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Conserved domains on  [gi|58260980|ref|XP_567900|]
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hypothetical protein CNK03070 [Cryptococcus neoformans var. neoformans JEC21]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
65-90 6.12e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.60  E-value: 6.12e-07
                           10        20
                   ....*....|....*....|....*.
gi 58260980     65 YLKRHQRKHQDDRPFQCKDCSKAFAR 90
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
fungal_TF_MHR super family cl23766
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 669-784 2.80e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


The actual alignment was detected with superfamily member pfam04082:

Pssm-ID: 419994  Cd Length: 262  Bit Score: 47.10  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980    669 RASANMFLGTIVNVTRQIGFftseNDHyaqtirvpeepytPNELDRCWREWI-QLETRRRTAYLVYQLDTISALESNIPC 747
Cdd:pfam04082  110 RKLHWRYHGLAIRLARSLGL----HRD-------------PSYVSPSWKLWIeEAELRRRLFWACFYLDRLISLILGRPP 172

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 58260980    748 ILSpCEVAHIPLPAPD-TLWKAPTAEAWLKAVKKYRPM 784
Cdd:pfam04082  173 LLS-DSDIDLPLPCDDdDLWESDSADEVTLPLISLESK 209
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 49-73 4.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.98e-03
                           10        20
                   ....*....|....*....|....*
gi 58260980     49 FACtfPGCGQTYSRMEYLKRHQRKH 73
Cdd:pfam00096    1 YKC--PDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
65-90 6.12e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.60  E-value: 6.12e-07
                           10        20
                   ....*....|....*....|....*.
gi 58260980     65 YLKRHQRKHQDDRPFQCKDCSKAFAR 90
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 669-784 2.80e-05

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 47.10  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980    669 RASANMFLGTIVNVTRQIGFftseNDHyaqtirvpeepytPNELDRCWREWI-QLETRRRTAYLVYQLDTISALESNIPC 747
Cdd:pfam04082  110 RKLHWRYHGLAIRLARSLGL----HRD-------------PSYVSPSWKLWIeEAELRRRLFWACFYLDRLISLILGRPP 172

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 58260980    748 ILSpCEVAHIPLPAPD-TLWKAPTAEAWLKAVKKYRPM 784
Cdd:pfam04082  173 LLS-DSDIDLPLPCDDdDLWESDSADEVTLPLISLESK 209
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 635-770 6.61e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 46.67  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980  635 SLAKGVLMTEYNVALLQALILYHapnFLSEDERERASANMFLGTIVnvtrqigfftsendHYAQTIRVPEEPYTPNELDr 714
Cdd:cd12148   85 QLLDLALFLPPSLETLQALLLLA---LYLLGTGDPSSAWLLLGLAI--------------RLAQSLGLHRDPSSLPGLS- 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 58260980  715 cwreWIQLETRRRTAYLVYQLDTISALESNIPCILSPCEVaHIPLPAPDTLWKAPT 770
Cdd:cd12148  147 ----PFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDI-DVPLPSNEDDELSPS 197
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 646-763 1.37e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 38.97  E-value: 1.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980     646 NVALLQALILYhapnFLSEDERERASANMFLGTIVNVTRQIGFftsendHYaqtirvpEEPYTPNELdrcwrewiqLETR 725
Cdd:smart00906    1 SLETVQALLLA----LLSLYLGGRDAAWMLLGLAIRLAQALGL------HR-------DPSNSDLEE---------RERR 54

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 58260980     726 RRTAYLVYQLDTISALESNIPCILSPCEVaHIPLPAPD 763
Cdd:smart00906   55 RRRFWWLYILDRLLSLSLGRPPLIDDDDI-DVPLPSDL 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 49-73 4.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.98e-03
                           10        20
                   ....*....|....*....|....*
gi 58260980     49 FACtfPGCGQTYSRMEYLKRHQRKH 73
Cdd:pfam00096    1 YKC--PDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
65-90 6.12e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.60  E-value: 6.12e-07
                           10        20
                   ....*....|....*....|....*.
gi 58260980     65 YLKRHQRKHQDDRPFQCKDCSKAFAR 90
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 669-784 2.80e-05

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 47.10  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980    669 RASANMFLGTIVNVTRQIGFftseNDHyaqtirvpeepytPNELDRCWREWI-QLETRRRTAYLVYQLDTISALESNIPC 747
Cdd:pfam04082  110 RKLHWRYHGLAIRLARSLGL----HRD-------------PSYVSPSWKLWIeEAELRRRLFWACFYLDRLISLILGRPP 172

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 58260980    748 ILSpCEVAHIPLPAPD-TLWKAPTAEAWLKAVKKYRPM 784
Cdd:pfam04082  173 LLS-DSDIDLPLPCDDdDLWESDSADEVTLPLISLESK 209
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 635-770 6.61e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 46.67  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980  635 SLAKGVLMTEYNVALLQALILYHapnFLSEDERERASANMFLGTIVnvtrqigfftsendHYAQTIRVPEEPYTPNELDr 714
Cdd:cd12148   85 QLLDLALFLPPSLETLQALLLLA---LYLLGTGDPSSAWLLLGLAI--------------RLAQSLGLHRDPSSLPGLS- 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 58260980  715 cwreWIQLETRRRTAYLVYQLDTISALESNIPCILSPCEVaHIPLPAPDTLWKAPT 770
Cdd:cd12148  147 ----PFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDI-DVPLPSNEDDELSPS 197
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 646-763 1.37e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 38.97  E-value: 1.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58260980     646 NVALLQALILYhapnFLSEDERERASANMFLGTIVNVTRQIGFftsendHYaqtirvpEEPYTPNELdrcwrewiqLETR 725
Cdd:smart00906    1 SLETVQALLLA----LLSLYLGGRDAAWMLLGLAIRLAQALGL------HR-------DPSNSDLEE---------RERR 54

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 58260980     726 RRTAYLVYQLDTISALESNIPCILSPCEVaHIPLPAPD 763
Cdd:smart00906   55 RRRFWWLYILDRLLSLSLGRPPLIDDDDI-DVPLPSDL 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 79-102 4.43e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.43e-03
                           10        20
                   ....*....|....*....|....
gi 58260980     79 FQCKDCSKAFARSDVLLRHRRRcH 102
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT-H 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 49-73 4.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.98e-03
                           10        20
                   ....*....|....*....|....*
gi 58260980     49 FACtfPGCGQTYSRMEYLKRHQRKH 73
Cdd:pfam00096    1 YKC--PDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 45-114 7.80e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 7.80e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58260980     45 EKETFACTFPGCGQTYSRMEYLKRHQRKH-QDDRPFQCKDCSKAFARSDVLLRHRRRChptpppVDHSTSP 114
Cdd:pfam15909   32 EGKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKCENCLLRFRTHRSLFKHLHVC------AEHAQSP 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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