|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
76-481 |
7.12e-73 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 234.75 E-value: 7.12e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVL--FVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFamekdsd 235
Cdd:cd17352 79 ALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLL------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 236 PFYGFVWGLRTLGFVNLFLLIVALVLakeRLphkklnereraiptwrrvfntyilqsfdifgFKDLKYTFCVMGTVFGEI 315
Cdd:cd17352 152 DNYGWRGALLILGGLCLNLCVCGLLL---RL-------------------------------LKDPTFVLLALGVSFAML 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 316 SIISGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSD--IFGRFNVAMITLVFLGIITFVMWlpFATTRAV 393
Cdd:cd17352 198 GFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkpRIGRLYLYIFTLLILGLSLLAFP--LATTYVG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 394 LFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGpekSFKGYDHYVIWCGVTSFV 473
Cdd:cd17352 276 LIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRD---YTGDYDAAFYFCGACLLL 352
|
....*...
gi 50310889 474 SAICYMIS 481
Cdd:cd17352 353 SGVLLFLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
76-480 |
9.00e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.81 E-value: 9.00e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMENFIERNQlsSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFFAMekds 234
Cdd:COG2271 86 GLATLLFGFATSFWQLLL-LRFLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAA---- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 235 dpfYGFVWGLRTLGFVNLFLLIVALVLAkerlphkklnereraiptwrrvfntyilqsfdIFGFkdlkytFCVMGTVFGe 314
Cdd:COG2271 161 ---FGWRAAFLILGLPGLLLALLRFWLL--------------------------------ALAY------FLVYFALYG- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 315 isiisGITYFTSYAMK-QGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTRAV 393
Cdd:COG2271 199 -----FLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 394 LFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIgpekSFKGYDHYVIWCGVTSFV 473
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL----DATGYQAAFLLLAALALL 349
|
....*..
gi 50310889 474 SAICYMI 480
Cdd:COG2271 350 AALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
76-477 |
5.35e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.20 E-value: 5.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMENFIerNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPL--AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLISVPSHYFLV-KRGTATAIATTGGSIGGVIFPVILRKFFAMekds 234
Cdd:COG2223 81 GIGLLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAA---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 235 dpfygfvWGLRTLGFVNLFLLIVALVLA---KERLPHKKLNERERAIPTWRRVFNTYILqsfdifgfkdLKYTFCVMGTV 311
Cdd:COG2223 156 -------FGWRNAFLILGILLLVVAVLAwlfLRDPPAGAAAAAKASLRDQLEALRDPRF----------WLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 312 FGEISIISgitYFTSYAMKQ-GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATT 390
Cdd:COG2223 219 GSFIGFSS---WLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 391 RAVLFAFSAI---YGFSSGSIFSILPvccgQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGpekSFKGYDHYVIWC 467
Cdd:COG2223 296 WLFLVLFLLLglaLGGGNGAVFALVP----DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVF 368
|
410
....*....|
gi 50310889 468 GVTSFVSAIC 477
Cdd:COG2223 369 AVLALVALVL 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
76-477 |
1.03e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 105.77 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIpVFGMLNTIGVMENFIERNQlsSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17353 2 RWLVLLGAVLMHL-ILGYQYAWSVFNPPLSSAL--GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAmekdsd 235
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLIN------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 236 pFYGFVWGLRTLGFVnlFLLIVALVLAKERLPHKKLNERERAIPTWRRVFNTYILQSFDIFgfkdLKYTFCVMGTVFGeI 315
Cdd:cd17353 153 -TVGVPTTFLILGII--FLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREML----RTPTFWLLWLMFF-L 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 316 SIISGITYFTSYA-MKQGLSQSDSYLLVMVVNLAGI---PGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTR 391
Cdd:cd17353 225 NATAGLMLIGQAKpIGQEFAGLDAGIAALAVSILSIfngGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL--PFIGSV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 392 AVLF-AFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIgpekSFKGYDHYVIWCGVT 470
Cdd:cd17353 303 AVLFvLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL----YTGGYNAAFIIAAAL 378
|
....*..
gi 50310889 471 SFVSAIC 477
Cdd:cd17353 379 SLVALAL 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
112-439 |
9.08e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.97 E-value: 9.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 112 TSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLI 191
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 192 SVPSHYFLV-KRGTATAIATTGGSIGGVIFPVILrkffamekdsdPFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKK 270
Cdd:COG2814 121 ALIADLVPPeRRGRALGLLGAGLGLGPALGPLLG-----------GLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 271 LNERERAIPTWRRVfntyilqsfdifgFKDLKYTFCVMGTVFGEISIISGITYFTSYAMKQ-GLSQSDSYLLVMVVNLAG 349
Cdd:COG2814 190 PAARARLRGSLREL-------------LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 350 IPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRY 429
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL--ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334
|
330
....*....|
gi 50310889 430 STMYFVVAFG 439
Cdd:COG2814 335 GLYNSAFFLG 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
76-476 |
3.36e-22 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 98.11 E-value: 3.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVF--IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGIL-MSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAmekds 234
Cdd:cd17355 79 AAGLVLLALATSLWQLYLLWGLLGGGGAGTLaAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 235 dpFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKL-----NERERAIPTWRRVFNT--YILQSFDIFgfkdlkytFCV 307
Cdd:cd17355 154 --AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALrayddASPASPGSTLKEALRSasFWLLALAFF--------LCG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 308 MGTVFgeisiisGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDifgRFNVAMITLVFLGIITFVM-WLP 386
Cdd:cd17355 224 FAVVG-------LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD---RYSPRRLLAASYALRALGLaLLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 387 FATTRA-VLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGPeksFKGYDHYVI 465
Cdd:cd17355 294 LLPFPPlALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR---TGSYTAAWA 370
|
410
....*....|.
gi 50310889 466 WCGVTSFVSAI 476
Cdd:cd17355 371 LAVALGLIAAL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
83-443 |
7.52e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.56 E-value: 7.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 83 CFCGFIPVFGMLNTIGVMENFIERNQlsSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGM 162
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 163 ANSTELWQFILsFSIVTGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFFAmekdsdpFYGFV 241
Cdd:pfam07690 80 LFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLAS-------LFGWR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 242 WGLRTLGFVNLFLLIVALVLAKERLPHKKLNERERAIPTWRRVFNTYILQSFDIFgfkdlkYTFCVMGTVFGEISiisgi 321
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL------LALLLFGFAFFGLL----- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 322 TYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITF-VMWLPFATTRAVLFAFSAI 400
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 50310889 401 YGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVA 443
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
77-475 |
3.75e-18 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 86.31 E-value: 3.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMENFIERNqlSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDA--FGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAmekdsdp 236
Cdd:cd17314 80 AGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWV------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 237 FYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKLNERERAIPTWRRVFNTYILQSFDIFgfkdlkytFCVMGTVFGEIS 316
Cdd:cd17314 153 FYGLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILF--------IAIFLVLIGGFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 317 IISGITYFTSyaMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIF-GRFNVAMITLVFLGIITFVMWLPFATTRAVLF 395
Cdd:cd17314 225 FIANMASLVR--SLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFgGRLSTLSILLTILGLGLCAFLFLLKMTPVGLV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 396 AFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIgpeKSFKGYDHYVIWCGVTSFVSA 475
Cdd:cd17314 303 LTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFY---DRTPSYISAVYIYAVIVFLAS 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
113-478 |
8.51e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.01 E-value: 8.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:cd06174 29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFfamekdsdpFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKL 271
Cdd:cd06174 108 LIADLFPEReRGRALGLLQAFGSVGGILGPLLGGIL---------ASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 272 NERERAIPTWRRVFNTYILQSfdifgFKDLKYTFCVMGTVFGEISIISGITYFTSYAMKQGLSQSDSYLLVMVVN-LAGI 350
Cdd:cd06174 179 SARAKNEEASSKSVLKLLKRV-----LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFgLAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 351 PGRWLPGFFSD-IFGRFNVAMITLVFLGIITFVMWLpfATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRY 429
Cdd:cd06174 254 LGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 50310889 430 STMYFVVAFGTLVAVPITGAIIGpekSFKGYDHYVIWCGVTSFVSAICY 478
Cdd:cd06174 332 GLLNTFGFLGGAIGPLLAGFLLA---ATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
76-412 |
1.53e-15 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 78.34 E-value: 1.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMENFI---ERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGS 152
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLlerLTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 153 VLHVGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFamek 232
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 233 DSdpfYGFVWGLRTLGFVNLFLLIVALVLaKERLPHKKLNERERAIPTWRRVFNTYILQSFDIFGFKDLKYTFCVMGTVF 312
Cdd:cd17420 157 DS---YGLEGTLRVLSLFMFVLILCSFTY-RPLHPSPEDPKSKPGRRTLHSRINLFLRKIFNVEIFKRKRYVIWALGIPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 313 GEISIISGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDI---FGRFNVAMITLVFLGIITfvMWLPFAT 389
Cdd:cd17420 233 ALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMppgVKKMYLQVLSFVSIGLMS--MMIPLCN 310
|
330 340
....*....|....*....|...
gi 50310889 390 TRAVLFAFSAIYGFSSGSIFSIL 412
Cdd:cd17420 311 SFGILISVCLVMGLFDGCFISIM 333
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
77-412 |
1.93e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.97 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIpVFGMLNTI--GVMENFIERNQLSSTSSstvGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVL 154
Cdd:COG0738 7 RRALIAIYLLFF-LWGFATALwgPLIPALKDAFGLSDAQA---GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 155 HVGGLFGMANSTELWQFILSFsIVTGLGNGIL---MSPLISVpshyfLVKRGTATAIATTGG--SIGGVIFPVILRKFFA 229
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLAL-FLLGLGLGLLdvaANPYVAA-----LGPETAASRLNLLHAffSLGALLGPLLGGLLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 230 MEKDSDPFYGFVWglrtlgfVNLFLLIVALVLAKERLPHKKLNERERAIPTwrrvfntyiLQSFDIFGFKDLKY-TFCVM 308
Cdd:COG0738 157 LGLSLSWHLPYLI-------LAVLLLLLALLFLRSKLPEIEEEEEEAAGSA---------ASLKSLLKNPRLLLgGLAIF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 309 GTVFGEISIIS-GITYFTSYAmkqGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWlpF 387
Cdd:COG0738 221 LYVGAEGAIGDwLPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--L 295
|
330 340
....*....|....*....|....*
gi 50310889 388 ATTRAVLFAFSAIYGFSSGSIFSIL 412
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTI 320
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
113-450 |
6.10e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.45 E-value: 6.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSfSIVTGLGNGILMSPLIS 192
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG-TALIGAGIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMekdsdpfYGFVWGLRTLGFVNLFLLIVALVLAKERlphKKLN 272
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA-------LGWRGALAVWALLALLALLLWLPLLRRR---PAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 273 ERERAIPTWRRVFNTYILQSFDIFgfkdlkytFCVMGTVFgeisiISGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPG 352
Cdd:COG2807 200 AAAPAAASLRSLWRSPLAWLLTLF--------FGLQSLLY-----YAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 353 RWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLpFATTrAVLFAFSAIYGFSSGSIFSILPVCCGQISKT-EEFGRRYST 431
Cdd:COG2807 267 SLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLL-LAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGM 344
|
330
....*....|....*....
gi 50310889 432 MYFVVAFGTLVAVPITGAI 450
Cdd:COG2807 345 AQSVGYLLAALGPLLVGAL 363
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
77-413 |
7.71e-15 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 75.89 E-value: 7.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSI-FSFVNFASCIFSGTYfDRNGAKGPLIVGSVLH 155
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVF--FVEFVEYFEESAQRVSWITSIgLAVQQLASPVGSALS-TRYGARPVVMLGGLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMekdsd 235
Cdd:cd17423 79 SLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDT----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 236 pfYGFVWGLRTLGFVNLFLLIVALVLakerlphKKLNERERAIPTWRRVFNTYILQSFDIFGFkdlkYTFCVMGTVFgei 315
Cdd:cd17423 154 --YAWRGALLLLSALSLHLVPCGALL-------RPLALPGDPPAPPRSLSAAFGLSLLTHRAF----LRYALATTLI--- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 316 siisGITYFTSY------AMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIfGRFNVAMITLVFLGIITFVMWL-PFA 388
Cdd:cd17423 218 ----NTGYFIPYvhlvahARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADL-GPLRLLHLLVLWTALTGLSLLLlPLA 292
|
330 340
....*....|....*....|....*....
gi 50310889 389 TTRAVLFAFSAIYGFSSGS----IFSILP 413
Cdd:cd17423 293 KVYGSLLALAVAYGFCAGAlaplVFSVLP 321
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
113-451 |
2.06e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.53 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSfSIVTGLGNGILMSPLIS 192
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA-RFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYF-LVKRGTATAIATTGGSIGGVIFPVI---LRKFFAMEKdsdPFYgfVWGLrtLGFVNLFLLIVALVLAKERLPH 268
Cdd:cd17325 108 LIADIApPEERGRAMGIFSSAIGLGFLIGPLLgglLADALGYRA---PFL--VCAA--LALLALVLALLLLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 269 KKLNERERAIPTWRRVFNTYILQSFdifgfkdlkYTFCVMGTVFGEIsiisgITYFTSYAM-KQGLSQSDSYLLVMVVNL 347
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALF---------LAIFVLAFAFGAL-----EPFLPLYAAeLGGLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 348 AGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGR 427
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL--PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
330 340
....*....|....*....|....
gi 50310889 428 RYSTMYFVVAFGTLVAVPITGAII 451
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLY 348
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
70-479 |
2.03e-12 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 69.00 E-value: 2.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 70 PEGGFAaWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLI 149
Cdd:TIGR00892 12 PDGGWG-WVVLGATFVSIGFSYAFPKAVTVF--FKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 150 VGSVLHVGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFA 229
Cdd:TIGR00892 89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 230 MekdsdpfYGFVWGLRTLGFVNLFLLIVALVL-------------AKERLPHKKLNERERAIPTWRRVfNTYIlqSFDIF 296
Cdd:TIGR00892 169 S-------FGWRGSFLILGGLLLHCCVCGALMrpvgpsqrvskskSKEGLPPDGSTKKLSKKSTAEKI-NRFL--DFSLF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 297 ---GFkdLKYTFCVMGTVFGeisIISGITYFTSYAMKQGLSQSDSYLLVMVVNlagipgrwlpgfFSDIFGRFNVAMI-- 371
Cdd:TIGR00892 239 thrGF--LVYLSGNVIMFLG---FFAPIIFLVPYAKDKGVDEYEAAFLLSIIG------------FVDIFARPSCGLIag 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 372 --------------TLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVA 437
Cdd:TIGR00892 302 lkwirphvqylfsfALLFNGLTHLLC--ALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVEC 379
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 50310889 438 FGTLVAVPITGAIIGPEKSFKgydhYVIWCGVTSFVSAICYM 479
Cdd:TIGR00892 380 CAVLIGPPLAGRLVDATKNYK----YIFYASGSIVVSAGLFL 417
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
80-476 |
8.19e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 8.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 80 IFGCFCGFIPVFGMLNTIGVMENFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGL 159
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 160 FGMANSTELWQFILsFSIVTGLGNGILM---SPLI--SVPSHYflvkRGTATAIATTGGSIGGVIfpVILRKFFAMekds 234
Cdd:cd17316 81 LLIGLLPTPILLLV-LRFLQGIGIGGEYpgaSTYVaeFAPSKR----RGFALGLLQSGWALGALL--AALVASLLI---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 235 dPFYGFVWGLRTLGFVNLFLLIVALVLakerlphkklnereraiptwrrvfntyilqsfdifgfkdLKYTFCVMGTVFGE 314
Cdd:cd17316 150 -PLLSGDWGWRILFLIGALPALLALLL---------------------------------------RRRTLLLILLWFFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 315 ISIISGITYFTSYAMKQ--GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTRA 392
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTvlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 393 VLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGPEKSFKGYDHYVIWCGVTSF 472
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
....
gi 50310889 473 VSAI 476
Cdd:cd17316 350 IVAL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
77-479 |
7.64e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.77 E-value: 7.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFipvfGMLNTigVMENFIERNQLSSTsssTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17489 2 LLANFFFFLSF----YLLLP--VLPLYAHDLGGSEA---VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILsFSIVTGLGNGIL------MSPLISVPSHyflvkRGTATAIATTGGSIGGVIFPvILRKFFAM 230
Cdd:cd17489 73 LATLLYLLATSVALLLV-LRLIHGIGWGAFttaaatLVADIIPPSR-----RGEGIGYYGLATTLAMALGP-ALGLFLYQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 231 EkdsdpfygfvWGLRTLGFVNLFLLIVALVLA--KERLPHKKLNERERAIPTWRRVFNTYILQSFDIfgfkdlkytFCVM 308
Cdd:cd17489 146 H----------LGFAVLFIVAAVLALLALLLVflVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALI---------LFLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 309 GTVFGEISiisgiTYFTSYAMKQGLSQSDSYLLVMVVNLAGIpgRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWlpFA 388
Cdd:cd17489 207 SIAYGAIS-----TFLPLYAAERGISNAGLFFTVYAIALLLS--RPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS--FA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 389 TTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIgpekSFKGYDHYVIWCG 468
Cdd:cd17489 278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA----ELFGYRAMFLLAA 353
|
410
....*....|.
gi 50310889 469 VTSFVSAICYM 479
Cdd:cd17489 354 VVVLLALVLYI 364
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
113-414 |
1.85e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.57 E-value: 1.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL-LVALAGIGSAAFHPEGAR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLVKRGTATAIATTGGSIGGVIFPVIlrkffamekdSDPFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKLN 272
Cdd:cd17478 108 LASQAAGGRRGLAMSIFSVGGNLGFALGPLI----------AAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 273 ERERAIPTWRRVFNTYILQSFDIFGFKDLKYTFcvmgtvfgeisIISGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPG 352
Cdd:cd17478 178 KKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV-----------LSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50310889 353 RWLPGFFSDIFGRFNVAMITLVflgIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPV 414
Cdd:cd17478 247 TLIGGPLSDRFGRRRVIIASLL---LAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVV 305
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
113-452 |
5.53e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.46 E-value: 5.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKG----PLIVGSVLHVGGLFGM------ANSTELWQFILSFSIVTGLG 182
Cdd:COG2211 44 SAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 183 NGILMSPLISVPS----HYflVKRGTATAIATTGGSIGGVIFPVILRKFFAMeKDSDPFYGFVWGLRTLGFVNLFLLIVA 258
Cdd:COG2211 124 YTLVNIPYSALGAeltpDY--EERTRLSSWRFAFAGLGGLLASVLPPPLVAA-FGGDAALGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 259 LVLAKERLPhkklneRERAIPTWRRVFntyilqsFDIFGFKDLKYTFCVMGTVFGEISIISG-ITYFTSYAMkqGLSQSD 337
Cdd:COG2211 201 FFGTKERPV------PEEEKVSLKESL-------KALLKNRPFLLLLLAYLLFFLALALVAAlLLYYFKYVL--GLSAAL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 338 SYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCG 417
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 50310889 418 QISKTEE--FGRR-----YSTMYFVVAFGTLVAVPITGAIIG 452
Cdd:COG2211 346 DVVDYDEwkTGRRreglyFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
77-448 |
4.75e-09 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 57.90 E-value: 4.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVL--YPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPvilrkffAMEKDSDP 236
Cdd:cd17428 80 GGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYA-------ALQRELIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 237 FYGFVWGLRTLGFVNLFLLIVALVLakeRLphkklnereraiptwrrvfntyilqsfdifgFKDLKYTFCVMGTVFGEIS 316
Cdd:cd17428 153 LYGLDGCLLIVGALALNLLACGSLM---RL-------------------------------FKNRVFSALFIAILLFDIG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 317 IISGITYFTSYAMKQGLSQSDSYL-LVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTRAVLF 395
Cdd:cd17428 199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 50310889 396 AFSAIYGFSSGSiFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITG 448
Cdd:cd17428 279 VLSAILGFLSGN-WSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVG 330
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
76-480 |
4.86e-09 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 57.92 E-value: 4.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGIL--NMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILrKFFAMEkdsd 235
Cdd:cd17429 79 SLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILL-KYLCAE---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 236 pfYGFVWGLRTLGFVNLFLLIVALVLakeRLPHKKlnereraiptwrrVFNTYILQSFDIFGfkdlkyTFCVMGTVFGEI 315
Cdd:cd17429 154 --FGWRNAMFIQGAVSLNLCVCGALM---RLFTNK-------------VFVAFIFWALFAYC------SFVIPFIHLPEI 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 316 SIISGITyftsyamkqglSQSDSYLLVMVVNLAGIPGRWLPGFFSD--IFGRFNVAMITLVFLGIITFVmwLPFATTRAV 393
Cdd:cd17429 210 VKLYGLS-----------EQNDKFPLTSIIAIVHIFGKVILGIICDlpCISVWNVFILANFTLGVCILI--LPLMHTYTG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 394 LFAFSAIYGFSSGsIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGPEKSfkgYDHYVIWCGVTSFV 473
Cdd:cd17429 277 LAIVCALIGFSSG-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQK---YDFSFYVCGLLYMV 352
|
....*..
gi 50310889 474 SAICYMI 480
Cdd:cd17429 353 GIICLLL 359
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
108-450 |
5.59e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.72 E-value: 5.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 108 QLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSFSIVtGLGNGILM 187
Cdd:cd17333 24 EAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLA-GLGAGILD 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 188 SPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMEKDsdpFYGFVWGLRTLGFVNLFLLIVALVLAKERLP 267
Cdd:cd17333 103 TGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELS---WSWAYLIIGLIYLLLAILILLTLFPELPSAR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 268 HKKLNERERAIPTWRRVFNTYILqsfdIFGFkdlkYTFCVMGTvfgEISIISgitYFTSYAM-KQGLSQSDSYLLVMVVN 346
Cdd:cd17333 180 NPQQSVGAFSASASRLLRNPSII----LGAL----ALFLYVGA---ETAFSS---WVPSYLVeKKHVSDGLAGYLLSGFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 347 LAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWlpFATTRAVLFAFSAIYGFSSGSIFSILpvccgqISKTEEFG 426
Cdd:cd17333 246 VGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILL--LAPTLVVGLVATALLGLFMAALFPTI------LSLGISNL 317
|
330 340
....*....|....*....|....*....
gi 50310889 427 RRYS---TMYFVVA--FGTLVAVPITGAI 450
Cdd:cd17333 318 PYAKgkgTSVLLAAgsIGGAIIPFIMGFI 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
113-476 |
1.09e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.78 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVG----SVLHVGgLFGMANStelWQFILSFSIVTGLGNGILMS 188
Cdd:cd17370 32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILgyglSALAKP-LLALAGS---WQLVLLLRILERLGKGIRTP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 189 P---LIS--VPShyflVKRGTATAIATTGGSIGGVIFPVILrkFFAMekdsdpfYGFVWGLRT---LGFVNLFLLIVALV 260
Cdd:cd17370 108 PrdaLLAdaTPP----SGRGKAFGLHRALDTLGAVLGPLLA--ALLL-------YLLGGNYRTiflLAAIPALLALLILL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 261 LAKERLPHKKLNERERAIPTWR---RVFNTYILQSFdIFGFKDLKYTFCVMgtvfgeisiisgityftsYAMKQGLSQSD 337
Cdd:cd17370 175 FVVKEYPRPPKLRKKSKKTSLKklpKAFWLYLLAVA-LFALGNFSFAFLIL------------------RAQELGLSAAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 338 SYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTrAVLFAFsAIYGFSSGSIFSILPVCCG 417
Cdd:cd17370 236 IPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLW-LLLLGF-ILWGLYMGAQESIERAAVA 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50310889 418 QISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIigpeksfkgYDHY-----VIWCGVTSFVSAI 476
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL---------WDLIspsaaFLFSAVLALIALL 368
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
113-421 |
1.51e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.40 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSfSIVTGLGNGILMSPLIS 192
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLV-KRGTATAIATTGGSIGGVIFPVILRkffamekdsdpFYGFVWGLR-TLGFVNLFLLIVALVLAK--ERLPH 268
Cdd:cd17324 111 YAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGG-----------LLGQLLGWRaAFLAIAVLALLAALLLWRllPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 269 KK-----LNERERAIPTWRRVFNTYILqsfdifgfkdlkyTFCVMGTVFGeisiisGITYFTSYAMKQ-GLSQSDSYLLV 342
Cdd:cd17324 180 KKpgslgLLSSLLLLLRNPRLRLAYLI-------------TFLLFGGFFA------LYTYLAPFLTDVpGFSSSAIIGLL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50310889 343 MVVNLAGIPGRWLPGFFSDIFGRFNVaMITLVFLGIITFVMWLpFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISK 421
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRAL-LIALLLLAAALLLLTL-LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
72-265 |
1.52e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 1.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 72 GGFAAWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTsssTVGWIFSIFSFVNFASCIFSGTYFDR--NGAKGPLI 149
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLA---QAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLA 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 150 VGSVLHVGGLFGMANSTELWQFILSFSIVtGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFF 228
Cdd:COG2271 253 IGLLLAALALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLL 331
|
170 180 190
....*....|....*....|....*....|....*..
gi 50310889 229 AMekdsdpfYGFVWGLRTLGFVNLFLLIVALVLAKER 265
Cdd:COG2271 332 DA-------TGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
113-262 |
1.67e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLL-LLALLGLGLGLVFPATLA 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50310889 193 VPSHYFLV-KRGTATAIATTGGSIGGVIFPVILrkffamekdsdpfyGFVWGlrTLGFVNLFLLIVALVLA 262
Cdd:cd17325 312 LLADIVPPeGRGTAMGLFNTAFSLGMVLGPLLG--------------GFLYD--AFGFATPFLAAAALLLL 366
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
97-404 |
1.74e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 97 IGVMENFIeRNQLSsTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWqFILSFS 176
Cdd:cd17475 15 IPALAPFL-QEDLH-LSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP-VLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 177 IVTGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILrKFFAMEkdsdpfYGFVWGLRTLGFVNLFLL 255
Cdd:cd17475 92 FLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALL-PPLALH------YGWRAAFVVAGLVSILAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 256 IVALVLAKERLPHKKLNERERAIPTWRRVfntyilqsfdIFGFKDLKYTFCVMGT-VFGEISIisgITYFTSYAMKQ-GL 333
Cdd:cd17475 165 VLFWLFYREPPAASAATESASTLLRSLKE----------VLRNRDVWLIAIAGALlVAPQFAL---LTFLLLFLHDHlGL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50310889 334 SQSDSYLLVMVVNLAGIPGRWLPGFFSD--IFGRFNVAMITLVFLGIITFVM--WLPFATTRAVLFAFSAIYGFS 404
Cdd:cd17475 232 SVVAAGALLAVAQLGGALGRIGLGRVSDrvFGGRRRPVLVITAAIAAAALLVlsLLSPGTPLWLLVLLLILLGLF 306
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
77-217 |
2.23e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTsssTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSAS---AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50310889 157 GGLFGMANSTELWQFILSFsIVTGLGNGILMSPLISVPSHYF-LVKRGTATAIATTGGSIGG 217
Cdd:COG2814 285 LGLLLLALAGSLWLLLLAL-FLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
113-449 |
2.37e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQ-FILSFsiVTGLGNGILM---- 187
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVwFLLRF--VMGIGLAGLFvvse 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 188 -SPLISVPSHyflvKRGTATAIATTGGSIGGVIFPVILRKFfamekDSDPFYGFVwglrtLGFVNLFLLIVALVLAKERL 266
Cdd:cd17477 107 sWLNALATNE----NRGRVLGLYSTVLGLGFALGPLLLALV-----GTAGALPFL-----IAAVLLLLALVPLLLTRRAA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 267 PHKKLNERERAIPTWRRVFntyilqsfdifgfkdlkytFCVMGTVFGEISIISGITYFTSYAMKQGLSQSDSYLLVMVVN 346
Cdd:cd17477 173 PEIEEAESISLRRLLRIAP-------------------LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 347 LAGIPGRWLPGFFSDIFGRFNVaMITLVFLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFG 426
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRRV-LLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELV 312
|
330 340
....*....|....*....|...
gi 50310889 427 RRYSTMYFVVAFGTLVAVPITGA 449
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGA 335
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
77-257 |
1.42e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.73 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVmenfiernQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLV--------DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTE-LWQFILSFsIVTGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFFAMEKDS 234
Cdd:COG2223 283 LGLLLLALALGsLWLFLVLF-LLLGLALGGGNGAVFALVPDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY 361
|
170 180
....*....|....*....|...
gi 50310889 235 DPFYGFVWGLRTLGFVNLFLLIV 257
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
77-411 |
1.47e-07 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 53.21 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVF--FNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPvilrKFFAMEKDSdp 236
Cdd:cd17422 80 LGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFA----PAFTALKES-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 237 fYGFVWGLRTLGFVNLFLLIVALVLakerlphkklnereraiptwrRVFNTYILQSFDIFGfkdlkytfcvmgtVFGEIS 316
Cdd:cd17422 154 -IGWRYCLLVVGALQLNIVVCGALL---------------------RVLKEPGFICYALFG-------------LFATLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 317 IISGITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTRAVLFA 396
Cdd:cd17422 199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLV 278
|
330
....*....|....*
gi 50310889 397 FSAIYGFSSGSIFSI 411
Cdd:cd17422 279 CSIFYGFMFGTVAGT 293
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
113-453 |
2.19e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 2.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLVK-RGTATAIATTGGSIGGvifpvILRKFFAmekdsdPFYGFVWGLRTLGFV-NLFLLIVALVLAK------- 263
Cdd:TIGR00895 129 LVSEYAPKRfRGTAVGLMFCGYPIGA-----AVGGFLA------GWLIPVFGWRSLFYVgGIAPLLLLLLLMRflpesid 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 264 ---------------------ERLPHKKLNERERAIPTWRRVFNTyilqsfdIFGFKDLKYTFCVMGTVFGEISIISGIT 322
Cdd:TIGR00895 198 flvskrpetvrrivnaiapqmQAEAQSALPEQKSTQGTKRSVFKA-------LFQGKTARITVLLWLLYFMLLVGVYFLT 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 323 YFTSYAMKQ-GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRfNVAMITLVFLGIITFVMWLPFaTTRAVLFAFSAIY 401
Cdd:TIGR00895 271 NWLPKLMVElGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-RVTALLLLLGAVFAVLVGSTL-FSPTLLLLLGAIA 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 50310889 402 GFSSGSIFSILPVCCGQIskteefgrrYSTMYFVVAFGTLVAVPITGAIIGP 453
Cdd:TIGR00895 349 GFFVNGGQSGLYALMALF---------YPTAIRATGVGWAIGIGRLGAIIGP 391
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
113-401 |
3.24e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSFSIvTGLGNGILMSP--- 189
Cdd:cd17329 33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL-TGFGGGLFEPAsea 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 190 -LISVPSHYflvKRGTATAIATTGGSIGGVIFPVILRKFFAmekdsdpfYGFVWGLRTLGFVNLFLLIVALVLAKERLPH 268
Cdd:cd17329 112 mIADVTTPE---NRTRAFSLLYWAINLGVAIGPLLGGLLLL--------YSFRLLFLAAAVLFLLAALVLLFLLPETRPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 269 KKLNERERAIPTWRRVFNTYILqsfdifgfkdLKYTFCVMGTVFGEISIISGITYFTSYAMkqGLSQSDSYLLVMVVNLA 348
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRDRAF----------LLFLLASFLISLIYFQLESTLPVYVVEIL--GLGESLLGLLLALNALL 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 50310889 349 GIPGRWLPGFFSDIFGRFNVAMITLVFLGIitFVMWLPFATTRAVLFAFSAIY 401
Cdd:cd17329 249 IVLLQFPVARLVERFRLRKILMIGILLFAI--GFAVLAFANTLAVLILAMIVL 299
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
113-262 |
7.87e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.02 E-value: 7.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMA---NSTELWQFILSFsIVTGLGNGILMSP 189
Cdd:cd17321 202 SPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgADSSVWLLLPGL-VLLGLGLGLFATP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 190 -----LISVPSHyflvKRGTATAIATT----GGSIGGVIFPVILRKFFAMEKDSDPFYGFVWGLR---TLGFVNLFLLIV 257
Cdd:cd17321 281 ltnaaLSSVPKE----KAGAASGILNTarqlGGALGVALLGALLTAGLSANLGDSGVAALLSAAAaafAAGFHLAFLVAA 356
|
....*
gi 50310889 258 ALVLA 262
Cdd:cd17321 357 ALALL 361
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
113-411 |
1.02e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.84 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:TIGR00881 28 SKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAA-LWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYF-LVKRGTATAIATTGGSIGGVIFPVILRKFFAMekdsdpFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKL 271
Cdd:TIGR00881 107 TVTKWFsRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE------LYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 272 --------------NERERAIPTWRRVFNTYILQSFDIFGFKdLKYTFcVMGTVFGeisIISGITYFTSYAMKQGLSQSD 337
Cdd:TIGR00881 181 ppaeempneepdgdAEKKEEELTKKQIFLQYVLLNKVLWYIS-LGYVF-VYVVRTG---ILDWSPLYLTQEKGFSKEKAS 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50310889 338 SYLLVMvvNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITF---VMWLPFATTRAVLFAFSAIYGFSS-GSIFSI 411
Cdd:TIGR00881 256 WAFTLY--ELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVsllVYWLNPAANPLMDLICLFALGFLVyGPQMLI 331
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
332-451 |
1.04e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 332 GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSI 411
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC--ALAPSLWLLLAARFLQGLGAGALFPA 118
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 50310889 412 LPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAII 451
Cdd:COG2814 119 ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
111-385 |
1.11e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.19 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 111 STSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPL 190
Cdd:COG0477 45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 191 ISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILrkFFAMEkdsdpfygfVWGLRTLGFVNLFLLIVALVLAkerlphk 269
Cdd:COG0477 124 LALIAELFPAReRGRALGLWGAAIGLGLALGPLLG--GLLVA---------ALGWRWIFLINAPLGLLALVLR------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 270 klnereRAIPTWRRVFNTYILQSFDIFGFKDLKYTFCVMGTVFGEISIISGITYFTSYAMKQGLSQSDSYLLVMVVNLAG 349
Cdd:COG0477 186 ------LRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLL 259
|
250 260 270
....*....|....*....|....*....|....*.
gi 50310889 350 IPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWL 385
Cdd:COG0477 260 AALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
78-221 |
4.78e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 78 LVIFGCFCGFIPVFGMLNTIGVMenfierNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVG 157
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLY------QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50310889 158 GLFGMA--NSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLV-KRGTATAIATTGGSIGGVIFP 221
Cdd:pfam07690 278 AALGLLllSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
77-215 |
6.05e-06 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 48.27 E-value: 6.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVF--FKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCS 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSI 215
Cdd:cd17427 80 LGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPV 138
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
76-261 |
9.02e-06 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 47.84 E-value: 9.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIF--FTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFfamekdsd 235
Cdd:cd17425 79 GVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYL-------- 150
|
170 180
....*....|....*....|....*.
gi 50310889 236 pfygfvwgLRTLGFVNLFLLIVALVL 261
Cdd:cd17425 151 --------LEEMGWRGSFLVFGGVLL 168
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
113-480 |
1.03e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.57 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH--VGGLFGMANStelWQFILSFSIVTGLGNGILMSPL 190
Cdd:cd17319 36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWslFTALTGFATS---LTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 191 ISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILrkffamekdsdpfygfVWGLRTLGFVNLFLL--IVALVLakerlp 267
Cdd:cd17319 113 IKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLS----------------GWLLLLFGWRWAFIIegLLGLLL------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 268 hkklnererAIPTWRRVFNTYILqsfdIFGFkdlkytFCVMGTVFGeisiisGITYFTSYAMKQ-GLSQSDSYLLVMVVN 346
Cdd:cd17319 171 ---------AVLWWFYLRQVWGL----ALGY------FGINYALYG------LLTWLPTYLKQArGFSLKQVGLLAAIPF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 347 LAGIPGRWLPGFFSDIFGRFNVAMITLV-FLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEF 425
Cdd:cd17319 226 LAGAIGMILGGRLSDRLLRGARRLVIIIgLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 50310889 426 GRRYSTMYFVVAFGTLVAVPITGAIIGpekSFKGYDHYVIWCGVTSFVSAICYMI 480
Cdd:cd17319 306 ATAGGLINSGGNLGGFVAPLLIGYLVD---ATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
321-476 |
1.06e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 321 ITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAI 400
Cdd:cd17325 16 IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF--AFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50310889 401 YGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIgpekSFKGYDHYVIWCGVTSFVSAI 476
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA----DALGYRAPFLVCAALALLALV 165
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
76-212 |
1.38e-05 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 47.12 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 76 AWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIF--FVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 50310889 156 VGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTG 212
Cdd:cd17421 79 SAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSG 135
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
113-450 |
1.45e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:cd17474 32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA-GRALQGIGAAGLGPLALT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLV-KRGTATAIATTGGSIGGVIFPvILRKFFAMEKDSDPFYGFVwglrtLGFVNLFLLIVALV---LAKERLPH 268
Cdd:cd17474 111 LIGDLFEGgERAKAMGLYEAALGLGIAVGP-LLGGLLAAISWRYPFFLLA-----ALIPVAFLAILFLLpepKEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 269 KKLNERERAIPTWRRVFNTYILQSFDIFGFkdlkytfcvmGTVFGEISIISGITYFTSYAMKqGLSQSDSYLLVMVVNLA 348
Cdd:cd17474 185 ATKLRDLKKALRGRGLLTFLVSAFLYFFLY----------FAFLTYLPFLLELLYGISPIII-GLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 349 GipGRWLPGFFsdifGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGrR 428
Cdd:cd17474 254 V--GRLLKKRF----GARRILVIGLLLYALSLLLL--GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG-T 324
|
330 340
....*....|....*....|...
gi 50310889 429 YSTMY-FVVAFGTLVAVPITGAI 450
Cdd:cd17474 325 ASSLYnFVRFLGQAVGPLLFGLL 347
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
86-413 |
1.54e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 47.27 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 86 GFIPVFGMLNTIGVMENFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANS 165
Cdd:pfam00083 17 GVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 166 TELWQFILSF--SIVTGLGNGIL--MSPL-ISVPSHYFLVKR-GTATAIATTGGSIGGVIFPVILRKFFAMEKDSDPFY- 238
Cdd:pfam00083 97 KGKWSVYQLIvgRVLVGIGVGGAsvLAPMyISEIAPKKLRGAlGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGl 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 239 GFVWGLRTLGFVNL------FLLIVAL------VLAKER---LPHKKLNERERAIPTWRRVFNTYILQSFDIFGFKdLKY 303
Cdd:pfam00083 177 QLVPALLLIIGLLFlpesprWLVEKGRleeareVLAKLRgvpDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRR-QRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 304 TFCVMGTVFGEISIISGITYFTSYAMKQGLSQSDSY--LLVMVVNLAGIPGRWlpgFFSDIFGRFN-------VAMITLV 374
Cdd:pfam00083 256 LIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLvtIIVGVVNFVFTFIAI---FLVDRFGRRPllllgaaGMAICFV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 50310889 375 FLGIITFV-----MWLPFATTRAVLFaFSAIYGFSSGSIFSILP 413
Cdd:pfam00083 333 ILGIVALLgvsksDWAGIVAIVFIAL-FIAFFAMGWGPVPWVIV 375
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
201-443 |
1.62e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.14 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 201 KRGTATAIATTGGSIG-----GVIFPVilrkffAMEKDSDPFygFVWGLRTLGFVNLFLLIVALVLakeRLphkKLNERe 275
Cdd:cd17369 138 RRGFYGSFPQLGAPVGlllatGVFLLL------SALLSDEAF--LSWGWRIPFLLSAVLVAVGLYI---RL---RLEET- 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 276 raiPTWRRVFNTYILQSFDIFGF--KDLKYTFCVMGTVFGEISII-SGITYFTSYAMKQ-GLSQSDSYLLVMVVNLAGIP 351
Cdd:cd17369 203 ---PVFRRAKEAGQVVRAPLVEVlrRHWRALLLAIGLRLAENVLFyLFTTFALSYATQTlGVDRSTVLLAVLIASVVAAI 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 352 GRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPFATTR--AVLFAFSAIYGFSSGSIFSILPVCCgqiskTEEFGR-- 427
Cdd:cd17369 280 TIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGStwLIVLAAVVVLGVLHGMMYGPQAAFL-----AELFPTrv 354
|
250
....*....|....*.
gi 50310889 428 RYSTMYFVVAFGTLVA 443
Cdd:cd17369 355 RYTGASLGYQLGAILG 370
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
77-451 |
1.77e-05 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 46.73 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIF--FVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIF-PVI--LRKFFAMEKD 233
Cdd:cd17424 80 TGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILaPVVqlLIEQFSWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 234 SDPFYGFVWGLRTLGFVNLFLLIVA-LVLAKERLphkklnereraiptwrrvfntyilqsFDIFGFKDLkytfcvmgtvf 312
Cdd:cd17424 160 LLILGGFVLNLCVCGALMRFLLMPDfLVLAVSVL--------------------------FLAYGCSPP----------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 313 geisiisgITYFTSYAMKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFG----RFNVAMITLVFLGIITfvMWLPFA 388
Cdd:cd17424 203 --------FVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRClkkyRYFCYLFAVGMDGLCC--LFLPIL 272
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50310889 389 TTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAVPITGAII 451
Cdd:cd17424 273 KTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLV 335
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
79-262 |
2.92e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 79 VIFGCFCGFIPVFGMLNTIGVMENFIERNQ--LSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17504 179 VLLANITALLAGFGMFMVFQLLPQLLQLPTptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMA-NSTELWQFILsFSIVTGLGNGILMSPLI-----SVPSHYFLVKRGTATAIATTGGSIGGVIFPVILrkffAM 230
Cdd:cd17504 259 VGLLLLAlLHSSLWALVV-ALLLIGIGLGLAFASLPnivveSVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL----TT 333
|
170 180 190
....*....|....*....|....*....|..
gi 50310889 231 EKDSDPFYGFVwglRTLGFVNLFLLIVALVLA 262
Cdd:cd17504 334 YTVSITSGGVP---TEGAYVLAFLIGAALALA 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
111-412 |
2.92e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 111 STSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPL 190
Cdd:cd17321 27 GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA-ARALQGIGAAAIMPAS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 191 ISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVIlrkffamekdsdpfYGFV---WGLRTLGFVNLFLLIVALVLAkerl 266
Cdd:cd17321 106 LALIAATFPGErRGRALGLWGAVVGIGAALGPLL--------------GGLLlelFGWRWIFLINVPIGLVALLLA---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 267 phkklnereraiPTWRRVfntyilqsfdifgfkdlkyTFCVMGTVFGEISIISGITYFTSYAmkQGLSQSDSYLLVMVVN 346
Cdd:cd17321 168 ------------RTFSGA-------------------VLAAFLLGAALGGLLFLLPLYLQGV--LGYSPLQAGLALLPLA 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50310889 347 LAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVM-WLPFATTRAVLFAFSAIYGFSSGSIFSIL 412
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPL 281
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
81-262 |
3.01e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 81 FGCFCGFIPVFGMLNTIGVMENFIErnQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLF 160
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLPLYLQ--NVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 161 GMANSTE---LWQFILsFSIVTGLGNGILMSP-----LISVPSHyflvKRGTATAIATT----GGSIGGVIFPVILRKF- 227
Cdd:cd17503 260 LLAFLTPdtsLWLIIL-PLFIRGLGMGLVFMPlntlaLNSLPPE----QIGDATALFNTirqlGGSIGTALLATLLTNRt 334
|
170 180 190
....*....|....*....|....*....|....*..
gi 50310889 228 -FAMEKDSDPFYGFVWGLRTL-GFVNLFLLIVALVLA 262
Cdd:cd17503 335 qFHHSRLSELLAQQVQKQALIiAFNDAFLVSAILLLV 371
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
104-225 |
3.66e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.08 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 104 IERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNG-AKGPLIVGSVLHVGGLFGMANSTELWQ-FILSFSIVTGL 181
Cdd:cd06179 287 QQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNKaLAIAFSVLAGI 366
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 50310889 182 GNGILMSPLI-----SVPSHYFlvkrGTATAIATT----GGSIGGVIFPVILR 225
Cdd:cd06179 367 GIGGPLVLAIvivqlSVPPEDI----GTASGLLGSaralGGAVGTAIFTSILS 415
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
75-262 |
5.09e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 75 AAWLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLsstSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVL 154
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLF--LLDLGGL---SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 155 HVGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLV-KRGTATAIATTGGSIGGVIFPVILRKFFAMekd 233
Cdd:cd06174 279 LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPeIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA--- 355
|
170 180
....*....|....*....|....*....
gi 50310889 234 sdpfygfVWGLRTLGFVNLFLLIVALVLA 262
Cdd:cd06174 356 -------TFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
108-255 |
5.65e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 108 QLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILSfSIVTGLGNGILM 187
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLG-AILAGLGFGLLL 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50310889 188 SPLIS-VPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMEKDSDPFYGFVWGLRTLGFVNLFLL 255
Cdd:cd17473 305 PTLNSwAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
111-412 |
7.90e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.87 E-value: 7.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 111 STSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMS-- 188
Cdd:cd17503 27 GASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII-FRILQGFGGGVLIPla 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 189 ---PLISVPSHyflvKRGTATAIATTGGSIGGVIFPVIlrkffamekdsdpfYGFV---WGLRTLGFVNLFLLIVALVLA 262
Cdd:cd17503 106 qtiLLRIYPPE----KRGAAMGLVGLVILLAPAIGPTL--------------GGWLtdnLSWRWIFYINLPIGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 263 KerlphkklnereraiptwrrvfntyiLQSFDIfgFKDLKYTFCVMGTVFGEISIISGITYFTSYA-MKQGLSQSDSYLL 341
Cdd:cd17503 168 P--------------------------LLDLRL--FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLqNVLGYSAFESGLV 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50310889 342 VMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVM-WLPFATTRAVLFAFSAIYGFSSGSIFSIL 412
Cdd:cd17503 220 LAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLaFLTPDTSLWLIILPLFIRGLGMGLVFMPL 291
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
77-262 |
1.08e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenfieRNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPF-----LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 157 GGLFGMANSTELWQFILSFsIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMekdsdp 236
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH------ 348
|
170 180
....*....|....*....|....*.
gi 50310889 237 fygfvWGLRTLGFVNLFLLIVALVLA 262
Cdd:cd17324 349 -----GGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
77-215 |
1.53e-04 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMenFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV 156
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVF--FKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSG 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 50310889 157 GGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSI 215
Cdd:cd17426 80 AGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPV 138
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
113-451 |
2.02e-04 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMA-------NSTELWQFILSFSIVTGLGNGI 185
Cdd:cd17354 35 YSQQQNNLLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWlvvtgliSDLSFWLMCLCFFLIGNSTSSL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 186 LMSPLISVpSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAmEKDSDPFYGFVWGLRTLGFVNLFLLivalvlaker 265
Cdd:cd17354 115 YTAALVTC-AKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFF-HDSARVFLFLAVLPAVVGLLAWFSV---------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 266 lphkklnereraiptwrRVFNTYILQSFdifgfkdLKYTFCVMGTVFGeISIISGITYFT-----SYAMKQGLSQSDsyl 340
Cdd:cd17354 183 -----------------RIVSIEEGEFL-------KDIDFWLLFISLF-LGVGPGEMFINnlgqiGQSLTGPSNTST--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 341 LVMVVNLAGIPGRWLPGFFSDIFGR--------FNVAMITLVFLGIITFVMWLPFATtravLFAFSAIYGFSSGSIFSIL 412
Cdd:cd17354 235 LVSLFSIFSFLGRLLSGLLSDLFVRkfrlprpsRMVLLLLILSLGHLLQAFGLPSGA----LYVASALIGFGYGGLFSIA 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 50310889 413 PvccgqISKTEEFGRRystmYFVVAFGTLVAVPITGAII 451
Cdd:cd17354 311 P-----TIVSELFGLK----NFGTNYGFLMLAPAIGSLI 340
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
113-452 |
2.85e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 113 SSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTELWQFILsFSIVTGLGNGILMSPLIS 192
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 193 VPSHYFLVK-RGTATAIA----TTGGSIGGVIFPVILRkffamekdsdpfygfVWGLRTLGFVNLFLLIVALVLakerlp 267
Cdd:cd17365 111 LVSEYAPARrRSLAVTLMfcgyPLGAALGGFLAAALIP---------------AFGWRSVFLLGGVPPLILLPL------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 268 hkklnereraiptwrrVFNTYILQSFdifgfkdlkyTFCVMGTVFGEISiisgityFTSYAMKQ-GLSQSDSYLLVMVVN 346
Cdd:cd17365 170 ----------------LRGTLLLWVT----------FFMGLLLVYLLNS-------WLPKLMVEaGYSLSQALTITLLLN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 347 LAGIPGRWLPGFFSDIFGRFNVAMITLvFLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEFG 426
Cdd:cd17365 217 IGGVIGSLLLGWLADRFGPKRVLALFF-ALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRA 295
|
330 340
....*....|....*....|....*.
gi 50310889 427 RRYSTMYFVVAFGTLVAVPITGAIIG 452
Cdd:cd17365 296 TGVGWALGVGRLGAILGPLLGGLLLA 321
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
81-185 |
4.60e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.56 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 81 FGCFCGFIpvFGMLN-TIGVMENFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGL 159
Cdd:cd17315 1 VAALGGLL--FGYDLgVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGA 78
|
90 100
....*....|....*....|....*.
gi 50310889 160 FGMANSTELWQFILSfSIVTGLGNGI 185
Cdd:cd17315 79 LLSALAPNVWVLIVG-RFLLGLGVGL 103
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
112-415 |
4.78e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 42.39 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 112 TSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHV-GGLFGMAnsTELWQ----FILSFSIVTGLGNGIL 186
Cdd:cd17334 36 LSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAlGSVLKCI--PLGQQpkfaLLVLGQVLNALAQVLV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 187 MS--PLISvpSHYFLVK-RGTATAIATTGGSIGG----VIFPVILRKffaMEKDSDPFYGFVWGlrTLGFVNLfLLIVAL 259
Cdd:cd17334 114 LSlpPLIA--AVWFPPKeRTTATAIASLANFLGCaigfLLPPVVVPP---PKGTKKEFGAVFYG--EFGFACL-LLALVL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 260 VLAKERLPHK---KLNERERAIPTWRRVFNTyILQSFDIFGFKDLKYTFCVMGTVFGEISIIsgityFTSYAMKQGLSQS 336
Cdd:cd17334 186 ALFPPKPKYPpsaASARQQNSEHVILELQKS-ISELLRNEPFVLLAVAFSIMMGVFAGFSSV-----LAQILLPFGVSQT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 337 DSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWLPF---ATTRAVLFAFSAIYGFSSGSIFSILP 413
Cdd:cd17334 260 SAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLvdrYGLPYVTLAFYLLCGLLGFFQNSMVP 339
|
..
gi 50310889 414 VC 415
Cdd:cd17334 340 IM 341
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
133-420 |
6.59e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.85 E-value: 6.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 133 IFSGTYFDRNGAKGPLIVGSVLHVGGLFGMANSTE-LWQFILSfSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATT 211
Cdd:cd17341 52 LPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVL-GFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 212 GGSIGGVIFPVILRKFFAMEKDSDPFYGFvwglRTLGFVNLFLLIVALVLAKERLphkklnereRAIPTWRRVFNTYILQ 291
Cdd:cd17341 131 AGNMGVAVSQLLAPLIAGAIVFDGGFVGW----RNAFFVPGILLAIAAVLVLLFG---------DDLPTGKASALEFLKV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 292 SFDIFGFKDLKYTFCVMGTVFG-EISIISGI-TYFTSyamKQGLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFG----- 364
Cdd:cd17341 198 QLAVLKNYRTWILSLLYGVTFGsFVGFSNVLpTYFKT---RFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGgrrrl 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 50310889 365 --RFNVAMITLVFLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQIS 420
Cdd:cd17341 275 wwLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRREL 332
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
77-403 |
1.17e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.07 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMENF-IERNQLSSTSsstVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLH 155
Cdd:cd17345 2 WQVFLGIFIGYAGYYLVRNNFSLAQPYlIEQYGLSKTE---IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 156 --VGGLFGMANSTELWQFILS-FSIVTGLGNGILMSPLISVPSHYFLVK-RGTATAIATTGGSIGGVIFPVILRKFFAME 231
Cdd:cd17345 79 aiINILIGFVPSATSSVGLMFiLLFLNGWFQGMGWPPSGRTMVHWFSKKeRGTWTSIWNISHNVGGGLVGPLAGLGLAIF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 232 KDSDPFYGFVwglrTLGFVNLFLLIVALVLAKERlphkklnERERAIPTWRRVFNTYI-----------LQSFDIFgfkd 300
Cdd:cd17345 159 GDGWWRGAFI----FPAIIAIIVAVIVLFLGKDT-------PESEGLPPIEEYKGDYPeeadgeeeeqeLSAWEIF---- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 301 LKYTFCVMGTVFgeISIISGITYFTSYAMKQ----------GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFN--- 367
Cdd:cd17345 224 VKYVLKNKLLWY--IAIANVFVYLVRYGILDwaptylsevkGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRrap 301
|
330 340 350
....*....|....*....|....*....|....*.
gi 50310889 368 VAMITLVFLGIITFVMWlpFATTRAVLFAFSAIYGF 403
Cdd:cd17345 302 TGIIFMILVIVALIVYW--LAPNVLVDLIALIALGF 335
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
118-453 |
1.19e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 118 GWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVgSVLhVGGLFGMAnSTELWQF--ILSFSIVTGLGNGILMSPLI---- 191
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIV-SVA-LFGLFSLA-TAQAWDFpsLLVARLLTGVGLGGALPNLIalts 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 192 -SVPSHYflvkRGTATAIATTGGSIGGVIFPVILrkfFAMEKDSDPFYGFVWGlrtlGFVNLFLLIVALVLAKE-RLPHK 269
Cdd:PRK11551 130 eAVGPRL----RGTAVSLMYCGVPFGGALASVIG---VLAAGDAAWRHIFYVG----GVGPLLLVPLLMRWLPEsRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 270 KLNERERAIPTWRRVFN-----TYILQSFDIFGfkdlkyTFCVMgtvfgeisiisgitYF-----TSYAMKQGLSQSDSY 339
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGegratATLLLWISYFF------TLIVL--------------YFllnwlPSLLVGQGLSRSQAG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 340 LLVMVVNLAGIPGRWLPGFFSDIFGRfnVAMITLVFLGIITFVMWLPFATTravlFAFSAIYGFSSGsifsiLPVCCGQI 419
Cdd:PRK11551 259 LVQIAFNIGGALGSLLIGALMDRLRP--RRVVLLIYAGILASLAALAAAPS----FAGMLLAGFAAG-----LFVVGGQS 327
|
330 340 350
....*....|....*....|....*....|....
gi 50310889 420 SKTEEFGRRYSTMYFVVAFGTLVAVPITGAIIGP 453
Cdd:PRK11551 328 VLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGP 361
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
70-230 |
1.44e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 70 PEGGFAA------WLVIFGCFCGFIPVFGMLNTIGVmenFIERNQLSSTSSSTVGWIFSIFSFVnfASCIFSGTYFDRNG 143
Cdd:cd17502 157 PIGGLALallrtiLLSSIFGFLFGGALFGLIYYLPL---YFQLVLGDSATKSGVRLLPLIIGLV--IGSIISGALISKTG 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 144 AKGPLIV-GSVLHVGGLFGMA---NSTELWQFILsFSIVTGLGNGILM-SPLISVPSHYFLVKRGTATAIATTGGSIGGV 218
Cdd:cd17502 232 RYKPLIViGTILMSVGAGLLTtltLDTSKWLLIG-YLILLGLGLGIGFqQPLVAVQNAVPPADVGVATATNTFFRSLGGT 310
|
170
....*....|..
gi 50310889 219 IFPVILRKFFAM 230
Cdd:cd17502 311 LGVAITDVFLVA 322
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
208-488 |
1.76e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 40.76 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 208 IATTGGSIGGVIFPVILRKFFAMEKDSDPFYgFVWGLRTLGFVNLFLLIVALVLAKERLPHKKLNERERAIPTWRRVFNt 287
Cdd:pfam13347 141 FFSVGGGLLAAALAFPLVLILGGTGLERKGY-RIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLK- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 288 yilqsfDIFGFKDLKYTFCVMGTVFGEISIISGIT-YFTSYAMKQGLSQSDSYLLVMVVNLAGIPgrwLPGFFSDIFGRF 366
Cdd:pfam13347 219 ------EVFRNRAFLILLASFLLAALAMGVLNGLLlYYFRYVLGNGFAASAFPLVFTIGALLGIP---LWPPLAKRIGKK 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 367 NVAMITLVFLGIITFVMWLPFATTRAVLFAFSAIYGFSSGSIFSILPVCCGQISKTEEF---GRRYSTMYFVVAFGTLVA 443
Cdd:pfam13347 290 NTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELrtgKRREGTFFAMWSFISKLA 369
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 50310889 444 VPITGAIIGPEKSFKGY---DHYVIWCGVTSFVSAICYMISKTLAVGF 488
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYnagDSVQSPQAVTAIRLLYAVLPAVLFLVAL 417
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
77-186 |
2.12e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.31 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVF------GMLNTIGVMENFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIV 150
Cdd:cd17356 1 LLCAFVSLGGFLFGYdtgsisGILNMKSFQKYFADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 50310889 151 GSVLHVGGLFGMANSTELWQFILSFSIVTGLGNGIL 186
Cdd:cd17356 81 GCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFA 116
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
77-226 |
3.69e-03 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 39.40 E-value: 3.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVMENFI---ERNQLSSTSSSTVGWIFSI-FSFVNFASCIFSgTYFDRNGAKGPLIVGS 152
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLlneQEDQKDQAVQFKTAWVGALaMGMIFFCSPVVS-IFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50310889 153 VLHVGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRK 226
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKM 154
|
|
| COG4262 |
COG4262 |
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ... |
146-271 |
3.75e-03 |
|
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];
Pssm-ID: 443404 [Multi-domain] Cd Length: 426 Bit Score: 39.46 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 146 GPLIVGSVLHVGGLFGMANSTELWQFILSFSIVTGLGNGiLMSPLISVPSHYFLVKRGTAT----AIATTGGSIGGVIFP 221
Cdd:COG4262 82 ALLGGLSALLLFALFAFLLGALFLLALYLLVLLIGLLIG-AEIPLLMRLLERRREELGSAVgrvyAADYLGALVGSLLFP 160
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 50310889 222 VILRkffamekdsdPFYGFVWGLRTLGFVNLFLLIVALVLAKERLPHKKL 271
Cdd:COG4262 161 FLLL----------PALGLVRTALLFGLLNAAVALVLLWLFRKRLRRKAL 200
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
321-408 |
3.86e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 321 ITYFTSYAMKQ-GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMWlpFATTRAVLFAFSA 399
Cdd:COG2270 258 IAFAGIYAAGVlGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAY--FLTTALAFWILGL 335
|
....*....
gi 50310889 400 IYGFSSGSI 408
Cdd:COG2270 336 LIGLVMGGI 344
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
81-262 |
4.93e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 81 FGCFCGFIPVFGMLntigvmenFIERNQLSSTsssTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLF 160
Cdd:cd17341 218 FGSFVGFSNVLPTY--------FKTRFGLPLV---TAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 161 -----GMANSTELWQFILSF---SIVTGLGNGILMSplisVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRKFFAMEk 232
Cdd:cd17341 287 llslsLPTSGTNLVLFLALFvalGLGAGAGNGSVFR----MVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMT- 361
|
170 180 190
....*....|....*....|....*....|
gi 50310889 233 dsdpfygfvwGLRTLGFVNLFLLIVALVLA 262
Cdd:cd17341 362 ----------GSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
77-292 |
5.48e-03 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 39.01 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 77 WLVIFGCFCGFIPVFGMLNTIGVM-----ENFIERNqlSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVG 151
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLfvsllEEFGSKD--DAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 152 SVLHVGGLFGMANSTELWQFILSFSIVTGLGNGILMSPLISVPSHYFLVKRGTATAIATTGGSIGGVIFPVILRkfFAME 231
Cdd:cd17464 80 AAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLR--VLLD 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50310889 232 KdsdpfYGFVWGLRTLGfVNLFLLIVALVLAKERLPHKKLNERERA---IPTWRRVFNTYILQS 292
Cdd:cd17464 158 S-----VGLFNTLRVLC-IFMFVLFLAGFTYKPLVPMKKDKEGKKRkfkCPPLKKIFNFNIWKS 215
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
85-412 |
6.13e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 6.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 85 CGFIPVFGMLNTIGVMENFIERNQLSSTSSSTVGWIFSIFSFVNFASCIFSGTYFDRNGAKGPLIVGSVLHVGGLFGMAN 164
Cdd:cd17330 4 VVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 165 STELWQFILSfSIVTGLGNGilmspLISVPSHYFLV-----KRGTATAIATTGGSIGGVIFPVIlrkffamekdsDPFYG 239
Cdd:cd17330 84 SRNLWLLFLA-RFLDGLTGG-----NVSVAQAYIADitdeeERAKAFGIISAAFGLGFILGPAL-----------GGFLS 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 240 FVWGLRTLGFVNLFLLIVALVLAKerlphkklnereRAIPTWRRVFNTYILQSFDIFGFK-----DLKYTFCVMGTVFGE 314
Cdd:cd17330 147 TPYGYALPFLVAAALALLNLVLVL------------FFLPPLRRLLLVYFLIALAFAGLEsvfslFLKDRFGFSPSQIGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 315 ISIISGITYftsyamkqglsqsdsyllvMVVNLAGIPgrWLPGFFSDIfgrfnVAMITLVFLGIITFVMwLPFATTRAVL 394
Cdd:cd17330 215 LLALVGIAG-------------------ILAQLLLIP--RLAKRLGER-----KLLRLGLLLAIIGLLL-LPFASSVPLL 267
|
330
....*....|....*...
gi 50310889 395 FAFSAIYGFSSGSIFSIL 412
Cdd:cd17330 268 VLAAAILAFGTGIVFPAL 285
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
321-444 |
8.02e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.51 E-value: 8.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 321 ITYFTSYAMKQ--GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITF-VMWL-----PFATTRA 392
Cdd:cd17368 241 TTVYTPTYAKTvlGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYpVFAWltaapSFGRLLL 320
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 50310889 393 VLFAFSAIYGFSSGSIFSILpvccgqiskTEEFGRRYSTMYFVVAFGTLVAV 444
Cdd:cd17368 321 VLLVLSFFFGMYGGAMVVAL---------VELFPVRVRSTGFSLVYALAVAI 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
332-451 |
8.60e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 8.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50310889 332 GLSQSDSYLLVMVVNLAGIPGRWLPGFFSDIFGRFNVAMITLVFLGIITFVMwlPFATTRAVLFAFSAIYGFSSGSIFSI 411
Cdd:COG0477 45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC--GLAPSPELLIAARALQGIGAGGLMPG 122
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 50310889 412 LPVCCGQISKTEEFGRRYSTMYFVVAFGTLVAvPITGAII 451
Cdd:COG0477 123 ALALIAELFPARERGRALGLWGAAIGLGLALG-PLLGGLL 161
|
|
| |
