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Conserved domains on  [gi|50426521|ref|XP_461857|]
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DEHA2G07106p [Debaryomyces hansenii CBS767]

Protein Classification

prefoldin subunit 6( domain architecture ID 19227319)

prefoldin subunit 6 (PFDN6) is a beta subunit of prefoldin, a hexameric co-chaperone prefoldin complex that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly

Gene Ontology:  GO:0016272|GO:0061077|GO:0051082|GO:0003714
PubMed:  9630229|11106732|33137104

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 1.74e-37

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 122.21  E-value: 1.74e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  11 SLEFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVET 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 50426521  91 KIGDEEKKIEATREKLIAIRS 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 1.74e-37

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 122.21  E-value: 1.74e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  11 SLEFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVET 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 50426521  91 KIGDEEKKIEATREKLIAIRS 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 13-108 5.22e-14

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 62.63  E-value: 5.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521    13 EFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKI 92
Cdd:pfam01920   3 KFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQL 82

                          90
                  ....*....|....*.
gi 50426521    93 GDEEKKIEATREKLIA 108
Cdd:pfam01920  83 EKLEKELEELKEELYK 98
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
13-106 2.09e-07

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 45.65  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  13 EFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKI 92
Cdd:COG1382  15 QLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKTLEKQE 94

                        90
                ....*....|....
gi 50426521  93 GDEEKKIEATREKL 106
Cdd:COG1382  95 ERLQKQLEELQEKL 108
valS PRK05729
valyl-tRNA synthetase; Reviewed
 70-113 2.16e-04

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 38.93  E-value: 2.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 50426521   70 AKLNvtKRIEFIEGEIKRVETKIGDE-------EKKIEATREKLIAIRSQM 113
Cdd:PRK05729 814 ARLE--KELAKLEKEIERVEKKLSNEgfvakapEEVVEKEREKLAEYEEKL 862
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 1.74e-37

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 122.21  E-value: 1.74e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  11 SLEFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVET 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 50426521  91 KIGDEEKKIEATREKLIAIRS 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 13-108 5.22e-14

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 62.63  E-value: 5.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521    13 EFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKI 92
Cdd:pfam01920   3 KFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQL 82

                          90
                  ....*....|....*.
gi 50426521    93 GDEEKKIEATREKLIA 108
Cdd:pfam01920  83 EKLEKELEELKEELYK 98
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
13-106 2.09e-07

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 45.65  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  13 EFSNSQGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKI 92
Cdd:COG1382  15 QLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKTLEKQE 94

                        90
                ....*....|....
gi 50426521  93 GDEEKKIEATREKL 106
Cdd:COG1382  95 ERLQKQLEELQEKL 108
Prefoldin_beta_GimC cd23162
Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric ...
 18-106 1.49e-05

Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467478 [Multi-domain]  Cd Length: 102  Bit Score: 40.54  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  18 QGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKIGDEEK 97
Cdd:cd23162  10 QQQLQAVLLQKQQLEAELREIERALEELEKLPDDAEVYKSVGTILVKVDKEEVIKELKERKETLELRLKTLEKQEERLRK 89


                ....*....
gi 50426521  98 KIEATREKL 106
Cdd:cd23162  90 QLEELQKKI 98
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 23-97 1.88e-04

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 37.32  E-value: 1.88e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50426521  23 ELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKIGDEEK 97
Cdd:cd00632   4 ALKSQKEELERKINEQKVVLDELSNLKKNRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKEK 78
valS PRK05729
valyl-tRNA synthetase; Reviewed
 70-113 2.16e-04

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 38.93  E-value: 2.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 50426521   70 AKLNvtKRIEFIEGEIKRVETKIGDE-------EKKIEATREKLIAIRSQM 113
Cdd:PRK05729 814 ARLE--KELAKLEKEIERVEKKLSNEgfvakapEEVVEKEREKLAEYEEKL 862
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 18-106 1.41e-03

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 35.82  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521   18 QGTLNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKIGDEEK 97
Cdd:PRK09343  20 QQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKVDKTKVEKELKERKELLELRSRTLEKQEKKLRE 99


                 ....*....
gi 50426521   98 KIEATREKL 106
Cdd:PRK09343 100 KLKELQAKI 108
Prefoldin_2 cd23163
prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic ...
 21-105 9.15e-03

prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467479  Cd Length: 100  Bit Score: 33.26  E-value: 9.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50426521  21 LNELMTARSTLETQYQENKIVLNEFDNLNEDSKIYKLTGPILMPQEYGEAKLNVTKRIEFIEGEIKRVETKIGDEEKKIE 100
Cdd:cd23163  13 QQQLASKIAELEQELNEHKLVIDTLKPLDPDRKCFRLVGGVLVERTVGEVLPALEENKENLEEVIEQLNEQLEEKEKELN 92


                ....*
gi 50426521 101 ATREK 105
Cdd:cd23163  93 EFREK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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