIM 158
Cdd:PTZ00187  83 AKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  159 PGHIHKPGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEA 238
Cdd:PTZ00187 163 PGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEA 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66805061  239 AQWLIDNPTDKPVVSFIAGLSAPPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKMNEKK 313
Cdd:PTZ00187 243 AEWIKNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 21-309 4.08e-174

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 483.41  E-value: 4.08e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  21 SVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAA 100
Cdd:COG0074   1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061 101 IKEAIDAEMELVVCITEGIPQQDMVKVKYLLnKQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGTLTYE 180
Cdd:COG0074  81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYA-KAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061 181 AVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTdKPVVSFIAGLSA 260
Cdd:COG0074 160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT-KPVVAYIAGRTA 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66805061 261 PPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKM 309
Cdd:COG0074 239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 22-306 5.43e-159

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 444.94  E-value: 5.43e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    22 VLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAAI 101
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   102 KEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQnKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGTLTYEA 181
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEES-GTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   182 VAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTdKPVVSFIAGLSAP 261
Cdd:TIGR01019 160 VHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS-KPVVGFIAGATAP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 66805061   262 PGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETIL 306
Cdd:TIGR01019 239 PGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLA 283
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 25-118 5.67e-34

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 119.62  E-value: 5.67e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    25 NKHTKVICQGFTGN--QGT-FHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAAI 101
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 66805061   102 KEAIDAEMELVVCITEG 118
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 23-119 1.44e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.77  E-value: 1.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061     23 LINKHTKVICQGFTGNQGTFHSKQAI---EYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAA 99
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRnllEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 66805061    100 AIKEAIDAEMELVVCITEGI 119
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-313 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 558.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    1 MISAGMIARNFGKRFFSTKPSVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHL--DLPVFNTVKE 78
Cdd:PTZ00187   3 GAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   79 AKEATGANATVIYVPPPHAAAAIKEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQNKTRLIGPNCPGIIKPGECKIGIM 158
Cdd:PTZ00187  83 AKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  159 PGHIHKPGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEA 238
Cdd:PTZ00187 163 PGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEA 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66805061  239 AQWLIDNPTDKPVVSFIAGLSAPPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKMNEKK 313
Cdd:PTZ00187 243 AEWIKNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 21-309 4.08e-174

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 483.41  E-value: 4.08e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  21 SVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAA 100
Cdd:COG0074   1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061 101 IKEAIDAEMELVVCITEGIPQQDMVKVKYLLnKQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGTLTYE 180
Cdd:COG0074  81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYA-KAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061 181 AVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTdKPVVSFIAGLSA 260
Cdd:COG0074 160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT-KPVVAYIAGRTA 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66805061 261 PPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKM 309
Cdd:COG0074 239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 21-312 1.45e-173

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 481.98  E-value: 1.45e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   21 SVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAA 100
Cdd:PRK05678   2 SILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  101 IKEAIDAEMELVVCITEGIPQQDMVKVKYLLnKQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGTLTYE 180
Cdd:PRK05678  82 ILEAIDAGIDLIVCITEGIPVLDMLEVKAYL-ERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  181 AVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTdKPVVSFIAGLSA 260
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVT-KPVVGYIAGVTA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 66805061  261 PPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKMNEK 312
Cdd:PRK05678 240 PPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 17-313 3.06e-167

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 466.75  E-value: 3.06e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   17 STKPSVLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPH 96
Cdd:PLN00125   2 SPPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   97 AAAAIKEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGT 176
Cdd:PLN00125  82 AAAAILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  177 LTYEAVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTDKPVVSFIA 256
Cdd:PLN00125 162 LTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGTEKPVVAFIA 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 66805061  257 GLSAPPGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETILQKMNEKK 313
Cdd:PLN00125 242 GLTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERG 298
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 22-306 5.43e-159

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 444.94  E-value: 5.43e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    22 VLINKHTKVICQGFTGNQGTFHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAAI 101
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   102 KEAIDAEMELVVCITEGIPQQDMVKVKYLLNKQnKTRLIGPNCPGIIKPGECKIGIMPGHIHKPGKIGIVSRSGTLTYEA 181
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEES-GTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   182 VAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTdKPVVSFIAGLSAP 261
Cdd:TIGR01019 160 VHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS-KPVVGFIAGATAP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 66805061   262 PGRRMGHAGAIISGGKGDANSKIEALKAAGVTVTFSPAKLGETIL 306
Cdd:TIGR01019 239 PGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLA 283
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 25-118 5.67e-34

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 119.62  E-value: 5.67e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061    25 NKHTKVICQGFTGN--QGT-FHSKQAIEYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAAAI 101
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 66805061   102 KEAIDAEMELVVCITEG 118
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 23-119 1.44e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.77  E-value: 1.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061     23 LINKHTKVICQGFTGNQGTFHSKQAI---EYGTNMVGGVSPGKGGQKHLDLPVFNTVKEAKEATGANATVIYVPPPHAAA 99
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRnllEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 66805061    100 AIKEAIDAEMELVVCITEGI 119
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 171-292 1.65e-24

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 96.17  E-value: 1.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   171 VSRSGTLTYEAVAQTTAVGLGQSTCIGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLID-----N 245
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDPAGGLLKaikeaR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 66805061   246 PTDKPVVSFIAGLSAPPGRRMGHAGAIISGGKGDANSKIEALKAAGV 292
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 56-305 1.12e-20

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 92.19  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   56 GGVSPGKG-------GQKHLDLPVFNTVKEA-KEATGANATVIYVPPPHAAAAIKEAIDAE-MELVVCITEGIPQQDMVK 126
Cdd:PLN02522  42 GIINPGSEgfqklffGQEEIAIPVHGSIEAAcKAHPTADVFINFASFRSAAASSMEALKQPtIRVVAIIAEGVPESDTKQ 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  127 VKYLLNKQNKTrLIGPNCPGIIKPGECKIG--------IMPGHIHKPGKIGIVSRSGTLT---YEAVAQTTAvglGQSTC 195
Cdd:PLN02522 122 LIAYARANNKV-VIGPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSnemYNVIARVTD---GIYEG 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  196 IGIGGDPFNGTNFIDCLKMFTQDPQTEGIILIGEIGGEAEEEAAQWLIDNPTDKPVVSFIAGLSA---PPGRRMGHAGAI 272
Cdd:PLN02522 198 IAIGGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALKQGKVSKPVVAWVSGTCArlfKSEVQFGHAGAK 277

                        250       260       270
                 ....*....|....*....|....*....|...
gi 66805061  273 ISGGKGDANSKIEALKAAGVTVTFSPAKLGETI 305
Cdd:PLN02522 278 SGGDMESAQAKNKALKDAGAIVPTSFEALEAAI 310
PRK06091 PRK06091
membrane protein FdrA; Validated
 61-221 3.29e-09

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 57.75  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061   61 GKGGQKHLDLPVFNTVKEAKE-ATGANATVIYVPPPHAAAAIKEAIDAEMElVVCITEGIPQQDMVKVKyllNKQNKTRL 139
Cdd:PRK06091  93 AQGSGSSQSLTQVRRWDSACQkLPDANLALISVAGEYAAELAEQALDRNLN-VMMFSDNVTLEDEIRLK---TRAREKGL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66805061  140 I--GPNCpgiikpGECKIGIMP---GHIHKPGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGGDPFN----GTNFID 210
Cdd:PRK06091 169 LvmGPDC------GTAMIAGTPlafANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSaevgGISALT 242

                        170
                 ....*....|.
gi 66805061  211 CLKMFTQDPQT 221
Cdd:PRK06091 243 ALEMLSADEKS 253
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 165-221 2.05e-04

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 40.53  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66805061   165 PGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGgdpfNGT--NFIDCLKMFTQDPQT 221
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPET 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH