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Conserved domains on  [gi|294659792|ref|XP_462217|]
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DEHA2G15510p [Debaryomyces hansenii CBS767]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
67-493 6.51e-52

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17352:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 180.06  E-value: 6.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIQSYVSSHQlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGG 146
Cdd:cd17352    4 VVFASFLVNFFTDGILNSFGVLFVELLEEF--GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 147 FMATANCTKVWQFILSF-ICVGTGHGLCITPLVGVVSqHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSI 225
Cdd:cd17352   82 LLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 226 RILGFFCLACMICAMLLArekyctdlipmdsastdyeemnkrkkfkaasknilsfnALRDIKYSFLIIGVFFGELALMLI 305
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR--------------------------------------LLKDPTFVLLALGVSFAMLGFFVP 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 306 VTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMAD---IWGPYNVMILMLIClDISIMVVWLPFgsNVGVLYAF 382
Cdd:cd17352  203 FVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkprIGRLYLYIFTLLIL-GLSLLAFPLAT--TYVGLIVF 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 383 AALSGAFSASILSLlpvslssvtiysikkvkvtkqqNPFVEGEVESTEvryplEFGQKYGLLYFFVSLGNLFGIPIASAV 462
Cdd:cd17352  280 SVLFGFCSGSYSSL----------------------TPVILADLVGLE-----KLSNAYGLVLLFQGLAALVGPPIAGLL 332
                        410       420       430
                 ....*....|....*....|....*....|.
gi 294659792 463 IGdqSKHNYDMFVLLSGIFAIIGTVFWIISR 493
Cdd:cd17352  333 RD--YTGDYDAAFYFCGACLLLSGVLLFLLP 361
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
67-493 6.51e-52

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 180.06  E-value: 6.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIQSYVSSHQlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGG 146
Cdd:cd17352    4 VVFASFLVNFFTDGILNSFGVLFVELLEEF--GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 147 FMATANCTKVWQFILSF-ICVGTGHGLCITPLVGVVSqHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSI 225
Cdd:cd17352   82 LLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 226 RILGFFCLACMICAMLLArekyctdlipmdsastdyeemnkrkkfkaasknilsfnALRDIKYSFLIIGVFFGELALMLI 305
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR--------------------------------------LLKDPTFVLLALGVSFAMLGFFVP 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 306 VTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMAD---IWGPYNVMILMLIClDISIMVVWLPFgsNVGVLYAF 382
Cdd:cd17352  203 FVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkprIGRLYLYIFTLLIL-GLSLLAFPLAT--TYVGLIVF 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 383 AALSGAFSASILSLlpvslssvtiysikkvkvtkqqNPFVEGEVESTEvryplEFGQKYGLLYFFVSLGNLFGIPIASAV 462
Cdd:cd17352  280 SVLFGFCSGSYSSL----------------------TPVILADLVGLE-----KLSNAYGLVLLFQGLAALVGPPIAGLL 332
                        410       420       430
                 ....*....|....*....|....*....|.
gi 294659792 463 IGdqSKHNYDMFVLLSGIFAIIGTVFWIISR 493
Cdd:cd17352  333 RD--YTGDYDAAFYFCGACLLLSGVLLFLLP 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
54-393 1.04e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 87.34  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  54 PSEEPTNGLKAYSVVIGSFLGLIANFGVLNSIGAIQSYVsshqlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSF 133
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL------GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 134 TPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLR 213
Cdd:COG2814   76 RVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 214 SLFPKVGFAWSIRILGFFCLACMICAMLLAREkyctdlipmdsastdyeemnkRKKFKAASKNILSFNALRDIKYSFLII 293
Cdd:COG2814  156 LLADLFGWRWVFLVNAVLALLALLLLLRLLPE---------------------SRPAARARLRGSLRELLRRPRLLLLLL 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 294 GVFFGELALMLIVTYYASYAIAQ-GMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLdiSIMVVWLPF 372
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL--ALGLLLLAL 292
                        330       340
                 ....*....|....*....|.
gi 294659792 373 GSNVGVLYAFAALSGAFSASI 393
Cdd:COG2814  293 AGSLWLLLLALFLLGFGFGLL 313
MFS_1 pfam07690
Major Facilitator Superfamily;
72-393 2.80e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.07  E-value: 2.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   72 FLGLIANFGVLNSIGAIQSYVSSHQLkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGGFMATA 151
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  152 NCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFF 231
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  232 CLACMICAMLLAREKyctdlipmdsastdyEEMNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYAS 311
Cdd:pfam07690 161 SLLAAVLLLLPRPPP---------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  312 YAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDI-SIMVVWLPFGSNVGVLYAFAALSGAFS 390
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaALGLLLLSLTLSSLWLLLALLLLGFGF 305

                  ...
gi 294659792  391 ASI 393
Cdd:pfam07690 306 GLV 308
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
54-345 1.02e-06

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 51.28  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   54 PSEEPTNGLKAYSVVIGSFLGLIANFGVLNSIGaiqsyVSSHQLKDI---ETSSISWIFSIYMYLSFAIGIIVGPIFVMK 130
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVT-----VFFKELQQIfqaTYSETAWISSIMLAVLYAGGPISSILVNRF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  131 GSFTPLLYGTVLIVGGFMATANCTKVWQFILSfICVGTGHGLCIT--PLVGVVSQHWTANAIgRATGFATIGGSIGGVIL 208
Cdd:TIGR00892  82 GCRPVVIAGGLLASLGMILASFSSNVIELYLT-AGFITGLGLAFNfqPSLTMLGKYFYRRRP-LANGLAMAGSPVFLSTL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  209 PLMLRSLFPKVGFAWSIRILGFFCLACMICAMLL-------AREKYCT-DLIPMDSAStdyEEMNKRKKFKAASKnILSF 280
Cdd:TIGR00892 160 APLNQYLFESFGWRGSFLILGGLLLHCCVCGALMrpvgpsqRVSKSKSkEGLPPDGST---KKLSKKSTAEKINR-FLDF 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 294659792  281 NALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFN--------ACGVLG--RWIPGHMA 345
Cdd:TIGR00892 236 SLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGfvdifarpSCGLIAglKWIRPHVQ 310
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
67-493 6.51e-52

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 180.06  E-value: 6.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIQSYVSSHQlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGG 146
Cdd:cd17352    4 VVFASFLVNFFTDGILNSFGVLFVELLEEF--GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 147 FMATANCTKVWQFILSF-ICVGTGHGLCITPLVGVVSqHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSI 225
Cdd:cd17352   82 LLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 226 RILGFFCLACMICAMLLArekyctdlipmdsastdyeemnkrkkfkaasknilsfnALRDIKYSFLIIGVFFGELALMLI 305
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR--------------------------------------LLKDPTFVLLALGVSFAMLGFFVP 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 306 VTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMAD---IWGPYNVMILMLIClDISIMVVWLPFgsNVGVLYAF 382
Cdd:cd17352  203 FVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkprIGRLYLYIFTLLIL-GLSLLAFPLAT--TYVGLIVF 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 383 AALSGAFSASILSLlpvslssvtiysikkvkvtkqqNPFVEGEVESTEvryplEFGQKYGLLYFFVSLGNLFGIPIASAV 462
Cdd:cd17352  280 SVLFGFCSGSYSSL----------------------TPVILADLVGLE-----KLSNAYGLVLLFQGLAALVGPPIAGLL 332
                        410       420       430
                 ....*....|....*....|....*....|.
gi 294659792 463 IGdqSKHNYDMFVLLSGIFAIIGTVFWIISR 493
Cdd:cd17352  333 RD--YTGDYDAAFYFCGACLLLSGVLLFLLP 361
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
67-393 2.39e-22

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 98.88  E-value: 2.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIqsYVSSHQLKDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGG 146
Cdd:cd17355    4 VLAVTFLILILSWGIRYYFGVF--IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 147 FMATANCTKVWQFILSF-ICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSI 225
Cdd:cd17355   82 LVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 226 RILGFFCLACMICAMLLAREKYCTDLIPMDSASTDYEEMNKRKKfkaasknilsfnALRDIKYSFLIIGVFFGELALMLI 305
Cdd:cd17355  162 LVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKE------------ALRSASFWLLALAFFLCGFAVVGL 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 306 VTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPynVMILMLICLDISIMVVWLPFGSNVG-VLYAFAA 384
Cdd:cd17355  230 IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP--RRLLAASYALRALGLALLLLLPFPPlALLLFAA 307

                 ....*....
gi 294659792 385 LSGAFSASI 393
Cdd:cd17355  308 LFGLGWGAT 316
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
54-393 1.04e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 87.34  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  54 PSEEPTNGLKAYSVVIGSFLGLIANFGVLNSIGAIQSYVsshqlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSF 133
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL------GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 134 TPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLR 213
Cdd:COG2814   76 RVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 214 SLFPKVGFAWSIRILGFFCLACMICAMLLAREkyctdlipmdsastdyeemnkRKKFKAASKNILSFNALRDIKYSFLII 293
Cdd:COG2814  156 LLADLFGWRWVFLVNAVLALLALLLLLRLLPE---------------------SRPAARARLRGSLRELLRRPRLLLLLL 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 294 GVFFGELALMLIVTYYASYAIAQ-GMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLdiSIMVVWLPF 372
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL--ALGLLLLAL 292
                        330       340
                 ....*....|....*....|.
gi 294659792 373 GSNVGVLYAFAALSGAFSASI 393
Cdd:COG2814  293 AGSLWLLLLALFLLGFGFGLL 313
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
57-393 5.08e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 85.69  E-value: 5.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  57 EPTNGLKAYSVVIGSFLGLIANFGVLNSIGAIQSYVSSHQlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPL 136
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 137 LYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLF 216
Cdd:COG2271   79 AIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 217 PKVGFAWSIRILGFFCLACMICAMLLarekyctdlipmdsastdyeemnkrkkfkaasknilsfnalrdikysfLIIGVF 296
Cdd:COG2271  159 AAFGWRAAFLILGLPGLLLALLRFWL------------------------------------------------LALAYF 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 297 FGELALMLIVTYYASYAI-AQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWLPFGSN 375
Cdd:COG2271  191 LVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPS 270
                        330
                 ....*....|....*...
gi 294659792 376 VGVLYAFAALSGAFSASI 393
Cdd:COG2271  271 PALAIALLFLAGFGLGGA 288
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
63-493 9.01e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.93  E-value: 9.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  63 KAYSVVIGSFLGLIANFGVLNSIGAIQSYVSshQLKDIETSSISWIFSIYMyLSFAIGIIVGPIFVMK-GSFTPLLYGTV 141
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLA--EEFGLSAAQLGLLFAIPV-LVGALLRIPLGFLVDRfGPRRVLLIGLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 142 LIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGF 221
Cdd:COG2223   79 LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 222 AWSIRILGFFCLACMICAMLLAREKYCTDLIPMDSASTDYEEMNKRKKFkaasknilsfnalrdIKYSFLIIGVFFGELA 301
Cdd:COG2223  159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF---------------WLLSLLYFGTFGSFIG 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 302 LMLIVTYYasYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWLPFGSNVGVLYA 381
Cdd:COG2223  224 FSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 382 FAALSGAFSASILsllpvslssvTIYSIkkvkvtkqqnpfvegevesTEVRYPL-EFGQKYGLLYFFVSLGNLFGIPIAS 460
Cdd:COG2223  302 FLLLGLALGGGNG----------AVFAL-------------------VPDIFPTkNAGAVYGLVGAAGGLGGFLGPLLFG 352
                        410       420       430
                 ....*....|....*....|....*....|...
gi 294659792 461 AVIgdQSKHNYDMFVLLSGIFAIIGTVFWIISR 493
Cdd:COG2223  353 ALL--DATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_1 pfam07690
Major Facilitator Superfamily;
72-393 2.80e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.07  E-value: 2.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   72 FLGLIANFGVLNSIGAIQSYVSSHQLkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGGFMATA 151
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  152 NCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFF 231
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  232 CLACMICAMLLAREKyctdlipmdsastdyEEMNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYAS 311
Cdd:pfam07690 161 SLLAAVLLLLPRPPP---------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  312 YAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDI-SIMVVWLPFGSNVGVLYAFAALSGAFS 390
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaALGLLLLSLTLSSLWLLLALLLLGFGF 305

                  ...
gi 294659792  391 ASI 393
Cdd:pfam07690 306 GLV 308
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
103-393 7.25e-14

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 73.37  E-value: 7.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 103 SSISWIFSIYMyLSFAIGIIVGPIFVMK-GSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVV 181
Cdd:COG2807   53 TQAGLLTTLPL-LAFGLFAPLAPRLARRfGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 182 SqHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFFCLACMICAMLLAREkyctdlipmdsastdy 261
Cdd:COG2807  132 K-RWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR---------------- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 262 eemnKRKKFKAASKNILSFNALRDIKysFLIIGVFFG--ELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRW 339
Cdd:COG2807  195 ----RPAAAAAAPAAASLRSLWRSPL--AWLLTLFFGlqSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSL 268
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 294659792 340 IPGHMAD-IWGPYNVMILMLICLDISIMVVWLPFGSnvgVLYAFAALSGAFSASI 393
Cdd:COG2807  269 LVPLLADrLGDRRPLLLLLGLLGLAGLLGLLLAPGS---LPWLWAVLLGLGQGGL 320
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
64-389 1.23e-11

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 66.40  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  64 AYSVVIGSFLGLIANFGVLNSIGAIQSYVSSH--QLKDIETSS-ISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGT 140
Cdd:cd17420    1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERltKLGDPEASFkAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 141 VLIVGGFMATANCTKVWQFILSF-ICVGTGHGLCITPLVgVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKV 219
Cdd:cd17420   81 AVSFGGLLLSSFCSSIGALYFTYgIMFGCGCSFAYQPSL-VILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 220 GFAWSIRILGFFCLACMICAMLLArekyctdliPMDSASTDYEEMNKR----KKFKAASKNILSFNALRDIKYSFLIIGV 295
Cdd:cd17420  160 GLEGTLRVLSLFMFVLILCSFTYR---------PLHPSPEDPKSKPGRrtlhSRINLFLRKIFNVEIFKRKRYVIWALGI 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 296 FFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMAD-IWGPYNVMILMLICLDISIMVVWLPFGS 374
Cdd:cd17420  231 PLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADmPPGVKKMYLQVLSFVSIGLMSMMIPLCN 310
                        330
                 ....*....|....*
gi 294659792 375 NVGVLYAFAALSGAF 389
Cdd:cd17420  311 SFGILISVCLVMGLF 325
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
105-493 1.30e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.06  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 105 ISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQH 184
Cdd:cd17325   33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 185 WTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFFCLACMICAMLLAREKyctdlipmdsastdyEEM 264
Cdd:cd17325  113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP---------------RPP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 265 NKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQ-GMSESAAYILLTIFNACGVLGRWIPGH 343
Cdd:cd17325  178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGK 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 344 MADIWGPYNVMILMLICldISIMVVWLPFGSNVGVLYAFAALSGAFSASILSLLpvslssvtiysikkvkvtkqqNPFVe 423
Cdd:cd17325  258 LSDRIGRKPLILIGLLL--SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT---------------------LALL- 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 424 geveSTEVRyPLEFGQKYGLLYFFVSLGNLFGiPIASAVIGDQSKHNYDMfvLLSGIFAIIGTVFWIISR 493
Cdd:cd17325  314 ----ADIVP-PEGRGTAMGLFNTAFSLGMVLG-PLLGGFLYDAFGFATPF--LAAAALLLLAAVLFLLLR 375
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
131-393 1.62e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 66.08  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 131 GSFTP-LLYGTVLIVGGFMATANC------TKVWQFILSFICVGTGHGLCITP---LVGVVSQhwTANAIGRATGFATIG 200
Cdd:COG2211   78 GRRRPwILIGAIPLALSFVLLFTApdlsptGKLIYALVTYLLLGLAYTLVNIPysaLGAELTP--DYEERTRLSSWRFAF 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 201 GSIGGVI---LPLMLRSLFPK---VGFAWSIRILGFFCLACMICAMLLAREKYctdlipmdsastdyEEMNKRKKFKAAS 274
Cdd:COG2211  156 AGLGGLLasvLPPPLVAAFGGdaaLGYRLTALIFAVLGLLAFLLTFFGTKERP--------------VPEEEKVSLKESL 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 275 KNILSFNALRdikysFLIIGVFFGELALMLI---VTYYASYAIaqGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPY 351
Cdd:COG2211  222 KALLKNRPFL-----LLLLAYLLFFLALALVaalLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKK 294
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 294659792 352 NVMILMLICLDISIMVVWLPFGSNVGVLYAFAALSGAFSASI 393
Cdd:COG2211  295 KAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAI 336
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
63-387 1.88e-11

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 65.71  E-value: 1.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  63 KAYSVVIGsFLGLIANFGVLNSIGAIQSYVSSHQlkDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVL 142
Cdd:cd17353    1 RRWLVLLG-AVLMHLILGYQYAWSVFNPPLSSAL--GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 143 IVGGFMATANCTKVWQFILSF-ICVGTGHGLCITPLVGVVsQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGF 221
Cdd:cd17353   78 FGLGFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTA-VKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 222 AWSIRILGFFCLACMICAMLLAREkyctdliPMDSaSTDYEEMNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELA 301
Cdd:cd17353  157 PTTFLILGIIFLIIIVIGAFLIRD-------PPKG-WVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATA 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 302 LMLIVTYYA----SYAIAQGMSESAAYILLTIFNAcgvLGRWIPGHMADIWGPYNVMILMLICLDISiMVVWLPFGSNVG 377
Cdd:cd17353  229 GLMLIGQAKpigqEFAGLDAGIAALAVSILSIFNG---GGRPFWGWLSDKIGRKNTLSIAFLIQGVA-MFLLPFIGSVAV 304
                        330
                 ....*....|
gi 294659792 378 VLYAFAALSG 387
Cdd:cd17353  305 LFVLGVALIG 314
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
96-489 2.07e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.44  E-value: 2.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  96 QLKDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCIT 175
Cdd:cd06174   24 QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 176 PLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLF--PKVGFAWSIRILGFFCLACMICAMLLAREKYCTDLIP 253
Cdd:cd06174  104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 254 MDSASTdyeemnkrkkfkaASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQGM-SESAAYILLTIFNA 332
Cdd:cd06174  184 NEEASS-------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGL 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 333 CGVLGRWIPGHMAD-IWGPYNVMILMLICLdiSIMVVWLPFGSNVGVLYAFAALSGAFSASILSLLPVSLssvtiysikk 411
Cdd:cd06174  251 AGALGSLLLGLLSDrLIGRKPLLLIGLLLM--ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI---------- 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 294659792 412 vkvtkqqnpfvegevesTEVRYPLEFGQKYGLLYFFVSLGNLFGiPIASAVIGDQSKHNYDMFVLLSGIFAIIGTVFW 489
Cdd:cd06174  319 -----------------AELFPPEIRGTAFGLLNTFGFLGGAIG-PLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
99-393 5.65e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 61.02  E-value: 5.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  99 DIETSSISWIFSIyMYLSFAIGIIVGPIFVMK-GSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLC---I 174
Cdd:COG0738   39 GLSDAQAGLLLFA-FFLGYLLASLPAGRLIDRfGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdvaA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 175 TPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPkVGFAWSIRILGFFCLACMICAMLLArekyctdlIPM 254
Cdd:COG0738  118 NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS-LSWHLPYLILAVLLLLLALLFLRSK--------LPE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 255 DSASTDyeemnkrkkfKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAI-AQGMSESAAYILLTIFNAC 333
Cdd:COG0738  189 IEEEEE----------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGG 258
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 334 GVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWlpFGSNVGVLYAFAALSGAFSASI 393
Cdd:COG0738  259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--LAPGPWLALIGLALVGLGLSLM 316
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
67-245 3.19e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.65  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIQSYVSS--HQLKDIETSSISWIFSIYMYLSFAIGIIVGPI--FVMKGSFTPLLYGTVL 142
Cdd:COG2271  178 ALLRFWLLALAYFLVYFALYGFLTWLPTylVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLsdRLGRRRKLVLAIGLLL 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 143 IVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFA 222
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
                        170       180
                 ....*....|....*....|...
gi 294659792 223 WSIRILGFFCLACMICAMLLARE 245
Cdd:COG2271  338 AAFLLLAALALLAALLALLLLRE 360
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
131-389 4.25e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 55.32  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 131 GSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGlCITPLVGVVSQHW-TANAIGRATGF----ATIGGSIGG 205
Cdd:cd17475   59 GERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG-SVQPGGGRAIMRWfPPRERGLAMGIrqtgVPLGGALAA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 206 VILPlmlrSLFPKVGFAWSIRILGFFCLACMICAMLLAREkyctdlipmdSASTDYEEMNKRKKFKAASKNILSFNALRD 285
Cdd:cd17475  138 ALLP----PLALHYGWRAAFVVAGLVSILAAVLFWLFYRE----------PPAASAATESASTLLRSLKEVLRNRDVWLI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 286 IKYSFLIIGVFFGelalmlIVTYYASYAIAQ-GMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYN----VMILMLIC 360
Cdd:cd17475  204 AIAGALLVAPQFA------LLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvLVITAAIA 277
                        250       260
                 ....*....|....*....|....*....
gi 294659792 361 LDISIMVVWLPFGSNVGVLYAFAALSGAF 389
Cdd:cd17475  278 AAALLVLSLLSPGTPLWLLVLLLILLGLF 306
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
96-393 7.18e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 54.63  E-value: 7.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  96 QLKDIETSSISWIFSIyMYLSFAIGIIVGPIFVMK-GSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGL-- 172
Cdd:cd17333   24 EAFNLNVADVSVIFSS-QNAGYLIGSLLAGFLMKRlGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIld 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 173 -CITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFpkvGFAWSIRILGFFCLACMICAMLlarekyctdl 251
Cdd:cd17333  103 tGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLIIGLIYLLLAILILL---------- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 252 ipmdsASTDYEEMNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAI-AQGMSESAAYILLTIF 330
Cdd:cd17333  170 -----TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVeKKHVSDGLAGYLLSGF 244
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 294659792 331 NACGVLGRWIPGHMADIWGPYNVmiLMLICLDISIMVVWLPFGSNVGVLYAFAALSGAFSASI 393
Cdd:cd17333  245 WVGITIGRLLGGPISRRIKPHTL--LVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAAL 305
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
47-237 9.55e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 9.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  47 EPIESQKPSEEPTNGLKAYSVVIGSFLGLIANFGVLN-SIGAIQSYVS--SHQLKDIETSSISWIFSIYMYLSFAIGIIV 123
Cdd:cd17325  176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAfAFGALEPFLPlyAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 124 GPIFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSI 203
Cdd:cd17325  256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
                        170       180       190
                 ....*....|....*....|....*....|....
gi 294659792 204 GGVILPLMLRSLFPKVGFAWSIRILGFFCLACMI 237
Cdd:cd17325  336 GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
99-391 1.01e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.09  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  99 DIETSSISWIFSIYMyLSFAIG-IIVGPIFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPL 177
Cdd:cd17324   30 GVSVAQAGLLVSAYA-LGYALGaLLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 178 VGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFFCLACMICAMLLarekyctdlipmdsa 257
Cdd:cd17324  109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL--------------- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 258 stdyeeMNKRKKFKAASKNILS--FNALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQ-GMSESAAYILLTIFNACG 334
Cdd:cd17324  174 ------LPSLPPKKPGSLGLLSslLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAG 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 294659792 335 VLGRWIPGHMADIWGPYNVMILMLICLdISIMVVWLPFGSNVGVLYAFAALSGAFSA 391
Cdd:cd17324  248 VVGSPLAGRLADRGGRRALLIALLLLA-AALLLLTLLGPSPLLLLVGLVLWGLGFFA 303
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
107-388 1.02e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.14  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 107 WIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGtvLIVGGFMATANCTKVWQ-------------------FILSFICVG 167
Cdd:cd17489    2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAG--LVVGLFTLAALLARPFAgrlldrfgrkrllliglliFALATLLYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 168 TG------------HGLCITpLVGVVSQHWTANAI-----GRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGF 230
Cdd:cd17489   80 LAtsvalllvlrliHGIGWG-AFTTAAATLVADIIppsrrGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 231 FCLACMICAMLLAREKyctdlipmdSASTDYEEMNKRKKFKAASKNILSFNalrdikysfliIGVFFGELALMLIVTYYA 310
Cdd:cd17489  159 LALLALLLVFLVKDPP---------PVAAEEAEAGTRAFRRLVEKKVLPPA-----------LILFLASIAYGAISTFLP 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 294659792 311 SYAIAQGMSESAayILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWlpFGSNVGVLYAFAALSGA 388
Cdd:cd17489  219 LYAAERGISNAG--LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS--FAGSPWMLLLAAVLYGL 292
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
64-246 2.11e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 2.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  64 AYSVVIGSFLGLIANFGVLnsigaiqsYVSSHQLKDIETSSISWIFSiymyLSFAIGIIVGPIFV--MKGSFTPLLYGTV 141
Cdd:COG2223  213 LYFGTFGSFIGFSSWLPPY--------LVDQFGLSAATAGLLAALFA----LLGALGRPLGGWLSdrIGGRRVLLIVFAL 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 142 LIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVG- 220
Cdd:COG2223  281 MALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGs 360
                        170       180
                 ....*....|....*....|....*.
gi 294659792 221 FAWSIRILGFFCLACMICAMLLAREK 246
Cdd:COG2223  361 YTAAFLVFAVLALVALVLTLLLYRRP 386
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
54-345 1.02e-06

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 51.28  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   54 PSEEPTNGLKAYSVVIGSFLGLIANFGVLNSIGaiqsyVSSHQLKDI---ETSSISWIFSIYMYLSFAIGIIVGPIFVMK 130
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVT-----VFFKELQQIfqaTYSETAWISSIMLAVLYAGGPISSILVNRF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  131 GSFTPLLYGTVLIVGGFMATANCTKVWQFILSfICVGTGHGLCIT--PLVGVVSQHWTANAIgRATGFATIGGSIGGVIL 208
Cdd:TIGR00892  82 GCRPVVIAGGLLASLGMILASFSSNVIELYLT-AGFITGLGLAFNfqPSLTMLGKYFYRRRP-LANGLAMAGSPVFLSTL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  209 PLMLRSLFPKVGFAWSIRILGFFCLACMICAMLL-------AREKYCT-DLIPMDSAStdyEEMNKRKKFKAASKnILSF 280
Cdd:TIGR00892 160 APLNQYLFESFGWRGSFLILGGLLLHCCVCGALMrpvgpsqRVSKSKSkEGLPPDGST---KKLSKKSTAEKINR-FLDF 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 294659792  281 NALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFN--------ACGVLG--RWIPGHMA 345
Cdd:TIGR00892 236 SLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGfvdifarpSCGLIAglKWIRPHVQ 310
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
157-393 1.44e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 50.25  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 157 WQFILSFICVGTGHGLcITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLfpkVGFAWSIRILGFFCLACM 236
Cdd:cd17478   85 WLLLLLVALAGIGSAA-FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL---VALFGGLGLLILLIIPGL 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 237 ICAMLLARekyctdlipmdsASTDYEEMNKRKKFKAASKNILSFNALrdiKYSFLIIGVFFGELALMLIVTYYASYAIAQ 316
Cdd:cd17478  161 AVALLLLR------------LRPLKKPEAKKAAAKSSARSTLKGVWR---ALLLLLIIVFLRSWVLSSLTTFLPFYLVQR 225
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294659792 317 GMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWLPFGSNVGVLYAFA--ALSGAFSASI 393
Cdd:cd17478  226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAgfLLFASFPVTV 304
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
84-393 1.89e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.86  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  84 SIGAIQSYVSSH-QLKDIETSSISWIFSIYmYLSFAIGIIVGPIFVMK-GSFTPLLYGTVLIVGGFMATANCTKVWQ-FI 160
Cdd:cd17477   11 GSGLLLPLLSLRlEREGVSTALIGLVASAY-YLGILLGSPLVPRLIRRvGHIRAFAAGAAITAVSVLLLALTDSPWVwFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 161 LSFIcvgtgHGLCITpLVGVVSQHW-----TANAIGRATGFATIGGSIGGVILPLMLrSLFPKVGFAWSIRILGFFCLAc 235
Cdd:cd17477   90 LRFV-----MGIGLA-GLFVVSESWlnalaTNENRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALPFLIAAVLLLLA- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 236 mICAMLLARekyctdlipmdSASTDYEEMNKRKKFKAASKNILSFnalrdikysfliIGVFFGELALMLIVTYYASYAIA 315
Cdd:cd17477  162 -LVPLLLTR-----------RAAPEIEEAESISLRRLLRIAPLAL------------LGAFVAGFLEGAFYSLLPLYGLR 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 294659792 316 QGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWLpFGSNVGVLYAFAALSGAFSASI 393
Cdd:cd17477  218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPL-VPGLPLALLVLLFLWGGAAGPL 294
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
46-391 2.43e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 49.66  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   46 TEPIESQKPSEeptnglKAYSVVIGSFLGLIANFGVLnsigAIQSYVSSHQLKD--IETSSISWIFSIYMyLSFAIGIIV 123
Cdd:TIGR00895   3 QNNIRKQPLSR------YQWRAIILSFLIMLMDGYDL----AAMGFAAPAISAEwgLDPVQLGFLFSAGL-IGMAFGALF 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  124 GPIFVMKGSFTPLLYGTVLIVGGFM-ATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGS 202
Cdd:TIGR00895  72 FGPLADRIGRRRVLLWSILLFSVFTlLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  203 IGGVILPLMLRSLFPKvgFAWsiRILgfFCLACMICAMLL---------------------AREKYCTDLIPMDSASTDY 261
Cdd:TIGR00895 152 IGAAVGGFLAGWLIPV--FGW--RSL--FYVGGIAPLLLLlllmrflpesidflvskrpetVRRIVNAIAPQMQAEAQSA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  262 EEMNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIP 341
Cdd:TIGR00895 226 LPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIF 305
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 294659792  342 GHMADIWGPyNVMILMLICLDISIMVVWLPFGSNVGVLYAfAALSGAFSA 391
Cdd:TIGR00895 306 GWLADRLGP-RVTALLLLLGAVFAVLVGSTLFSPTLLLLL-GAIAGFFVN 353
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
67-487 4.78e-05

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 45.48  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  67 VVIGSFLGLIANFGVLNSIGAIQSYVSSHQLKDIetSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGG 146
Cdd:cd17314    4 VLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSS--SQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 147 FMATA-NCTKVWQFILSFICVGTGHGLCITPLVGVVSQhWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSI 225
Cdd:cd17314   82 YTYLSyVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQ-YFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 226 RILGffclacmicaMLLAREKYCTDLIPMDSASTDYEEMNKRKKFKAASKNILSFNALRDIKYSFLiiGVFFGELALMLI 305
Cdd:cd17314  161 TILG----------ILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIF--LVLIGGFLFIAN 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 306 VTYYASyaIAQGMSESAAYILLTIFNACGVLGRWIPGHMAD--------IWGPYNVMILMLICLDISIM---VVWLPFGS 374
Cdd:cd17314  229 MASLVR--SLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADffggrlstLSILLTILGLGLCAFLFLLKmtpVGLVLTGS 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 375 NVGVLYAfaALSGAFSASILsllpvslssvTIYSIKKvkvtkqqnpfvegevestevrypleFGQKYGLLYFFVSLGNLF 454
Cdd:cd17314  307 LLGFSYG--GLFTVYPATVS----------TVFGTES-------------------------FATLYGILLFAPAIGSIL 349
                        410       420       430
                 ....*....|....*....|....*....|...
gi 294659792 455 GIPIASAVIgdQSKHNYDMFVLLSGIFAIIGTV 487
Cdd:cd17314  350 GPMLGAKFY--DRTPSYISAVYIYAVIVFLASA 380
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
97-389 6.39e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.30  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  97 LKDIETS-SISWIFSIYMYLSFAIG-IIVGPIF---VMKGSFTPLLYGTVLIVGGFM-ATANCTKVWQFILSFICVGTGH 170
Cdd:cd17328   22 LPDIQSDfLIDDSLAGLLQTVFIISyMVLSPIFgylGDRYNRKWILAVGILIWSAATlLSSFAPNFWQLLLFRALVGIGE 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 171 GLCITPLVGVVSQHWTANAIGRATG---FATIGGSIGGVILPLMLRSLFPkvGFAWSIRILGFFCLACMICAMLLAREKy 247
Cdd:cd17328  102 ASYSPIAPTIIADLFPKEKRTRALGvfyFAIPLGSGLGYVVGGLVAQATG--GWRWAFRVTGVLGVLLAILLLLFVREP- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 248 ctdliPMDSASTDYEEMNKRKKFKAASKNILSfnalrdiKYSFLII-----GVFFGELAL-MLIVTYYASYAIAQGMSES 321
Cdd:cd17328  179 -----PRGAAEGGVMAKSTATSFLADLKALAK-------NPSFILStlgftAVSFVTGALaFWAPTFFLRAFGVGDLSSA 246
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294659792 322 -AAYILLTIFNACGVLGRWIPGHMADIWGPYNV-------MILMLICLDISIMVVWLPFgSNVGVLYAFAALSGAF 389
Cdd:cd17328  247 dVGLIFGAITCIAGVLGVLLGGILADRLRRKTPradplvcAVGLLAAAPFLFLALVLAL-SNLLLAWVLLFLGEFL 321
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
46-205 7.20e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  46 TEPIESQKPSEEPTNGLKAYSVVIGSFLGLIANFGVLNSIGAIQSYVssHQLKDIETSSISWIFSIYMYLSFAIGIIVGP 125
Cdd:COG2814  188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL--QEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 126 IFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGG 205
Cdd:COG2814  266 LADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
72-209 1.03e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792   72 FLGLIANFGVLNSIGAIQSYVSSHQ-LKDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLY---GTVLIVGGF 147
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQeVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLallLLILAALGL 282
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 294659792  148 MATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGGSIGGVILP 209
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
290-391 2.02e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 290 FLIIGVFFGELALMLIVTYYASYAIAQ-GMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMIlmLICLDISIMVV 368
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVML--AGLLLRALGFA 80
                         90       100
                 ....*....|....*....|...
gi 294659792 369 WLPFGSNVGVLYAFAALSGAFSA 391
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGG 103
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
111-242 2.60e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.34  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 111 IYMYLSFAIGIIVGPIFVM----KGSFTPLLYGTVLIVGGFMATA-NCTKVWQFILSFICVGTGHGLCITPL----VGVV 181
Cdd:cd17504  221 LLLLPGALVMLIAGPLAGRliarVGPRRVLLIGLVISAVGLLLLAlLHSSLWALVVALLLIGIGLGLAFASLpnivVESV 300
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 182 SQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKV---------GFAWSIRILGFFCLACMICAMLL 242
Cdd:cd17504  301 PPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSItsggvptegAYVLAFLIGAALALAALLLSLLI 370
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
180-389 3.99e-04

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 42.86  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 180 VVSQHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFFCLacmicAMLLAREKYcTDLIPMDSAST 259
Cdd:cd17464  120 VILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMF-----VLFLAGFTY-KPLVPMKKDKE 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 260 DyeemNKRKKFKAASKNILSFNALRDIKYSFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRW 339
Cdd:cd17464  194 G----KKRKFKCPPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRL 269
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 294659792 340 IPGHMAD-IWGPYNVMILMLICLDISIMVVWLPFGSNVGVLYAFAALSGAF 389
Cdd:cd17464  270 IFGRVADyIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLF 320
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
195-393 6.27e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.21  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 195 GFATIGGSIGGVILPLMLRSL---FPKVGFAWSIRILGFFCLACMICAMLLAREKYctdlipmdsasTDYEEMNKRKKFK 271
Cdd:cd17332  143 FFATIGGLLVTVLPPPLVAYFgggNASRGYFLTALIIGIIGIILLLICFFGTRERV-----------VPPEEEKSKLPLL 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 272 AASKNILSFNALRdikysFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPY 351
Cdd:cd17332  212 KSLKALLKNRPFL-----ILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKK 286
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 294659792 352 NVMILMLICLDISIMVVWLPFGSNVGVLYAFAALSGAFSASI 393
Cdd:cd17332  287 KAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGA 328
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
291-391 2.86e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 291 LIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVvwL 370
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL--F 78
                         90       100
                 ....*....|....*....|.
gi 294659792 371 PFGSNVGVLYAFAALSGAFSA 391
Cdd:cd17325   79 AFATSYWQLLLARFLQGLASA 99
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
50-246 4.07e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  50 ESQKPSEEPTNGLKAYSVVIGSFLGLIANFGVLnsiGAIQSYVSS--HQLKDIETSSISWIFSIYMyLSFAIGIIVGPIF 127
Cdd:COG0738  194 EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAE---GAIGDWLPLylKDVLGLSEATAALGLSLFW-GGMTIGRFLGGFL 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 128 VMK-GSFTPLLYGTVLIVGGFMATANCTKVWQFILSFICVGTGHGLCITPLVGVVSQHWTANAIGRATGFATIGgSIGGV 206
Cdd:COG0738  270 LKRfGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGA 348
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 294659792 207 ILPLMLRSLFPKVGFAWSIRILGFFCLACMICAMLLAREK 246
Cdd:COG0738  349 IGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
283-389 4.73e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 283 LRDIKYSFLIIGVFFGELALMLIVTYYA-SYAIAQ-GMSESAAYILLTIFNACGVLgrWIP--GHMADIWGPYNVMILML 358
Cdd:cd17369  224 RRHWRALLLAIGLRLAENVLFYLFTTFAlSYATQTlGVDRSTVLLAVLIASVVAAI--TIPlfGWLSDRVGRRPVYLAGA 301
                         90       100       110
                 ....*....|....*....|....*....|.
gi 294659792 359 ICLDISIMVVWLPFGSNVGVLYAFAALSGAF 389
Cdd:cd17369  302 LLAALFAFPFFWLLDTGSTWLIVLAAVVVLG 332
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
60-244 5.34e-03

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 39.08  E-value: 5.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792  60 NGLKAYSVVIGSFLglianFGVlnSIGaiqSYVSshqlKDIETSSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYG 139
Cdd:COG4262   40 DSVLQFSIVIGVFL-----FAM--GLG---SYLS----RRVADRLLRAFIRLELLLALLGGLSALLLFALFAFLLGALFL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 140 TVLIvggfmatanctkvwqfiLSFICVGTGHGLCItPLVGVVSQ---HWTANAIGRATGFATIGGSIGGVILPLMLRslf 216
Cdd:COG4262  106 LALY-----------------LLVLLIGLLIGAEI-PLLMRLLErrrEELGSAVGRVYAADYLGALVGSLLFPFLLL--- 164
                        170       180
                 ....*....|....*....|....*...
gi 294659792 217 PKVGFAWSIRILGFFCLAcmICAMLLAR 244
Cdd:COG4262  165 PALGLVRTALLFGLLNAA--VALVLLWL 190
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
103-345 6.77e-03

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 38.60  E-value: 6.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 103 SSISWIFSIYMYLSFAIGIIVGPIFVMKGSFTPLLYGTVLIVGGFMATANCTKVWQFILS-FICVGTGHGLCITPLVGVV 181
Cdd:cd17425   38 SETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTaGFITGLGFCFSFQSSVTVL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 182 SqHWTANAIGRATGFATIGGSIGGVILPLMLRSLFPKVGFAWSIRILGFFCLACMICAMLLarEKYCTdlipmdsastdy 261
Cdd:cd17425  118 G-FYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVM--RPFCS------------ 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 262 eemNKRkkfkaasknilsfnalrdikYSFLIIGVFFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIP 341
Cdd:cd17425  183 ---NTR--------------------YQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLA 239

                 ....
gi 294659792 342 GHMA 345
Cdd:cd17425  240 GLLS 243
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
296-389 8.22e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 38.34  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294659792 296 FFGELALMLIVTYYASYAIAQGMSESAAYILLTIFNACGVLGRWIPGHMADIWGPYNVMILMLICLDISIMVVWLpFGSN 375
Cdd:cd17365  181 FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGV-SPAS 259
                         90
                 ....*....|....
gi 294659792 376 VGVLYAFAALSGAF 389
Cdd:cd17365  260 LVLLYVLVFLAGAC 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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